basal_PTP1B_KO vs wt_MEF (Mouse) [18515860] Gene Set

Dataset SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Gene Perturbations
Category proteomics
Type gene perturbation
Description gene perturbation identified as [gene perturbation]_[cell line] ([organism]) [[publication PMID]] (SILAC Phosphoproteomics)
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Genes

62 proteins differentially phosphorylated following the basal_PTP1B_KO vs wt_MEF (Mouse) [18515860] gene perturbation from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Gene Perturbations dataset.

increased phosphorylation

Symbol Name
ABI1 abl-interactor 1
ADGRL2 adhesion G protein-coupled receptor L2
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ARHGAP12 Rho GTPase activating protein 12
AXL AXL receptor tyrosine kinase
CTNND1 catenin (cadherin-associated protein), delta 1
CTNND2 catenin (cadherin-associated protein), delta 2
CTTN cortactin
DDR2 discoidin domain receptor tyrosine kinase 2
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
EGFR epidermal growth factor receptor
EPHA4 EPH receptor A4
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1
FCHSD2 FCH and double SH3 domains 2
FER fer (fps/fes related) tyrosine kinase
FERMT2 fermitin family member 2
FYN FYN proto-oncogene, Src family tyrosine kinase
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GJA1 gap junction protein, alpha 1, 43kDa
IGF1R insulin-like growth factor 1 receptor
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITSN2 intersectin 2
KIRREL kin of IRRE like (Drosophila)
LAPTM4A lysosomal protein transmembrane 4 alpha
LDLR low density lipoprotein receptor
LPP LIM domain containing preferred translocation partner in lipoma
MAPK1 mitogen-activated protein kinase 1
MEGF10 multiple EGF-like-domains 10
NCK2 NCK adaptor protein 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
OPHN1 oligophrenin 1
PARD3 par-3 family cell polarity regulator
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PEAK1 pseudopodium-enriched atypical kinase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLCG1 phospholipase C, gamma 1
PTK2 protein tyrosine kinase 2
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
PXN paxillin
RAB7A RAB7A, member RAS oncogene family
SDCBP syndecan binding protein (syntenin)
SGK223 homolog of rat pragma of Rnd2
SH3PXD2A SH3 and PX domains 2A
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
ST5 suppression of tumorigenicity 5
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TJP1 tight junction protein 1
TNK2 tyrosine kinase, non-receptor, 2
TNS1 tensin 1
UNC5B unc-5 homolog B (C. elegans)
VAV3 vav 3 guanine nucleotide exchange factor

decreased phosphorylation

Symbol Name
EFNB2 ephrin-B2
EPHB2 EPH receptor B2
EPHB3 EPH receptor B3
EPHB4 EPH receptor B4
GAB1 GRB2-associated binding protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
PDGFA platelet-derived growth factor alpha polypeptide
TNS2 tensin 2
ZDHHC8 zinc finger, DHHC-type containing 8