axon initial segment Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment. (Gene Ontology, GO_0043194)
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Genes

177 proteins co-occuring with the axon initial segment cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 2.70369
SPTBN4 spectrin, beta, non-erythrocytic 4 2.0271
SCN8A sodium channel, voltage gated, type VIII alpha subunit 1.75403
NFASC neurofascin 1.71684
PVALB parvalbumin 1.68909
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2 1.53896
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 1.474
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 1.38294
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 1.17568
FGF14 fibroblast growth factor 14 1.17414
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 1.13983
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 1.13829
NAV1 neuron navigator 1 1.11021
NRCAM neuronal cell adhesion molecule 1.10511
ANK2 ankyrin 2, neuronal 1.099
SCN2A sodium channel, voltage gated, type II alpha subunit 1.06903
ANK1 ankyrin 1, erythrocytic 1.04783
ADGRG2 adhesion G protein-coupled receptor G2 1.00448
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.00202
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 0.982446
AACS acetoacetyl-CoA synthetase 0.968884
RNASE10 ribonuclease, RNase A family, 10 (non-active) 0.951619
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 0.904602
CST8 cystatin 8 (cystatin-related epididymal specific) 0.904138
CALB1 calbindin 1, 28kDa 0.895331
CELF4 CUGBP, Elav-like family member 4 0.86123
CLU clusterin 0.859392
ETV4 ets variant 4 0.858933
HPGDS hematopoietic prostaglandin D synthase 0.852961
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.813946
CALB2 calbindin 2 0.807065
GPHN gephyrin 0.806606
FGF12 fibroblast growth factor 12 0.76726
CCK cholecystokinin 0.764982
CST11 cystatin 11 0.764072
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 0.759524
SCN1A sodium channel, voltage gated, type I alpha subunit 0.748641
SCHIP1 schwannomin interacting protein 1 0.715014
TNR tenascin R 0.712795
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1 0.710136
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 0.709693
ETV5 ets variant 5 0.692955
AQP9 aquaporin 9 0.676368
NLGN2 neuroligin 2 0.67463
CPNE6 copine VI (neuronal) 0.673762
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.666394
SCN2B sodium channel, voltage gated, type II beta subunit 0.633732
SORBS3 sorbin and SH3 domain containing 3 0.628613
PHTF1 putative homeodomain transcription factor 1 0.624355
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9 0.615437
L1CAM L1 cell adhesion molecule 0.612895
CST4 cystatin S 0.607818
CLDN10 claudin 10 0.60655
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2 0.603174
DEFB126 defensin, beta 126 0.587618
ADAM7 ADAM metallopeptidase domain 7 0.575078
ZNF91 zinc finger protein 91 0.559285
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 0.558871
BCAN brevican 0.558042
SYNPO synaptopodin 0.556387
ESR2 estrogen receptor 2 (ER beta) 0.554318
SCN3A sodium channel, voltage gated, type III alpha subunit 0.552664
LCN8 lipocalin 8 0.54936
MRRF mitochondrial ribosome recycling factor 0.545648
MFGE8 milk fat globule-EGF factor 8 protein 0.537005
CLTC clathrin, heavy chain (Hc) 0.533309
CNTN2 contactin 2 (axonal) 0.522659
ZIC4 Zic family member 4 0.513677
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 0.499042
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.497826
AR androgen receptor 0.492561
KIF5C kinesin family member 5C 0.480453
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.478843
FOXD3 forkhead box D3 0.463997
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase 0.459203
ESR1 estrogen receptor 1 0.446069
FGF11 fibroblast growth factor 11 0.438542
HRASLS5 HRAS-like suppressor family, member 5 0.43696
CNTNAP1 contactin associated protein 1 0.433407
SST somatostatin 0.433012
CA2 carbonic anhydrase II 0.431435
SERBP1 SERPINE1 mRNA binding protein 1 0.429859
HEXB hexosaminidase B (beta polypeptide) 0.429072
SLCO4C1 solute carrier organic anion transporter family, member 4C1 0.414164
PROM2 prominin 2 0.412601
SHBG sex hormone-binding globulin 0.41143
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.40714
ARAF A-Raf proto-oncogene, serine/threonine kinase 0.403637
CERKL ceramide kinase-like 0.397423
NVL nuclear VCP-like 0.396648
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 0.389296
FGF17 fibroblast growth factor 17 0.388523
AASS aminoadipate-semialdehyde synthase 0.379276
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.377738
FGF13 fibroblast growth factor 13 0.361277
DOCK7 dedicator of cytokinesis 7 0.360515
DUSP6 dual specificity phosphatase 6 0.359371
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 0.353662
SCN1B sodium channel, voltage gated, type I beta subunit 0.345692
BIN1 bridging integrator 1 0.345314
MFRP membrane frizzled-related protein 0.334356
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 0.331342
HEXA hexosaminidase A (alpha polypeptide) 0.331342
RELN reelin 0.328332
ETV1 ets variant 1 0.326829
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.325702
NCALD neurocalcin delta 0.324201
NAV2 neuron navigator 2 0.320077
LINGO1 leucine rich repeat and Ig domain containing 1 0.317456
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.313344
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.312224
PANX3 pannexin 3 0.311851
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.310358
DNAH8 dynein, axonemal, heavy chain 8 0.307749
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4 0.307749
SCN4A sodium channel, voltage gated, type IV alpha subunit 0.307377
FOXA3 forkhead box A3 0.301425
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.29994
SIN3B SIN3 transcription regulator family member B 0.281821
ADAM28 ADAM metallopeptidase domain 28 0.271167
SPAG11A sperm associated antigen 11A 0.267505
SLC1A7 solute carrier family 1 (glutamate transporter), member 7 0.267505
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 0.261296
RBP1 retinol binding protein 1, cellular 0.257652
SCN10A sodium channel, voltage gated, type X alpha subunit 0.252927
RHBG Rh family, B glycoprotein (gene/pseudogene) 0.252564
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4 0.251476
FGF1 fibroblast growth factor 1 (acidic) 0.250026
FOXA2 forkhead box A2 0.24894
SPAG11B sperm associated antigen 11B 0.243158
TBR1 T-box, brain, 1 0.240996
CSAD cysteine sulfinic acid decarboxylase 0.240636
MEGF6 multiple EGF-like-domains 6 0.239557
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 0.233817
TH tyrosine hydroxylase 0.230958
GYG1 glycogenin 1 0.227397
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 0.227041
CLDN8 claudin 8 0.220673
ADAM22 ADAM metallopeptidase domain 22 0.219265
DLG4 discs, large homolog 4 (Drosophila) 0.218563
CLCN2 chloride channel, voltage-sensitive 2 0.210894
ANXA6 annexin A6 0.206766
NEUROG2 neurogenin 2 0.206766
KIF5B kinesin family member 5B 0.200999
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 0.200663
DUSP5 dual specificity phosphatase 5 0.200328
LCN2 lipocalin 2 0.198991
GOLIM4 golgi integral membrane protein 4 0.195681
SPTBN2 spectrin, beta, non-erythrocytic 2 0.185469
GPER1 G protein-coupled estrogen receptor 1 0.18516
CABP1 calcium binding protein 1 0.184853
ELAVL4 ELAV like neuron-specific RNA binding protein 4 0.184241
RHCG Rh family, C glycoprotein 0.182422
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.178011
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.172735
SPTB spectrin, beta, erythrocytic 0.172201
CA3 carbonic anhydrase III 0.169604
STXBP1 syntaxin binding protein 1 0.169099
SOX1 SRY (sex determining region Y)-box 1 0.167611
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.166884
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 0.165231
TJP1 tight junction protein 1 0.16477
SCTR secretin receptor 0.163865
GPX5 glutathione peroxidase 5 0.163641
KRT5 keratin 5, type II 0.1632
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.161693
NPS neuropeptide S 0.161068
LGI1 leucine-rich, glioma inactivated 1 0.161068
LALBA lactalbumin, alpha- 0.160863
IMMT inner membrane protein, mitochondrial 0.160658
UNK unkempt family zinc finger 0.160254
ZFX zinc finger protein, X-linked 0.159658
PTGDS prostaglandin D2 synthase 21kDa (brain) 0.159658
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit 0.159268
PTPRF protein tyrosine phosphatase, receptor type, F 0.158692
ELAVL2 ELAV like neuron-specific RNA binding protein 2 0.158502
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.157039