autophagic vacuole Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A double-membrane-bounded compartment in which endogenous cellular material is sequestered; known as autophagosome in yeast. (Gene Ontology, GO_0005776)
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Genes

348 proteins co-occuring with the autophagic vacuole cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
BECN1 beclin 1, autophagy related 3.14348
ATG5 autophagy related 5 2.71531
ATG7 autophagy related 7 2.36417
SQSTM1 sequestosome 1 2.34803
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 2.32881
MAP4 microtubule-associated protein 4 2.25662
ATG12 autophagy related 12 2.15444
MTOR mechanistic target of rapamycin (serine/threonine kinase) 2.09109
MAP2 microtubule-associated protein 2 2.06704
MAPT microtubule-associated protein tau 2.06267
ULK1 unc-51 like autophagy activating kinase 1 1.91187
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 1.85593
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.74193
ATG3 autophagy related 3 1.72057
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.70507
LAMP2 lysosomal-associated membrane protein 2 1.58968
ATG14 autophagy related 14 1.53557
UVRAG UV radiation resistance associated 1.52089
GABARAP GABA(A) receptor-associated protein 1.46043
LAMP1 lysosomal-associated membrane protein 1 1.45421
ATG4B autophagy related 4B, cysteine peptidase 1.44516
CTSD cathepsin D 1.39573
NBR1 neighbor of BRCA1 gene 1 1.34174
ACPP acid phosphatase, prostate 1.33413
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha 1.29371
ZFYVE1 zinc finger, FYVE domain containing 1 1.27983
GABARAPL2 GABA(A) receptor-associated protein-like 2 1.25811
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.24917
VMP1 vacuole membrane protein 1 1.21066
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.19828
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.18748
AMBRA1 autophagy/beclin-1 regulator 1 1.13829
WIPI2 WD repeat domain, phosphoinositide interacting 2 1.12654
RB1CC1 RB1-inducible coiled-coil 1 1.11837
GABARAPL1 GABA(A) receptor-associated protein like 1 1.10613
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 1.06195
GAA glucosidase, alpha; acid 1.05287
ATG10 autophagy related 10 1.04984
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 1.02979
CTSB cathepsin B 1.02032
MAP1A microtubule-associated protein 1A 1.01833
CTSS cathepsin S 0.971297
STX17 syntaxin 17 0.96503
BAX BCL2-associated X protein 0.944007
TFEB transcription factor EB 0.93596
TP53INP2 tumor protein p53 inducible nuclear protein 2 0.923259
DRAM1 DNA-damage regulated autophagy modulator 1 0.909251
ATG4A autophagy related 4A, cysteine peptidase 0.90646
ATG4D autophagy related 4D, cysteine peptidase 0.905996
CALCOCO2 calcium binding and coiled-coil domain 2 0.902281
CHMP2B charged multivesicular body protein 2B 0.890245
ATG101 autophagy related 101 0.883782
ANXA5 annexin A5 0.860311
FYCO1 FYVE and coiled-coil domain containing 1 0.852042
CTSL cathepsin L 0.834597
UBQLN1 ubiquilin 1 0.833679
SH3GLB1 SH3-domain GRB2-like endophilin B1 0.83322
RAB24 RAB24, member RAS oncogene family 0.827254
ATG13 autophagy related 13 0.824041
ATG9A autophagy related 9A 0.818075
ATG4C autophagy related 4C, cysteine peptidase 0.79927
TMEM74 transmembrane protein 74 0.793313
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 0.783698
EPGN epithelial mitogen 0.781412
ATG2B autophagy related 2B 0.779583
BCL2L1 BCL2-like 1 0.768627
SCRG1 stimulator of chondrogenesis 1 0.759978
LRRK2 leucine-rich repeat kinase 2 0.759978
TP53 tumor protein p53 0.759524
IRGM immunity-related GTPase family, M 0.756345
INS insulin 0.742318
KIAA0226 KIAA0226 0.722134
GCG glucagon 0.701744
ULK2 unc-51 like autophagy activating kinase 2 0.682899
PI3 peptidase inhibitor 3, skin-derived 0.681155
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 0.668992
BHMT betaine--homocysteine S-methyltransferase 0.665529
WDFY3 WD repeat and FYVE domain containing 3 0.664232
BAG3 BCL2-associated athanogene 3 0.66164
HTT huntingtin 0.64915
OPTN optineurin 0.646574
PTEN phosphatase and tensin homolog 0.631598
VAMP8 vesicle-associated membrane protein 8 0.62393
DIRAS3 DIRAS family, GTP-binding RAS-like 3 0.621804
ATG2A autophagy related 2A 0.620529
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.617982
ATG9B autophagy related 9B 0.614165
TBC1D14 TBC1 domain family, member 14 0.613318
HDAC6 histone deacetylase 6 0.611625
BANF1 barrier to autointegration factor 1 0.610355
WDR45 WD repeat domain 45 0.599802
TM9SF1 transmembrane 9 superfamily member 1 0.590553
TBC1D17 TBC1 domain family, member 17 0.590133
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae) 0.579251
VTI1B vesicle transport through interaction with t-SNAREs 1B 0.577581
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.57008
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2 0.568416
ATP13A2 ATPase type 13A2 0.5597
PARK2 parkin RBR E3 ubiquitin protein ligase 0.5597
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.555973
MCOLN1 mucolipin 1 0.553905
MAP1S microtubule-associated protein 1S 0.553905
TECPR1 tectonin beta-propeller repeat containing 1 0.541117
FTL ferritin, light polypeptide 0.53906
IGKV3-20 immunoglobulin kappa variable 3-20 0.538649
SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 0.538238
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae) 0.533309
PRNP prion protein 0.532078
RPTOR regulatory associated protein of MTOR, complex 1 0.522659
FTH1 ferritin, heavy polypeptide 1 0.52225
NCOA4 nuclear receptor coactivator 4 0.521023
RAB33B RAB33B, member RAS oncogene family 0.516532
DAP death-associated protein 0.513677
LYG2 lysozyme G-like 2 0.51164
VCP valosin containing protein 0.510011
MTMR14 myotubularin related protein 14 0.507163
RHEB Ras homolog enriched in brain 0.50635
DNTT DNA nucleotidylexotransferase 0.504724
IGF2R insulin-like growth factor 2 receptor 0.502288
DNAH8 dynein, axonemal, heavy chain 8 0.501476
NRBF2 nuclear receptor binding factor 2 0.501476
MTM1 myotubularin 1 0.50107
TIGAR TP53 induced glycolysis regulatory phosphatase 0.486904
DAPK1 death-associated protein kinase 1 0.48287
APP amyloid beta (A4) precursor protein 0.479647
PSEN1 presenilin 1 0.477636
PARP1 poly (ADP-ribose) polymerase 1 0.471609
HMGB1 high mobility group box 1 0.471208
RAB1A RAB1A, member RAS oncogene family 0.468401
BCL2 B-cell CLL/lymphoma 2 0.466399
M6PR mannose-6-phosphate receptor (cation dependent) 0.462398
BRWD1 bromodomain and WD repeat domain containing 1 0.457208
ASB10 ankyrin repeat and SOCS box containing 10 0.452825
DAPK2 death-associated protein kinase 2 0.434985
ARSH arylsulfatase family, member H 0.433012
IRG1 immunoresponsive 1 homolog (mouse) 0.429465
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 0.418468
FOXO3 forkhead box O3 0.409089
GIMAP6 GTPase, IMAP family member 6 0.408699
SOD2 superoxide dismutase 2, mitochondrial 0.406361
SNX18 sorting nexin 18 0.406361
RALB v-ral simian leukemia viral oncogene homolog B 0.404026
HSPA8 heat shock 70kDa protein 8 0.401304
NPC1 Niemann-Pick disease, type C1 0.398587
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.397811
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.39471
NOD2 nucleotide-binding oligomerization domain containing 2 0.393936
ERN1 endoplasmic reticulum to nucleus signaling 1 0.391615
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.388909
TLR4 toll-like receptor 4 0.387751
VAMP3 vesicle-associated membrane protein 3 0.380814
HSPB8 heat shock 22kDa protein 8 0.377738
CD4 CD4 molecule 0.377738
RAB33A RAB33A, member RAS oncogene family 0.37697
DCAF17 DDB1 and CUL4 associated factor 17 0.37505
PGRMC1 progesterone receptor membrane component 1 0.374666
PNPLA5 patatin-like phospholipase domain containing 5 0.370833
C10ORF10 chromosome 10 open reading frame 10 0.368919
KEAP1 kelch-like ECH-associated protein 1 0.366623
SERPINA13P serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 13, pseudogene 0.365859
JUN jun proto-oncogene 0.359752
SPNS1 spinster homolog 1 (Drosophila) 0.353662
GUSB glucuronidase, beta 0.351382
SNAPIN SNAP-associated protein 0.349863
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.349105
CDKL3 cyclin-dependent kinase-like 3 0.343421
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 0.341529
SIRT1 sirtuin 1 0.336996
EGFR epidermal growth factor receptor 0.334733
COMTD1 catechol-O-methyltransferase domain containing 1 0.334356
C9ORF72 chromosome 9 open reading frame 72 0.328708
WNK2 WNK lysine deficient protein kinase 2 0.325702
DOCK3 dedicator of cytokinesis 3 0.324576
OSBPL7 oxysterol binding protein-like 7 0.32345
ZFYVE26 zinc finger, FYVE domain containing 26 0.3227
SPINK1 serine peptidase inhibitor, Kazal type 1 0.322325
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 0.32195
MAPK14 mitogen-activated protein kinase 14 0.318953
TECPR2 tectonin beta-propeller repeat containing 2 0.317082
RNF185 ring finger protein 185 0.31596
HSPA4 heat shock 70kDa protein 4 0.311105
CAT catalase 0.309986
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.308122
TP53INP1 tumor protein p53 inducible nuclear protein 1 0.30626
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase 0.305888
CLN3 ceroid-lipofuscinosis, neuronal 3 0.304771
HDAC10 histone deacetylase 10 0.304771
ACBD5 acyl-CoA binding domain containing 5 0.304399
SNX13 sorting nexin 13 0.298084
ZC3H12A zinc finger CCCH-type containing 12A 0.295489
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1 0.295119
LRPPRC leucine-rich pentatricopeptide repeat containing 0.295119
GLB1 galactosidase, beta 1 0.290308
TRIM13 tripartite motif containing 13 0.286983
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 0.285507
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant 0.282926
REG3G regenerating islet-derived 3 gamma 0.280349
SIL1 SIL1 nucleotide exchange factor 0.275569
NBEAL2 neurobeachin-like 2 0.274468
RTP2 receptor (chemosensory) transporter protein 2 0.271167
PIKFYVE phosphoinositide kinase, FYVE finger containing 0.269701
DDIT3 DNA-damage-inducible transcript 3 0.268969
CAPNS1 calpain, small subunit 1 0.267871
BAG1 BCL2-associated athanogene 0.265311
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 0.263485
PTP4A3 protein tyrosine phosphatase type IVA, member 3 0.26166
NSF N-ethylmaleimide-sensitive factor 0.256197
VAC14 Vac14 homolog (S. cerevisiae) 0.255107
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.250389
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.249664
TLR9 toll-like receptor 9 0.243879
FADD Fas (TNFRSF6)-associated via death domain 0.240996
MAP1B microtubule-associated protein 1B 0.240276
TSC2 tuberous sclerosis 2 0.239557
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 0.239197
LYST lysosomal trafficking regulator 0.237401
ESR1 estrogen receptor 1 0.237401
UBA6 ubiquitin-like modifier activating enzyme 6 0.236324
FOXO1 forkhead box O1 0.235966
UBQLN4 ubiquilin 4 0.235607
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.231315
ATF4 activating transcription factor 4 0.228819
HMOX1 heme oxygenase 1 0.227041
TBKBP1 TBK1 binding protein 1 0.226686
MYD88 myeloid differentiation primary response 88 0.225267
TARDBP TAR DNA binding protein 0.225267
ATXN3 ataxin 3 0.224558
UBQLN2 ubiquilin 2 0.222436
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 0.221025
RAB7A RAB7A, member RAS oncogene family 0.220321
SLC25A30 solute carrier family 25, member 30 0.219969
AP4B1 adaptor-related protein complex 4, beta 1 subunit 0.214366
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon 0.210549
TFRC transferrin receptor 0.209169
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.208137
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta 0.206423
FNIP2 folliculin interacting protein 2 0.205399
SUMF1 sulfatase modifying factor 1 0.203361
SPHK1 sphingosine kinase 1 0.202684
FNIP1 folliculin interacting protein 1 0.200999
TRIM50 tripartite motif containing 50 0.198991
ACP2 acid phosphatase 2, lysosomal 0.198325
SCOC short coiled-coil protein 0.198325
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae) 0.194698
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) 0.194698
LGALS8 lectin, galactoside-binding, soluble, 8 0.194371
MAPK8 mitogen-activated protein kinase 8 0.194045
ALB albumin 0.191456
TBC1D5 TBC1 domain family, member 5 0.191135
PARP10 poly (ADP-ribose) polymerase family, member 10 0.185469
GBP1 guanylate binding protein 1, interferon-inducible 0.184853
ASS1 argininosuccinate synthase 1 0.184853
HSPA1B heat shock 70kDa protein 1B 0.183025
PEG3 paternally expressed 3 0.182122
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 0.181823
NLRP10 NLR family, pyrin domain containing 10 0.180045
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 0.178877
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.178299
BBC3 BCL2 binding component 3 0.178011
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.177439
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 0.177439
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 0.176024
CLEC16A C-type lectin domain family 16, member A 0.175745
ACIN1 apoptotic chromatin condensation inducer 1 0.174911
RPS6 ribosomal protein S6 0.174635
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor 0.173273
FUNDC1 FUN14 domain containing 1 0.172201
TBC1D15 TBC1 domain family, member 15 0.171937
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae) 0.170888
TPCN2 two pore segment channel 2 0.170888
CRYAB crystallin, alpha B 0.170114
MAVS mitochondrial antiviral signaling protein 0.170114
MTMR3 myotubularin related protein 3 0.169604
ALS2 amyotrophic lateral sclerosis 2 (juvenile) 0.168598
EXOC2 exocyst complex component 2 0.168349
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.167611
PRSS3 protease, serine, 3 0.167366
NQO1 NAD(P)H dehydrogenase, quinone 1 0.166405
WAC WW domain containing adaptor with coiled-coil 0.165932
RAB1B RAB1B, member RAS oncogene family 0.165932
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 0.165463
MIR137 microRNA 137 0.165463
CDC16 cell division cycle 16 0.165
CSNK1A1 casein kinase 1, alpha 1 0.163641
DMD dystrophin 0.163641
IFNG interferon, gamma 0.16342
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.162763
SVIP small VCP/p97-interacting protein 0.162546
UBE2A ubiquitin-conjugating enzyme E2A 0.162546
DNM1L dynamin 1-like 0.16233
IGF1 insulin-like growth factor 1 (somatomedin C) 0.162117
GOPC golgi-associated PDZ and coiled-coil motif containing 0.161693
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 0.161275
PLD1 phospholipase D1, phosphatidylcholine-specific 0.160863
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.160658
NEK4 NIMA-related kinase 4 0.160456
PCDH17 protocadherin 17 0.159074
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.158502
IK IK cytokine, down-regulator of HLA II 0.158439
STX12 syntaxin 12 0.157943
ONECUT3 one cut homeobox 3 0.157397
RPL28 ribosomal protein L28 0.157397
AEN apoptosis enhancing nuclease 0.156863
CA3 carbonic anhydrase III 0.143806
TSN translin 0.141481
TPPP tubulin polymerization promoting protein 0.141152
LGMN legumain 0.14103
HCFC1 host cell factor C1 0.140757
EI24 etoposide induced 2.4 0.139372
CISH cytokine inducible SH2-containing protein 0.138905
MAP2K2 mitogen-activated protein kinase kinase 2 0.138502
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein 0.138437
CPNE1 copine I 0.138225
VAMP5 vesicle-associated membrane protein 5 0.137964
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.137341
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 0.136839
DCTN2 dynactin 2 (p50) 0.136511
DIRC2 disrupted in renal carcinoma 2 0.136098
RAB12 RAB12, member RAS oncogene family 0.136002
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 0.135743
CERS1 ceramide synthase 1 0.135522
BAMBI BMP and activin membrane-bound inhibitor 0.135443
RAB8A RAB8A, member RAS oncogene family 0.134958
CSTB cystatin B (stefin B) 0.134682
RAB27A RAB27A, member RAS oncogene family 0.134284
SEC31A SEC31 homolog A (S. cerevisiae) 0.133509
EXOC3 exocyst complex component 3 0.133163
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta 0.133106
TSKU tsukushi, small leucine rich proteoglycan 0.132731
CD164 CD164 molecule, sialomucin 0.132448
PSAP prosaposin 0.132296
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 0.132296
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.131763
HLA-B major histocompatibility complex, class I, B 0.131535
NPPB natriuretic peptide B 0.131319
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.130944
DCLK3 doublecortin-like kinase 3 0.130117
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 0.129872
ITCH itchy E3 ubiquitin protein ligase 0.129543
MT3 metallothionein 3 0.129503
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.129444
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) 0.129325
NPPA natriuretic peptide A 0.129103
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 0.129062
FASLG Fas ligand (TNF superfamily, member 6) 0.128624
TGM2 transglutaminase 2 0.128517
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.128344
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.128235