autoimmune response Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description condition in which cells and/or antibodies arise from and are directed against one's own tissues (Mammalian Phenotype Ontology, MP_0001844)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001844
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Genes

301 gene mutations causing the autoimmune response phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACAN aggrecan
ACKR4 atypical chemokine receptor 4
ADAM8 ADAM metallopeptidase domain 8
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AIF1 allograft inflammatory factor 1
AIRE autoimmune regulator
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APCS amyloid P component, serum
APOE apolipoprotein E
ARID5A AT rich interactive domain 5A (MRF1-like)
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
B2M beta-2-microglobulin
BATF basic leucine zipper transcription factor, ATF-like
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BHLHE40 basic helix-loop-helix family, member e40
BLNK B-cell linker
BMX BMX non-receptor tyrosine kinase
BTK Bruton agammaglobulinemia tyrosine kinase
BTLA B and T lymphocyte associated
C1QA complement component 1, q subcomponent, A chain
C1QTNF3 C1q and tumor necrosis factor related protein 3
C3 complement component 3
C3AR1 complement component 3a receptor 1
C4A complement component 4A (Rodgers blood group)
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL13 chemokine (C-C motif) ligand 13
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR6 chemokine (C-C motif) receptor 6
CCR7 chemokine (C-C motif) receptor 7
CCR8 chemokine (C-C motif) receptor 8
CD19 CD19 molecule
CD1D CD1d molecule
CD200 CD200 molecule
CD22 CD22 molecule
CD247 CD247 molecule
CD274 CD274 molecule
CD276 CD276 molecule
CD28 CD28 molecule
CD300LF CD300 molecule-like family member f
CD38 CD38 molecule
CD4 CD4 molecule
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD5 CD5 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD69 CD69 molecule
CD72 CD72 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD79A CD79a molecule, immunoglobulin-associated alpha
CD86 CD86 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CFP complement factor properdin
CIITA class II, major histocompatibility complex, transactivator
CLEC4D C-type lectin domain family 4, member D
CLEC4E C-type lectin domain family 4, member E
CLEC5A C-type lectin domain family 5, member A
CNTF ciliary neurotrophic factor
CORO1A coronin, actin binding protein, 1A
CR2 complement component (3d/Epstein Barr virus) receptor 2
CRH corticotropin releasing hormone
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTSB cathepsin B
CTSS cathepsin S
CTSV cathepsin V
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCR2 chemokine (C-X-C motif) receptor 2
CYSLTR2 cysteinyl leukotriene receptor 2
CYTL1 cytokine-like 1
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DNASE1 deoxyribonuclease I
DTX1 deltex 1, E3 ubiquitin ligase
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP2 dual specificity phosphatase 2
E2F1 E2F transcription factor 1
E2F2 E2F transcription factor 2
ECM1 extracellular matrix protein 1
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPHB6 EPH receptor B6
ESR1 estrogen receptor 1
F2 coagulation factor II (thrombin)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBN1 fibrillin 1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCMR Fc fragment of IgM receptor
FCRLB Fc receptor-like B
FFAR2 free fatty acid receptor 2
FOXP3 forkhead box P3
FPR2 formyl peptide receptor 2
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA1 GATA binding protein 1 (globin transcription factor 1)
GHR growth hormone receptor
GHRH growth hormone releasing hormone
GHRHR growth hormone releasing hormone receptor
GPR132 G protein-coupled receptor 132
GPSM3 G-protein signaling modulator 3
GPX7 glutathione peroxidase 7
HAVCR1 hepatitis A virus cellular receptor 1
HCST hematopoietic cell signal transducer
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-E major histocompatibility complex, class I, E
HR hair growth associated
HRH3 histamine receptor H3
ICA1 islet cell autoantigen 1, 69kDa
ICOS inducible T-cell co-stimulator
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IGHM immunoglobulin heavy constant mu
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL10RA interleukin 10 receptor, alpha
IL12RB2 interleukin 12 receptor, beta 2
IL13 interleukin 13
IL17A interleukin 17A
IL17C interleukin 17C
IL17F interleukin 17F
IL17RC interleukin 17 receptor C
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL21 interleukin 21
IL21R interleukin 21 receptor
IL23A interleukin 23, alpha subunit p19
IL23R interleukin 23 receptor
IL25 interleukin 25
IL27 interleukin 27
IL27RA interleukin 27 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL4 interleukin 4
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
IL9R interleukin 9 receptor
INS insulin
IRAK1 interleukin-1 receptor-associated kinase 1
IRF1 interferon regulatory factor 1
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
JAK1 Janus kinase 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KSR1 kinase suppressor of ras 1
LAT linker for activation of T cells
LAT2 linker for activation of T cells family, member 2
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LEPR leptin receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS9B lectin, galactoside-binding, soluble, 9B
LIG4 ligase IV, DNA, ATP-dependent
LTA lymphotoxin alpha
LTB4R leukotriene B4 receptor
LTB4R2 leukotriene B4 receptor 2
LTC4S leukotriene C4 synthase
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAPK3 mitogen-activated protein kinase 3
MBP myelin basic protein
MERTK MER proto-oncogene, tyrosine kinase
MIR140 microRNA 140
MIR210 microRNA 210
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MOG myelin oligodendrocyte glycoprotein
MPG N-methylpurine-DNA glycosylase
MPO myeloperoxidase
MPZ myelin protein zero
MR1 major histocompatibility complex, class I-related
MT-ND2 MTND2
MTA2 metastasis associated 1 family, member 2
MTUS1 microtubule associated tumor suppressor 1
MUC19 mucin 19, oligomeric
MYD88 myeloid differentiation primary response 88
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NGFR nerve growth factor receptor
NINJ1 ninjurin 1
NLRP10 NLR family, pyrin domain containing 10
NLRP3 NLR family, pyrin domain containing 3
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PADI2 peptidyl arginine deiminase, type II
PDCD1 programmed cell death 1
PDCD1LG2 programmed cell death 1 ligand 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PECAM1 platelet/endothelial cell adhesion molecule 1
PGAP3 post-GPI attachment to proteins 3
PGLYRP1 peptidoglycan recognition protein 1
PGLYRP2 peptidoglycan recognition protein 2
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PKN1 protein kinase N1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLAU plasminogen activator, urokinase
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLCL2 phospholipase C-like 2
POLB polymerase (DNA directed), beta
PPARG peroxisome proliferator-activated receptor gamma
PRF1 perforin 1 (pore forming protein)
PRKCD protein kinase C, delta
PRKCQ protein kinase C, theta
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRN protein tyrosine phosphatase, receptor type, N
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RAG1 recombination activating gene 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASGRP4 RAS guanyl releasing protein 4
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RC3H1 ring finger and CCCH-type domains 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RFTN1 raftlin, lipid raft linker 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SCARA5 scavenger receptor class A, member 5
SCARF1 scavenger receptor class F, member 1
SELL selectin L
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SHCBP1 SHC SH2-domain binding protein 1
SIAE sialic acid acetylesterase
SIGLEC10 sialic acid binding Ig-like lectin 10
SIRT1 sirtuin 1
SIT1 signaling threshold regulating transmembrane adaptor 1
SKAP2 src kinase associated phosphoprotein 2
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SOCS3 suppressor of cytokine signaling 3
SOD3 superoxide dismutase 3, extracellular
SPN sialophorin
SPP1 secreted phosphoprotein 1
STAT4 signal transducer and activator of transcription 4
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK17B serine/threonine kinase 17b
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYK spleen tyrosine kinase
SYT7 synaptotagmin VII
SYVN1 synovial apoptosis inhibitor 1, synoviolin
TANK TRAF family member-associated NFKB activator
TBC1D10C TBC1 domain family, member 10C
TBX21 T-box 21
THBS1 thrombospondin 1
TIGIT T cell immunoreceptor with Ig and ITIM domains
TIMD4 T-cell immunoglobulin and mucin domain containing 4
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNIP1 TNFAIP3 interacting protein 1
TPSAB1 tryptase alpha/beta 1
TRAF3IP2 TRAF3 interacting protein 2
TREX1 three prime repair exonuclease 1
TRIM21 tripartite motif containing 21
TROVE2 TROVE domain family, member 2
TSC22D3 TSC22 domain family, member 3
TUSC2 tumor suppressor candidate 2
TYK2 tyrosine kinase 2
TYROBP TYRO protein tyrosine kinase binding protein
UNC93B1 unc-93 homolog B1 (C. elegans)
USP25 ubiquitin specific peptidase 25
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VTCN1 V-set domain containing T cell activation inhibitor 1
VWF von Willebrand factor
WAS Wiskott-Aldrich syndrome
XCL1 chemokine (C motif) ligand 1
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZC3H12A zinc finger CCCH-type containing 12A
ZC3H12D zinc finger CCCH-type containing 12D