attention deficit hyperactivity disorder Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A specific developmental disorder that is characterized by co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone and symptoms starting before seven years of age. (Human Disease Ontology, DOID_1094)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0007018
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Genes

265 genes associated with the attention deficit hyperactivity disorder phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
TRIM26 tripartite motif containing 26 1.54733
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 1.53903
MIR137HG MIR137 host gene 1.48419
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 1.32793
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 1.30781
SYNE1 spectrin repeat containing, nuclear envelope 1 1.29386
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 1.28282
ZNRD1 zinc ribbon domain containing 1 1.25845
MOBP myelin-associated oligodendrocyte basic protein 1.24751
GPC6 glypican 6 1.24751
NT5C2 5'-nucleotidase, cytosolic II 1.24751
AS3MT arsenite methyltransferase 1.24751
TENM4 teneurin transmembrane protein 4 1.18704
CSMD1 CUB and Sushi multiple domains 1 1.18704
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 1.18704
AK8 adenylate kinase 8 1.17192
ITGA11 integrin, alpha 11 1.15352
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 1.15352
ASTN2 astrotactin 2 1.15352
DPCR1 diffuse panbronchiolitis critical region 1 1.12851
TCF4 transcription factor 4 1.12851
CFAP221 cilia and flagella associated protein 221 1.11203
CSMD2 CUB and Sushi multiple domains 2 1.08774
RERE arginine-glutamic acid dipeptide (RE) repeats 1.08774
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) 1.07729
BRD2 bromodomain containing 2 1.07729
PRKG1 protein kinase, cGMP-dependent, type I 1.07407
MIR99AHG mir-99a-let-7c cluster host gene 1.0674
EMP2 epithelial membrane protein 2 1.0674
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 1.05869
PIWIL4 piwi-like RNA-mediated gene silencing 4 1.05066
CEP112 centrosomal protein 112kDa 1.04365
CPLX2 complexin 2 1.04365
GRM5 glutamate receptor, metabotropic 5 1.04365
MAN2A2 mannosidase, alpha, class 2A, member 2 1.04365
FERMT3 fermitin family member 3 1.04365
NUCB1 nucleobindin 1 1.02683
FLNC filamin C, gamma 1.00155
BMPR1B bone morphogenetic protein receptor, type IB 1.00059
KIF6 kinesin family member 6 1.00059
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 1.00059
PALB2 partner and localizer of BRCA2 1.00059
MAP1B microtubule-associated protein 1B 1.00059
TLL2 tolloid-like 2 1.00059
KIF21B kinesin family member 21B 1.00059
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 1.00059
DNM1 dynamin 1 1.00059
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 0.969694
PTCD3 pentatricopeptide repeat domain 3 0.969417
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.969142
GPR139 G protein-coupled receptor 139 0.969142
NCKAP5 NCK-associated protein 5 0.969142
ZNF423 zinc finger protein 423 0.969142
CHMP7 charged multivesicular body protein 7 0.964624
TRPT1 tRNA phosphotransferase 1 0.942765
MMP24 matrix metallopeptidase 24 (membrane-inserted) 0.942765
STIP1 stress-induced phosphoprotein 1 0.942765
IL16 interleukin 16 0.942765
LRRC7 leucine rich repeat containing 7 0.942765
NAV2 neuron navigator 2 0.942765
UNC5B unc-5 homolog B (C. elegans) 0.942765
PAWR PRKC, apoptosis, WT1, regulator 0.942765
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 0.942765
CFAP43 cilia and flagella associated protein 43 0.942765
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.942765
MAPRE1 microtubule-associated protein, RP/EB family, member 1 0.942765
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.942765
NHEG1 neuroblastoma highly expressed 1 0.938866
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.926524
GRIK1 glutamate receptor, ionotropic, kainate 1 0.919744
KIRREL3 kin of IRRE like 3 (Drosophila) 0.919744
PARD3B par-3 family cell polarity regulator beta 0.919744
C2ORF82 chromosome 2 open reading frame 82 0.919744
KMT2A lysine (K)-specific methyltransferase 2A 0.919744
NT5DC3 5'-nucleotidase domain containing 3 0.919744
CREB5 cAMP responsive element binding protein 5 0.919744
FTSJ2 FtsJ RNA methyltransferase homolog 2 (E. coli) 0.919744
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.919744
ZMIZ1 zinc finger, MIZ-type containing 1 0.919744
ARSB arylsulfatase B 0.919744
EFCAB8 EF-hand calcium binding domain 8 0.919744
GLT8D1 glycosyltransferase 8 domain containing 1 0.919744
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.919744
MARK2 MAP/microtubule affinity-regulating kinase 2 0.917141
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 0.91506
KCNIP4 Kv channel interacting protein 4 0.911485
FGF14 fibroblast growth factor 14 0.905894
TCERG1L transcription elongation regulator 1-like 0.904931
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.899912
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 0.899912
FOXP1 forkhead box P1 0.899912
TRIO trio Rho guanine nucleotide exchange factor 0.886919
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.882984
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 0.882984
PKD1L2 polycystic kidney disease 1-like 2 (gene/pseudogene) 0.882984
SULF2 sulfatase 2 0.882984
PKD1L3 polycystic kidney disease 1-like 3 0.882984
MYRFL myelin regulatory factor-like 0.882984
CDH13 cadherin 13 0.882984
PRPF3 pre-mRNA processing factor 3 0.882984
NEURL1 neuralized E3 ubiquitin protein ligase 1 0.882984
CLEC17A C-type lectin domain family 17, member A 0.882984
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 0.874717
MYT1L myelin transcription factor 1-like 0.868241
ZNF544 zinc finger protein 544 0.868241
ZNF804A zinc finger protein 804A 0.868241
CRYGC crystallin, gamma C 0.868241
ELOVL6 ELOVL fatty acid elongase 6 0.868241
LOC100652824 0.868241
NOS1 nitric oxide synthase 1 (neuronal) 0.868241
FHIT fragile histidine triad 0.868241
HDAC4 histone deacetylase 4 0.868241
LOC344887 NmrA-like family domain containing 1 pseudogene 0.868241
REEP5 receptor accessory protein 5 0.868241
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.86321
ATXN2 ataxin 2 0.860123
SH2B3 SH2B adaptor protein 3 0.856413
CELF2 CUGBP, Elav-like family member 2 0.855449
RGL1 ral guanine nucleotide dissociation stimulator-like 1 0.855449
NAPRT nicotinate phosphoribosyltransferase 0.855449
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.855449
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 0.853789
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 0.844241
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.843198
HK1 hexokinase 1 0.840142
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.840142
NXPH1 neurexophilin 1 0.839148
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.838165
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 0.833415
PHF2P1 PHD finger protein 2 pseudogene 1 0.833415
AGBL1 ATP/GTP binding protein-like 1 0.828053
PLXNA2 plexin A2 0.823019
PLCL1 phospholipase C-like 1 0.819829
DOCK10 dedicator of cytokinesis 10 0.819829
FURIN furin (paired basic amino acid cleaving enzyme) 0.81601
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.811465
ZNF75A zinc finger protein 75a 0.806402
ATXN1 ataxin 1 0.801631
DOCK9 dedicator of cytokinesis 9 0.801631
PTPRJ protein tyrosine phosphatase, receptor type, J 0.799025
DHCR7 7-dehydrocholesterol reductase 0.797753
ERICH3 glutamate-rich 3 0.793451
PTPRG protein tyrosine phosphatase, receptor type, G 0.789144
YAE1D1 Yae1 domain containing 1 0.787244
IL20RA interleukin 20 receptor, alpha 0.785384
TLL1 tolloid-like 1 0.783563
WIPI1 WD repeat domain, phosphoinositide interacting 1 0.77023
GRID2 glutamate receptor, ionotropic, delta 2 0.768197
LOC100132891 0.765174
NADSYN1 NAD synthetase 1 0.760868
DCLK1 doublecortin-like kinase 1 0.758275
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) 0.757258
AAA1 aortic aneurysm, familial abdominal 1 0.742794
PRUNE2 prune homolog 2 (Drosophila) 0.742794
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 0.741086
PEX5L peroxisomal biogenesis factor 5-like 0.739827
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 0.738137
SLIT1 slit homolog 1 (Drosophila) 0.737224
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.737224
GPX6 glutathione peroxidase 6 0.735423
ATP11A ATPase, class VI, type 11A 0.732349
XPO1 exportin 1 0.730636
MYBPC1 myosin binding protein C, slow type 0.7273
NRXN1 neurexin 1 0.721344
TRIOBP TRIO and F-actin binding protein 0.72096
MAP2K3 mitogen-activated protein kinase kinase 3 0.71502
XKR3 XK, Kell blood group complex subunit-related family, member 3 0.713947
MED27 mediator complex subunit 27 0.70533
ALDH1L1-AS2 ALDH1L1 antisense RNA 2 0.704969
KANK2 KN motif and ankyrin repeat domains 2 0.702479
HKDC1 hexokinase domain containing 1 0.699367
ACSL1 acyl-CoA synthetase long-chain family member 1 0.698351
LOC63930 uncharacterized LOC63930 0.698351
ITGA1 integrin, alpha 1 0.698015
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I 0.697346
ZNF385B zinc finger protein 385B 0.696021
GRM7 glutamate receptor, metabotropic 7 0.692786
NPAS3 neuronal PAS domain protein 3 0.689656
PUM2 pumilio RNA-binding family member 2 0.685732
HDGFRP3 hepatoma-derived growth factor, related protein 3 0.67722
THSD7B thrombospondin, type I, domain containing 7B 0.674532
STX8 syntaxin 8 0.66742
CNTNAP5 contactin associated protein-like 5 0.66391
NSD1 nuclear receptor binding SET domain protein 1 0.656743
ADAMTSL1 ADAMTS-like 1 0.656005
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 0.655516
CALCR calcitonin receptor 0.652159
KCNIP1 Kv channel interacting protein 1 0.647116
RORA RAR-related orphan receptor A 0.646616
CCSER1 coiled-coil serine-rich protein 1 0.646616
LHFP lipoma HMGIC fusion partner 0.645871
LENG8 leukocyte receptor cluster (LRC) member 8 0.644396
RYR3 ryanodine receptor 3 0.641745
NTM neurotrimin 0.637775
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 0.631333
RUFY4 RUN and FYVE domain containing 4 0.624865
CNTN5 contactin 5 0.62426
FLRT2 fibronectin leucine rich transmembrane protein 2 0.622863
CDCP1 CUB domain containing protein 1 0.617271
XKR4 XK, Kell blood group complex subunit-related family, member 4 0.614779
SAMD3 sterile alpha motif domain containing 3 0.61421
KCTD1 potassium channel tetramerization domain containing 1 0.609951
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 0.607266
IQGAP2 IQ motif containing GTPase activating protein 2 0.600105
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain 0.599776
UVRAG UV radiation resistance associated 0.597666
TNR tenascin R 0.597185
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 0.596548
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 0.596389
MYO5B myosin VB 0.596231
TMEM132B transmembrane protein 132B 0.593729
NUAK1 NUAK family, SNF1-like kinase, 1 0.593575
STC2 stanniocalcin 2 0.59159
HNF1B HNF1 homeobox B 0.587303
SLC38A1 solute carrier family 38, member 1 0.586582
NUMB numb homolog (Drosophila) 0.585136
SIRPB1 signal-regulatory protein beta 1 0.58452
GPC5 glypican 5 0.582698
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.582578
DSCC1 DNA replication and sister chromatid cohesion 1 0.582219
ADCK1 aarF domain containing kinase 1 0.581861
LRP1B low density lipoprotein receptor-related protein 1B 0.581031
TP53BP1 tumor protein p53 binding protein 1 0.581031
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like 0.57836
ADCY10 adenylate cyclase 10 (soluble) 0.577224
NXN nucleoredoxin 0.574229
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.573361
AKAP6 A kinase (PRKA) anchor protein 6 0.570703
KRT71 keratin 71, type II 0.569663
CRTAC1 cartilage acidic protein 1 0.564644
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.560832
IRAK2 interleukin-1 receptor-associated kinase 2 0.560832
ZNF516 zinc finger protein 516 0.559371
COX7B2 cytochrome c oxidase subunit VIIb2 0.557335
NCAM2 neural cell adhesion molecule 2 0.557335
CADPS2 Ca++-dependent secretion activator 2 0.556012
CPLX4 complexin 4 0.55536
ZNF385D zinc finger protein 385D 0.552194
MFSD9 major facilitator superfamily domain containing 9 0.549174
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 0.54245
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 0.54245
CPA1 carboxypeptidase A1 (pancreatic) 0.54245
MAP1A microtubule-associated protein 1A 0.541565
ZFAT zinc finger and AT hook domain containing 0.53828
E2F3 E2F transcription factor 3 0.53828
KSR2 kinase suppressor of ras 2 0.53828
CPA5 carboxypeptidase A5 0.53828
MAST3 microtubule associated serine/threonine kinase 3 0.537883
EMP3 epithelial membrane protein 3 0.537883
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 0.534811
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.534439
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.53407
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 0.532619
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 0.531908
CLECL1 C-type lectin-like 1 0.529158
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) 0.528162
CASC15 cancer susceptibility candidate 15 (non-protein coding) 0.526276
POU6F2 POU class 6 homeobox 2 0.52536
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2 0.525058
LOC100506023 uncharacterized LOC100506023 0.525058
SARDH sarcosine dehydrogenase 0.524758
GRIK4 glutamate receptor, ionotropic, kainate 4 0.512994
PPP1R1C protein phosphatase 1, regulatory (inhibitor) subunit 1C 0.504316
GFI1B growth factor independent 1B transcription repressor 0.50044
DENND3 DENN/MADD domain containing 3 0.493212