atherosclerosis Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
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Genes

354 genes associated with the disease atherosclerosis in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5
ACE angiotensin I converting enzyme
ACTA1 actin, alpha 1, skeletal muscle
ADAM33 ADAM metallopeptidase domain 33
ADAM8 ADAM metallopeptidase domain 8
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADORA2A adenosine A2a receptor
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX12 arachidonate 12-lipoxygenase
ALOX15 arachidonate 15-lipoxygenase
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMPD1 adenosine monophosphate deaminase 1
AMPD2 adenosine monophosphate deaminase 2
APCS amyloid P component, serum
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOA4 apolipoprotein A-IV
APOA5 apolipoprotein A-V
APOB apolipoprotein B
APOC2 apolipoprotein C-II
APOC3 apolipoprotein C-III
APOE apolipoprotein E
AR androgen receptor
ATG9B autophagy related 9B
AXL AXL receptor tyrosine kinase
BHMT betaine--homocysteine S-methyltransferase
BHMT2 betaine--homocysteine S-methyltransferase 2
BLVRA biliverdin reductase A
C2 complement component 2
C3 complement component 3
C5 complement component 5
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CAMLG calcium modulating ligand
CANT1 calcium activated nucleotidase 1
CAPN10 calpain 10
CAPN5 calpain 5
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CBS cystathionine-beta-synthase
CCL11 chemokine (C-C motif) ligand 11
CCL2 chemokine (C-C motif) ligand 2
CD14 CD14 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CEL carboxyl ester lipase
CETP cholesteryl ester transfer protein, plasma
CFH complement factor H
CHUK conserved helix-loop-helix ubiquitous kinase
CMA1 chymase 1, mast cell
COL4A1 collagen, type IV, alpha 1
CPE carboxypeptidase E
CPT1A carnitine palmitoyltransferase 1A (liver)
CRP C-reactive protein, pentraxin-related
CSF1 colony stimulating factor 1 (macrophage)
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF3 colony stimulating factor 3 (granulocyte)
CTH cystathionine gamma-lyase
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR3 chemokine (C-X-C motif) receptor 3
CYBA cytochrome b-245, alpha polypeptide
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DMPK dystrophia myotonica-protein kinase
DSCR10 Down syndrome critical region 10 (non-protein coding)
ECE1 endothelin converting enzyme 1
EDN1 endothelin 1
EDNRA endothelin receptor type A
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELN elastin
ENOSF1 enolase superfamily member 1
EPHX2 epoxide hydrolase 2, cytoplasmic
ERCC6 excision repair cross-complementation group 6
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
F13A1 coagulation factor XIII, A1 polypeptide
F13B coagulation factor XIII, B polypeptide
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FBLN5 fibulin 5
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FEM1A fem-1 homolog a (C. elegans)
FEM1B fem-1 homolog b (C. elegans)
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FOXO1 forkhead box O1
FTO fat mass and obesity associated
G6PC2 glucose-6-phosphatase, catalytic, 2
GAS6 growth arrest-specific 6
GCG glucagon
GCK glucokinase (hexokinase 4)
GCKR glucokinase (hexokinase 4) regulator
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GJA4 gap junction protein, alpha 4, 37kDa
GNAS GNAS complex locus
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GPR132 G protein-coupled receptor 132
GPX3 glutathione peroxidase 3
GPX4 glutathione peroxidase 4
GRK4 G protein-coupled receptor kinase 4
GSR glutathione reductase
GSS glutathione synthetase
GSTA4 glutathione S-transferase alpha 4
GSTM1 glutathione S-transferase mu 1
GSTM2 glutathione S-transferase mu 2 (muscle)
GSTM3 glutathione S-transferase mu 3 (brain)
GSTM4 glutathione S-transferase mu 4
GSTM5 glutathione S-transferase mu 5
GSTO1 glutathione S-transferase omega 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HFE hemochromatosis
HHEX hematopoietically expressed homeobox
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMCN1 hemicentin 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMOX1 heme oxygenase 1
HMOX2 heme oxygenase 2
HNF4A hepatocyte nuclear factor 4, alpha
HTRA1 HtrA serine peptidase 1
ICAM1 intercellular adhesion molecule 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IGF2-AS IGF2 antisense RNA
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP1 insulin-like growth factor binding protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL10 interleukin 10
IL12A interleukin 12A
IL12B interleukin 12B
IL13 interleukin 13
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL4 interleukin 4
IL6 interleukin 6
INS insulin
INSIG2 insulin induced gene 2
INSR insulin receptor
IRAK1 interleukin-1 receptor-associated kinase 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA6 integrin, alpha 6
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNK1 potassium channel, two pore domain subfamily K, member 1
KCNK2 potassium channel, two pore domain subfamily K, member 2
LAMA4 laminin, alpha 4
LCAT lecithin-cholesterol acyltransferase
LCT lactase
LDLR low density lipoprotein receptor
LIPC lipase, hepatic
LIPG lipase, endothelial
LMNA lamin A/C
LPA lipoprotein, Lp(a)
LPL lipoprotein lipase
LRP1 low density lipoprotein receptor-related protein 1
LRP5 low density lipoprotein receptor-related protein 5
LTA lymphotoxin alpha
LTA4H leukotriene A4 hydrolase
LTB lymphotoxin beta (TNF superfamily, member 3)
MASP2 mannan-binding lectin serine peptidase 2
MCPH1 microcephalin 1
MERTK MER proto-oncogene, tyrosine kinase
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MMP13 matrix metallopeptidase 13
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MRPL10 mitochondrial ribosomal protein L10
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
MSH3 mutS homolog 3
MSR1 macrophage scavenger receptor 1
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTNR1B melatonin receptor 1B
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MYO7A myosin VIIA
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NOD1 nucleotide-binding oligomerization domain containing 1
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPA natriuretic peptide A
NPY neuropeptide Y
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUMB numb homolog (Drosophila)
OLFML2B olfactomedin-like 2B
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PAX6 paired box 6
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK9 proprotein convertase subtilisin/kexin type 9
PDE4D phosphodiesterase 4D, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDGFC platelet derived growth factor C
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDYN prodynorphin
PECAM1 platelet/endothelial cell adhesion molecule 1
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLAT plasminogen activator, tissue
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
PLTP phospholipid transfer protein
PON1 paraoxonase 1
PON2 paraoxonase 2
PON3 paraoxonase 3
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPIA peptidylprolyl isomerase A (cyclophilin A)
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RETN resistin
RGS2 regulator of G-protein signaling 2
RGS9 regulator of G-protein signaling 9
RGS9BP regulator of G protein signaling 9 binding protein
S1PR1 sphingosine-1-phosphate receptor 1
S1PR2 sphingosine-1-phosphate receptor 2
SCAP SREBF chaperone
SCARA3 scavenger receptor class A, member 3
SCARB1 scavenger receptor class B, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCNN1B sodium channel, non voltage gated 1 beta subunit
SCNN1G sodium channel, non voltage gated 1 gamma subunit
SDC2 syndecan 2
SDC4 syndecan 4
SELE selectin E
SELL selectin L
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SELPLG selectin P ligand
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC17A4 solute carrier family 17, member 4
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SOD3 superoxide dismutase 3, extracellular
SORCS1 sortilin-related VPS10 domain containing receptor 1
SPP1 secreted phosphoprotein 1
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCN2 transcobalamin II
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFB3 transforming growth factor, beta 3
THBD thrombomodulin
THBS1 thrombospondin 1
THBS2 thrombospondin 2
THBS4 thrombospondin 4
TIMP2 TIMP metallopeptidase inhibitor 2
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR7 toll-like receptor 7
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TONSL tonsoku-like, DNA repair protein
TP53 tumor protein p53
TPO thyroid peroxidase
TXN thioredoxin
TYRO3 TYRO3 protein tyrosine kinase
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
USF1 upstream transcription factor 1
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VEGFB vascular endothelial growth factor B
VIMP VCP-interacting membrane selenoprotein
VKORC1 vitamin K epoxide reductase complex, subunit 1
VWF von Willebrand factor
WRN Werner syndrome, RecQ helicase-like
WWTR1 WW domain containing transcription regulator 1
XK X-linked Kx blood group