asthma Gene Set

Dataset DISEASES Experimental Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety. (Human Disease Ontology, DOID_2841)
Similar Terms
Downloads & Tools

Genes

90 genes associated with the disease asthma in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
ZPBP2 zona pellucida binding protein 2 1.50071
NOTCH4 notch 4 1.49392
IKZF3 IKAROS family zinc finger 3 (Aiolos) 1.47477
PBX2 pre-B-cell leukemia homeobox 2 1.07383
TSLP thymic stromal lymphopoietin 1.02486
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 0.945428
IKZF4 IKAROS family zinc finger 4 (Eos) 0.945428
STAC2 SH3 and cysteine rich domain 2 0.945428
SLC30A8 solute carrier family 30 (zinc transporter), member 8 0.916033
IL33 interleukin 33 0.872896
USP38 ubiquitin specific peptidase 38 0.872896
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.842276
TOP2A topoisomerase (DNA) II alpha 170kDa 0.835734
CDK2 cyclin-dependent kinase 2 0.724323
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.69843
HNMT histamine N-methyltransferase 0.647573
IL1RL1 interleukin 1 receptor-like 1 0.63207
IL18R1 interleukin 18 receptor 1 0.63207
MAGEE1 melanoma antigen family E1 0.602429
NRG1 neuregulin 1 0.602429
HLA-DOA major histocompatibility complex, class II, DO alpha 0.572184
PYHIN1 pyrin and HIN domain family, member 1 0.572184
SMAD3 SMAD family member 3 0.572184
GSDMA gasdermin A 0.561725
IL2RB interleukin 2 receptor, beta 0.52461
ANTXR1 anthrax toxin receptor 1 0.52461
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 0.52461
C1ORF53 chromosome 1 open reading frame 53 0.52461
IL6R interleukin 6 receptor 0.486425
SUMF1 sulfatase modifying factor 1 0.486425
C11ORF30 chromosome 11 open reading frame 30 0.486425
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.486425
PDE4D phosphodiesterase 4D, cAMP-specific 0.464771
TUSC3 tumor suppressor candidate 3 0.438544
DENND1B DENN/MADD domain containing 1B 0.429338
GAB1 GRB2-associated binding protein 1 0.4215
GSDMB gasdermin B 0.403461
RORA RAR-related orphan receptor A 0.403461
IL13 interleukin 13 0.403461
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 0.368757
RAD50 RAD50 homolog (S. cerevisiae) 0.345945
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.327313
PRKG1 protein kinase, cGMP-dependent, type I 0.311576
SYNE2 spectrin repeat containing, nuclear envelope 2 0.297866
ERO1LB ERO1-like beta (S. cerevisiae) 0.285417
CHCHD2P9 coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9 0.285417
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 0.285417
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.274608
SPATS2L spermatogenesis associated, serine-rich 2-like 0.256228
PCDH15 protocadherin-related 15 0.256228
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa 0.256228
PLXNA4 plexin A4 0.197766
C5ORF56 chromosome 5 open reading frame 56 0.197766
SCG3 secretogranin III 0.197766
DCLK1 doublecortin-like kinase 1 0.15771
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.15771
ZNF28 zinc finger protein 28 0.126165
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.126165
ZNF665 zinc finger protein 665 0.126165
CCDC67 coiled-coil domain containing 67 0.126165
C20ORF85 chromosome 20 open reading frame 85 0.126165
ACO1 aconitase 1, soluble 0.126165
NDFIP1 Nedd4 family interacting protein 1 0.126165
PCDH9 protocadherin 9 0.126165
ZNF644 zinc finger protein 644 0.100789
ANK1 ankyrin 1, erythrocytic 0.100789
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding) 0.100789
C10ORF54 chromosome 10 open reading frame 54 0.080593
CTNND2 catenin (cadherin-associated protein), delta 2 0.080593
CDH23 cadherin-related 23 0.080593
T T, brachyury homolog (mouse) 0.080593
LCE3C late cornified envelope 3C 0.080593
PDE9A phosphodiesterase 9A 0.080593
RPL10AP3 ribosomal protein L10a pseudogene 3 0.064973
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 0.064973
WDR11 WD repeat domain 11 0.064973
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.064973
USP15 ubiquitin specific peptidase 15 0.064973
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) 0.064973
PRKCE protein kinase C, epsilon 0.064973
MAVS mitochondrial antiviral signaling protein 0.052255
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.043246
CPO carboxypeptidase O 0.043246
CNTLN centlein, centrosomal protein 0.043246
CSMD1 CUB and Sushi multiple domains 1 0.043246
KANK1 KN motif and ankyrin repeat domains 1 0.043246
TRPM8 transient receptor potential cation channel, subfamily M, member 8 0.043246
S100B S100 calcium binding protein B 0.043246
COL22A1 collagen, type XXII, alpha 1 0.043246
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 0.043246