asthma; Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety. (Human Disease Ontology, DOID_2841)
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Genes

110 genes associated with the disease asthma; in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACE angiotensin I converting enzyme
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ADAM33 ADAM metallopeptidase domain 33
ADRB2 adrenoceptor beta 2, surface
BDNF brain-derived neurotrophic factor
C3 complement component 3
CAT catalase
CCL11 chemokine (C-C motif) ligand 11
CCL2 chemokine (C-C motif) ligand 2
CCL24 chemokine (C-C motif) ligand 24
CCL26 chemokine (C-C motif) ligand 26
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD28 CD28 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD86 CD86 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIA chitinase, acidic
CHML choroideremia-like (Rab escort protein 2)
CHRM1 cholinergic receptor, muscarinic 1
CHRM3 cholinergic receptor, muscarinic 3
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTTN cortactin
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DPP10 dipeptidyl-peptidase 10 (non-functional)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPHX2 epoxide hydrolase 2, cytoplasmic
ERO1LB ERO1-like beta (S. cerevisiae)
GC group-specific component (vitamin D binding protein)
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HAVCR1 hepatitis A virus cellular receptor 1
HAVCR2 hepatitis A virus cellular receptor 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLX H2.0-like homeobox
IFNG interferon, gamma
IL10 interleukin 10
IL12A interleukin 12A
IL13 interleukin 13
IL17A interleukin 17A
IL17RB interleukin 17 receptor B
IL18R1 interleukin 18 receptor 1
IL18RAP interleukin 18 receptor accessory protein
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RL1 interleukin 1 receptor-like 1
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
IL6R interleukin 6 receptor
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITLN1 intelectin 1 (galactofuranose binding)
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
MYLK myosin light chain kinase
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPA natriuretic peptide A
NPSR1 neuropeptide S receptor 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NRG1 neuregulin 1
OPN3 opsin 3
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3
PARP1 poly (ADP-ribose) polymerase 1
PDE4D phosphodiesterase 4D, cAMP-specific
PHF11 PHD finger protein 11
PON1 paraoxonase 1
PON2 paraoxonase 2
PTGDR prostaglandin D2 receptor (DP)
PTGDR2 prostaglandin D2 receptor 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SNW1 SNW domain containing 1
SPINK5 serine peptidase inhibitor, Kazal type 5
STAT2 signal transducer and activator of transcription 2, 113kDa
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TBX21 T-box 21
TIMD4 T-cell immunoglobulin and mucin domain containing 4
TLE4 transducin-like enhancer of split 4
TLR1 toll-like receptor 1
TLR10 toll-like receptor 10
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR6 toll-like receptor 6
TLR9 toll-like receptor 9
TNF tumor necrosis factor
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor