arthritis Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A bone inflammation disease that involves a response to irritation or injury, characterized by joint pain, swelling, stiffness located_in joint and/or redness located_in skin over the joint. (Human Disease Ontology, DOID_848)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002993
Similar Terms
Downloads & Tools

Genes

102 gene mutations causing the arthritis phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACAN aggrecan
ADAM8 ADAM metallopeptidase domain 8
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AIF1 allograft inflammatory factor 1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANKH ANKH inorganic pyrophosphate transport regulator
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATP7A ATPase, Cu++ transporting, alpha polypeptide
BGN biglycan
BMX BMX non-receptor tyrosine kinase
C1QTNF3 C1q and tumor necrosis factor related protein 3
C3 complement component 3
CD1D CD1d molecule
CD200 CD200 molecule
CD274 CD274 molecule
CD44 CD44 molecule (Indian blood group)
CD69 CD69 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CFP complement factor properdin
CHSY1 chondroitin sulfate synthase 1
CLEC5A C-type lectin domain family 5, member A
COL11A1 collagen, type XI, alpha 1
COL9A1 collagen, type IX, alpha 1
COMP cartilage oligomeric matrix protein
CTSS cathepsin S
CXCR2 chemokine (C-X-C motif) receptor 2
CYTL1 cytokine-like 1
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ERRFI1 ERBB receptor feedback inhibitor 1
F2 coagulation factor II (thrombin)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FFAR2 free fatty acid receptor 2
FMOD fibromodulin
FPR2 formyl peptide receptor 2
GPSM3 G-protein signaling modulator 3
HSPG2 heparan sulfate proteoglycan 2
HYAL1 hyaluronoglucosaminidase 1
IFNGR1 interferon gamma receptor 1
IGHM immunoglobulin heavy constant mu
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL27RA interleukin 27 receptor, alpha
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
IRF1 interferon regulatory factor 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KSR1 kinase suppressor of ras 1
LGALS9B lectin, galactoside-binding, soluble, 9B
LTA lymphotoxin alpha
LTB4R leukotriene B4 receptor
LTB4R2 leukotriene B4 receptor 2
LTBP3 latent transforming growth factor beta binding protein 3
MATN3 matrilin 3
MEFV Mediterranean fever
MIR140 microRNA 140
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MYD88 myeloid differentiation primary response 88
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOD2 nucleotide-binding oligomerization domain containing 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDCD1 programmed cell death 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PGLYRP1 peptidoglycan recognition protein 1
PGLYRP2 peptidoglycan recognition protein 2
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PPARG peroxisome proliferator-activated receptor gamma
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RASGRP4 RAS guanyl releasing protein 4
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SMAD3 SMAD family member 3
SOCS3 suppressor of cytokine signaling 3
SOD3 superoxide dismutase 3, extracellular
SYVN1 synovial apoptosis inhibitor 1, synoviolin
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TPSAB1 tryptase alpha/beta 1
TYK2 tyrosine kinase 2
TYROBP TYRO protein tyrosine kinase binding protein
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZFP36 ZFP36 ring finger protein