apoptosome Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A multisubunit protein complex involved in the signaling phase of the apoptotic process. In mammals it is typically composed of seven Apaf-1 subunits bound to cytochrome c and caspase-9. A similar complex to promote apoptosis is formed from homologous gene products in other eukaryotic organisms. (Gene Ontology, GO_0043293)
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63 proteins co-occuring with the apoptosome cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
APAF1 apoptotic peptidase activating factor 1 3.5669
CASP9 caspase 9, apoptosis-related cysteine peptidase 2.4125
DIABLO diablo, IAP-binding mitochondrial protein 1.68055
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 1.52541
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.50396
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.49549
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.23766
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 1.21428
CASP2 caspase 2, apoptosis-related cysteine peptidase 1.21169
BCL2L1 BCL2-like 1 1.1342
BAX BCL2-associated X protein 1.05387
APIP APAF1 interacting protein 0.966474
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 0.951142
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.90321
HTRA2 HtrA serine peptidase 2 0.873647
BIRC3 baculoviral IAP repeat containing 3 0.799728
FADD Fas (TNFRSF6)-associated via death domain 0.730628
ASMTL acetylserotonin O-methyltransferase-like 0.715458
CASP6 caspase 6, apoptosis-related cysteine peptidase 0.65388
BCL2 B-cell CLL/lymphoma 2 0.651729
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 0.645287
TP53 tumor protein p53 0.585523
BIRC2 baculoviral IAP repeat containing 2 0.570496
ANP32C acidic (leucine-rich) nuclear phosphoprotein 32 family, member C 0.566338
API5 apoptosis inhibitor 5 0.558042
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.540294
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.530438
BCL2L12 BCL2-like 12 (proline rich) 0.523067
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.515716
MTCH1 mitochondrial carrier 1 0.501881
ENDOG endonuclease G 0.496205
NAIP NLR family, apoptosis inhibitory protein 0.476429
FASLG Fas ligand (TNF superfamily, member 6) 0.461998
EIF3M eukaryotic translation initiation factor 3, subunit M 0.447259
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.439333
C20ORF144 chromosome 20 open reading frame 144 0.436565
ELAVL1 ELAV like RNA binding protein 1 0.430647
ACSL5 acyl-CoA synthetase long-chain family member 5 0.426711
PCSK9 proprotein convertase subtilisin/kexin type 9 0.405971
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.394323
HSPA4 heat shock 70kDa protein 4 0.391615
TBX22 T-box 22 0.373899
MLKL mixed lineage kinase domain-like 0.365859
EFHD2 EF-hand domain family, member D2 0.350243
BIRC5 baculoviral IAP repeat containing 5 0.340773
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.340017
CFLAR CASP8 and FADD-like apoptosis regulator 0.294378
BECN1 beclin 1, autophagy related 0.293267
NELFB negative elongation factor complex member B 0.273734
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.2708
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.264946
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.248578
PARP1 poly (ADP-ribose) polymerase 1 0.231672
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.214017
MAPK9 mitogen-activated protein kinase 9 0.175745
HRK harakiri, BCL2 interacting protein 0.171937
HCCS holocytochrome c synthase 0.168349
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.167856
BID BH3 interacting domain death agonist 0.164089
FCF1 FCF1 rRNA-processing protein 0.163641
DDIT3 DNA-damage-inducible transcript 3 0.1632
HTT huntingtin 0.16298
LGALS3 lectin, galactoside-binding, soluble, 3 0.161693