apical junction complex Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability. (Gene Ontology, GO_0043296)
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Genes

114 proteins localized to the apical junction complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
ECT2 epithelial cell transforming 2 0.663342
INADL InaD-like (Drosophila) 0.663342
PDZD3 PDZ domain containing 3 0.663342
PLXDC1 plexin domain containing 1 0.663342
RAB13 RAB13, member RAS oncogene family 0.663342
CRB3 crumbs family member 3 0.663342
BVES blood vessel epicardial substance 0.663342
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.663342
CLDN9 claudin 9 0.663342
TJP1 tight junction protein 1 0.663342
TJP3 tight junction protein 3 0.663342
TJP2 tight junction protein 2 0.663342
STRN striatin, calmodulin binding protein 0.663342
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) 0.663342
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) 0.663342
CAMSAP3 calmodulin regulated spectrin-associated protein family, member 3 0.663342
PARD6B par-6 family cell polarity regulator beta 0.663342
PARD6A par-6 family cell polarity regulator alpha 0.663342
PKN2 protein kinase N2 0.663342
TGFBR1 transforming growth factor, beta receptor 1 0.663342
CLDN1 claudin 1 0.663342
CLDN4 claudin 4 0.663342
CLDN5 claudin 5 0.663342
OCLN occludin 0.663342
UBN1 ubinuclein 1 0.663342
CLDN12 claudin 12 0.663342
CLDN11 claudin 11 0.663342
CLDN16 claudin 16 0.663342
CLDN17 claudin 17 0.663342
CLDN14 claudin 14 0.663342
CLDN15 claudin 15 0.663342
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.663342
AMOT angiomotin 0.663342
MPDZ multiple PDZ domain protein 0.663342
CLDN7 claudin 7 0.663342
CLDN8 claudin 8 0.663342
NPHP1 nephronophthisis 1 (juvenile) 0.663342
NPHP4 nephronophthisis 4 0.663342
CLDN19 claudin 19 0.663342
PLEKHA7 pleckstrin homology domain containing, family A member 7 0.663342
CLDN20 claudin 20 0.663342
ARHGAP17 Rho GTPase activating protein 17 0.663342
CLDN18 claudin 18 0.663342
RHOA ras homolog family member A 0.663342
CXADR coxsackie virus and adenovirus receptor 0.663342
AMICA1 adhesion molecule, interacts with CXADR antigen 1 0.663342
PARD3 par-3 family cell polarity regulator 0.663342
EPCAM epithelial cell adhesion molecule 0.663342
CLMP CXADR-like membrane protein 0.663342
AMOTL1 angiomotin like 1 0.663342
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.663342
RPGRIP1L RPGRIP1-like 0.663342
APC adenomatous polyposis coli 0.663342
KIFC3 kinesin family member C3 0.663342
CGN cingulin 0.663342
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.663342
FRMPD2 FERM and PDZ domain containing 2 0.663342
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.663342
SYMPK symplekin 0.663342
PARD3B par-3 family cell polarity regulator beta 0.663342
CLDN10 claudin 10 0.237908
CLDN22 claudin 22 0.237908
CLDN2 claudin 2 0.237908
DLG1 discs, large homolog 1 (Drosophila) 0.237908
WNK4 WNK lysine deficient protein kinase 4 0.237908
MARVELD2 MARVEL domain containing 2 0.237908
MARVELD3 MARVEL domain containing 3 0.237908
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.237908
MTDH metadherin 0.237908
TBCD tubulin folding cofactor D 0.237908
SHROOM3 shroom family member 3 0.237908
SHROOM2 shroom family member 2 0.237908
CCDC85C coiled-coil domain containing 85C 0.237908
MICALL2 MICAL-like 2 0.237908
CLDN6 claudin 6 0.237908
SORBS1 sorbin and SH3 domain containing 1 0.237908
LIN7B lin-7 homolog B (C. elegans) 0.098109
SYNPO synaptopodin 0.098109
CGNL1 cingulin-like 1 0.098109
CLDN24 claudin 24 0.098109
LIN7C lin-7 homolog C (C. elegans) 0.098109
LIN7A lin-7 homolog A (C. elegans) 0.098109
IGSF5 immunoglobulin superfamily, member 5 0.098109
F11R F11 receptor 0.098109
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 0.098109
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.098109
VASP vasodilator-stimulated phosphoprotein 0.098109
TRAF4 TNF receptor-associated factor 4 0.098109
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.098109
JUP junction plakoglobin 0.098109
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 0.098109
TJAP1 tight junction associated protein 1 (peripheral) 0.098109
JAM2 junctional adhesion molecule 2 0.098109
YBX3 Y box binding protein 3 0.098109
ESAM endothelial cell adhesion molecule 0.098109
CLDN3 claudin 3 0.098109
POF1B premature ovarian failure, 1B 0.098109
CLDN25 claudin 25 0.098109
WNK3 WNK lysine deficient protein kinase 3 0.098109
PARD6G par-6 family cell polarity regulator gamma 0.098109
PVRL3 poliovirus receptor-related 3 0.03318
CYTH1 cytohesin 1 0.03318
PRKCZ protein kinase C, zeta 0.03318
CCND1 cyclin D1 0.03318
CTNND1 catenin (cadherin-associated protein), delta 1 0.03318
DLG3 discs, large homolog 3 (Drosophila) 0.03318
FRMD6 FERM domain containing 6 0.03318
FZD5 frizzled class receptor 5 0.03318
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.03318
AMOTL2 angiomotin like 2 0.03318
CDK4 cyclin-dependent kinase 4 0.03318
CDH5 cadherin 5, type 2 (vascular endothelium) 0.03318
FRMD4A FERM domain containing 4A 0.03318
JAM3 junctional adhesion molecule 3 0.03318