ap-type membrane coat adaptor complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa). (Gene Ontology, GO_0030119)
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326 proteins co-occuring with the ap-type membrane coat adaptor complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
MYO1G myosin IG 2.01988
AKAP13 A kinase (PRKA) anchor protein 13 1.92229
HMHA1 histocompatibility (minor) HA-1 1.88141
AP1M2 adaptor-related protein complex 1, mu 2 subunit 1.76174
HAS1 hyaluronan synthase 1 1.68055
AP2M1 adaptor-related protein complex 2, mu 1 subunit 1.68055
AP2B1 adaptor-related protein complex 2, beta 1 subunit 1.52484
EPS15 epidermal growth factor receptor pathway substrate 15 1.47174
KRT38 keratin 38, type I 1.43331
HLA-A major histocompatibility complex, class I, A 1.40914
SNAP91 synaptosomal-associated protein, 91kDa 1.32384
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 1.20086
EPN1 epsin 1 1.15979
AP1M1 adaptor-related protein complex 1, mu 1 subunit 1.13012
CLINT1 clathrin interactor 1 1.11888
KRT37 keratin 37, type I 1.05236
ARF1 ADP-ribosylation factor 1 1.0413
GSTM1 glutathione S-transferase mu 1 1.00645
AP1B1 adaptor-related protein complex 1, beta 1 subunit 1.00153
STON2 stonin 2 1.00054
KRT36 keratin 36, type I 0.998577
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 0.952096
TF transferrin 0.939269
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.928422
LDLRAP1 low density lipoprotein receptor adaptor protein 1 0.914842
SYNRG synergin, gamma 0.870885
TFRC transferrin receptor 0.820829
AP1G2 adaptor-related protein complex 1, gamma 2 subunit 0.816699
HLA-C major histocompatibility complex, class I, C 0.813487
NECAP1 NECAP endocytosis associated 1 0.810276
ADORA3 adenosine A3 receptor 0.802021
CORO7 coronin 7 0.795145
KIF13A kinesin family member 13A 0.795145
HIP1 huntingtin interacting protein 1 0.793313
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 0.792854
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 0.79148
ARHGAP23 Rho GTPase activating protein 23 0.786902
TGOLN2 trans-golgi network protein 2 0.786444
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.751357
ARHGAP20 Rho GTPase activating protein 20 0.741416
ARHGAP25 Rho GTPase activating protein 25 0.726152
ARHGAP12 Rho GTPase activating protein 12 0.723919
ARHGAP19 Rho GTPase activating protein 19 0.721688
AP3D1 adaptor-related protein complex 3, delta 1 subunit 0.720797
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 0.713682
CD4 CD4 molecule 0.711465
MOB4 MOB family member 4, phocein 0.701304
AFTPH aftiphilin 0.684207
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.67246
ARHGAP22 Rho GTPase activating protein 22 0.670292
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae) 0.66726
FCHO1 FCH domain only 1 0.666394
ARHGAP9 Rho GTPase activating protein 9 0.662503
GAK cyclin G associated kinase 0.659913
AAK1 AP2 associated kinase 1 0.658188
ARRB1 arrestin, beta 1 0.648291
M6PR mannose-6-phosphate receptor (cation dependent) 0.646574
ARF6 ADP-ribosylation factor 6 0.646574
LRRN3 leucine rich repeat neuronal 3 0.646145
HIP1R huntingtin interacting protein 1 related 0.644001
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 0.633732
AAGAB alpha- and gamma-adaptin binding protein 0.630745
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.629465
DENND1A DENN/MADD domain containing 1A 0.616709
ARHGAP6 Rho GTPase activating protein 6 0.612895
BICC1 BicC family RNA binding protein 1 0.602331
EPN2 epsin 2 0.600644
ARHGAP26 Rho GTPase activating protein 26 0.600223
NECAP2 NECAP endocytosis associated 2 0.59896
GMIP GEM interacting protein 0.596014
RABEP1 rabaptin, RAB GTPase binding effector protein 1 0.585105
A2M alpha-2-macroglobulin 0.582176
SYNJ1 synaptojanin 1 0.580922
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit 0.580086
MGAM maltase-glucoamylase 0.576747
RCAN1 regulator of calcineurin 1 0.572162
HPS1 Hermansky-Pudlak syndrome 1 0.568416
AMPH amphiphysin 0.567169
AP2S1 adaptor-related protein complex 2, sigma 1 subunit 0.554732
EGFR epidermal growth factor receptor 0.554732
CDKN2A cyclin-dependent kinase inhibitor 2A 0.549773
PGRMC1 progesterone receptor membrane component 1 0.548122
HSPA8 heat shock 70kDa protein 8 0.544411
NAV2 neuron navigator 2 0.54194
AP1AR adaptor-related protein complex 1 associated regulatory protein 0.53906
CHN1 chimerin 1 0.537005
PICALM phosphatidylinositol binding clathrin assembly protein 0.533719
ST8SIA5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 0.532488
ARHGAP27 Rho GTPase activating protein 27 0.532488
STON1 stonin 1 0.531258
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 0.530847
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 0.516532
ARF5 ADP-ribosylation factor 5 0.515308
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 0.512455
BST2 bone marrow stromal cell antigen 2 0.50757
GSTA2 glutathione S-transferase alpha 2 0.503912
ARHGAP15 Rho GTPase activating protein 15 0.498636
ARHGAP24 Rho GTPase activating protein 24 0.492561
ARHGAP17 Rho GTPase activating protein 17 0.488923
UBE2W ubiquitin-conjugating enzyme E2W (putative) 0.488519
IGLV1-50 immunoglobulin lambda variable 1-50 (non-functional) 0.4865
ARHGAP5 Rho GTPase activating protein 5 0.483273
COPE coatomer protein complex, subunit epsilon 0.48005
RHOU ras homolog family member U 0.475625
DVL2 dishevelled segment polarity protein 2 0.473215
GSTA3 glutathione S-transferase alpha 3 0.470406
FURIN furin (paired basic amino acid cleaving enzyme) 0.470406
GSTA4 glutathione S-transferase alpha 4 0.468401
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.468001
GSTA1 glutathione S-transferase alpha 1 0.465998
LDLR low density lipoprotein receptor 0.462798
HPCA hippocalcin 0.458803
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.450438
ADRB2 adrenoceptor beta 2, surface 0.450438
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 0.447259
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.443689
SCNN1G sodium channel, non voltage gated 1 gamma subunit 0.440916
ARHGAP4 Rho GTPase activating protein 4 0.44052
STX6 syntaxin 6 0.438937
FCHO2 FCH domain only 2 0.43617
HAL histidine ammonia-lyase 0.429859
ERVW-1 endogenous retrovirus group W, member 1 0.429465
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.426711
ARRB2 arrestin, beta 2 0.426318
SLC2A12 solute carrier family 2 (facilitated glucose transporter), member 12 0.425138
AP4B1 adaptor-related protein complex 4, beta 1 subunit 0.423567
MYO6 myosin VI 0.420428
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.419644
PACS1 phosphofurin acidic cluster sorting protein 1 0.41886
RNF111 ring finger protein 111 0.412601
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.41182
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 0.405582
AP1S2 adaptor-related protein complex 1, sigma 2 subunit 0.403637
HBA1 hemoglobin, alpha 1 0.403248
HBA2 hemoglobin, alpha 2 0.397423
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.392775
CST3 cystatin C 0.389682
SYT1 synaptotagmin I 0.389296
ARHGAP10 Rho GTPase activating protein 10 0.383895
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.382354
FZD4 frizzled class receptor 4 0.381969
STRN striatin, calmodulin binding protein 0.381969
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 0.380814
MIDN midnolin 0.380045
IGF2R insulin-like growth factor 2 receptor 0.371599
STARD8 StAR-related lipid transfer (START) domain containing 8 0.369301
CHN2 chimerin 2 0.365095
STX4 syntaxin 4 0.364713
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.359371
SCYL2 SCY1-like 2 (S. cerevisiae) 0.359371
DNM1 dynamin 1 0.356705
STRN4 striatin, calmodulin binding protein 4 0.354422
RAB32 RAB32, member RAS oncogene family 0.354042
LRP10 low density lipoprotein receptor-related protein 10 0.350622
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.347587
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 0.345692
TRAC T cell receptor alpha constant 0.344556
AP1S1 adaptor-related protein complex 1, sigma 1 subunit 0.333979
SURF4 surfeit 4 0.329461
RAP2B RAP2B, member of RAS oncogene family 0.326453
RAB8A RAB8A, member RAS oncogene family 0.325702
NCR2 natural cytotoxicity triggering receptor 2 0.324576
ARHGAP21 Rho GTPase activating protein 21 0.324576
SAR1A secretion associated, Ras related GTPase 1A 0.320077
ARF3 ADP-ribosylation factor 3 0.319328
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 0.318205
RAB1B RAB1B, member RAS oncogene family 0.316708
ADRBK2 adrenergic, beta, receptor kinase 2 0.313344
RAB4B RAB4B, member RAS oncogene family 0.310358
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 0.306632
NUMB numb homolog (Drosophila) 0.292157
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.289569
DNER delta/notch-like EGF repeat containing 0.288091
SLC9B2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 0.284032
TSG101 tumor susceptibility 101 0.282926
CSTA cystatin A (stefin A) 0.281453
RACGAP1 Rac GTPase activating protein 1 0.278141
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 0.278141
ALPPL2 alkaline phosphatase, placental-like 2 0.277774
ALPL alkaline phosphatase, liver/bone/kidney 0.277406
ALPP alkaline phosphatase, placental 0.277038
ADRA1B adrenoceptor alpha 1B 0.275569
HLA-B major histocompatibility complex, class I, B 0.2719
FIG4 FIG4 phosphoinositide 5-phosphatase 0.267871
CERS2 ceramide synthase 2 0.265311
KRT32 keratin 32, type I 0.264581
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1 0.260931
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.260566
OCRL oculocerebrorenal syndrome of Lowe 0.260202
KRT35 keratin 35, type I 0.258745
TRAPPC2 trafficking protein particle complex 2 0.252202
BLOC1S6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin 0.250751
GLB1 galactosidase, beta 1 0.24713
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 0.246769
OPTN optineurin 0.244601
HSPA4 heat shock 70kDa protein 4 0.242797
GPR39 G protein-coupled receptor 39 0.242437
PDGFB platelet-derived growth factor beta polypeptide 0.242437
KIF16B kinesin family member 16B 0.240276
TXNDC17 thioredoxin domain containing 17 0.23776
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.237401
DLG1 discs, large homolog 1 (Drosophila) 0.236683
ARHGAP18 Rho GTPase activating protein 18 0.227397
NBPF10 neuroblastoma breakpoint family, member 10 0.225622
SIGLEC7 sialic acid binding Ig-like lectin 7 0.223497
LY9 lymphocyte antigen 9 0.22279
PLIN3 perilipin 3 0.219265
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.215761
LAMP1 lysosomal-associated membrane protein 1 0.214366
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.213322
PRB3 proline-rich protein BstNI subfamily 3 0.212974
IGHV4-39 immunoglobulin heavy variable 4-39 0.21124
PDCD6IP programmed cell death 6 interacting protein 0.204718
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.204039
ADORA2B adenosine A2b receptor 0.203361
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 0.202009
IL2RA interleukin 2 receptor, alpha 0.198991
RAB31 RAB31, member RAS oncogene family 0.196999
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 0.194371
NOTCH1 notch 1 0.18702
ARFRP1 ADP-ribosylation factor related protein 1 0.186087
GCM2 glial cells missing homolog 2 (Drosophila) 0.184241
NSF N-ethylmaleimide-sensitive factor 0.184241
TSPAN7 tetraspanin 7 0.182122
GRIP1 glutamate receptor interacting protein 1 0.180339
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 0.176587
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.174911
ULBP2 UL16 binding protein 2 0.173003
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3 0.165
KRT75 keratin 75, type II 0.16477
RD3 retinal degeneration 3 0.164315
SNX4 sorting nexin 4 0.162117
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.161693
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 0.160658
SH3GL2 SH3-domain GRB2-like 2 0.160456
L1CAM L1 cell adhesion molecule 0.160254
BOLL boule-like RNA-binding protein 0.158882
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 0.157943
CD207 CD207 molecule, langerin 0.141765
BCL2A1 BCL2-related protein A1 0.137249
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.137164
KRT31 keratin 31, type I 0.136883
HYAL1 hyaluronoglucosaminidase 1 0.136837
C19ORF48 chromosome 19 open reading frame 48 0.136737
SOS1 son of sevenless homolog 1 (Drosophila) 0.136647
CTSH cathepsin H 0.136527
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.136307
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma 0.136194
NTSR1 neurotensin receptor 1 (high affinity) 0.135973
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.135804
PPAN peter pan homolog (Drosophila) 0.135785
CDK20 cyclin-dependent kinase 20 0.135732
TECR trans-2,3-enoyl-CoA reductase 0.135459
UNC13D unc-13 homolog D (C. elegans) 0.135445
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) 0.135398
GADD45A growth arrest and DNA-damage-inducible, alpha 0.13533
GSAP gamma-secretase activating protein 0.135316
PCLO piccolo presynaptic cytomatrix protein 0.13522
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.135192
ARHGAP1 Rho GTPase activating protein 1 0.135192
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 0.135178
NEUROG1 neurogenin 1 0.13508
RTN1 reticulon 1 0.134889
ALB albumin 0.134745
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.134672
USO1 USO1 vesicle transport factor 0.134643
NTS neurotensin 0.134576
TFIP11 tuftelin interacting protein 11 0.134569
CD80 CD80 molecule 0.134292
LYST lysosomal trafficking regulator 0.13396
CD63 CD63 molecule 0.133585
CTSB cathepsin B 0.13312
CD1B CD1b molecule 0.132949
SNAPIN SNAP-associated protein 0.132678
IL2 interleukin 2 0.132562
CLTC clathrin, heavy chain (Hc) 0.131811
LAMP2 lysosomal-associated membrane protein 2 0.128066
STX2 syntaxin 2 0.127781
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4 0.127362
MGAT4C MGAT4 family, member C 0.123832
RAB27A RAB27A, member RAS oncogene family 0.123307
RPS13 ribosomal protein S13 0.122823
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.122677
CABIN1 calcineurin binding protein 1 0.122404
SPINT1 serine peptidase inhibitor, Kunitz type 1 0.122383
SNAP23 synaptosomal-associated protein, 23kDa 0.121457
KRT83 keratin 83, type II 0.121457
NDN necdin, melanoma antigen (MAGE) family member 0.121435
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.121065
CAT catalase 0.120756
GLA galactosidase, alpha 0.120612
DRD3 dopamine receptor D3 0.120514
OSGEP O-sialoglycoprotein endopeptidase 0.120319
DRD4 dopamine receptor D4 0.120094
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.120044
ARF4 ADP-ribosylation factor 4 0.119891
HPD 4-hydroxyphenylpyruvate dioxygenase 0.119738
CTSL cathepsin L 0.119557
GP2 glycoprotein 2 (zymogen granule membrane) 0.119426
NT5C1A 5'-nucleotidase, cytosolic IA 0.119268
DDIT3 DNA-damage-inducible transcript 3 0.119214
GCDH glutaryl-CoA dehydrogenase 0.118644
TARP TCR gamma alternate reading frame protein 0.118053
FYB FYN binding protein 0.117995
HPS4 Hermansky-Pudlak syndrome 4 0.117995
IL4R interleukin 4 receptor 0.117468
CD19 CD19 molecule 0.117438
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2 0.116425
SEPT5 septin 5 0.116425
PIGR polymeric immunoglobulin receptor 0.116234
FZD6 frizzled class receptor 6 0.116234
NBPF8 neuroblastoma breakpoint family, member 8 0.116009
ITSN1 intersectin 1 (SH3 domain protein) 0.115911
SLPI secretory leukocyte peptidase inhibitor 0.115911
PER3 period circadian clock 3 0.115878
PER2 period circadian clock 2 0.115078
SH2D1A SH2 domain containing 1A 0.114207
PCSK6 proprotein convertase subtilisin/kexin type 6 0.114098
MSMB microseminoprotein, beta- 0.114026
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.113918
C4A complement component 4A (Rodgers blood group) 0.113809
HCFC1 host cell factor C1 0.113773
IGHV3-30 immunoglobulin heavy variable 3-30 0.113737
AMPD2 adenosine monophosphate deaminase 2 0.113367
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 0.113293
RAB38 RAB38, member RAS oncogene family 0.112915