aortic Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

409 genes co-occuring with the biological term aortic in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AAA1 aortic aneurysm, familial abdominal 1
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ACTA2 actin, alpha 2, smooth muscle, aorta
ADAM15 ADAM metallopeptidase domain 15
ADAM8 ADAM metallopeptidase domain 8
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
ADM2 adrenomedullin 2
ADORA2A adenosine A2a receptor
ADRA1B adrenoceptor alpha 1B
ADRB1 adrenoceptor beta 1
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
AHSG alpha-2-HS-glycoprotein
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMPD1 adenosine monophosphate deaminase 1
ANGPT2 angiopoietin 2
ANGPTL2 angiopoietin-like 2
ANXA2 annexin A2
AOC3 amine oxidase, copper containing 3
APLN apelin
APLNR apelin receptor
APOA1 apolipoprotein A-I
APOA5 apolipoprotein A-V
APOB apolipoprotein B
APOE apolipoprotein E
APOM apolipoprotein M
ARG2 arginase 2
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
AVP arginine vasopressin
AXIN1 axin 1
B2M beta-2-microglobulin
BAK1 BCL2-antagonist/killer 1
BCL2 B-cell CLL/lymphoma 2
BGN biglycan
BMP2 bone morphogenetic protein 2
BSG basigin (Ok blood group)
C1QA complement component 1, q subcomponent, A chain
C3 complement component 3
C5 complement component 5
C6 complement component 6
C7 complement component 7
C8B complement component 8, beta polypeptide
C9 complement component 9
CA1 carbonic anhydrase I
CALCA calcitonin-related polypeptide alpha
CAPN2 calpain 2, (m/II) large subunit
CARD8 caspase recruitment domain family, member 8
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASR calcium-sensing receptor
CAV1 caveolin 1, caveolae protein, 22kDa
CCL13 chemokine (C-C motif) ligand 13
CCL22 chemokine (C-C motif) ligand 22
CCL26 chemokine (C-C motif) ligand 26
CCL5 chemokine (C-C motif) ligand 5
CCND1 cyclin D1
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD4 CD4 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CD59 CD59 molecule, complement regulatory protein
CD68 CD68 molecule
CDH13 cadherin 13
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2B-AS1 CDKN2B antisense RNA 1
CFL1 cofilin 1 (non-muscle)
CIITA class II, major histocompatibility complex, transactivator
CLU clusterin
CMA1 chymase 1, mast cell
CNR1 cannabinoid receptor 1 (brain)
CNR2 cannabinoid receptor 2 (macrophage)
COL3A1 collagen, type III, alpha 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRP C-reactive protein, pentraxin-related
CRYAB crystallin, alpha B
CSF1 colony stimulating factor 1 (macrophage)
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CST3 cystatin C
CTF1 cardiotrophin 1
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CTSL cathepsin L
CTSS cathepsin S
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
CXCR6 chemokine (C-X-C motif) receptor 6
CYBA cytochrome b-245, alpha polypeptide
CYBB cytochrome b-245, beta polypeptide
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DAB2IP DAB2 interacting protein
DCN decorin
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DHCR7 7-dehydrocholesterol reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLX5 distal-less homeobox 5
DPP4 dipeptidyl-peptidase 4
DSTN destrin (actin depolymerizing factor)
DUOX1 dual oxidase 1
EDN1 endothelin 1
EDNRA endothelin receptor type A
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EFNB1 ephrin-B1
EGR1 early growth response 1
ELANE elastase, neutrophil expressed
ELAVL1 ELAV like RNA binding protein 1
ELN elastin
ENG endoglin
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ESR2 estrogen receptor 2 (ER beta)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F13A1 coagulation factor XIII, A1 polypeptide
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM172A family with sequence similarity 172, member A
FBLN1 fibulin 1
FBLN5 fibulin 5
FBLN7 fibulin 7
FBN1 fibrillin 1
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FGF2 fibroblast growth factor 2 (basic)
FGF23 fibroblast growth factor 23
FHL1 four and a half LIM domains 1
FLNA filamin A, alpha
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FOXO1 forkhead box O1
GAS6 growth arrest-specific 6
GATA5 GATA binding protein 5
GDF15 growth differentiation factor 15
GGT1 gamma-glutamyltransferase 1
GHRL ghrelin/obestatin prepropeptide
GJA5 gap junction protein, alpha 5, 40kDa
GLA galactosidase, alpha
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPR68 G protein-coupled receptor 68
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HAS2 hyaluronan synthase 2
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGA2 high mobility group AT-hook 2
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
HOXA4 homeobox A4
HP haptoglobin
HPSE heparanase
HSPB1 heat shock 27kDa protein 1
ICAM1 intercellular adhesion molecule 1
ICOS inducible T-cell co-stimulator
IFNG interferon, gamma
IGES immunoglobulin E concentration, serum
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGKC immunoglobulin kappa constant
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL10 interleukin 10
IL17A interleukin 17A
IL18 interleukin 18
IL18BP interleukin 18 binding protein
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RL1 interleukin 1 receptor-like 1
IL1RN interleukin 1 receptor antagonist
IL23A interleukin 23, alpha subunit p19
IL2RA interleukin 2 receptor, alpha
IL33 interleukin 33
IL6 interleukin 6
IL6R interleukin 6 receptor
INHBA inhibin, beta A
IRF1 interferon regulatory factor 1
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JAK2 Janus kinase 2
JARID2 jumonji, AT rich interactive domain 2
JUN jun proto-oncogene
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KL klotho
KLF15 Kruppel-like factor 15
KLF4 Kruppel-like factor 4 (gut)
KLK1 kallikrein 1
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LEP leptin
LGALS3 lectin, galactoside-binding, soluble, 3
LIMK1 LIM domain kinase 1
LOX lysyl oxidase
LPA lipoprotein, Lp(a)
LPL lipoprotein lipase
LRP1 low density lipoprotein receptor-related protein 1
LRP5 low density lipoprotein receptor-related protein 5
LTBP4 latent transforming growth factor beta binding protein 4
LUM lumican
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MASP2 mannan-binding lectin serine peptidase 2
MAT2A methionine adenosyltransferase II, alpha
MBL2 mannose-binding lectin (protein C) 2, soluble
MFAP5 microfibrillar associated protein 5
MFGE8 milk fat globule-EGF factor 8 protein
MGP matrix Gla protein
MICA MHC class I polypeptide-related sequence A
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR1260A microRNA 1260a
MIR155 microRNA 155
MIR195 microRNA 195
MIR21 microRNA 21
MIR221 microRNA 221
MIR29A microRNA 29a
MIR30B microRNA 30b
MIR516A1 microRNA 516a-1
MIR516A2 microRNA 516a-2
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP12 matrix metallopeptidase 12
MMP13 matrix metallopeptidase 13
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MSTN myostatin
MT1F metallothionein 1F
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MUC16 mucin 16, cell surface associated
MYH11 myosin, heavy chain 11, smooth muscle
MYH7 myosin, heavy chain 7, cardiac muscle, beta
MYLK myosin light chain kinase
NCF1 neutrophil cytosolic factor 1
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLRP3 NLR family, pyrin domain containing 3
NOG noggin
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NOTCH3 notch 3
NOX4 NADPH oxidase 4
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
NPPB natriuretic peptide B
NPPC natriuretic peptide C
NPR2 natriuretic peptide receptor 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NR3C2 nuclear receptor subfamily 3, group C, member 2
NRP1 neuropilin 1
NTM neurotrimin
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PARP1 poly (ADP-ribose) polymerase 1
PDGFB platelet-derived growth factor beta polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDIA2 protein disulfide isomerase family A, member 2
PECAM1 platelet/endothelial cell adhesion molecule 1
PEPD peptidase D
PF4 platelet factor 4
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLA2G10 phospholipase A2, group X
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G5 phospholipase A2, group V
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PLTP phospholipid transfer protein
PMPCA peptidase (mitochondrial processing) alpha
PMPCB peptidase (mitochondrial processing) beta
PON1 paraoxonase 1
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPIA peptidylprolyl isomerase A (cyclophilin A)
PRDX1 peroxiredoxin 1
PRF1 perforin 1 (pore forming protein)
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKG1 protein kinase, cGMP-dependent, type I
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGES prostaglandin E synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTH parathyroid hormone
PTH1R parathyroid hormone 1 receptor
PTK2B protein tyrosine kinase 2 beta
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RB1 retinoblastoma 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REN renin
RETN resistin
RGCC regulator of cell cycle
RHOA ras homolog family member A
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPK2 receptor-interacting serine-threonine kinase 2
RIPK3 receptor-interacting serine-threonine kinase 3
RTN4 reticulon 4
RUNX2 runt-related transcription factor 2
S100A12 S100 calcium binding protein A12
S100A9 S100 calcium binding protein A9
S1PR1 sphingosine-1-phosphate receptor 1
S1PR2 sphingosine-1-phosphate receptor 2
S1PR3 sphingosine-1-phosphate receptor 3
SCAF1 SR-related CTD-associated factor 1
SELE selectin E
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SELPLG selectin P ligand
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SFTPB surfactant protein B
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIRT1 sirtuin 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SOD3 superoxide dismutase 3, extracellular
SORT1 sortilin 1
SOST sclerostin
SP1 Sp1 transcription factor
SP7 Sp7 transcription factor
SPEG SPEG complex locus
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSH1 slingshot protein phosphatase 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SUCLG1 succinate-CoA ligase, alpha subunit
TBXA2R thromboxane A2 receptor
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
THBD thrombomodulin
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TNC tenascin C
TNF tumor necrosis factor
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNNT2 troponin T type 2 (cardiac)
TNXB tenascin XB
TP73 tumor protein p73
TPSAB1 tryptase alpha/beta 1
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TXN thioredoxin
USF1 upstream transcription factor 1
UTS2 urotensin 2
UTS2R urotensin 2 receptor
VCAM1 vascular cell adhesion molecule 1
VCAN versican
VEGFA vascular endothelial growth factor A
VKORC1 vitamin K epoxide reductase complex, subunit 1
VWF von Willebrand factor
WIF1 WNT inhibitory factor 1
XYLT1 xylosyltransferase I