aortic valve Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description One of the four valves in the heart, this valve is situated at exit of the left ventricle of the heart where the aorta begins. The aortic valve lets blood from the left ventricle be pumped up into the aorta but prevents blood once it is in the aorta from returning to the heart. (BRENDA Tissue and Enzyme Source Ontology, BTO_0004628)
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Genes

281 proteins co-occuring with the tissue aortic valve in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
CRP C-reactive protein, pentraxin-related 1.48364
SPP1 secreted phosphoprotein 1 1.48036
NOTCH1 notch 1 1.46868
SCAI suppressor of cancer cell invasion 1.38871
ACE angiotensin I converting enzyme 1.37225
HGD homogentisate 1,2-dioxygenase 1.33681
PTH1R parathyroid hormone 1 receptor 1.31379
F2 coagulation factor II (thrombin) 1.27919
VWF von Willebrand factor 1.25458
APOE apolipoprotein E 1.24208
GATA5 GATA binding protein 5 1.22469
RUNX2 runt-related transcription factor 2 1.20022
MMP2 matrix metallopeptidase 2 1.19711
FBN1 fibrillin 1 1.19001
TNNT2 troponin T type 2 (cardiac) 1.17624
MMP9 matrix metallopeptidase 9 1.16515
BGLAP bone gamma-carboxyglutamate (gla) protein 1.12881
LDLR low density lipoprotein receptor 1.1266
HP haptoglobin 1.12615
HPR haptoglobin-related protein 1.11331
BMP2 bone morphogenetic protein 2 1.08545
TNNI3 troponin I type 3 (cardiac) 1.0806
NELFA negative elongation factor complex member A 1.05941
LECT1 leukocyte cell derived chemotaxin 1 1.05457
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 1.04752
AHSG alpha-2-HS-glycoprotein 1.019
ALPL alkaline phosphatase, liver/bone/kidney 1.00632
ALPPL2 alkaline phosphatase, placental-like 2 0.995425
ALPP alkaline phosphatase, placental 0.993684
EFS embryonal Fyn-associated substrate 0.970253
TIMP4 TIMP metallopeptidase inhibitor 4 0.961607
MGP matrix Gla protein 0.943935
NPPB natriuretic peptide B 0.908387
LRSAM1 leucine rich repeat and sterile alpha motif containing 1 0.901998
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 0.900721
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.89477
TNC tenascin C 0.877397
PTH parathyroid hormone 0.865577
PDLIM1 PDZ and LIM domain 1 0.848325
MFAP4 microfibrillar-associated protein 4 0.846225
PRTN3 proteinase 3 0.816486
NPPA natriuretic peptide A 0.809803
ZBTB8OS zinc finger and BTB domain containing 8 opposite strand 0.807716
IDS iduronate 2-sulfatase 0.80563
BGN biglycan 0.803961
ACTA2 actin, alpha 2, smooth muscle, aorta 0.803127
TIMP1 TIMP metallopeptidase inhibitor 1 0.796041
TGFB1 transforming growth factor, beta 1 0.791877
F3 coagulation factor III (thromboplastin, tissue factor) 0.787716
CD68 CD68 molecule 0.778155
MB myoglobin 0.776494
HBA2 hemoglobin, alpha 2 0.774834
CST3 cystatin C 0.766125
APOB apolipoprotein B 0.759086
TIFA TRAF-interacting protein with forkhead-associated domain 0.757845
ALB albumin 0.756604
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.743801
FN1 fibronectin 1 0.736382
MMP1 matrix metallopeptidase 1 0.729385
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.714189
NOS3 nitric oxide synthase 3 (endothelial cell) 0.713369
TIMP2 TIMP metallopeptidase inhibitor 2 0.705993
ICAM1 intercellular adhesion molecule 1 0.702308
CASC3 cancer susceptibility candidate 3 0.698625
OR4F29 olfactory receptor, family 4, subfamily F, member 29 0.692902
PRAC1 prostate cancer susceptibility candidate 1 0.683919
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.67984
IL6 interleukin 6 0.678617
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.67821
ELN elastin 0.67821
HBA1 hemoglobin, alpha 1 0.668029
VCAN versican 0.652589
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.651371
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.644884
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.63274
CPLX4 complexin 4 0.631123
CA5B carbonic anhydrase VB, mitochondrial 0.630718
OR10K2 olfactory receptor, family 10, subfamily K, member 2 0.627081
TBX1 T-box 1 0.626677
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 0.62385
LAX1 lymphocyte transmembrane adaptor 1 0.623043
F8 coagulation factor VIII, procoagulant component 0.622235
VCAM1 vascular cell adhesion molecule 1 0.621428
DCN decorin 0.612958
PER1 period circadian clock 1 0.612555
HHAT hedgehog acyltransferase 0.612555
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.607722
ZNF74 zinc finger protein 74 0.605709
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.603295
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.599675
F5 coagulation factor V (proaccelerin, labile factor) 0.598067
IGLV3-10 immunoglobulin lambda variable 3-10 0.584022
COG2 component of oligomeric golgi complex 2 0.581218
MYL12B myosin, light chain 12B, regulatory 0.580818
PLAT plasminogen activator, tissue 0.564035
FGF23 fibroblast growth factor 23 0.563238
B3GAT3 beta-1,3-glucuronyltransferase 3 0.556467
RHOF ras homolog family member F (in filopodia) 0.555274
TIMP3 TIMP metallopeptidase inhibitor 3 0.553683
TLR4 toll-like receptor 4 0.553286
EMILIN1 elastin microfibril interfacer 1 0.548914
SMAD2 SMAD family member 2 0.548914
PRB3 proline-rich protein BstNI subfamily 3 0.545739
PRIMA1 proline rich membrane anchor 1 0.538209
CPLX3 complexin 3 0.523982
SMTN smoothelin 0.516891
TGFBR1 transforming growth factor, beta receptor 1 0.512564
PDZK1IP1 PDZK1 interacting protein 1 0.511384
TWIST1 twist family bHLH transcription factor 1 0.50942
PIR pirin (iron-binding nuclear protein) 0.496874
APOA1 apolipoprotein A-I 0.496483
CXCL8 chemokine (C-X-C motif) ligand 8 0.492963
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 0.490619
CTSS cathepsin S 0.489838
F7 coagulation factor VII (serum prothrombin conversion accelerator) 0.487496
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.486326
MMP13 matrix metallopeptidase 13 0.48087
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.48048
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 0.478534
FBLIM1 filamin binding LIM protein 1 0.474258
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.4634
LYPD1 LY6/PLAUR domain containing 1 0.462626
TNXB tenascin XB 0.461465
TNXA tenascin XA (pseudogene) 0.461465
PDIA2 protein disulfide isomerase family A, member 2 0.454898
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.452969
FUT2 fucosyltransferase 2 (secretor status included) 0.452969
LRP5 low density lipoprotein receptor-related protein 5 0.448731
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein 0.447961
VCX variable charge, X-linked 0.444499
IDUA iduronidase, alpha-L- 0.442194
IBSP integrin-binding sialoprotein 0.441042
VCX2 variable charge, X-linked 2 0.439507
GALNS galactosamine (N-acetyl)-6-sulfatase 0.439123
BLVRA biliverdin reductase A 0.437589
APOH apolipoprotein H (beta-2-glycoprotein I) 0.434523
UFD1L ubiquitin fusion degradation 1 like (yeast) 0.431077
VCX3B variable charge, X-linked 3B 0.430312
PRAMEF6 PRAME family member 6 0.430312
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) 0.42993
KL klotho 0.426872
CNN3 calponin 3, acidic 0.426109
VCX3A variable charge, X-linked 3A 0.418099
SOX9 SRY (sex determining region Y)-box 9 0.412391
CA10 carbonic anhydrase X 0.408972
BMP4 bone morphogenetic protein 4 0.406694
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa 0.405555
MPG N-methylpurine-DNA glycosylase 0.400628
MMP21 matrix metallopeptidase 21 0.398735
INA internexin neuronal intermediate filament protein, alpha 0.397979
APC2 adenomatosis polyposis coli 2 0.3976
FBLN1 fibulin 1 0.397222
MMP3 matrix metallopeptidase 3 0.391931
CD79A CD79a molecule, immunoglobulin-associated alpha 0.38665
RGS18 regulator of G-protein signaling 18 0.382508
INS insulin 0.378748
NOG noggin 0.373493
CHRM5 cholinergic receptor, muscarinic 5 0.372369
SCARB1 scavenger receptor class B, member 1 0.368998
S100A5 S100 calcium binding protein A5 0.367502
HSPB8 heat shock 22kDa protein 8 0.362646
KNG1 kininogen 1 0.360036
LPA lipoprotein, Lp(a) 0.360036
AVEN apoptosis, caspase activation inhibitor 0.360036
TLR2 toll-like receptor 2 0.358546
ARSB arylsulfatase B 0.358174
TNF tumor necrosis factor 0.348519
SP7 Sp7 transcription factor 0.348519
SCPEP1 serine carboxypeptidase 1 0.347038
IGLV2-8 immunoglobulin lambda variable 2-8 0.347038
PTCH1 patched 1 0.342233
PBX3 pre-B-cell leukemia homeobox 3 0.341126
SMC1A structural maintenance of chromosomes 1A 0.340388
KMT2A lysine (K)-specific methyltransferase 2A 0.337072
ACSL1 acyl-CoA synthetase long-chain family member 1 0.335968
SOST sclerostin 0.333763
IGLV5-48 immunoglobulin lambda variable 5-48 (non-functional) 0.333396
BIN3 bridging integrator 3 0.331927
NT5M 5',3'-nucleotidase, mitochondrial 0.330094
FOXF2 forkhead box F2 0.330094
C1ORF174 chromosome 1 open reading frame 174 0.32753
ENO2 enolase 2 (gamma, neuronal) 0.326798
CD36 CD36 molecule (thrombospondin receptor) 0.326067
RGS8 regulator of G-protein signaling 8 0.325335
NCR3 natural cytotoxicity triggering receptor 3 0.323144
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.322414
RPA3 replication protein A3, 14kDa 0.319863
SMAD3 SMAD family member 3 0.319134
PF4 platelet factor 4 0.31877
AGTR1 angiotensin II receptor, type 1 0.316224
ARL2BP ADP-ribosylation factor-like 2 binding protein 0.31332
AGER advanced glycosylation end product-specific receptor 0.312957
F9 coagulation factor IX 0.312595
LOX lysyl oxidase 0.31187
CD34 CD34 molecule 0.309697
ANXA5 annexin A5 0.308251
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.303198
NKX2-5 NK2 homeobox 5 0.29996
HOXA1 homeobox A1 0.299242
EDN1 endothelin 1 0.294939
IVD isovaleryl-CoA dehydrogenase 0.293151
MMP8 matrix metallopeptidase 8 0.290295
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle 0.289226
HAND1 heart and neural crest derivatives expressed 1 0.288514
KLF6 Kruppel-like factor 6 0.285671
MIRLET7D microRNA let-7d 0.28213
IGLV5-52 immunoglobulin lambda variable 5-52 0.280012
CTSL cathepsin L 0.279307
COL1A2 collagen, type I, alpha 2 0.277549
C6ORF25 chromosome 6 open reading frame 25 0.276846
FICD FIC domain containing 0.276495
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.274744
PBX2 pre-B-cell leukemia homeobox 2 0.273346
LCN2 lipocalin 2 0.272997
FOXO4 forkhead box O4 0.272649
GLS2 glutaminase 2 (liver, mitochondrial) 0.271604
RIPK4 receptor-interacting serine-threonine kinase 4 0.271604
RANBP3 RAN binding protein 3 0.271604
HIST2H3D histone cluster 2, H3d 0.270909
HIST2H3C histone cluster 2, H3c 0.270909
HIST2H3A histone cluster 2, H3a 0.270909
PEX10 peroxisomal biogenesis factor 10 0.270561
PRG4 proteoglycan 4 0.270561
MPO myeloperoxidase 0.270214
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 0.267791
CCL2 chemokine (C-C motif) ligand 2 0.266757
SCARB2 scavenger receptor class B, member 2 0.265038
CBS cystathionine-beta-synthase 0.261964
MMP24 matrix metallopeptidase 24 (membrane-inserted) 0.260606
AOC2 amine oxidase, copper containing 2 (retina-specific) 0.258243
CTGF connective tissue growth factor 0.258243
CS citrate synthase 0.257907
ADRB1 adrenoceptor beta 1 0.257907
GREM2 gremlin 2, DAN family BMP antagonist 0.257237
COL3A1 collagen, type III, alpha 1 0.254239
NPPC natriuretic peptide C 0.253908
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.25259
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.250953
ARSH arylsulfatase family, member H 0.250627
PLG plasminogen 0.249977
PTGDR prostaglandin D2 receptor (DP) 0.246442
CTHRC1 collagen triple helix repeat containing 1 0.24486
ARR3 arrestin 3, retinal (X-arrestin) 0.243918
S100B S100 calcium binding protein B 0.243294
PRRC2A proline-rich coiled-coil 2A 0.242054
COX5A cytochrome c oxidase subunit Va 0.241438
FRZB frizzled-related protein 0.241132
PLCH2 phospholipase C, eta 2 0.240826
TXNL4B thioredoxin-like 4B 0.24052
TXNIP thioredoxin interacting protein 0.24052
EHD1 EH-domain containing 1 0.239007
FAM120A family with sequence similarity 120A 0.239007
MMP12 matrix metallopeptidase 12 0.237513
PID1 phosphotyrosine interaction domain containing 1 0.23459
GRB14 growth factor receptor-bound protein 14 0.233162
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.23176
ICK intestinal cell (MAK-like) kinase 0.231206
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 0.230931
TBX5 T-box 5 0.230382
FTL ferritin, light polypeptide 0.229032
BMPER BMP binding endothelial regulator 0.228497
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.227707
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.227445
REN renin 0.226667
GBA glucosidase, beta, acid 0.224398
PPP4C protein phosphatase 4, catalytic subunit 0.22415
FTH1 ferritin, heavy polypeptide 1 0.223906
ICA1 islet cell autoantigen 1, 69kDa 0.222224
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.221755
FBXL20 F-box and leucine-rich repeat protein 20 0.221291
UST uronyl-2-sulfotransferase 0.219485
TTR transthyretin 0.218186
CTSV cathepsin V 0.218186
FBXL15 F-box and leucine-rich repeat protein 15 0.217554
KHK ketohexokinase (fructokinase) 0.217139
CYTIP cytohesin 1 interacting protein 0.216325
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 0.21573
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 0.214202
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 0.21365
MECOM MDS1 and EVI1 complex locus 0.213112
MMP17 matrix metallopeptidase 17 (membrane-inserted) 0.212586