aortic valve stenosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description An aortic valve disease that has_physical_basis_in incomplete opening of the aortic valve. (Human Disease Ontology, DOID_1712)
Similar Terms
Downloads & Tools

Genes

269 genes co-occuring with the disease aortic valve stenosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
ELN elastin 2.3613
PDLIM1 PDZ and LIM domain 1 2.09009
ACE angiotensin I converting enzyme 1.35158
VWF von Willebrand factor 1.32148
GTF2IRD1 GTF2I repeat domain containing 1 1.26298
GTF2I general transcription factor IIi 1.25167
ADRB1 adrenoceptor beta 1 1.14305
SPP1 secreted phosphoprotein 1 1.13247
NPPA natriuretic peptide A 1.12193
BMP2 bone morphogenetic protein 2 1.1072
CRP C-reactive protein, pentraxin-related 1.09377
HGD homogentisate 1,2-dioxygenase 1.09335
LIMK1 LIM domain kinase 1 1.09293
LECT1 leukocyte cell derived chemotaxin 1 1.06438
JAG1 jagged 1 1.05219
NPPB natriuretic peptide B 1.02355
ADRB2 adrenoceptor beta 2, surface 1.0071
FBN1 fibrillin 1 0.976323
SPTBN1 spectrin, beta, non-erythrocytic 1 0.97128
SP7 Sp7 transcription factor 0.97002
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 0.947852
EXTL3 exostosin-like glycosyltransferase 3 0.915963
CALN1 calneuron 1 0.894589
NELFA negative elongation factor complex member A 0.890898
MMP2 matrix metallopeptidase 2 0.889258
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.882292
TNNI3 troponin I type 3 (cardiac) 0.873281
ACYP1 acylphosphatase 1, erythrocyte (common) type 0.853631
TNNT2 troponin T type 2 (cardiac) 0.835198
DNAH8 dynein, axonemal, heavy chain 8 0.829459
RUNX2 runt-related transcription factor 2 0.80977
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.783116
MMP9 matrix metallopeptidase 9 0.781888
MYL2 myosin, light chain 2, regulatory, cardiac, slow 0.769618
NOTCH1 notch 1 0.753713
ACYP2 acylphosphatase 2, muscle type 0.752898
ACP6 acid phosphatase 6, lysophosphatidic 0.752492
TIMP1 TIMP metallopeptidase inhibitor 1 0.748017
REN renin 0.730976
SOX9 SRY (sex determining region Y)-box 9 0.729762
NOS3 nitric oxide synthase 3 (endothelial cell) 0.728143
FBLN1 fibulin 1 0.711183
MMP1 matrix metallopeptidase 1 0.710378
PTGDR prostaglandin D2 receptor (DP) 0.694301
MGP matrix Gla protein 0.67551
APOB apolipoprotein B 0.674315
CPLX4 complexin 4 0.664372
TNC tenascin C 0.659215
TGFB1 transforming growth factor, beta 1 0.658818
EFS embryonal Fyn-associated substrate 0.652484
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 0.63907
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.638676
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit 0.632777
APOC4 apolipoprotein C-IV 0.630813
PLN phospholamban 0.623751
WBSCR22 Williams Beuren syndrome chromosome region 22 0.622967
PRB3 proline-rich protein BstNI subfamily 3 0.622575
NSUN5 NOP2/Sun domain family, member 5 0.622575
TIMP2 TIMP metallopeptidase inhibitor 2 0.620617
LDLR low density lipoprotein receptor 0.60342
RGS18 regulator of G-protein signaling 18 0.593674
IGLV1-36 immunoglobulin lambda variable 1-36 0.592895
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 0.583163
AHSG alpha-2-HS-glycoprotein 0.583163
BGLAP bone gamma-carboxyglutamate (gla) protein 0.57655
ALPL alkaline phosphatase, liver/bone/kidney 0.575772
BCL7B B-cell CLL/lymphoma 7B 0.574994
APOA1 apolipoprotein A-I 0.573828
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.573439
GATA5 GATA binding protein 5 0.572662
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.562169
PLAC8 placenta-specific 8 0.553627
TTN titin 0.553239
ALPPL2 alkaline phosphatase, placental-like 2 0.550911
ALPP alkaline phosphatase, placental 0.550522
TBL2 transducin (beta)-like 2 0.548583
ICAM1 intercellular adhesion molecule 1 0.546256
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.531154
GLS glutaminase 0.530768
VCX variable charge, X-linked 0.529994
LRSAM1 leucine rich repeat and sterile alpha motif containing 1 0.529994
IGLV1-47 immunoglobulin lambda variable 1-47 0.52729
FN1 fibronectin 1 0.524974
GH2 growth hormone 2 0.517649
CMA1 chymase 1, mast cell 0.507273
VCX2 variable charge, X-linked 2 0.505356
PDZK1IP1 PDZK1 interacting protein 1 0.498849
NPPC natriuretic peptide C 0.490835
GATA4 GATA binding protein 4 0.485505
CD68 CD68 molecule 0.478289
IBSP integrin-binding sialoprotein 0.472982
F3 coagulation factor III (thromboplastin, tissue factor) 0.470711
VCX3B variable charge, X-linked 3B 0.469576
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.469576
FBLN5 fibulin 5 0.465416
COG2 component of oligomeric golgi complex 2 0.462394
TPM1 tropomyosin 1 (alpha) 0.459751
MYH7 myosin, heavy chain 7, cardiac muscle, beta 0.459373
PROM1 prominin 1 0.456355
VCX3A variable charge, X-linked 3A 0.448817
APOE apolipoprotein E 0.448441
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.447311
AGTR1 angiotensin II receptor, type 1 0.446558
LUM lumican 0.445805
DCN decorin 0.445429
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.444676
HES5 hes family bHLH transcription factor 5 0.444394
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 0.4443
ZMYM3 zinc finger, MYM-type 3 0.440914
EDN1 endothelin 1 0.431144
RCAN1 regulator of calcineurin 1 0.428516
HP haptoglobin 0.425139
EHD1 EH-domain containing 1 0.42139
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 0.420266
HPR haptoglobin-related protein 0.419142
TBX1 T-box 1 0.416521
BAMBI BMP and activin membrane-bound inhibitor 0.40904
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.406051
JARID2 jumonji, AT rich interactive domain 2 0.405678
APLNR apelin receptor 0.404557
HBA2 hemoglobin, alpha 2 0.403811
JPH2 junctophilin 2 0.397843
TIMP4 TIMP metallopeptidase inhibitor 4 0.397471
MYOM2 myomesin 2 0.396725
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) 0.393001
VARS valyl-tRNA synthetase 0.393001
KLF15 Kruppel-like factor 15 0.392257
FMOD fibromodulin 0.390025
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.387423
GLS2 glutaminase 2 (liver, mitochondrial) 0.384822
BCL7A B-cell CLL/lymphoma 7A 0.384451
WDR20 WD repeat domain 20 0.383708
MYL12B myosin, light chain 12B, regulatory 0.382223
BGN biglycan 0.378885
TLR4 toll-like receptor 4 0.374809
CCNDBP1 cyclin D-type binding-protein 1 0.372587
HBA1 hemoglobin, alpha 1 0.371477
KNG1 kininogen 1 0.363347
CCL2 chemokine (C-C motif) ligand 2 0.361502
TIMP3 TIMP metallopeptidase inhibitor 3 0.361133
PGRMC1 progesterone receptor membrane component 1 0.355604
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 0.355235
GATA6 GATA binding protein 6 0.344941
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 0.342006
CTSV cathepsin V 0.341272
OGN osteoglycin 0.339806
ACTN1 actinin, alpha 1 0.337608
ZIC3 Zic family member 3 0.333583
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 0.328743
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.328469
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.32774
COL18A1 collagen, type XVIII, alpha 1 0.32701
PRAMEF6 PRAME family member 6 0.325916
USO1 USO1 vesicle transport factor 0.324458
C7ORF49 chromosome 7 open reading frame 49 0.32373
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.323002
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) 0.32009
TPTE transmembrane phosphatase with tensin homology 0.319726
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.319726
PRAC1 prostate cancer susceptibility candidate 1 0.317182
PLTP phospholipid transfer protein 0.316456
MUS81 MUS81 structure-specific endonuclease subunit 0.313552
ATP2A3 ATPase, Ca++ transporting, ubiquitous 0.313552
GALNS galactosamine (N-acetyl)-6-sulfatase 0.311377
C1ORF174 chromosome 1 open reading frame 174 0.310652
SLC30A2 solute carrier family 30 (zinc transporter), member 2 0.309928
TBX20 T-box 20 0.307395
LIN7A lin-7 homolog A (C. elegans) 0.305226
AUTS2 autism susceptibility candidate 2 0.300894
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.299812
TXNIP thioredoxin interacting protein 0.299092
AK2 adenylate kinase 2 0.298011
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.296571
FAM131C family with sequence similarity 131, member C 0.292975
VCAM1 vascular cell adhesion molecule 1 0.284371
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 0.279367
HPD 4-hydroxyphenylpyruvate dioxygenase 0.279011
MON1A MON1 secretory trafficking family member A 0.277227
PTH parathyroid hormone 0.270464
BMF Bcl2 modifying factor 0.267977
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.267977
IGLV2-8 immunoglobulin lambda variable 2-8 0.260891
PRRC2A proline-rich coiled-coil 2A 0.259565
FBLN2 fibulin 2 0.257711
BCL9 B-cell CLL/lymphoma 9 0.257358
MMP3 matrix metallopeptidase 3 0.257005
GJA1 gap junction protein, alpha 1, 43kDa 0.256652
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 0.256299
TUBGCP4 tubulin, gamma complex associated protein 4 0.255946
SMAD2 SMAD family member 2 0.254888
FBN2 fibrillin 2 0.253831
TAS1R1 taste receptor, type 1, member 1 0.251718
MYBPC3 myosin binding protein C, cardiac 0.251366
PIR pirin (iron-binding nuclear protein) 0.248554
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.24715
LACTB lactamase, beta 0.246799
PNKD paroxysmal nonkinesigenic dyskinesia 0.246799
TLR2 toll-like receptor 2 0.243295
ALB albumin 0.242245
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 0.236312
IL6 interleukin 6 0.236312
LY6E lymphocyte antigen 6 complex, locus E 0.233878
TMEM245 transmembrane protein 245 0.233878
EDN3 endothelin 3 0.232836
PERP PERP, TP53 apoptosis effector 0.231795
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.231102
AURKAIP1 aurora kinase A interacting protein 1 0.231102
MYO7A myosin VIIA 0.230755
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 0.230409
F8 coagulation factor VIII, procoagulant component 0.230409
BMP4 bone morphogenetic protein 4 0.230063
OR10K2 olfactory receptor, family 10, subfamily K, member 2 0.224196
LPA lipoprotein, Lp(a) 0.219398
MTTP microsomal triglyceride transfer protein 0.218374
PTPRF protein tyrosine phosphatase, receptor type, F 0.217012
ESPN espin 0.212945
MGEA5 meningioma expressed antigen 5 (hyaluronidase) 0.211597
PEX10 peroxisomal biogenesis factor 10 0.211261
ALYREF Aly/REF export factor 0.207578
CD34 CD34 molecule 0.205916
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.205916
WNT3A wingless-type MMTV integration site family, member 3A 0.204593
LAX1 lymphocyte transmembrane adaptor 1 0.204263
ACTC1 actin, alpha, cardiac muscle 1 0.20229
KLHL17 kelch-like family member 17 0.200656
THBS4 thrombospondin 4 0.199356
ENO3 enolase 3 (beta, muscle) 0.199356
BLVRA biliverdin reductase A 0.199033
UST uronyl-2-sulfotransferase 0.199033
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 0.195501
KRAS Kirsten rat sarcoma viral oncogene homolog 0.194865
LEMD3 LEM domain containing 3 0.192971
PDS5B PDS5 cohesin associated factor B 0.191408
IDS iduronate 2-sulfatase 0.190168
CALCA calcitonin-related polypeptide alpha 0.188326
GRIA3 glutamate receptor, ionotropic, AMPA 3 0.187113
OPN3 opsin 3 0.185016
MPG N-methylpurine-DNA glycosylase 0.183541
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 0.179802
IGLV3-10 immunoglobulin lambda variable 3-10 0.17952
HIP1 huntingtin interacting protein 1 0.179239
RERE arginine-glutamic acid dipeptide (RE) repeats 0.178126
TERF2 telomeric repeat binding factor 2 0.177851
DLX5 distal-less homeobox 5 0.177029
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.175947
CS citrate synthase 0.175679
LSR lipolysis stimulated lipoprotein receptor 0.174881
HYAL1 hyaluronoglucosaminidase 1 0.171286
GDF15 growth differentiation factor 15 0.170054
AGER advanced glycosylation end product-specific receptor 0.165655
CORIN corin, serine peptidase 0.163729
VEGFA vascular endothelial growth factor A 0.163523
JUNB jun B proto-oncogene 0.162109
GJC1 gap junction protein, gamma 1, 45kDa 0.161912
FOS FBJ murine osteosarcoma viral oncogene homolog 0.159658
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 0.158605
NPC1L1 NPC1-like 1 0.158266
IL18 interleukin 18 0.157929
HRAS Harvey rat sarcoma viral oncogene homolog 0.157929
NOX4 NADPH oxidase 4 0.157929
PICALM phosphatidylinositol binding clathrin assembly protein 0.146056
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.141351
ZKSCAN7 zinc finger with KRAB and SCAN domains 7 0.140732
MLXIPL MLX interacting protein-like 0.13993
NOS1 nitric oxide synthase 1 (neuronal) 0.138967
CKM creatine kinase, muscle 0.13821
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.136275
SCN5A sodium channel, voltage gated, type V alpha subunit 0.130596
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 0.129616