aortic root Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description The part of the aorta attached to the atrioventricular fibrous rings and myocardium. (BRENDA Tissue and Enzyme Source Ontology, BTO_0004695)
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Genes

163 proteins co-occuring with the tissue aortic root in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
APOE apolipoprotein E 2.80042
FBN1 fibrillin 1 2.28761
LDLR low density lipoprotein receptor 2.20454
VCAM1 vascular cell adhesion molecule 1 1.36723
TGFBR1 transforming growth factor, beta receptor 1 1.33003
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 1.25905
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 1.2296
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.22737
LPA lipoprotein, Lp(a) 1.1173
FBN2 fibrillin 2 1.04708
KANSL1 KAT8 regulatory NSL complex subunit 1 1.04181
GAR1 GAR1 ribonucleoprotein 1.03609
SGMS2 sphingomyelin synthase 2 1.02206
APOA1 apolipoprotein A-I 1.01156
SCARB1 scavenger receptor class B, member 1 0.988466
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 0.987162
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 0.97935
LRRC3 leucine rich repeat containing 3 0.971984
MMP9 matrix metallopeptidase 9 0.953409
ACE angiotensin I converting enzyme 0.924194
CCL2 chemokine (C-C motif) ligand 2 0.916069
CETP cholesteryl ester transfer protein, plasma 0.913507
CNR2 cannabinoid receptor 2 (macrophage) 0.885862
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 0.880781
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 0.874016
APOB apolipoprotein B 0.854629
CRP C-reactive protein, pentraxin-related 0.830291
ICAM1 intercellular adhesion molecule 1 0.826942
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.810221
RAET1L retinoic acid early transcript 1L 0.794375
PRAC1 prostate cancer susceptibility candidate 1 0.771514
ELN elastin 0.760328
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.746689
SPPL2C signal peptide peptidase like 2C 0.742976
C1QA complement component 1, q subcomponent, A chain 0.695763
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 0.694946
TNNT2 troponin T type 2 (cardiac) 0.694128
SAMD8 sterile alpha motif domain containing 8 0.684327
MMP2 matrix metallopeptidase 2 0.683919
SMAD3 SMAD family member 3 0.678617
NPPA natriuretic peptide A 0.677395
NOTCH1 notch 1 0.670878
SCARB2 scavenger receptor class B, member 2 0.659085
NOS3 nitric oxide synthase 3 (endothelial cell) 0.652589
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.641643
CD36 CD36 molecule (thrombospondin receptor) 0.629506
B3GAT3 beta-1,3-glucuronyltransferase 3 0.624254
ACTA2 actin, alpha 2, smooth muscle, aorta 0.619814
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.614571
ALB albumin 0.604502
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 0.603697
IL12B interleukin 12B 0.59124
CD68 CD68 molecule 0.586828
PPARG peroxisome proliferator-activated receptor gamma 0.586828
TBRG1 transforming growth factor beta regulator 1 0.573217
AMD1 adenosylmethionine decarboxylase 1 0.55408
APOC1 apolipoprotein C-I 0.551298
NPPB natriuretic peptide B 0.540981
PDZK1 PDZ domain containing 1 0.533856
PRSS30P protease, serine, 30, pseudogene 0.529903
GEN1 GEN1 Holliday junction 5' flap endonuclease 0.51453
CD4 CD4 molecule 0.514136
CES3 carboxylesterase 3 0.513743
FH fumarate hydratase 0.503533
HBS1L HBS1-like translational GTPase 0.503141
JKAMP JNK1/MAPK8-associated membrane protein 0.500007
TGFB1 transforming growth factor, beta 1 0.497266
IL6 interleukin 6 0.492182
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.48048
BGN biglycan 0.475423
SAA1 serum amyloid A1 0.457987
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1 0.457987
LAX1 lymphocyte transmembrane adaptor 1 0.45567
REN renin 0.453355
WRN Werner syndrome, RecQ helicase-like 0.445653
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 0.443731
TNF tumor necrosis factor 0.439123
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.436055
MERTK MER proto-oncogene, tyrosine kinase 0.435672
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.43414
BIN3 bridging integrator 3 0.429165
NT5M 5',3'-nucleotidase, mitochondrial 0.426872
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.426109
TSPO translocator protein (18kDa) 0.418861
MMP3 matrix metallopeptidase 3 0.415814
TNNI3 troponin I type 3 (cardiac) 0.414673
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.411631
LACTB lactamase, beta 0.405176
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.397222
BVES blood vessel epicardial substance 0.394197
SELE selectin E 0.388535
SMCP sperm mitochondria-associated cysteine-rich protein 0.383637
CDK13 cyclin-dependent kinase 13 0.38326
POMT2 protein-O-mannosyltransferase 2 0.374993
CCR2 chemokine (C-C motif) receptor 2 0.373493
F3 coagulation factor III (thromboplastin, tissue factor) 0.371245
INS insulin 0.368998
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 0.367502
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 0.367129
AEBP1 AE binding protein 1 0.366007
AAAS achalasia, adrenocortical insufficiency, alacrimia 0.366007
ALOX5AP arachidonate 5-lipoxygenase-activating protein 0.357058
APOA2 apolipoprotein A-II 0.35557
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.347408
PDLIM1 PDZ and LIM domain 1 0.346668
SAA2 serum amyloid A2 0.346668
HOXC4 homeobox C4 0.34371
CRCP CGRP receptor component 0.342971
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 0.341495
PGRMC1 progesterone receptor membrane component 1 0.338914
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 0.335233
EDN1 endothelin 1 0.332661
LYST lysosomal trafficking regulator 0.32753
SOD2 superoxide dismutase 2, mitochondrial 0.327164
PRRC2A proline-rich coiled-coil 2A 0.321685
PLTP phospholipid transfer protein 0.319863
NRG2 neuregulin 2 0.315498
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.314046
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 0.314046
LCAT lecithin-cholesterol acyltransferase 0.310421
ADGRE1 adhesion G protein-coupled receptor E1 0.310421
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 0.308974
LGALS3 lectin, galactoside-binding, soluble, 3 0.308612
OSBP oxysterol binding protein 0.305001
PLA2G10 phospholipase A2, group X 0.302118
RAET1E retinoic acid early transcript 1E 0.299242
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 0.294581
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 0.291722
LIN7A lin-7 homolog A (C. elegans) 0.28887
MMP13 matrix metallopeptidase 13 0.282483
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.28213
PGF placental growth factor 0.28107
NPC1 Niemann-Pick disease, type C1 0.2779
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.275444
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 0.272997
GZMK granzyme K (granzyme 3; tryptase II) 0.266757
PLN phospholamban 0.262986
NNMT nicotinamide N-methyltransferase 0.260945
NPY5R neuropeptide Y receptor Y5 0.259591
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2 0.257907
MMP8 matrix metallopeptidase 8 0.252919
LRSAM1 leucine rich repeat and sterile alpha motif containing 1 0.250301
STK10 serine/threonine kinase 10 0.246442
HAX1 HCLS1 associated protein X-1 0.24486
CCR7 chemokine (C-C motif) receptor 7 0.243605
BMP8B bone morphogenetic protein 8b 0.241132
PERP PERP, TP53 apoptosis effector 0.240826
NCBP1 nuclear cap binding protein subunit 1, 80kDa 0.23961
MSR1 macrophage scavenger receptor 1 0.239007
NPY2R neuropeptide Y receptor Y2 0.23781
PON3 paraoxonase 3 0.233446
ALOX5 arachidonate 5-lipoxygenase 0.232039
S100A9 S100 calcium binding protein A9 0.23176
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.229032
UBAP1 ubiquitin associated protein 1 0.225647
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 0.223662
IL27RA interleukin 27 receptor, alpha 0.223662
TIMP2 TIMP metallopeptidase inhibitor 2 0.222699
PLA2G1B phospholipase A2, group IB (pancreas) 0.222224
SQLE squalene epoxidase 0.222224
TRIB3 tribbles pseudokinase 3 0.221989
NPY1R neuropeptide Y receptor Y1 0.221521
PTCH2 patched 2 0.214576