aortic disease Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description An artery disease that is characterized by degeneration of the cells composing the aortic wall. (Human Disease Ontology, DOID_520)
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Genes

384 genes co-occuring with the disease aortic disease in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
APOE apolipoprotein E 1.67412
FBN1 fibrillin 1 1.55158
LDLR low density lipoprotein receptor 1.42191
ACTA2 actin, alpha 2, smooth muscle, aorta 1.25341
CRP C-reactive protein, pentraxin-related 1.149
APOB apolipoprotein B 1.11561
AAAS achalasia, adrenocortical insufficiency, alacrimia 1.02777
RAET1L retinoic acid early transcript 1L 1.01047
SCAI suppressor of cancer cell invasion 0.982215
ARHGAP31 Rho GTPase activating protein 31 0.97296
CETP cholesteryl ester transfer protein, plasma 0.925452
LCAT lecithin-cholesterol acyltransferase 0.904854
MYH11 myosin, heavy chain 11, smooth muscle 0.865093
LPA lipoprotein, Lp(a) 0.848716
SCARB1 scavenger receptor class B, member 1 0.831508
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.815924
TGM5 transglutaminase 5 0.807308
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 0.785574
PGRMC1 progesterone receptor membrane component 1 0.736649
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.72127
TGFBR1 transforming growth factor, beta receptor 1 0.715215
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 0.712392
REN renin 0.703536
ACE angiotensin I converting enzyme 0.690293
SMAD3 SMAD family member 3 0.674713
COG2 component of oligomeric golgi complex 2 0.613965
ZNF197 zinc finger protein 197 0.61162
COL3A1 collagen, type III, alpha 1 0.610448
CCL2 chemokine (C-C motif) ligand 2 0.606152
GIP gastric inhibitory polypeptide 0.604981
APOA1 apolipoprotein A-I 0.596792
SOAT2 sterol O-acyltransferase 2 0.595233
SPATA5 spermatogenesis associated 5 0.594454
SCARB2 scavenger receptor class B, member 2 0.58939
CD36 CD36 molecule (thrombospondin receptor) 0.573439
KALRN kalirin, RhoGEF kinase 0.563335
IDUA iduronidase, alpha-L- 0.560616
BAK1 BCL2-antagonist/killer 1 0.529222
GRK5 G protein-coupled receptor kinase 5 0.523816
LPL lipoprotein lipase 0.522659
VCAM1 vascular cell adhesion molecule 1 0.506507
IL6 interleukin 6 0.498849
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 0.498085
MAN2C1 mannosidase, alpha, class 2C, member 1 0.497321
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.497321
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.476772
TGFB2 transforming growth factor, beta 2 0.474877
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 0.466928
MMP1 matrix metallopeptidase 1 0.460883
ICAM1 intercellular adhesion molecule 1 0.460506
GZMK granzyme K (granzyme 3; tryptase II) 0.457487
VLDLR very low density lipoprotein receptor 0.451078
HOXA4 homeobox A4 0.449194
GPIHBP1 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 0.449194
CTSS cathepsin S 0.439786
A2M alpha-2-macroglobulin 0.429642
MYLK myosin light chain kinase 0.424014
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.42139
TIMP1 TIMP metallopeptidase inhibitor 1 0.419142
MPO myeloperoxidase 0.416521
CD68 CD68 molecule 0.410909
CXXC5 CXXC finger protein 5 0.408666
PEX14 peroxisomal biogenesis factor 14 0.406798
MMP3 matrix metallopeptidase 3 0.394491
DUOXA1 dual oxidase maturation factor 1 0.386308
DUOX1 dual oxidase 1 0.382594
MMP9 matrix metallopeptidase 9 0.37629
UTS2 urotensin 2 0.364085
DUOX2 dual oxidase 2 0.362609
GRHL1 grainyhead-like 1 (Drosophila) 0.360764
ELN elastin 0.347658
PRKG1 protein kinase, cGMP-dependent, type I 0.346777
MMP2 matrix metallopeptidase 2 0.344207
TIMP4 TIMP metallopeptidase inhibitor 4 0.341052
CMKLR1 chemerin chemokine-like receptor 1 0.337975
PF4 platelet factor 4 0.335412
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.334681
DAB2IP DAB2 interacting protein 0.330368
TIMP2 TIMP metallopeptidase inhibitor 2 0.328105
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 0.325916
MBD1 methyl-CpG binding domain protein 1 0.323002
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.31849
NT5C2 5'-nucleotidase, cytosolic II 0.312827
MDH1 malate dehydrogenase 1, NAD (soluble) 0.311377
UTS2R urotensin 2 receptor 0.311377
TIMP3 TIMP metallopeptidase inhibitor 3 0.303275
HECA headcase homolog (Drosophila) 0.302698
RERE arginine-glutamic acid dipeptide (RE) repeats 0.300173
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.298587
LRSAM1 leucine rich repeat and sterile alpha motif containing 1 0.298011
IL1RN interleukin 1 receptor antagonist 0.295132
C17ORF85 chromosome 17 open reading frame 85 0.2924
IL6ST interleukin 6 signal transducer 0.290821
SOAT1 sterol O-acyltransferase 1 0.286519
TLR4 toll-like receptor 4 0.284728
BGN biglycan 0.284013
SPP1 secreted phosphoprotein 1 0.280796
MMP12 matrix metallopeptidase 12 0.280082
CFAP74 cilia and flagella associated protein 74 0.275089
MMP8 matrix metallopeptidase 8 0.273095
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 0.271317
S1PR3 sphingosine-1-phosphate receptor 3 0.264431
MKL1 megakaryoblastic leukemia (translocation) 1 0.263014
AGER advanced glycosylation end product-specific receptor 0.261245
FBXL20 F-box and leucine-rich repeat protein 20 0.259689
PRTN3 proteinase 3 0.254183
LCA10 lung carcinoma-associated 10 0.252774
TNF tumor necrosis factor 0.252422
ATG12 autophagy related 12 0.25207
TSPO translocator protein (18kDa) 0.250311
MED28 mediator complex subunit 28 0.245747
GIPR gastric inhibitory polypeptide receptor 0.243645
TNXB tenascin XB 0.237845
INS insulin 0.234573
MMP13 matrix metallopeptidase 13 0.232697
CLPS colipase, pancreatic 0.230409
TNXA tenascin XA (pseudogene) 0.227573
CMA1 chymase 1, mast cell 0.22578
C5ORF38 chromosome 5 open reading frame 38 0.223853
IL6R interleukin 6 receptor 0.217012
C1ORF105 chromosome 1 open reading frame 105 0.216332
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G 0.211597
CES1 carboxylesterase 1 0.210253
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 0.210052
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 0.208245
BAD BCL2-associated agonist of cell death 0.20658
LIPG lipase, endothelial 0.200006
NPEPPS aminopeptidase puromycin sensitive 0.199033
MFAP4 microfibrillar-associated protein 4 0.197099
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.193285
CR1L complement component (3b/4b) receptor 1-like 0.190229
PCYT1A phosphate cytidylyltransferase 1, choline, alpha 0.18591
KLK15 kallikrein-related peptidase 15 0.185016
CST3 cystatin C 0.1836
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 0.183248
PLG plasminogen 0.172697
MFAP2 microfibrillar-associated protein 2 0.17219
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.170987
ARRB2 arrestin, beta 2 0.170789
ALB albumin 0.169091
PLAT plasminogen activator, tissue 0.167498
CSN1S1 casein alpha s1 0.167224
F2 coagulation factor II (thrombin) 0.164958
PHF12 PHD finger protein 12 0.163111
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 0.162306
IL12B interleukin 12B 0.160203
SORT1 sortilin 1 0.159911
PLAU plasminogen activator, urokinase 0.15902
CMC4 C-x(9)-C motif containing 4 0.155624
F3 coagulation factor III (thromboplastin, tissue factor) 0.155277
ELANE elastase, neutrophil expressed 0.15469
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.151966
GPLD1 glycosylphosphatidylinositol specific phospholipase D1 0.151015
IL1B interleukin 1, beta 0.150764
PTGES prostaglandin E synthase 0.150503
ADAM17 ADAM metallopeptidase domain 17 0.150448
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 0.149721
AURKC aurora kinase C 0.148644
ARL4C ADP-ribosylation factor-like 4C 0.148143
LOX lysyl oxidase 0.147006
TNNI3 troponin I type 3 (cardiac) 0.146721
LTBP4 latent transforming growth factor beta binding protein 4 0.146605
VCAN versican 0.146255
TGFB1 transforming growth factor, beta 1 0.146198
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.14578
HBA2 hemoglobin, alpha 2 0.145556
HBA1 hemoglobin, alpha 1 0.14534
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.145203
HP haptoglobin 0.145182
HPR haptoglobin-related protein 0.145085
EXOC3 exocyst complex component 3 0.145079
CPB2 carboxypeptidase B2 (plasma) 0.145077
MMP25 matrix metallopeptidase 25 0.144876
CTSG cathepsin G 0.144869
LCN2 lipocalin 2 0.144852
AGTR1 angiotensin II receptor, type 1 0.144815
C8G complement component 8, gamma polypeptide 0.144738
ALOX5 arachidonate 5-lipoxygenase 0.144672
JUN jun proto-oncogene 0.144672
C8A complement component 8, alpha polypeptide 0.144663
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.144635
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1 0.144606
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.144569
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 0.144493
HAS1 hyaluronan synthase 1 0.144481
ENOSF1 enolase superfamily member 1 0.144436
PIGC phosphatidylinositol glycan anchor biosynthesis, class C 0.144368
ALYREF Aly/REF export factor 0.144267
NOS3 nitric oxide synthase 3 (endothelial cell) 0.144222
SMTN smoothelin 0.144222
FGD1 FYVE, RhoGEF and PH domain containing 1 0.144169
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.144144
RRBP1 ribosome binding protein 1 0.144132
IL9R interleukin 9 receptor 0.144085
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 0.144059
C8B complement component 8, beta polypeptide 0.144054
S100A12 S100 calcium binding protein A12 0.143994
SRA1 steroid receptor RNA activator 1 0.143974
CXCL8 chemokine (C-X-C motif) ligand 8 0.14394
FBN2 fibrillin 2 0.1439
CCR2 chemokine (C-C motif) receptor 2 0.1439
CTSB cathepsin B 0.143855
TNNT2 troponin T type 2 (cardiac) 0.143821
PRUNE2 prune homolog 2 (Drosophila) 0.143802
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 0.143733
CTSD cathepsin D 0.143675
DDO D-aspartate oxidase 0.143596
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.143505
BHMT2 betaine--homocysteine S-methyltransferase 2 0.143485
ATG4B autophagy related 4B, cysteine peptidase 0.143468
LTB4R leukotriene B4 receptor 0.14345
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.143386
DNM3 dynamin 3 0.143329
ERAS ES cell expressed Ras 0.143329
ACTA1 actin, alpha 1, skeletal muscle 0.143254
PMF1 polyamine-modulated factor 1 0.143247
NOTCH1 notch 1 0.143227
THBS2 thrombospondin 2 0.14319
THBD thrombomodulin 0.14318
BHMT betaine--homocysteine S-methyltransferase 0.143157
ZFYVE1 zinc finger, FYVE domain containing 1 0.143149
MARCKSL1 MARCKS-like 1 0.143147
IL10 interleukin 10 0.14305
TNC tenascin C 0.143024
CD4 CD4 molecule 0.142878
MMP7 matrix metallopeptidase 7 0.142861
AMH anti-Mullerian hormone 0.142815
BCO1 beta-carotene oxygenase 1 0.14273
COL1A2 collagen, type I, alpha 2 0.142685
C5AR1 complement component 5a receptor 1 0.142664
VEGFA vascular endothelial growth factor A 0.142621
SCPEP1 serine carboxypeptidase 1 0.142574
FLNB filamin B, beta 0.142488
SMAD4 SMAD family member 4 0.142413
SEPT1 septin 1 0.14238
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.14234
KIAA0101 KIAA0101 0.142326
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 0.142316
PRRC2A proline-rich coiled-coil 2A 0.142174
AARD alanine and arginine rich domain containing protein 0.142142
MAL mal, T-cell differentiation protein 0.142058
HMGB1 high mobility group box 1 0.142047
IGF1 insulin-like growth factor 1 (somatomedin C) 0.142037
CCDC27 coiled-coil domain containing 27 0.142029
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.142018
MAPK8 mitogen-activated protein kinase 8 0.141863
CKLF chemokine-like factor 0.141851
VWF von Willebrand factor 0.141789
MMP24 matrix metallopeptidase 24 (membrane-inserted) 0.141781
MPL MPL proto-oncogene, thrombopoietin receptor 0.14157
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) 0.141481
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.141347
CTGF connective tissue growth factor 0.141276
GYLTL1B glycosyltransferase-like 1B 0.14119
FRG2B FSHD region gene 2 family, member B 0.141149
MYRF myelin regulatory factor 0.141139
UBIAD1 UbiA prenyltransferase domain containing 1 0.140984
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 0.140974
CD40LG CD40 ligand 0.140853
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16 0.14062
SELE selectin E 0.140457
CD79A CD79a molecule, immunoglobulin-associated alpha 0.140403
PDE9A phosphodiesterase 9A 0.140316
LTBP1 latent transforming growth factor beta binding protein 1 0.140288
FKBP2 FK506 binding protein 2, 13kDa 0.14017
SLC1A7 solute carrier family 1 (glutamate transporter), member 7 0.140079
HMOX1 heme oxygenase 1 0.14005
PTGER3 prostaglandin E receptor 3 (subtype EP3) 0.139855
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 0.139677
CTSA cathepsin A 0.139608
FAM131C family with sequence similarity 131, member C 0.139571
CNTN3 contactin 3 (plasmacytoma associated) 0.139519
XYLT1 xylosyltransferase I 0.139513
ANGPTL2 angiopoietin-like 2 0.139487
NTM neurotrimin 0.139475
CCL3 chemokine (C-C motif) ligand 3 0.139344
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.139224
CAT catalase 0.139025
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.138607
CTXN2 cortexin 2 0.13844
NEUROD4 neuronal differentiation 4 0.137779
LHB luteinizing hormone beta polypeptide 0.137449
CNN3 calponin 3, acidic 0.137333
NCOA1 nuclear receptor coactivator 1 0.136971
PDHX pyruvate dehydrogenase complex, component X 0.136885
FARSA phenylalanyl-tRNA synthetase, alpha subunit 0.136641
SMAD2 SMAD family member 2 0.136191
OR10K2 olfactory receptor, family 10, subfamily K, member 2 0.135901
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 0.13551
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.135429
AGPS alkylglycerone phosphate synthase 0.135417
NOD1 nucleotide-binding oligomerization domain containing 1 0.135038
UBE4A ubiquitination factor E4A 0.134691
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 0.134356
DCXR dicarbonyl/L-xylulose reductase 0.134116
SEBOX SEBOX homeobox 0.134089
DLL4 delta-like 4 (Drosophila) 0.133744
EXTL3 exostosin-like glycosyltransferase 3 0.13356
ADAMTSL4 ADAMTS-like 4 0.133327
TXNL4B thioredoxin-like 4B 0.13292
ADAMTSL2 ADAMTS-like 2 0.132813
UCN urocortin 0.132608
NSL1 NSL1, MIS12 kinetochore complex component 0.131902
NONO non-POU domain containing, octamer-binding 0.13166
FBLN5 fibulin 5 0.131608
OR10T2 olfactory receptor, family 10, subfamily T, member 2 0.131573
MB myoglobin 0.131466
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 0.131288
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 0.131214
PRF1 perforin 1 (pore forming protein) 0.1309
HLA-C major histocompatibility complex, class I, C 0.1309
IL21R interleukin 21 receptor 0.130596
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit 0.130164
BMPER BMP binding endothelial regulator 0.130024
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle 0.129653
MFGE8 milk fat globule-EGF factor 8 protein 0.129547
HSPG2 heparan sulfate proteoglycan 2 0.129547
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.129094
CHRM4 cholinergic receptor, muscarinic 4 0.128851
LCK LCK proto-oncogene, Src family tyrosine kinase 0.128601
F7 coagulation factor VII (serum prothrombin conversion accelerator) 0.128465
PER2 period circadian clock 2 0.128207
CD34 CD34 molecule 0.12809
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.127848
RAG2 recombination activating gene 2 0.127703
KLF15 Kruppel-like factor 15 0.127504
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 0.127379
ACVRL1 activin A receptor type II-like 1 0.127178
MMP11 matrix metallopeptidase 11 0.126919
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.126497
SDF4 stromal cell derived factor 4 0.1253
DLL1 delta-like 1 (Drosophila) 0.125211
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 0.125152
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 0.125123
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.125005
SOD2 superoxide dismutase 2, mitochondrial 0.124916
EDN1 endothelin 1 0.124798
RARS arginyl-tRNA synthetase 0.124707
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 0.124463
MYL12B myosin, light chain 12B, regulatory 0.12428
SCNN1D sodium channel, non voltage gated 1 delta subunit 0.124249
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.124217
KLHL17 kelch-like family member 17 0.123996
ADCY7 adenylate cyclase 7 0.12387
TBPL1 TBP-like 1 0.12387
LGALS3 lectin, galactoside-binding, soluble, 3 0.123549
MMP23B matrix metallopeptidase 23B 0.123321
ADAM10 ADAM metallopeptidase domain 10 0.123256
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.12299
CD69 CD69 molecule 0.122956
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.122788
UCN2 urocortin 2 0.122619
CDC27 cell division cycle 27 0.122482
DCN decorin 0.122377
ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10 0.122238
PDE5A phosphodiesterase 5A, cGMP-specific 0.122099
APOLD1 apolipoprotein L domain containing 1 0.122099
MBL2 mannose-binding lectin (protein C) 2, soluble 0.121994
CDON cell adhesion associated, oncogene regulated 0.121959
MYH10 myosin, heavy chain 10, non-muscle 0.121923
DSTN destrin (actin depolymerizing factor) 0.121851
CTSL cathepsin L 0.121743
TAS1R1 taste receptor, type 1, member 1 0.121635
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.121383
PLA2G10 phospholipase A2, group X 0.121125
SDC1 syndecan 1 0.121125
HSPA8 heat shock 70kDa protein 8 0.120827
MMP28 matrix metallopeptidase 28 0.120715
SELL selectin L 0.12064
KERA keratocan 0.120101
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.120101
PRKCD protein kinase C, delta 0.119945
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.119587
DHFR dihydrofolate reductase 0.119587
CXCR2 chemokine (C-X-C motif) receptor 2 0.119548
S100A4 S100 calcium binding protein A4 0.119468
TPI1 triosephosphate isomerase 1 0.119186
HLA-A major histocompatibility complex, class I, A 0.118857
PEPD peptidase D 0.118816
CREM cAMP responsive element modulator 0.118734
LGALS2 lectin, galactoside-binding, soluble, 2 0.118569
CAST calpastatin 0.118569
KLRB1 killer cell lectin-like receptor subfamily B, member 1 0.118484
FN1 fibronectin 1 0.118187