aortic aneurysm Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description An aortic disease that is characterized by an enlargement (dilation) of the aorta to greater than 1.5 times normal size. (Human Disease Ontology, DOID_3627)
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Genes

301 genes co-occuring with the disease aortic aneurysm in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
AAAS achalasia, adrenocortical insufficiency, alacrimia 3.75754
FBN1 fibrillin 1 1.94877
MMP9 matrix metallopeptidase 9 1.87975
MMP2 matrix metallopeptidase 2 1.77406
ACTA2 actin, alpha 2, smooth muscle, aorta 1.50359
APOE apolipoprotein E 1.45968
TIMP1 TIMP metallopeptidase inhibitor 1 1.3481
TGFBR1 transforming growth factor, beta receptor 1 1.32367
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.29877
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 1.22042
CRP C-reactive protein, pentraxin-related 1.20613
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 1.13924
C17ORF85 chromosome 17 open reading frame 85 1.13163
TIMP2 TIMP metallopeptidase inhibitor 2 1.12572
SRA1 steroid receptor RNA activator 1 1.11099
MMP1 matrix metallopeptidase 1 1.1072
MMP12 matrix metallopeptidase 12 1.09545
CCL2 chemokine (C-C motif) ligand 2 1.06648
IL6 interleukin 6 1.06102
PGRMC1 progesterone receptor membrane component 1 1.05219
CTSS cathepsin S 1.01976
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.990644
ELN elastin 0.976323
COL3A1 collagen, type III, alpha 1 0.9696
MMP3 matrix metallopeptidase 3 0.966244
ACTA1 actin, alpha 1, skeletal muscle 0.965825
PMF1 polyamine-modulated factor 1 0.964567
ACE angiotensin I converting enzyme 0.937459
MFAP2 microfibrillar-associated protein 2 0.937459
CMA1 chymase 1, mast cell 0.93497
MFAP4 microfibrillar-associated protein 4 0.934141
AURKC aurora kinase C 0.897051
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 0.897051
C1ORF105 chromosome 1 open reading frame 105 0.878605
FBXL20 F-box and leucine-rich repeat protein 20 0.870825
PLAT plasminogen activator, tissue 0.847898
CST3 cystatin C 0.844621
SEPT1 septin 1 0.840115
TIMP4 TIMP metallopeptidase inhibitor 4 0.838476
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.832329
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 0.832329
F2 coagulation factor II (thrombin) 0.823308
DAB2IP DAB2 interacting protein 0.822488
ALB albumin 0.818796
AARD alanine and arginine rich domain containing protein 0.811821
PLG plasminogen 0.81018
SMAD3 SMAD family member 3 0.801974
CCDC27 coiled-coil domain containing 27 0.799103
CR1L complement component (3b/4b) receptor 1-like 0.797052
TIMP3 TIMP metallopeptidase inhibitor 3 0.789672
MMP8 matrix metallopeptidase 8 0.781888
PHF12 PHD finger protein 12 0.775341
SPP1 secreted phosphoprotein 1 0.763902
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.754934
MYH11 myosin, heavy chain 11, smooth muscle 0.752085
MPL MPL proto-oncogene, thrombopoietin receptor 0.751271
LOX lysyl oxidase 0.750864
F3 coagulation factor III (thromboplastin, tissue factor) 0.743954
PTGES prostaglandin E synthase 0.740299
LDLR low density lipoprotein receptor 0.736243
PLAU plasminogen activator, urokinase 0.728143
TGFB1 transforming growth factor, beta 1 0.72127
ELANE elastase, neutrophil expressed 0.716828
MMP13 matrix metallopeptidase 13 0.716828
CD68 CD68 molecule 0.713601
MYRF myelin regulatory factor 0.711587
FGD1 FYVE, RhoGEF and PH domain containing 1 0.706754
UBIAD1 UbiA prenyltransferase domain containing 1 0.698313
MPO myeloperoxidase 0.676706
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.675909
TNF tumor necrosis factor 0.667947
IL1B interleukin 1, beta 0.663578
TNNI3 troponin I type 3 (cardiac) 0.652484
LCN2 lipocalin 2 0.622183
GPLD1 glycosylphosphatidylinositol specific phospholipase D1 0.612401
VCAM1 vascular cell adhesion molecule 1 0.60108
ICAM1 intercellular adhesion molecule 1 0.6003
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.583941
ARL4C ADP-ribosylation factor-like 4C 0.57655
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.565666
ALOX5 arachidonate 5-lipoxygenase 0.558285
FBN2 fibrillin 2 0.556344
LRSAM1 leucine rich repeat and sterile alpha motif containing 1 0.555956
KLK15 kallikrein-related peptidase 15 0.548583
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 0.547807
LTBP4 latent transforming growth factor beta binding protein 4 0.545868
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.541992
CPB2 carboxypeptidase B2 (plasma) 0.541217
TNXB tenascin XB 0.538893
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.535796
CTXN2 cortexin 2 0.534248
GRHL1 grainyhead-like 1 (Drosophila) 0.533861
TNXA tenascin XA (pseudogene) 0.531541
HBA2 hemoglobin, alpha 2 0.527676
CTSG cathepsin G 0.51919
HBA1 hemoglobin, alpha 1 0.518034
PCYT1A phosphate cytidylyltransferase 1, choline, alpha 0.514186
ERAS ES cell expressed Ras 0.509192
NOS3 nitric oxide synthase 3 (endothelial cell) 0.503824
NEUROD4 neuronal differentiation 4 0.502675
JUN jun proto-oncogene 0.493122
CCR2 chemokine (C-C motif) receptor 2 0.491215
HP haptoglobin 0.490835
HAS1 hyaluronan synthase 1 0.487027
HPR haptoglobin-related protein 0.484364
EXOC3 exocyst complex component 3 0.483985
CNN3 calponin 3, acidic 0.483224
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.482464
TGFB2 transforming growth factor, beta 2 0.471468
CTSB cathepsin B 0.469954
NCOA1 nuclear receptor coactivator 1 0.468441
CXCL8 chemokine (C-X-C motif) ligand 8 0.466928
C8G complement component 8, gamma polypeptide 0.456355
FARSA phenylalanyl-tRNA synthetase, alpha subunit 0.455601
ADAM17 ADAM metallopeptidase domain 17 0.455224
MMP7 matrix metallopeptidase 7 0.449947
C8A complement component 8, alpha polypeptide 0.449194
SORT1 sortilin 1 0.449194
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1 0.443171
SMAD2 SMAD family member 2 0.439034
NOTCH1 notch 1 0.438658
TNC tenascin C 0.43753
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.43753
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 0.431144
OR10K2 olfactory receptor, family 10, subfamily K, member 2 0.428891
ENOSF1 enolase superfamily member 1 0.424765
LTB4R leukotriene B4 receptor 0.42364
PIGC phosphatidylinositol glycan anchor biosynthesis, class C 0.416896
CMC4 C-x(9)-C motif containing 4 0.415773
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 0.415773
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.413153
ALYREF Aly/REF export factor 0.405305
ARRB2 arrestin, beta 2 0.400826
RRBP1 ribosome binding protein 1 0.390397
UBE4A ubiquitination factor E4A 0.390397
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.389653
TNNT2 troponin T type 2 (cardiac) 0.386308
CTSD cathepsin D 0.385936
VCAN versican 0.385936
IL9R interleukin 9 receptor 0.385193
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 0.382223
C8B complement component 8, beta polypeptide 0.381852
DCXR dicarbonyl/L-xylulose reductase 0.374068
SEBOX SEBOX homeobox 0.373328
AMH anti-Mullerian hormone 0.364085
BGN biglycan 0.361502
PRUNE2 prune homolog 2 (Drosophila) 0.356341
ADAMTSL4 ADAMTS-like 4 0.353395
SMTN smoothelin 0.352291
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 0.349717
IL10 interleukin 10 0.348246
ADAMTSL2 ADAMTS-like 2 0.340906
THBD thrombomodulin 0.340906
HMGB1 high mobility group box 1 0.337975
DDO D-aspartate oxidase 0.337608
BHMT2 betaine--homocysteine S-methyltransferase 2 0.328105
ATG4B autophagy related 4B, cysteine peptidase 0.326646
CD4 CD4 molecule 0.325916
NSL1 NSL1, MIS12 kinetochore complex component 0.320454
IGF1 insulin-like growth factor 1 (somatomedin C) 0.32009
C5AR1 complement component 5a receptor 1 0.319363
DNM3 dynamin 3 0.315729
MMP25 matrix metallopeptidase 25 0.315729
NONO non-POU domain containing, octamer-binding 0.315366
FBLN5 fibulin 5 0.314278
MB myoglobin 0.311377
AGTR1 angiotensin II receptor, type 1 0.309566
VWF von Willebrand factor 0.309566
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 0.307757
BHMT betaine--homocysteine S-methyltransferase 0.303059
ZFYVE1 zinc finger, FYVE domain containing 1 0.302698
MARCKSL1 MARCKS-like 1 0.302337
PRF1 perforin 1 (pore forming protein) 0.300173
CLPS colipase, pancreatic 0.298011
IL21R interleukin 21 receptor 0.294413
MAPK8 mitogen-activated protein kinase 8 0.290103
BAD BCL2-associated agonist of cell death 0.289027
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit 0.286519
COL1A2 collagen, type I, alpha 2 0.28294
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle 0.277584
BCO1 beta-carotene oxygenase 1 0.275445
VEGFA vascular endothelial growth factor A 0.269043
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.268332
THBS2 thrombospondin 2 0.267267
SCPEP1 serine carboxypeptidase 1 0.266203
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.265849
CHRM4 cholinergic receptor, muscarinic 4 0.264431
FLNB filamin B, beta 0.261599
F7 coagulation factor VII (serum prothrombin conversion accelerator) 0.258417
PER2 period circadian clock 2 0.254536
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.253479
CD34 CD34 molecule 0.252774
KIAA0101 KIAA0101 0.252774
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.249257
PRRC2A proline-rich coiled-coil 2A 0.248554
KLF15 Kruppel-like factor 15 0.244345
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 0.242595
MAL mal, T-cell differentiation protein 0.23945
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.237706
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.230755
CKLF chemokine-like factor 0.230063
MMP24 matrix metallopeptidase 24 (membrane-inserted) 0.226952
CD40LG CD40 ligand 0.226607
SMAD4 SMAD family member 4 0.215992
DLL1 delta-like 1 (Drosophila) 0.214975
SELE selectin E 0.214297
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) 0.214297
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 0.213959
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.212608
SOD2 superoxide dismutase 2, mitochondrial 0.211597
EDN1 endothelin 1 0.210253
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.209248
CD79A CD79a molecule, immunoglobulin-associated alpha 0.208914
HMOX1 heme oxygenase 1 0.206913
CTGF connective tissue growth factor 0.205916
MYL12B myosin, light chain 12B, regulatory 0.204593
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.203933
GYLTL1B glycosyltransferase-like 1B 0.203275
FRG2B FSHD region gene 2 family, member B 0.201962
KLHL17 kelch-like family member 17 0.201635
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 0.19582
CCL3 chemokine (C-C motif) ligand 3 0.195501
CAT catalase 0.194548
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.191408
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.189859
APOB apolipoprotein B 0.188632
DUOX1 dual oxidase 1 0.187113
ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10 0.185016
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16 0.185016
APOLD1 apolipoprotein L domain containing 1 0.183835
PDE5A phosphodiesterase 5A, cGMP-specific 0.183835
PF4 platelet factor 4 0.182666
MYH10 myosin, heavy chain 10, non-muscle 0.182375
DSTN destrin (actin depolymerizing factor) 0.181798
CTSL cathepsin L 0.180937
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.180084
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.178126
PDE9A phosphodiesterase 9A 0.176757
SDC1 syndecan 1 0.176215
FKBP2 FK506 binding protein 2, 13kDa 0.173314
SELL selectin L 0.172799
DUOX2 dual oxidase 2 0.172038
SLC1A7 solute carrier family 1 (glutamate transporter), member 7 0.171286
S100A12 S100 calcium binding protein A12 0.167224
PTGER3 prostaglandin E receptor 3 (subtype EP3) 0.166768
DHFR dihydrofolate reductase 0.166319
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.166319
CTSA cathepsin A 0.162505
PEPD peptidase D 0.162306
FAM131C family with sequence similarity 131, member C 0.161912
CNTN3 contactin 3 (plasmacytoma associated) 0.161139
LGALS2 lectin, galactoside-binding, soluble, 2 0.161139
XYLT1 xylosyltransferase I 0.161139
CAST calpastatin 0.161139
KLRB1 killer cell lectin-like receptor subfamily B, member 1 0.160761
ANGPTL2 angiopoietin-like 2 0.160761
FN1 fibronectin 1 0.15948
LTBP1 latent transforming growth factor beta binding protein 1 0.144731
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 0.144423
NTM neurotrimin 0.144335
MYLK myosin light chain kinase 0.144308
LHB luteinizing hormone beta polypeptide 0.143518
PDHX pyruvate dehydrogenase complex, component X 0.143284
AGPS alkylglycerone phosphate synthase 0.142652
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 0.142181
DLL4 delta-like 4 (Drosophila) 0.141905
TXNL4B thioredoxin-like 4B 0.141531
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 0.140747
AGER advanced glycosylation end product-specific receptor 0.140343
BMPER BMP binding endothelial regulator 0.140195
MFGE8 milk fat globule-EGF factor 8 protein 0.139974
LCK LCK proto-oncogene, Src family tyrosine kinase 0.139534
ACVRL1 activin A receptor type II-like 1 0.13887
MMP11 matrix metallopeptidase 11 0.138749
SDF4 stromal cell derived factor 4 0.137988
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 0.137919
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 0.137593
SCNN1D sodium channel, non voltage gated 1 delta subunit 0.137491
ADCY7 adenylate cyclase 7 0.137311
TBPL1 TBP-like 1 0.137311
LGALS3 lectin, galactoside-binding, soluble, 3 0.137158
MMP23B matrix metallopeptidase 23B 0.137049
ADAM10 ADAM metallopeptidase domain 10 0.137018
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.136891
CD69 CD69 molecule 0.136875
UCN2 urocortin 2 0.136713
CDC27 cell division cycle 27 0.136647
DCN decorin 0.136597
MBL2 mannose-binding lectin (protein C) 2, soluble 0.136412
CDON cell adhesion associated, oncogene regulated 0.136395
TAS1R1 taste receptor, type 1, member 1 0.13624
PLA2G10 phospholipase A2, group X 0.135992
HSPA8 heat shock 70kDa protein 8 0.135846
MMP28 matrix metallopeptidase 28 0.135791
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.13549
KERA keratocan 0.13549
PRKCD protein kinase C, delta 0.135414
CXCR2 chemokine (C-X-C motif) receptor 2 0.135218
S100A4 S100 calcium binding protein A4 0.135179
TPI1 triosephosphate isomerase 1 0.135038
CREM cAMP responsive element modulator 0.134812