alzheimer disease Gene Set

Dataset HPO Gene-Disease Associations
Category disease or phenotype associations
Type phenotype
Description A tauopathy that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. It is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability. (Human Disease Ontology, DOID_10652)
External Link http://compbio.charite.de/hpoweb/showterm?id=HP:0002511
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Genes

4 genes associated with the alzheimer disease phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

Symbol Name
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
GATA1 GATA binding protein 1 (globin transcription factor 1)
PSEN1 presenilin 1