alzheimer disease Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A tauopathy that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. It is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability. (Human Disease Ontology, DOID_10652)
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Genes

80 genes associated with the disease alzheimer disease in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADCY8 adenylate cyclase 8 (brain)
AEN apoptosis enhancing nuclease
ANK1 ankyrin 1, erythrocytic
APOC1 apolipoprotein C-I
APOE apolipoprotein E
ARHGAP18 Rho GTPase activating protein 18
ATXN1 ataxin 1
BIN1 bridging integrator 1
BRMS1L breast cancer metastasis-suppressor 1-like
C1ORF168 chromosome 1 open reading frame 168
CADPS Ca++-dependent secretion activator
CCDC134 coiled-coil domain containing 134
CD2AP CD2-associated protein
CD33 CD33 molecule
CLU clusterin
CLVS1 clavesin 1
CNTNAP2 contactin associated protein-like 2
COL22A1 collagen, type XXII, alpha 1
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CUBN cubilin (intrinsic factor-cobalamin receptor)
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
DBT dihydrolipoamide branched chain transacylase E2
DCHS2 dachsous cadherin-related 2
DGKH diacylglycerol kinase, eta
DIAPH3 diaphanous-related formin 3
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DISC1 disrupted in schizophrenia 1
DNAH11 dynein, axonemal, heavy chain 11
EML1 echinoderm microtubule associated protein like 1
ENSAP3 endosulfine alpha pseudogene 3
ERBB4 erb-b2 receptor tyrosine kinase 4
F13A1 coagulation factor XIII, A1 polypeptide
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FBLN2 fibulin 2
GAB2 GRB2-associated binding protein 2
GFRA2 GDNF family receptor alpha 2
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
HIAT1 hippocampus abundant transcript 1
LRRC39 leucine rich repeat containing 39
MGST3 microsomal glutathione S-transferase 3
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
NCAM1 neural cell adhesion molecule 1
NCR2 natural cytotoxicity triggering receptor 2
NDP Norrie disease (pseudoglioma)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NHSL1 NHS-like 1
NME9 NME/NM23 family member 9
NPAS3 neuronal PAS domain protein 3
OSBPL10 oxysterol binding protein-like 10
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PCDH11X protocadherin 11 X-linked
PIEZO2 piezo-type mechanosensitive ion channel component 2
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
POLN polymerase (DNA directed) nu
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RORA RAR-related orphan receptor A
RTN1 reticulon 1
RYR2 ryanodine receptor 2 (cardiac)
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SLC44A5 solute carrier family 44, member 5
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
STK11 serine/threonine kinase 11
STK24 serine/threonine kinase 24
TENM4 teneurin transmembrane protein 4
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast)
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
UTS2B urotensin 2B
VPS13B vacuolar protein sorting 13 homolog B (yeast)
VSNL1 visinin-like 1
WBSCR17 Williams-Beuren syndrome chromosome region 17
ZNF292 zinc finger protein 292
ZNF320 zinc finger protein 320