alzheimer disease specific cell type Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description Alzheimer is a disease marked by the loss of cognitive ability, generally over a period of 10 to 15 years, and associated with the development of abnormal tissues and protein deposits in the cerebral cortex. (BRENDA Tissue and Enzyme Source Ontology, BTO_0000590)
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Genes

226 proteins co-occuring with the tissue alzheimer disease specific cell type in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
APP amyloid beta (A4) precursor protein 3.07164
PSEN1 presenilin 1 2.70515
BACE1 beta-site APP-cleaving enzyme 1 2.6122
PRNP prion protein 2.40769
APOE apolipoprotein E 2.21034
COL25A1 collagen, type XXV, alpha 1 2.00332
MAPT microtubule-associated protein tau 1.81328
IDE insulin-degrading enzyme 1.79094
NCSTN nicastrin 1.76525
APH1A APH1A gamma secretase subunit 1.72882
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 1.67256
PSEN2 presenilin 2 1.6131
ITM2B integral membrane protein 2B 1.48083
BACE2 beta-site APP-cleaving enzyme 2 1.47055
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 1.45007
ADAM10 ADAM metallopeptidase domain 10 1.40478
MME membrane metallo-endopeptidase 1.39972
ACHE acetylcholinesterase (Yt blood group) 1.39881
APLP1 amyloid beta (A4) precursor-like protein 1 1.38688
IAPP islet amyloid polypeptide 1.34678
SYP synaptophysin 1.2595
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 1.21891
PSENEN presenilin enhancer gamma secretase subunit 1.21268
APLP2 amyloid beta (A4) precursor-like protein 2 1.20289
BCHE butyrylcholinesterase 1.18556
CTSB cathepsin B 1.13457
RTN3 reticulon 3 1.11243
CSTB cystatin B (stefin B) 1.04533
CDK5 cyclin-dependent kinase 5 1.01725
PHF1 PHD finger protein 1 0.992814
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.991944
HECTD2 HECT domain containing E3 ubiquitin protein ligase 2 0.974149
SLC30A3 solute carrier family 30 (zinc transporter), member 3 0.96809
PICALM phosphatidylinositol binding clathrin assembly protein 0.933624
APCS amyloid P component, serum 0.926336
LDLR low density lipoprotein receptor 0.920344
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.881204
IL1B interleukin 1, beta 0.879512
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 0.842447
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.836575
SDC2 syndecan 2 0.833223
NGFR nerve growth factor receptor 0.793543
GBAS glioblastoma amplified sequence 0.776909
CLU clusterin 0.773589
GFAP glial fibrillary acidic protein 0.756604
ADAM9 ADAM metallopeptidase domain 9 0.747927
BDNF brain-derived neurotrophic factor 0.724041
DBN1 drebrin 1 0.72322
MAP2 microtubule-associated protein 2 0.716241
CTSD cathepsin D 0.700262
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 0.699444
NGF nerve growth factor (beta polypeptide) 0.695763
RNF146 ring finger protein 146 0.689226
NOTCH1 notch 1 0.682287
A2M alpha-2-macroglobulin 0.657866
LRRTM3 leucine rich repeat transmembrane neuronal 3 0.65056
TTR transthyretin 0.648532
SNCB synuclein, beta 0.639619
IGHV3-30 immunoglobulin heavy variable 3-30 0.637594
PTPN5 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) 0.634358
ADAM17 ADAM metallopeptidase domain 17 0.629506
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 0.629101
TMEM176B transmembrane protein 176B 0.620217
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 0.61175
S100A9 S100 calcium binding protein A9 0.610541
PEA15 phosphoprotein enriched in astrocytes 15 0.605306
DPYSL2 dihydropyrimidinase-like 2 0.595656
IL6 interleukin 6 0.593649
PRND prion protein 2 (dublet) 0.588832
MAP4 microtubule-associated protein 4 0.588832
TARDBP TAR DNA binding protein 0.582019
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.578816
AGER advanced glycosylation end product-specific receptor 0.56284
CHAT choline O-acetyltransferase 0.561644
FURIN furin (paired basic amino acid cleaving enzyme) 0.556865
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.556467
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.556467
QPCT glutaminyl-peptide cyclotransferase 0.551695
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 0.549709
S100B S100 calcium binding protein B 0.549709
SORT1 sortilin 1 0.546136
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 0.539
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.538604
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 0.532274
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 0.530693
TFEB transcription factor EB 0.530298
AIF1 allograft inflammatory factor 1 0.530298
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.52556
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.523982
GSK3A glycogen synthase kinase 3 alpha 0.518465
GSN gelsolin 0.518072
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.510206
MAP1B microtubule-associated protein 1B 0.507064
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 0.506672
AMT aminomethyltransferase 0.503141
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor 0.501574
SIGLEC11 sialic acid binding Ig-like lectin 11 0.500398
RTN2 reticulon 2 0.493354
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 0.4914
MATN4 matrilin 4 0.489057
CALHM1 calcium homeostasis modulator 1 0.488276
AGRN agrin 0.485935
RHOT1 ras homolog family member T1 0.484766
RELN reelin 0.477756
GSK3B glycogen synthase kinase 3 beta 0.462626
PLB1 phospholipase B1 0.459918
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.452969
CD44 CD44 molecule (Indian blood group) 0.450271
FSIP1 fibrous sheath interacting protein 1 0.43989
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 0.424581
C1S complement component 1, s subcomponent 0.422673
LONP1 lon peptidase 1, mitochondrial 0.422673
TNF tumor necrosis factor 0.421148
NPTX1 neuronal pentraxin I 0.418861
GLO1 glyoxalase I 0.415814
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.411251
DCX doublecortin 0.410491
NRD1 nardilysin (N-arginine dibasic convertase) 0.401765
PREP prolyl endopeptidase 0.401007
SLC30A1 solute carrier family 30 (zinc transporter), member 1 0.399114
PKP4 plakophilin 4 0.397979
COTL1 coactosin-like F-actin binding protein 1 0.396844
MMP9 matrix metallopeptidase 9 0.390044
HM13 histocompatibility (minor) 13 0.388912
ATP7A ATPase, Cu++ transporting, alpha polypeptide 0.383637
HPCAL1 hippocalcin-like 1 0.382508
TRIM32 tripartite motif containing 32 0.377996
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.377996
GDF2 growth differentiation factor 2 0.375368
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.373118
INS insulin 0.368998
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 0.364886
NRG1 neuregulin 1 0.363393
RER1 retention in endoplasmic reticulum sorting receptor 1 0.362273
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 0.360409
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.359664
STMN2 stathmin 2 0.357058
KIF5C kinesin family member 5C 0.354084
GRN granulin 0.350001
UBQLN1 ubiquilin 1 0.342602
SNCG synuclein, gamma (breast cancer-specific protein 1) 0.342602
GCOM1 GRINL1A complex locus 1 0.342602
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 0.342233
NEU4 sialidase 4 0.341863
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.340757
ITPKB inositol-trisphosphate 3-kinase B 0.340757
GIP gastric inhibitory polypeptide 0.340019
DEPTOR DEP domain containing MTOR-interacting protein 0.338177
FLOT1 flotillin 1 0.336336
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.333763
PNMA2 paraneoplastic Ma antigen 2 0.333028
MIR212 microRNA 212 0.332294
BLMH bleomycin hydrolase 0.33046
FANCD2 Fanconi anemia, complementation group D2 0.326798
CD47 CD47 molecule 0.324605
THOP1 thimet oligopeptidase 1 0.323509
EFNA4 ephrin-A4 0.323144
MATN2 matrilin 2 0.322779
OPA1 optic atrophy 1 (autosomal dominant) 0.319498
CLTB clathrin, light chain B 0.319498
PPARG peroxisome proliferator-activated receptor gamma 0.313683
UBE2L3 ubiquitin-conjugating enzyme E2L 3 0.31332
NEU1 sialidase 1 (lysosomal sialidase) 0.31187
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein 0.308974
P4HB prolyl 4-hydroxylase, beta polypeptide 0.307528
DAPK3 death-associated protein kinase 3 0.306805
ADAM12 ADAM metallopeptidase domain 12 0.306805
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 0.305722
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 0.305361
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 0.303559
FKBP7 FK506 binding protein 7 0.302118
FKBP9 FK506 binding protein 9, 63 kDa 0.301758
DERL1 derlin 1 0.294223
VSNL1 visinin-like 1 0.293151
FKBP6 FK506 binding protein 6, 36kDa 0.292079
ATP7B ATPase, Cu++ transporting, beta polypeptide 0.291365
NRGN neurogranin (protein kinase C substrate, RC3) 0.290652
SYNJ1 synaptojanin 1 0.287803
MARCO macrophage receptor with collagenous structure 0.284607
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.284253
IL1A interleukin 1, alpha 0.282837
ALB albumin 0.282483
FKBP3 FK506 binding protein 3, 25kDa 0.28107
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 0.275794
RTN1 reticulon 1 0.274744
TFRC transferrin receptor 0.274045
SLC30A5 solute carrier family 30 (zinc transporter), member 5 0.272649
RAD18 RAD18 E3 ubiquitin protein ligase 0.271604
INSR insulin receptor 0.264353
PDIA6 protein disulfide isomerase family A, member 6 0.256902
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.255567
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase) 0.255234
RXRG retinoid X receptor, gamma 0.253578
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.249006
MIR107 microRNA 107 0.246442
SCG3 secretogranin III 0.246442
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) 0.244232
SULF2 sulfatase 2 0.236627
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 0.235167
C1QA complement component 1, q subcomponent, A chain 0.23459
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 0.234016
IREB2 iron-responsive element binding protein 2 0.233162
CA4 carbonic anhydrase IV 0.232317
CST3 cystatin C 0.230382
CCL2 chemokine (C-C motif) ligand 2 0.229032
KIF1A kinesin family member 1A 0.229032
IRS4 insulin receptor substrate 4 0.229032
CA13 carbonic anhydrase XIII 0.228764
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 0.22797
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 0.227186
MGEA5 meningioma expressed antigen 5 (hyaluronidase) 0.226926
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2 0.223177
DNAH14 dynein, axonemal, heavy chain 14 0.222699
DNAH12 dynein, axonemal, heavy chain 12 0.222699
RXRB retinoid X receptor, beta 0.222224
SCARB1 scavenger receptor class B, member 1 0.221755
FKBP10 FK506 binding protein 10, 65 kDa 0.221061
TREM2 triggering receptor expressed on myeloid cells 2 0.221061
MGAT4C MGAT4 family, member C 0.217974
CHN2 chimerin 2 0.217554
LAMA2 laminin, alpha 2 0.215147
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.214765
C3 complement component 3 0.213471
GAS6 growth arrest-specific 6 0.213291
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 0.212586
NEFM neurofilament, medium polypeptide 0.201378