alzheimer's Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A dementia that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting in late middle age and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. It is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability.|A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.|A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)|A dementia which is an incurable disease of unknown cause, starting in late middle age or in old age, that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood, that leads in advanced cases to a profound decline in cognitive and physical functioning, and that is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. (Experimental Factor Ontology, EFO_0000249)
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Genes

66 proteins co-occuring with the biological term alzheimer's in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
AKT1 v-akt murine thymoma viral oncogene homolog 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APLP2 amyloid beta (A4) precursor-like protein 2
APP amyloid beta (A4) precursor protein
ATXN1 ataxin 1
BACE1 beta-site APP-cleaving enzyme 1
BAD BCL2-associated agonist of cell death
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CASP6 caspase 6, apoptosis-related cysteine peptidase
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CLU clusterin
CPLX2 complexin 2
CREB1 cAMP responsive element binding protein 1
CRYAB crystallin, alpha B
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
DLG4 discs, large homolog 4 (Drosophila)
DLGAP1 discs, large (Drosophila) homolog-associated protein 1
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
ELK1 ELK1, member of ETS oncogene family
ENSA endosulfine alpha
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
HDAC6 histone deacetylase 6
INSR insulin receptor
JUN jun proto-oncogene
LRP1 low density lipoprotein receptor-related protein 1
MAOA monoamine oxidase A
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPT microtubule-associated protein tau
MARK2 MAP/microtubule affinity-regulating kinase 2
NOS3 nitric oxide synthase 3 (endothelial cell)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PRKCB protein kinase C, beta
PSEN1 presenilin 1
PSEN2 presenilin 2
PTK2 protein tyrosine kinase 2
PTPN5 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
PXN paxillin
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SET SET nuclear proto-oncogene
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STXBP1 syntaxin binding protein 1
YAP1 Yes-associated protein 1