alzheimer's disease Gene Set

Dataset DISEASES Experimental Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A tauopathy that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. It is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability. (Human Disease Ontology, DOID_10652)
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Genes

196 genes associated with the disease alzheimer's disease in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 1.37597
BCAM basal cell adhesion molecule (Lutheran blood group) 1.14929
HMGA2 high mobility group AT-hook 2 0.894262
APOC1 apolipoprotein C-I 0.894262
BCL3 B-cell CLL/lymphoma 3 0.774217
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 0.7623
GAB2 GRB2-associated binding protein 2 0.724323
FRMD4A FERM domain containing 4A 0.724323
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.69843
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.682635
EPHA1 EPH receptor A1 0.65413
CLU clusterin 0.65413
PICALM phosphatidylinositol binding clathrin assembly protein 0.63207
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 0.602429
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 0.602429
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.602429
CEACAM16 carcinoembryonic antigen-related cell adhesion molecule 16 0.602429
CD33 CD33 molecule 0.602429
PPP1R37 protein phosphatase 1, regulatory subunit 37 0.602429
GLIS3 GLIS family zinc finger 3 0.58494
CD2AP CD2-associated protein 0.5306
SRRM4 serine/arginine repetitive matrix 4 0.52461
BCHE butyrylcholinesterase 0.464771
ZNF292 zinc finger protein 292 0.464771
EDAR ectodysplasin A receptor 0.449873
SCARA3 scavenger receptor class A, member 3 0.449873
APOC4 apolipoprotein C-IV 0.403461
EMC1 ER membrane protein complex subunit 1 0.403461
UPP2 uridine phosphorylase 2 0.403461
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.403461
IRS1 insulin receptor substrate 1 0.403461
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 0.403461
CELF2 CUGBP, Elav-like family member 2 0.368757
PCDH11X protocadherin 11 X-linked 0.368757
EFNA5 ephrin-A5 0.368757
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.345945
PCED1B PC-esterase domain containing 1B 0.345945
F13A1 coagulation factor XIII, A1 polypeptide 0.345945
PPP1R3B protein phosphatase 1, regulatory subunit 3B 0.345945
EXOC1 exocyst complex component 1 0.345945
WDR1 WD repeat domain 1 0.345945
CLPTM1 cleft lip and palate associated transmembrane protein 1 0.327313
DTWD2 DTW domain containing 2 0.327313
CCR3 chemokine (C-C motif) receptor 3 0.327313
DCHS2 dachsous cadherin-related 2 0.311576
UNC5C unc-5 homolog C (C. elegans) 0.311576
RFC3 replication factor C (activator 1) 3, 38kDa 0.297866
TMEM74 transmembrane protein 74 0.297866
RBBP6 retinoblastoma binding protein 6 0.297866
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.297866
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 0.297866
SHB Src homology 2 domain containing adaptor protein B 0.297866
CADPS2 Ca++-dependent secretion activator 2 0.297866
VSNL1 visinin-like 1 0.297866
BOK BCL2-related ovarian killer 0.297866
PRUNE2 prune homolog 2 (Drosophila) 0.285417
KLHL23 kelch-like family member 23 0.285417
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.274608
LUZP2 leucine zipper protein 2 0.274608
CLEC16A C-type lectin domain family 16, member A 0.274608
GLYATL3 glycine-N-acyltransferase-like 3 0.274608
WFDC2 WAP four-disulfide core domain 2 0.264872
FGF10 fibroblast growth factor 10 0.264872
RFPL3 ret finger protein-like 3 0.264872
CSMD2 CUB and Sushi multiple domains 2 0.256228
MMP12 matrix metallopeptidase 12 0.256228
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 0.256228
MUC21 mucin 21, cell surface associated 0.256228
MSX1 msh homeobox 1 0.256228
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.256228
BIN1 bridging integrator 1 0.256228
ATP8B4 ATPase, class I, type 8B, member 4 0.256228
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 0.256228
TTLL7 tubulin tyrosine ligase-like family member 7 0.256228
STXBP6 syntaxin binding protein 6 (amisyn) 0.256228
ITGA1 integrin, alpha 1 0.256228
BIRC3 baculoviral IAP repeat containing 3 0.256228
RSPO2 R-spondin 2 0.256228
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.256228
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.256228
CCDC134 coiled-coil domain containing 134 0.256228
ATXN7L1 ataxin 7-like 1 0.256228
APOE apolipoprotein E 0.256228
MPZL1 myelin protein zero-like 1 0.256228
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 0.256228
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 0.256228
LMOD3 leiomodin 3 (fetal) 0.197766
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 0.197766
SLC44A5 solute carrier family 44, member 5 0.197766
AEBP2 AE binding protein 2 0.197766
TNRC6C trinucleotide repeat containing 6C 0.197766
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein 0.197766
RELN reelin 0.197766
MROH8 maestro heat-like repeat family member 8 0.197766
AKAP2 A kinase (PRKA) anchor protein 2 0.197766
PLXNA4 plexin A4 0.197766
NFIB nuclear factor I/B 0.197766
ZNF221 zinc finger protein 221 0.197766
CNTN5 contactin 5 0.197766
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 0.197766
ZNF326 zinc finger protein 326 0.197766
TMEM38B transmembrane protein 38B 0.197766
PALM2 paralemmin 2 0.197766
SCAMP1 secretory carrier membrane protein 1 0.197766
ZBP1 Z-DNA binding protein 1 0.197766
ADCY8 adenylate cyclase 8 (brain) 0.197766
DNAH11 dynein, axonemal, heavy chain 11 0.197766
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) 0.197766
NCR2 natural cytotoxicity triggering receptor 2 0.197766
ARID1B AT rich interactive domain 1B (SWI1-like) 0.15771
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.15771
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.15771
RBMS3 RNA binding motif, single stranded interacting protein 3 0.15771
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) 0.15771
FRMD6 FERM domain containing 6 0.15771
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.15771
DMXL1 Dmx-like 1 0.15771
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) 0.15771
PTMAP5 prothymosin, alpha pseudogene 5 0.15771
HRK harakiri, BCL2 interacting protein 0.15771
RORA RAR-related orphan receptor A 0.15771
PRSS55 protease, serine, 55 0.15771
CDON cell adhesion associated, oncogene regulated 0.15771
IKZF1 IKAROS family zinc finger 1 (Ikaros) 0.15771
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.15771
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 0.15771
LINC00588 long intergenic non-protein coding RNA 588 0.126165
CFAP45 cilia and flagella associated protein 45 0.126165
STX2 syntaxin 2 0.126165
CSNK1G3 casein kinase 1, gamma 3 0.126165
KIAA0020 KIAA0020 0.126165
GDA guanine deaminase 0.126165
C3ORF56 chromosome 3 open reading frame 56 0.126165
C3ORF17 chromosome 3 open reading frame 17 0.126165
STK24 serine/threonine kinase 24 0.126165
SLITRK3 SLIT and NTRK-like family, member 3 0.126165
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.126165
PDS5B PDS5 cohesin associated factor B 0.100789
DOK5 docking protein 5 0.100789
CCNG1 cyclin G1 0.100789
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.100789
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 0.100789
ROR1 receptor tyrosine kinase-like orphan receptor 1 0.100789
ZNF28 zinc finger protein 28 0.100789
MYOF myoferlin 0.100789
CAND1 cullin-associated and neddylation-dissociated 1 0.100789
DIAPH3 diaphanous-related formin 3 0.100789
RNF6 ring finger protein (C3H2C3 type) 6 0.100789
ZNF320 zinc finger protein 320 0.100789
CLVS1 clavesin 1 0.080593
RPN2 ribophorin II 0.080593
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 0.080593
POLN polymerase (DNA directed) nu 0.080593
PAX2 paired box 2 0.080593
S100A6 S100 calcium binding protein A6 0.080593
COL13A1 collagen, type XIII, alpha 1 0.080593
PCNX pecanex homolog (Drosophila) 0.080593
SLC17A2 solute carrier family 17, member 2 0.064973
C11ORF30 chromosome 11 open reading frame 30 0.064973
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial 0.064973
HMGB1 high mobility group box 1 0.064973
GFRA2 GDNF family receptor alpha 2 0.064973
MRPL14 mitochondrial ribosomal protein L14 0.064973
STAG2 stromal antigen 2 0.064973
ARSB arylsulfatase B 0.064973
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 0.064973
MGST3 microsomal glutathione S-transferase 3 0.064973
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 0.064973
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 0.052255
CNTNAP4 contactin associated protein-like 4 0.052255
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.052255
NME9 NME/NM23 family member 9 0.052255
SEC11C SEC11 homolog C (S. cerevisiae) 0.052255
PROX1 prospero homeobox 1 0.052255
CDH8 cadherin 8, type 2 0.052255
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 0.052255
STK11 serine/threonine kinase 11 0.052255
TRAM1L1 translocation associated membrane protein 1-like 1 0.052255
SASH1 SAM and SH3 domain containing 1 0.052255
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.052255
NAV1 neuron navigator 1 0.052255
SCAF11 SR-related CTD-associated factor 11 0.052255
BASP1 brain abundant, membrane attached signal protein 1 0.052255
KLHL29 kelch-like family member 29 0.052255
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 0.043246
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 0.043246
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.043246
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.043246
C7ORF72 chromosome 7 open reading frame 72 0.043246
RAD51AP2 RAD51 associated protein 2 0.043246
DISC1 disrupted in schizophrenia 1 0.043246
UTS2B urotensin 2B 0.043246
CNTNAP2 contactin associated protein-like 2 0.043246
NCAM1 neural cell adhesion molecule 1 0.043246
HAS2 hyaluronan synthase 2 0.043246
CHL1 cell adhesion molecule L1-like 0.035343