alzheimer's disease Gene Set

Dataset DISEASES Curated Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A tauopathy that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. It is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability. (Human Disease Ontology, DOID_10652)
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Genes

14 genes involed in the disease alzheimer's disease from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
CTSD cathepsin D
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
MAPT microtubule-associated protein tau
PLD3 phospholipase D family, member 3
PPP5C protein phosphatase 5, catalytic subunit
PSEN1 presenilin 1
PSEN2 presenilin 2
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing