allergic asthma Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description An asthma that is characterized by symptoms that are triggered by an allergic reaction caused by inhaled allergens such as dust mite allergen, pet dander, pollen and mold. Allergic asthma is airway obstruction and inflammation that is partially reversible with medication. The disease has_symptom coughing, has_symptom wheezing, has_symptom shortness of breath or has_symptom rapid breathing, and has_symptom chest tightness. (Human Disease Ontology, DOID_9415)
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Genes

363 genes co-occuring with the disease allergic asthma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
RNASE3 ribonuclease, RNase A family, 3 1.92201
CD4 CD4 molecule 1.91687
IL4 interleukin 4 1.83138
IL5 interleukin 5 1.74005
GATA3 GATA binding protein 3 1.71636
IL13 interleukin 13 1.7159
TSLP thymic stromal lymphopoietin 1.66195
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 1.65789
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 1.6534
CCL11 chemokine (C-C motif) ligand 11 1.57824
FOXP3 forkhead box P3 1.46232
CCR3 chemokine (C-C motif) receptor 3 1.39171
ITK IL2-inducible T-cell kinase 1.3664
TBX21 T-box 21 1.34853
IL4R interleukin 4 receptor 1.34286
CCL17 chemokine (C-C motif) ligand 17 1.32934
CD86 CD86 molecule 1.31362
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.30532
TLR4 toll-like receptor 4 1.24819
C5AR1 complement component 5a receptor 1 1.21608
EPX eosinophil peroxidase 1.2018
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 1.19359
PTGDS prostaglandin D2 synthase 21kDa (brain) 1.17765
CD276 CD276 molecule 1.15155
ICAM1 intercellular adhesion molecule 1 1.1312
MUC5B mucin 5B, oligomeric mucus/gel-forming 1.12445
SCGB3A2 secretoglobin, family 3A, member 2 1.11183
CCL22 chemokine (C-C motif) ligand 22 1.08621
TGFB1 transforming growth factor, beta 1 1.08327
TSPO translocator protein (18kDa) 1.08202
CCL13 chemokine (C-C motif) ligand 13 1.07992
FLNC filamin C, gamma 1.06228
CCL24 chemokine (C-C motif) ligand 24 1.05639
CHIA chitinase, acidic 1.0484
CD80 CD80 molecule 1.04546
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.04335
CRLF2 cytokine receptor-like factor 2 1.03282
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide 1.03072
IL17RB interleukin 17 receptor B 1.01638
CD69 CD69 molecule 1.00879
PDE4A phosphodiesterase 4A, cAMP-specific 0.997814
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 0.996549
VCAM1 vascular cell adhesion molecule 1 0.994439
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.98011
FLG filaggrin 0.97086
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 0.968341
NPSR1 neuropeptide S receptor 1 0.965405
TLR2 toll-like receptor 2 0.959123
ITLN2 intelectin 2 0.958705
CD40 CD40 molecule, TNF receptor superfamily member 5 0.955779
CCL26 chemokine (C-C motif) ligand 26 0.950769
ADAM33 ADAM metallopeptidase domain 33 0.934556
CCL2 chemokine (C-C motif) ligand 2 0.932898
TNF tumor necrosis factor 0.928759
PDCD1LG2 programmed cell death 1 ligand 2 0.924213
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 0.913903
IL10 interleukin 10 0.911433
CCL3 chemokine (C-C motif) ligand 3 0.897872
PTGDR prostaglandin D2 receptor (DP) 0.896641
NGF nerve growth factor (beta polypeptide) 0.872053
SYK spleen tyrosine kinase 0.871643
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 0.870006
NELFCD negative elongation factor complex member C/D 0.86714
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 0.86714
KIAA0101 KIAA0101 0.865912
IL16 interleukin 16 0.863456
IL1RL1 interleukin 1 receptor-like 1 0.86059
C3AR1 complement component 3a receptor 1 0.859362
PTGDR2 prostaglandin D2 receptor 2 0.856087
ZFP30 ZFP30 zinc finger protein 0.851992
TACR2 tachykinin receptor 2 0.84544
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 0.844211
ADGRA1 adhesion G protein-coupled receptor A1 0.839296
CD79A CD79a molecule, immunoglobulin-associated alpha 0.819616
HRH1 histamine receptor H1 0.815924
CCL5 chemokine (C-C motif) ligand 5 0.814693
PDC phosducin 0.781479
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.77575
LELP1 late cornified envelope-like proline-rich 1 0.768801
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 0.768801
FAM129A family with sequence similarity 129, member A 0.765535
SOCS3 suppressor of cytokine signaling 3 0.762271
IL1B interleukin 1, beta 0.761862
BATF basic leucine zipper transcription factor, ATF-like 0.752085
NOS2 nitric oxide synthase 2, inducible 0.750864
NOD1 nucleotide-binding oligomerization domain containing 1 0.748424
TLR9 toll-like receptor 9 0.74436
SELL selectin L 0.736243
CD1D CD1d molecule 0.731381
MED28 mediator complex subunit 28 0.728143
TBXA2R thromboxane A2 receptor 0.726524
IL18R1 interleukin 18 receptor 1 0.725311
CCL1 chemokine (C-C motif) ligand 1 0.717635
IL33 interleukin 33 0.701928
ARG1 arginase 1 0.699116
TLR7 toll-like receptor 7 0.688291
BDNF brain-derived neurotrophic factor 0.684692
CCR8 chemokine (C-C motif) receptor 8 0.682294
CXCL10 chemokine (C-X-C motif) ligand 10 0.677105
CD40LG CD40 ligand 0.675112
PDCL phosducin-like 0.673917
CMA1 chymase 1, mast cell 0.671925
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) 0.668742
CLTA clathrin, light chain A 0.667152
IL7R interleukin 7 receptor 0.664372
CD63 CD63 molecule 0.656441
LRFN1 leucine rich repeat and fibronectin type III domain containing 1 0.654067
CCR1 chemokine (C-C motif) receptor 1 0.649323
FANK1 fibronectin type III and ankyrin repeat domains 1 0.648533
ELP2 elongator acetyltransferase complex subunit 2 0.646165
CYSLTR2 cysteinyl leukotriene receptor 2 0.64577
LTA lymphotoxin alpha 0.644981
PHF11 PHD finger protein 11 0.639857
MMP9 matrix metallopeptidase 9 0.634742
SFTPD surfactant protein D 0.634349
DERL1 derlin 1 0.630813
LRFN2 leucine rich repeat and fibronectin type III domain containing 2 0.630027
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.628457
MYD88 myeloid differentiation primary response 88 0.628065
CISH cytokine inducible SH2-containing protein 0.622967
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 0.620617
CCL20 chemokine (C-C motif) ligand 20 0.619442
ALB albumin 0.612401
IDO1 indoleamine 2,3-dioxygenase 1 0.612011
IL17RC interleukin 17 receptor C 0.605372
SOCS5 suppressor of cytokine signaling 5 0.60342
IL31 interleukin 31 0.60069
IL18 interleukin 18 0.594843
CCR6 chemokine (C-C motif) receptor 6 0.594064
PTAFR platelet-activating factor receptor 0.592895
CCL14 chemokine (C-C motif) ligand 14 0.587054
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.586665
MPO myeloperoxidase 0.578883
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.576939
LAT linker for activation of T cells 0.575383
SPRED1 sprouty-related, EVH1 domain containing 1 0.573828
CCR7 chemokine (C-C motif) receptor 7 0.571495
TPT1 tumor protein, translationally-controlled 1 0.566831
CCR2 chemokine (C-C motif) receptor 2 0.563723
FAM188A family with sequence similarity 188, member A 0.555956
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.548195
CLCA1 chloride channel accessory 1 0.545868
SYNE2 spectrin repeat containing, nuclear envelope 2 0.543542
TLR3 toll-like receptor 3 0.543542
TRPA1 transient receptor potential cation channel, subfamily A, member 1 0.535022
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.532314
IL2RA interleukin 2 receptor, alpha 0.530381
TAC1 tachykinin, precursor 1 0.529222
SIGLEC8 sialic acid binding Ig-like lectin 8 0.528835
ARRB2 arrestin, beta 2 0.526904
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 0.526518
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.520731
SELE selectin E 0.520346
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.514956
IL13RA1 interleukin 13 receptor, alpha 1 0.512264
KNG1 kininogen 1 0.509192
EBI3 Epstein-Barr virus induced 3 0.502675
TACR1 tachykinin receptor 1 0.501909
YBX2 Y box binding protein 2 0.499231
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa 0.493885
PDE4B phosphodiesterase 4B, cAMP-specific 0.49274
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.489691
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.489311
XCL1 chemokine (C motif) ligand 1 0.48893
GZMK granzyme K (granzyme 3; tryptase II) 0.488549
IRF4 interferon regulatory factor 4 0.487788
YTHDC1 YTH domain containing 1 0.487407
SMAD7 SMAD family member 7 0.486646
CYSLTR1 cysteinyl leukotriene receptor 1 0.474119
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 0.465794
CCL8 chemokine (C-C motif) ligand 8 0.457109
IFNGR1 interferon gamma receptor 1 0.452962
TIMD4 T-cell immunoglobulin and mucin domain containing 4 0.450324
IL9 interleukin 9 0.449571
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 0.447311
PTPRE protein tyrosine phosphatase, receptor type, E 0.446182
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.443547
NTF3 neurotrophin 3 0.436026
CCL4 chemokine (C-C motif) ligand 4 0.432646
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.424389
TNC tenascin C 0.419892
FGFBP2 fibroblast growth factor binding protein 2 0.417644
HHAT hedgehog acyltransferase 0.415024
GIMAP4 GTPase, IMAP family member 4 0.413527
NPS neuropeptide S 0.411657
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 0.406051
IL17A interleukin 17A 0.402318
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 0.401572
MRC1 mannose receptor, C type 1 0.397843
CXCL8 chemokine (C-X-C motif) ligand 8 0.396353
P3H2 prolyl 3-hydroxylase 2 0.394491
EDN1 endothelin 1 0.391513
IL27RA interleukin 27 receptor, alpha 0.390397
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 0.390397
EOMES eomesodermin 0.386308
NGFR nerve growth factor receptor 0.382223
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.378885
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.373698
IFNG interferon, gamma 0.371107
TLR10 toll-like receptor 10 0.370737
SHE Src homology 2 domain containing E 0.369997
CRTAM cytotoxic and regulatory T cell molecule 0.366301
ABR active BCR-related 0.363716
LTB4R leukotriene B4 receptor 0.360395
JAK2 Janus kinase 2 0.359289
LPAR2 lysophosphatidic acid receptor 2 0.358551
CXCL9 chemokine (C-X-C motif) ligand 9 0.354131
ALOX5AP arachidonate 5-lipoxygenase-activating protein 0.352659
PPARG peroxisome proliferator-activated receptor gamma 0.351555
CX3CL1 chemokine (C-X3-C motif) ligand 1 0.351187
IL2RB interleukin 2 receptor, beta 0.350452
CXCL5 chemokine (C-X-C motif) ligand 5 0.346409
NTF4 neurotrophin 4 0.345675
LARS leucyl-tRNA synthetase 0.342372
FN1 fibronectin 1 0.340539
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.340539
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 0.340539
IFI6 interferon, alpha-inducible protein 6 0.33944
ARG2 arginase 2 0.338707
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 0.335046
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 0.334681
KPNA3 karyopherin alpha 3 (importin alpha 4) 0.334315
FCAR Fc fragment of IgA receptor 0.333218
LTB lymphotoxin beta (TNF superfamily, member 3) 0.331756
CXCR3 chemokine (C-X-C motif) receptor 3 0.331391
NCF4 neutrophil cytosolic factor 4, 40kDa 0.331391
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.325916
RETNLB resistin like beta 0.323365
IL2 interleukin 2 0.321545
CD1C CD1c molecule 0.321181
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 0.319363
RHOA ras homolog family member A 0.315366
C5 complement component 5 0.31464
CD44 CD44 molecule (Indian blood group) 0.313189
AOAH acyloxyacyl hydrolase (neutrophil) 0.312827
PCDH1 protocadherin 1 0.309566
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent) 0.307395
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.302698
ADRB2 adrenoceptor beta 2, surface 0.302698
ACTB actin, beta 0.298731
NVL nuclear VCP-like 0.298371
TIMP1 TIMP metallopeptidase inhibitor 1 0.297291
SMAD2 SMAD family member 2 0.296931
RIPK2 receptor-interacting serine-threonine kinase 2 0.296571
MYLK myosin light chain kinase 0.292975
IL10RA interleukin 10 receptor, alpha 0.292616
CD34 CD34 molecule 0.291898
IFNA5 interferon, alpha 5 0.288668
CHML choroideremia-like (Rab escort protein 2) 0.28831
RFX1 regulatory factor X, 1 (influences HLA class II expression) 0.28831
BATF3 basic leucine zipper transcription factor, ATF-like 3 0.287593
CDIP1 cell death-inducing p53 target 1 0.287235
CD83 CD83 molecule 0.286877
TRIM46 tripartite motif containing 46 0.286519
LMTK2 lemur tyrosine kinase 2 0.284013
IL22 interleukin 22 0.282582
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.281153
IFNL1 interferon, lambda 1 0.281153
NOS1 nitric oxide synthase 1 (neuronal) 0.279011
IL12B interleukin 12B 0.27687
ADAM8 ADAM metallopeptidase domain 8 0.276158
ALOX5 arachidonate 5-lipoxygenase 0.274021
IL1R2 interleukin 1 receptor, type II 0.271174
ACTG1 actin gamma 1 0.270108
MIR187 microRNA 187 0.269398
SYNPO2 synaptopodin 2 0.269398
SPI1 Spi-1 proto-oncogene 0.269043
SELPLG selectin P ligand 0.267622
PGAP3 post-GPI attachment to proteins 3 0.266913
LOXL1 lysyl oxidase-like 1 0.266203
IL3 interleukin 3 0.264785
BTK Bruton agammaglobulinemia tyrosine kinase 0.261599
HRH4 histamine receptor H4 0.261599
LCK LCK proto-oncogene, Src family tyrosine kinase 0.260891
MID1 midline 1 0.260184
CX3CR1 chemokine (C-X3-C motif) receptor 1 0.256299
ICAM3 intercellular adhesion molecule 3 0.256299
NFIL3 nuclear factor, interleukin 3 regulated 0.254888
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A 0.254888
PF4 platelet factor 4 0.253831
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.253127
CCL7 chemokine (C-C motif) ligand 7 0.251718
CCL27 chemokine (C-C motif) ligand 27 0.246448
STAT1 signal transducer and activator of transcription 1, 91kDa 0.246098
SMAD3 SMAD family member 3 0.243995
FBXO8 F-box protein 8 0.240847
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 0.240497
HNMT histamine N-methyltransferase 0.23666
LYN LYN proto-oncogene, Src family tyrosine kinase 0.235268
CD19 CD19 molecule 0.235268
VIPR1 vasoactive intestinal peptide receptor 1 0.234225
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 0.232489
VIMP VCP-interacting membrane selenoprotein 0.230755
TAC4 tachykinin 4 (hemokinin) 0.230409
CPA3 carboxypeptidase A3 (mast cell) 0.229716
LBP lipopolysaccharide binding protein 0.229024
TXK TXK tyrosine kinase 0.229024
NPW neuropeptide W 0.226262
PRF1 perforin 1 (pore forming protein) 0.225573
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 0.225229
NOD2 nucleotide-binding oligomerization domain containing 2 0.22454
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 0.222136
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.22145
JUN jun proto-oncogene 0.22145
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 0.220081
F2 coagulation factor II (thrombin) 0.218715
LY96 lymphocyte antigen 96 0.217693
UNC119 unc-119 homolog (C. elegans) 0.215314
CXCR2 chemokine (C-X-C motif) receptor 2 0.214636
AICDA activation-induced cytidine deaminase 0.213621
CD209 CD209 molecule 0.212945
SNX9 sorting nexin 9 0.211261
LTC4S leukotriene C4 synthase 0.210925
CXCL2 chemokine (C-X-C motif) ligand 2 0.210253
NOX3 NADPH oxidase 3 0.209248
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.209248
CCL21 chemokine (C-C motif) ligand 21 0.205254
LAG3 lymphocyte-activation gene 3 0.205254
GPR68 G protein-coupled receptor 68 0.199681
PDE7B phosphodiesterase 7B 0.199033
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.19742
PLAC1 placenta-specific 1 0.196779
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.196779
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 0.195183
STAT4 signal transducer and activator of transcription 4 0.194865
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 0.194232
DOCK1 dedicator of cytokinesis 1 0.189551
IL1RN interleukin 1 receptor antagonist 0.188632
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.188326
NOS3 nitric oxide synthase 3 (endothelial cell) 0.188022
IRF3 interferon regulatory factor 3 0.187719
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.187113
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 0.18621
ARRB1 arrestin, beta 1 0.185612
PFDN4 prefoldin subunit 4 0.18472
PARP14 poly (ADP-ribose) polymerase family, member 14 0.183541
IL7 interleukin 7 0.180937
SOD2 superoxide dismutase 2, mitochondrial 0.17952
CLEC7A C-type lectin domain family 7, member A 0.178682
TRPV1 transient receptor potential cation channel, subfamily V, member 1 0.177029
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.176757
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 0.176757
SPINK5 serine peptidase inhibitor, Kazal type 5 0.175947
CD226 CD226 molecule 0.174617
DLL4 delta-like 4 (Drosophila) 0.171785
CD48 CD48 molecule 0.171535
RETN resistin 0.171036
CKLF chemokine-like factor 0.168381
KCNIP4 Kv channel interacting protein 4 0.168148
TJP1 tight junction protein 1 0.167915
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 0.167915
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 0.167682
STIM1 stromal interaction molecule 1 0.166995
CLC Charcot-Leyden crystal galectin 0.164359
JAK3 Janus kinase 3 0.164149
PTGER3 prostaglandin E receptor 3 (subtype EP3) 0.162505
ZBTB32 zinc finger and BTB domain containing 32 0.162109
TLR6 toll-like receptor 6 0.161912
FER fer (fps/fes related) tyrosine kinase 0.160021
VIPR2 vasoactive intestinal peptide receptor 2 0.160021
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 0.159838
ITGAD integrin, alpha D 0.159658
USO1 USO1 vesicle transport factor 0.157929