aids Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A syndrome resulting from the acquired deficiency of cellular immunity caused by the human immunodeficiency virus (HIV). It is characterized by the reduction of the Helper T-lymphocytes in the peripheral blood and the lymph nodes. Symptoms include generalized lymphadenopathy, fever, weight loss, and chronic diarrhea. Patients with AIDS are especially susceptible to opportunistic infections (usually pneumocystis carinii pneumonia, cytomegalovirus (CMV) infections, tuberculosis, candida infections, and cryptococcosis), and the development of malignant neoplasms (usually non-Hodgkin's lymphoma and Kaposi's sarcoma). The human immunodeficiency virus is transmitted through sexual contact, sharing of contaminated needles, or transfusion of contaminated blood.|An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.|A syndrome resulting from the acquired deficiency of cellular immunity caused by the human immunodeficiency virus (HIV). It is characterized by the reduction of the Helper T-lymphocytes in the peripheral blood and the lymph nodes. Symptoms include generalized lymphadenopathy, fever, weight loss, and chronic diarrhea. Patients with AIDS are especially susceptible to opportunistic infections (usually pneumocystis carinii pneumonia, cytomegalovirus (CMV) infections, tuberculosis, candida infections, and cryptococcosis), and the development of malignant neoplasms (usually non-Hodgkin's lymphoma and Kaposi's sarcoma). The human immunodeficiency virus is transmitted through sexual contact, sharing of contaminated needles, or transfusion of contaminated blood. -- 2004|Acquired immunodeficiency syndrome is a HIV infection consisting of a disease of the human immune system that is characterized cytologically especially by a reduction in the numbers of CD4-bearing helper T cells to 20 percent or less of normal thereby rendering the subject highly vulnerable to life-threatening conditions (as Pneumocystis carinii pneumonia) and to some that become life threatening (as Kaposi's sarcoma) and that is caused by infection with HIV commonly transmitted in infected blood especially during illicit intravenous drug use and in bodily secretions (as semen) during sexual intercourse.|An HIV infectious disease that is a characterized cytologically by a reduction in the numbers of CD4-bearing helper T cells to 20 percent or less of normal thereby rendering the subject highly vulnerable to life-threatening conditions (as Pneumocystis carinii pneumonia) and to some that become life threatening (as Kaposi's sarcoma) and that is caused by infection with HIV commonly transmitted in infected blood especially during illicit intravenous drug use and in bodily secretions (as semen) during sexual intercourse.|A syndrome resulting from the acquired deficiency of cellular immunity caused by the human immunodeficiency virus (HIV). It is characterized by the reduction of the Helper T-lymphocytes in the peripheral blood and the lymph nodes. Symptoms include generalized lymphadenopathy, fever, weight loss, and chronic diarrhea. Patients with AIDS are especially susceptible to opportunistic infections (usually pneumocystis carinii pneumonia, cytomegalovirus (CMV) infections, tuberculosis, candida infections, and cryptococcosis), and the development of malignant neoplasms (usually non-Hodgkin's lymphoma and Kaposi's sarcoma). The human immunodeficiency virus is transmitted through sexual contact, sharing of contaminated needles, or transfusion of contaminated blood.|A Human immunodeficiency virus infectious disease that results_in reduction in the numbers of CD4-bearing helper T cells below 200 per ┬ÁL of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has_agent Human immunodeficiency virus 1 or has_agent Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. Opportunistic infections are common in people with AIDS. (Experimental Factor Ontology, EFO_0000765)
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Genes

97 genes co-occuring with the biological term aids in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACSM4 acyl-CoA synthetase medium-chain family member 4
AICDA activation-induced cytidine deaminase
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ARHGAP44 Rho GTPase activating protein 44
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL19 chemokine (C-C motif) ligand 19
CCL3L1 chemokine (C-C motif) ligand 3-like 1
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD209 CD209 molecule
CD274 CD274 molecule
CD4 CD4 molecule
CD47 CD47 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK9 cyclin-dependent kinase 9
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CRP C-reactive protein, pentraxin-related
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL5 cullin 5
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
CXCR6 chemokine (C-X-C motif) receptor 6
CYBA cytochrome b-245, alpha polypeptide
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DAPK1 death-associated protein kinase 1
DDB1 damage-specific DNA binding protein 1, 127kDa
ERCC2 excision repair cross-complementation group 2
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FN1 fibronectin 1
G6PD glucose-6-phosphate dehydrogenase
GLRA1 glycine receptor, alpha 1
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GOLM1 golgi membrane protein 1
GSK3B glycogen synthase kinase 3 beta
HAVCR1 hepatitis A virus cellular receptor 1
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-G major histocompatibility complex, class I, G
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL18 interleukin 18
IL2 interleukin 2
IL21 interleukin 21
IL4 interleukin 4
IL6 interleukin 6
IL7 interleukin 7
IL7R interleukin 7 receptor
LEP leptin
LRP1 low density lipoprotein receptor-related protein 1
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MBL2 mannose-binding lectin (protein C) 2, soluble
MEF2C myocyte enhancer factor 2C
MIR494 microRNA 494
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NKX2-2 NK2 homeobox 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUP98 nucleoporin 98kDa
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PARD3B par-3 family cell polarity regulator beta
PCNA proliferating cell nuclear antigen
PLAUR plasminogen activator, urokinase receptor
PLG plasminogen
PROX1 prospero homeobox 1
PTN pleiotrophin
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RP2 retinitis pigmentosa 2 (X-linked recessive)
RPRD1B regulation of nuclear pre-mRNA domain containing 1B
SFTPD surfactant protein D
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SLPI secretory leukocyte peptidase inhibitor
SNAI2 snail family zinc finger 2
SRSF6 serine/arginine-rich splicing factor 6
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TLR7 toll-like receptor 7
TLR9 toll-like receptor 9
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNPO3 transportin 3
TP53 tumor protein p53
TRG T cell receptor gamma locus
TSG101 tumor susceptibility 101
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
YBX1 Y box binding protein 1