aggresome Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules. (Gene Ontology, GO_0016235)
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Genes

178 proteins co-occuring with the aggresome cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
HDAC6 histone deacetylase 6 2.17125
SNCAIP synuclein, alpha interacting protein 1.62413
SQSTM1 sequestosome 1 1.3974
TRIM50 tripartite motif containing 50 1.25443
HSPA4 heat shock 70kDa protein 4 1.2387
ATXN3 ataxin 3 1.23609
BAG3 BCL2-associated athanogene 3 1.15262
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 1.10817
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 1.10103
CRYAB crystallin, alpha B 1.09238
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) 1.07613
SSBP2 single-stranded DNA binding protein 2 0.948284
UBQLN1 ubiquilin 1 0.940689
HTT huntingtin 0.939742
VCP valosin containing protein 0.922322
ASB10 ankyrin repeat and SOCS box containing 10 0.904138
PMP22 peripheral myelin protein 22 0.901818
HOOK2 hook microtubule-tethering protein 2 0.896257
PARK2 parkin RBR E3 ubiquitin protein ligase 0.895331
DISC1 disrupted in schizophrenia 1 0.893018
TP53INP1 tumor protein p53 inducible nuclear protein 1 0.850665
C10ORF10 chromosome 10 open reading frame 10 0.80523
PRNP prion protein 0.801104
UBE2K ubiquitin-conjugating enzyme E2K 0.795145
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.794229
NNAT neuronatin 0.759069
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.742769
TPMT thiopurine S-methyltransferase 0.734666
HSPB8 heat shock 22kDa protein 8 0.695587
UBE2S ubiquitin-conjugating enzyme E2S 0.68639
HDAC9 histone deacetylase 9 0.680284
KRT8 keratin 8, type II 0.663368
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.660345
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.643572
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.638434
ELOVL4 ELOVL fatty acid elongase 4 0.635868
ZFAND5 zinc finger, AN1-type domain 5 0.61883
TGM2 transglutaminase 2 0.618406
CARD6 caspase recruitment domain family, member 6 0.602331
TDRD9 tudor domain containing 9 0.596014
USP9X ubiquitin specific peptidase 9, X-linked 0.590133
TDRD6 tudor domain containing 6 0.566754
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.545648
HSPB3 heat shock 27kDa protein 3 0.540294
MAP1S microtubule-associated protein 1S 0.538649
CUL5 cullin 5 0.528388
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 0.518573
CANX calnexin 0.51694
BECN1 beclin 1, autophagy related 0.507977
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.497826
MAGED1 melanoma antigen family D1 0.484483
DCP1A decapping mRNA 1A 0.472412
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 0.472011
STIP1 stress-induced phosphoprotein 1 0.461199
DCTN1 dynactin 1 0.458803
NBR1 neighbor of BRCA1 gene 1 0.455214
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.451631
UBD ubiquitin D 0.446862
MAPT microtubule-associated protein tau 0.43538
TPPP tubulin polymerization promoting protein 0.433407
ATG7 autophagy related 7 0.427497
HSF1 heat shock transcription factor 1 0.427104
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 0.424745
DOCK3 dedicator of cytokinesis 3 0.416902
TDP2 tyrosyl-DNA phosphodiesterase 2 0.41612
DCTN2 dynactin 2 (p50) 0.415337
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.414946
TUBA1A tubulin, alpha 1a 0.410259
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 0.408699
PSEN1 presenilin 1 0.407919
UBE2H ubiquitin-conjugating enzyme E2H 0.402081
PINK1 PTEN induced putative kinase 1 0.400527
NLRP7 NLR family, pyrin domain containing 7 0.398975
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae) 0.397423
SLC30A2 solute carrier family 30 (zinc transporter), member 2 0.394323
HSPA8 heat shock 70kDa protein 8 0.392388
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 0.386208
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1 0.381969
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.379276
TDRD7 tudor domain containing 7 0.377738
GPSM1 G-protein signaling modulator 1 0.374666
CCP110 centriolar coiled coil protein 110kDa 0.374283
CTSF cathepsin F 0.373899
UBA1 ubiquitin-like modifier activating enzyme 1 0.373132
TDRD1 tudor domain containing 1 0.371216
PACRG PARK2 co-regulated 0.370067
RAB24 RAB24, member RAS oncogene family 0.369301
PML promyelocytic leukemia 0.368536
ATP7B ATPase, Cu++ transporting, beta polypeptide 0.367388
PARK7 parkinson protein 7 0.365477
CUL1 cullin 1 0.360896
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.360515
MAP4 microtubule-associated protein 4 0.357467
DES desmin 0.345314
NUB1 negative regulator of ubiquitin-like proteins 1 0.343799
HSPB2 heat shock 27kDa protein 2 0.343042
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.342664
RPL27 ribosomal protein L27 0.337373
RBX1 ring-box 1, E3 ubiquitin protein ligase 0.336241
RANBP9 RAN binding protein 9 0.327205
UBE2D2 ubiquitin-conjugating enzyme E2D 2 0.326453
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 0.32195
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.32195
BAG1 BCL2-associated athanogene 0.320826
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.320451
MUC4 mucin 4, cell surface associated 0.320077
IGKV1-17 immunoglobulin kappa variable 1-17 0.319328
P4HB prolyl 4-hydroxylase, beta polypeptide 0.309613
UBE3A ubiquitin protein ligase E3A 0.303655
SPG20 spastic paraplegia 20 (Troyer syndrome) 0.300682
BCOR BCL6 corepressor 0.29994
MARK4 MAP/microtubule affinity-regulating kinase 4 0.296601
XBP1 X-box binding protein 1 0.28846
SKP1 S-phase kinase-associated protein 1 0.282189
PSAP prosaposin 0.281453
UBQLN2 ubiquilin 2 0.281085
FOXC1 forkhead box C1 0.278877
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.278141
SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 0.266774
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.264581
LITAF lipopolysaccharide-induced TNF factor 0.260566
MEFV Mediterranean fever 0.258016
USP5 ubiquitin specific peptidase 5 (isopeptidase T) 0.257652
SIRT2 sirtuin 2 0.256197
SOX3 SRY (sex determining region Y)-box 3 0.25547
LRRK2 leucine-rich repeat kinase 2 0.249302
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.245323
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.242797
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.242437
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 0.232744
EGLN3 egl-9 family hypoxia-inducible factor 3 0.232386
SFTPC surfactant protein C 0.229888
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 0.227752
TOLLIP toll interacting protein 0.226686
RAB32 RAB32, member RAS oncogene family 0.222083
TP53 tumor protein p53 0.218212
IGHV3-30 immunoglobulin heavy variable 3-30 0.215761
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.215063
GOPC golgi-associated PDZ and coiled-coil motif containing 0.209513
ATP7A ATPase, Cu++ transporting, alpha polypeptide 0.208481
TOM1 target of myb1 (chicken) 0.206766
SCNN1B sodium channel, non voltage gated 1 beta subunit 0.205059
LAMP1 lysosomal-associated membrane protein 1 0.204378
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 0.202346
LAMP2 lysosomal-associated membrane protein 2 0.200663
KRT18 keratin 18, type I 0.197662
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.195681
EEA1 early endosome antigen 1 0.195681
CTRL chymotrypsin-like 0.195025
CTTN cortactin 0.194045
ATG4B autophagy related 4B, cysteine peptidase 0.191777
AR androgen receptor 0.189539
ATG14 autophagy related 14 0.18859
TARDBP TAR DNA binding protein 0.186397
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.186087
MAP2 microtubule-associated protein 2 0.183935
HAP1 huntingtin-associated protein 1 0.178877
RHO rhodopsin 0.178299
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 0.175466
BCL6 B-cell CLL/lymphoma 6 0.174361
FUS FUS RNA binding protein 0.172735
HLA-B major histocompatibility complex, class I, B 0.171673
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 0.16935
ANK1 ankyrin 1, erythrocytic 0.167366
LIM2 lens intrinsic membrane protein 2, 19kDa 0.165
RIPK2 receptor-interacting serine-threonine kinase 2 0.16477
TPP2 tripeptidyl peptidase II 0.164542
EPS15 epidermal growth factor receptor pathway substrate 15 0.16233
GJA8 gap junction protein, alpha 8, 50kDa 0.162117
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.160863
DDIT3 DNA-damage-inducible transcript 3 0.159462
ZNF763 zinc finger protein 763 0.157397
ZNF501 zinc finger protein 501 0.157397
ZNF569 zinc finger protein 569 0.157397
ZNF629 zinc finger protein 629 0.157397
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 0.156688
ZNF44 zinc finger protein 44 0.156513
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.156513