adrenal gland hyperfunction Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
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Genes

202 genes co-occuring with the disease adrenal gland hyperfunction in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
POMC proopiomelanocortin 3.98598
CRH corticotropin releasing hormone 2.80469
REN renin 2.4372
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 2.24098
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.98482
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 1.92951
SST somatostatin 1.82775
NR3C2 nuclear receptor subfamily 3, group C, member 2 1.81194
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 1.76139
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 1.70633
PRL prolactin 1.66015
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 1.64666
PDE11A phosphodiesterase 11A 1.55912
INS insulin 1.51853
TRH thyrotropin-releasing hormone 1.50667
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.49833
GHRH growth hormone releasing hormone 1.48077
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 1.43859
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 1.41358
GIPR gastric inhibitory polypeptide receptor 1.38865
ARMC5 armadillo repeat containing 5 1.33981
GIP gastric inhibitory polypeptide 1.31362
AVP arginine vasopressin 1.31013
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 1.28654
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 1.24037
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.19359
IGF1 insulin-like growth factor 1 (somatomedin C) 1.18798
PDE8B phosphodiesterase 8B 1.15624
MEN1 multiple endocrine neoplasia I 1.13966
SSTR5 somatostatin receptor 5 1.13712
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.11561
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 1.08831
LEP leptin 1.08286
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 1.06354
AVPR1B arginine vasopressin receptor 1B 1.05429
BGLAP bone gamma-carboxyglutamate (gla) protein 1.01934
SSTR2 somatostatin receptor 2 1.00077
CLCNKB chloride channel, voltage-sensitive Kb 0.988957
PRKCA protein kinase C, alpha 0.964567
CALCA calcitonin-related polypeptide alpha 0.946603
CRHBP corticotropin releasing hormone binding protein 0.939534
GNAS GNAS complex locus 0.93207
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 0.919261
CHGA chromogranin A 0.908553
SSTR1 somatostatin receptor 1 0.908142
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 0.896641
GHRL ghrelin/obestatin prepropeptide 0.893359
ACE angiotensin I converting enzyme 0.863456
KCNK9 potassium channel, two pore domain subfamily K, member 9 0.850354
GCG glucagon 0.849126
SYP synaptophysin 0.844621
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 0.843802
PTH parathyroid hormone 0.818385
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.816334
NPPA natriuretic peptide A 0.813873
ACBD3 acyl-CoA binding domain containing 3 0.777795
GAST gastrin 0.77207
CORT cortistatin 0.745985
ENO2 enolase 2 (gamma, neuronal) 0.718846
GH1 growth hormone 1 0.716828
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 0.715215
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 0.696306
SHBG sex hormone-binding globulin 0.695905
GHSR growth hormone secretagogue receptor 0.681096
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 0.648928
AVPR1A arginine vasopressin receptor 1A 0.644586
GHR growth hormone receptor 0.644192
FDX1 ferredoxin 1 0.637495
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 0.629242
SCG5 secretogranin V 0.619051
CRHR1 corticotropin releasing hormone receptor 1 0.617094
BSND barttin CLCNK-type chloride channel accessory beta subunit 0.615529
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.610448
RBAK RB-associated KRAB zinc finger 0.60303
ALPL alkaline phosphatase, liver/bone/kidney 0.595233
ALPPL2 alkaline phosphatase, placental-like 2 0.582773
ALPP alkaline phosphatase, placental 0.582384
VWF von Willebrand factor 0.569552
NPS neuropeptide S 0.562558
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.560227
MGP matrix Gla protein 0.554403
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta 0.549359
MC3R melanocortin 3 receptor 0.541992
ZNF226 zinc finger protein 226 0.540829
ALB albumin 0.52729
SLC26A3 solute carrier family 26 (anion exchanger), member 3 0.52536
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 0.524202
NPY neuropeptide Y 0.512264
SSTR4 somatostatin receptor 4 0.511112
NR5A1 nuclear receptor subfamily 5, group A, member 1 0.508041
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.498849
SCNN1G sodium channel, non voltage gated 1 gamma subunit 0.497321
LRRC75A-AS1 LRRC75A antisense RNA 1 0.493122
IGF2 insulin-like growth factor 2 0.475634
WNK4 WNK lysine deficient protein kinase 4 0.472982
F8 coagulation factor VIII, procoagulant component 0.455978
MC4R melanocortin 4 receptor 0.45447
IL6 interleukin 6 0.449571
PPARG peroxisome proliferator-activated receptor gamma 0.445052
LHCGR luteinizing hormone/choriogonadotropin receptor 0.444676
KCNK3 potassium channel, two pore domain subfamily K, member 3 0.430768
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 0.424389
UFC1 ubiquitin-fold modifier conjugating enzyme 1 0.421765
AGRP agouti related neuropeptide 0.418019
SNED1 sushi, nidogen and EGF-like domains 1 0.415773
PGR progesterone receptor 0.397843
MC5R melanocortin 5 receptor 0.397471
TP53 tumor protein p53 0.391513
MGAM maltase-glucoamylase 0.391141
DNAH8 dynein, axonemal, heavy chain 8 0.389281
INHA inhibin, alpha 0.381852
POR P450 (cytochrome) oxidoreductase 0.379626
CYB5A cytochrome b5 type A (microsomal) 0.37555
BMP4 bone morphogenetic protein 4 0.36187
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.354131
SCNN1B sodium channel, non voltage gated 1 beta subunit 0.340906
WNK1 WNK lysine deficient protein kinase 1 0.339806
KL klotho 0.337242
STAR steroidogenic acute regulatory protein 0.336876
ADD1 adducin 1 (alpha) 0.335046
VIP vasoactive intestinal peptide 0.33066
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.316456
INSR insulin receptor 0.298011
ADCY2 adenylate cyclase 2 (brain) 0.296931
CRHR2 corticotropin releasing hormone receptor 2 0.294772
TSC22D3 TSC22 domain family, member 3 0.291898
PCP4 Purkinje cell protein 4 0.28616
FKBP5 FK506 binding protein 5 0.281153
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.277584
CLASP2 cytoplasmic linker associated protein 2 0.276514
MRGPRX2 MAS-related GPR, member X2 0.27153
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 0.269043
F10 coagulation factor X 0.260891
DRD2 dopamine receptor D2 0.25983
HAT1 histone acetyltransferase 1 0.256652
PCSK2 proprotein convertase subtilisin/kexin type 2 0.256652
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.251366
TXN2 thioredoxin 2 0.243645
LPL lipoprotein lipase 0.241196
CREB1 cAMP responsive element binding protein 1 0.240847
GAL galanin/GMAP prepropeptide 0.237009
PCSK1 proprotein convertase subtilisin/kexin type 1 0.23492
GNA12 guanine nucleotide binding protein (G protein) alpha 12 0.230063
CRY1 cryptochrome circadian clock 1 0.228333
FGF23 fibroblast growth factor 23 0.222479
LEPR leptin receptor 0.218715
RET ret proto-oncogene 0.213959
TRPM6 transient receptor potential cation channel, subfamily M, member 6 0.212945
HLA-DMA major histocompatibility complex, class II, DM alpha 0.20658
CRY2 cryptochrome circadian clock 2 0.193915
TXNIP thioredoxin interacting protein 0.187719
HDAC2 histone deacetylase 2 0.187113
FGF21 fibroblast growth factor 21 0.182957
PGK1 phosphoglycerate kinase 1 0.180084
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 0.171785
OXT oxytocin/neurophysin I prepropeptide 0.170299
FOXRED1 FAD-dependent oxidoreductase domain containing 1 0.170054
PLG plasminogen 0.166995
SSR2 signal sequence receptor, beta (translocon-associated protein beta) 0.165435
SGK1 serum/glucocorticoid regulated kinase 1 0.165217
RETN resistin 0.163317
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 0.160995
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 0.160574
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.159124
LIFR leukemia inhibitory factor receptor alpha 0.158097
ADRB2 adrenoceptor beta 2, surface 0.140591
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 0.140438
PBK PDZ binding kinase 0.140384
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.140267
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.14026
ZNF222 zinc finger protein 222 0.140239
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.140148
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.140047
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 0.139809
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.13971
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.139687
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 0.138605
TRHR thyrotropin-releasing hormone receptor 0.138059
CYTL1 cytokine-like 1 0.137947
NAGS N-acetylglutamate synthase 0.13733
DNASE1L3 deoxyribonuclease I-like 3 0.136994
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 0.136899
CLDN8 claudin 8 0.136851
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3 0.136839
ARRB1 arrestin, beta 1 0.136668
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 0.134792
KNG1 kininogen 1 0.134457
SOX6 SRY (sex determining region Y)-box 6 0.134059
A4GALT alpha 1,4-galactosyltransferase 0.133462
GRM3 glutamate receptor, metabotropic 3 0.132824
ALDOB aldolase B, fructose-bisphosphate 0.13176
TM4SF5 transmembrane 4 L six family member 5 0.130129
MKI67 marker of proliferation Ki-67 0.129376
MLX MLX, MAX dimerization protein 0.129323
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae) 0.128857
COL1A2 collagen, type I, alpha 2 0.128829
MLANA melan-A 0.128687
F3 coagulation factor III (thromboplastin, tissue factor) 0.128658
SSTR3 somatostatin receptor 3 0.128371
SIX2 SIX homeobox 2 0.127592
CEL carboxyl ester lipase 0.126991
LRRC25 leucine rich repeat containing 25 0.126991