adrenal gland disease Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description An endocrine system disease that is located_in the adrenal gland. (Human Disease Ontology, DOID_9553)
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Genes

313 genes co-occuring with the disease adrenal gland disease in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
POMC proopiomelanocortin 4.02189
CRH corticotropin releasing hormone 2.78064
REN renin 2.44134
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 2.19829
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.97129
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 1.88805
SST somatostatin 1.81104
NR3C2 nuclear receptor subfamily 3, group C, member 2 1.77767
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 1.7555
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 1.72137
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 1.7077
PRL prolactin 1.6651
AIRE autoimmune regulator 1.61262
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 1.60681
INS insulin 1.58671
TRH thyrotropin-releasing hormone 1.53613
PDE11A phosphodiesterase 11A 1.51984
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.47242
GHRH growth hormone releasing hormone 1.46891
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 1.42762
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 1.39957
NUDT10 nudix (nucleoside diphosphate linked moiety X)-type motif 10 1.36902
AVP arginine vasopressin 1.35028
GIPR gastric inhibitory polypeptide receptor 1.34984
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 1.33109
ARMC5 armadillo repeat containing 5 1.30139
GIP gastric inhibitory polypeptide 1.27475
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 1.19143
IGF1 insulin-like growth factor 1 (somatomedin C) 1.17421
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.15581
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.13882
SSTR5 somatostatin receptor 5 1.12108
PDE8B phosphodiesterase 8B 1.11856
WFS1 Wolfram syndrome 1 (wolframin) 1.11856
MEN1 multiple endocrine neoplasia I 1.10216
AVPR1B arginine vasopressin receptor 1B 1.1009
LEP leptin 1.06144
BGLAP bone gamma-carboxyglutamate (gla) protein 1.03114
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 1.0265
SSTR2 somatostatin receptor 2 0.963728
CISD2 CDGSH iron sulfur domain 2 0.961634
CLCNKB chloride channel, voltage-sensitive Kb 0.951604
GNAS GNAS complex locus 0.944521
PRKCA protein kinase C, alpha 0.927519
CALCA calcitonin-related polypeptide alpha 0.920911
STAR steroidogenic acute regulatory protein 0.911845
CRHBP corticotropin releasing hormone binding protein 0.90321
CHGA chromogranin A 0.89623
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 0.894179
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 0.882701
SSTR1 somatostatin receptor 1 0.871643
PTH parathyroid hormone 0.861409
FDX1 ferredoxin 1 0.861409
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 0.861409
NPPA natriuretic peptide A 0.86059
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 0.86018
GHRL ghrelin/obestatin prepropeptide 0.856905
GCG glucagon 0.856905
ACE angiotensin I converting enzyme 0.850354
GAST gastrin 0.840934
SYP synaptophysin 0.814283
KCNK9 potassium channel, two pore domain subfamily K, member 9 0.813873
SHBG sex hormone-binding globulin 0.785165
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 0.782707
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.780251
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.775341
MICA MHC class I polypeptide-related sequence A 0.759824
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.753306
ACBD3 acyl-CoA binding domain containing 3 0.741923
CRHR1 corticotropin releasing hormone receptor 1 0.737865
CORT cortistatin 0.709975
ENO2 enolase 2 (gamma, neuronal) 0.689092
GH1 growth hormone 1 0.681096
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 0.661197
GHSR growth hormone secretagogue receptor 0.64577
ALPL alkaline phosphatase, liver/bone/kidney 0.615921
GHR growth hormone receptor 0.612792
AVPR1A arginine vasopressin receptor 1A 0.609666
ALPPL2 alkaline phosphatase, placental-like 2 0.604981
ALPP alkaline phosphatase, placental 0.604201
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 0.594843
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 0.591727
SCG5 secretogranin V 0.584719
BSND barttin CLCNK-type chloride channel accessory beta subunit 0.580828
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.576161
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.571884
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.571107
RBAK RB-associated KRAB zinc finger 0.568775
NPS neuropeptide S 0.558674
NR5A1 nuclear receptor subfamily 5, group A, member 1 0.55518
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.540442
VWF von Willebrand factor 0.535022
ALB albumin 0.534248
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.525746
MGP matrix Gla protein 0.520346
TPO thyroid peroxidase 0.518034
CLEC16A C-type lectin domain family 16, member A 0.51611
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta 0.51534
MC3R melanocortin 3 receptor 0.507657
ZNF226 zinc finger protein 226 0.50689
MC4R melanocortin 4 receptor 0.500761
SLC26A3 solute carrier family 26 (anion exchanger), member 3 0.491215
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 0.490072
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 0.485885
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.484364
NPY neuropeptide Y 0.478668
SSTR4 somatostatin receptor 4 0.477151
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.465038
SCNN1G sodium channel, non voltage gated 1 gamma subunit 0.463527
LRRC75A-AS1 LRRC75A antisense RNA 1 0.459751
IGF2 insulin-like growth factor 2 0.442042
WNK4 WNK lysine deficient protein kinase 4 0.439786
IL6 interleukin 6 0.433772
F8 coagulation factor VIII, procoagulant component 0.42289
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 0.416896
PPARG peroxisome proliferator-activated receptor gamma 0.412031
LHCGR luteinizing hormone/choriogonadotropin receptor 0.411657
CIITA class II, major histocompatibility complex, transactivator 0.411283
ADAM3A ADAM metallopeptidase domain 3A (pseudogene) 0.409787
CRHR2 corticotropin releasing hormone receptor 2 0.407919
TG thyroglobulin 0.405305
IFIH1 interferon induced with helicase C domain 1 0.401199
KCNK3 potassium channel, two pore domain subfamily K, member 3 0.397471
UFC1 ubiquitin-fold modifier conjugating enzyme 1 0.388538
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.385193
AGRP agouti related neuropeptide 0.384822
DNAH8 dynein, axonemal, heavy chain 8 0.384451
SNED1 sushi, nidogen and EGF-like domains 1 0.382966
POR P450 (cytochrome) oxidoreductase 0.379626
TP53 tumor protein p53 0.372958
PGR progesterone receptor 0.364824
MC5R melanocortin 5 receptor 0.364824
MGAM maltase-glucoamylase 0.358183
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.351555
HLA-C major histocompatibility complex, class I, C 0.348981
INHA inhibin, alpha 0.348981
CLEC2D C-type lectin domain family 2, member D 0.346409
CYB5A cytochrome b5 type A (microsomal) 0.343106
OSBPL9 oxysterol binding protein-like 9 0.340906
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.340539
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 0.338707
NLRP1 NLR family, pyrin domain containing 1 0.330295
BMP4 bone morphogenetic protein 4 0.329565
F10 coagulation factor X 0.324823
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.315366
PTPRD protein tyrosine phosphatase, receptor type, D 0.309204
SCNN1B sodium channel, non voltage gated 1 beta subunit 0.30848
WNK1 WNK lysine deficient protein kinase 1 0.307395
KL klotho 0.305226
ADD1 adducin 1 (alpha) 0.302698
VIP vasoactive intestinal peptide 0.298371
GAL galanin/GMAP prepropeptide 0.296931
HLA-DMA major histocompatibility complex, class II, DM alpha 0.289744
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.287235
INSR insulin receptor 0.279367
ADCY2 adenylate cyclase 2 (brain) 0.26514
PFKL phosphofructokinase, liver 0.264077
LEPR leptin receptor 0.261952
TSC22D3 TSC22 domain family, member 3 0.260184
PCP4 Purkinje cell protein 4 0.254536
FKBP5 FK506 binding protein 5 0.24996
TPH1 tryptophan hydroxylase 1 0.248554
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.246799
CLASP2 cytoplasmic linker associated protein 2 0.245046
MRGPRX2 MAS-related GPR, member X2 0.240497
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 0.237706
MIER1 mesoderm induction early response 1, transcriptional regulator 0.234225
DRD2 dopamine receptor D2 0.229024
PCSK2 proprotein convertase subtilisin/kexin type 2 0.225917
HAT1 histone acetyltransferase 1 0.225917
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 0.225229
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.220424
TXN2 thioredoxin 2 0.212945
LPL lipoprotein lipase 0.210589
CREB1 cAMP responsive element binding protein 1 0.210253
PCSK1 proprotein convertase subtilisin/kexin type 1 0.204593
GNA12 guanine nucleotide binding protein (G protein) alpha 12 0.200006
CRY1 cryptochrome circadian clock 1 0.198386
FGF23 fibroblast growth factor 23 0.193285
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28 0.190476
RET ret proto-oncogene 0.185612
TRPM6 transient receptor potential cation channel, subfamily M, member 6 0.18472
ALDOB aldolase B, fructose-bisphosphate 0.17952
PLG plasminogen 0.174354
CRY2 cryptochrome circadian clock 2 0.169091
CREM cAMP responsive element modulator 0.165655
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.165217
TXNIP thioredoxin interacting protein 0.164359
STXBP5 syntaxin binding protein 5 (tomosyn) 0.163938
HDAC2 histone deacetylase 2 0.163938
FGF21 fibroblast growth factor 21 0.161139
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.15948
PGK1 phosphoglycerate kinase 1 0.15948
C4A complement component 4A (Rodgers blood group) 0.137107
AAAS achalasia, adrenocortical insufficiency, alacrimia 0.136962
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 0.136466
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 0.136462
TSGA10 testis specific, 10 0.136401
NLRP5 NLR family, pyrin domain containing 5 0.136373
HLA-DQB3 major histocompatibility complex, class II, DQ beta 3 0.13616
FCRL3 Fc receptor-like 3 0.135985
HYLS1 hydrolethalus syndrome 1 0.134938
HLA-B major histocompatibility complex, class I, B 0.134842
WDR11 WD repeat domain 11 0.134462
FDXR ferredoxin reductase 0.134462
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.134014
MVD mevalonate (diphospho) decarboxylase 0.133857
SIAE sialic acid acetylesterase 0.133691
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 0.13349
GIF gastric intrinsic factor (vitamin B synthesis) 0.133305
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.132271
HLA-E major histocompatibility complex, class I, E 0.131991
C7ORF49 chromosome 7 open reading frame 49 0.131812
GIMAP5 GTPase, IMAP family member 5 0.131695
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.131439
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 0.131035
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.130588
CD79A CD79a molecule, immunoglobulin-associated alpha 0.130067
HLA-A major histocompatibility complex, class I, A 0.130022
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.129863
PDCD1 programmed cell death 1 0.129666
SGK1 serum/glucocorticoid regulated kinase 1 0.129628
CXCL10 chemokine (C-X-C motif) ligand 10 0.12921
LHX4 LIM homeobox 4 0.128446
CASR calcium-sensing receptor 0.127731
WHSC1 Wolf-Hirschhorn syndrome candidate 1 0.127393
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.126882
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3 0.126278
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 0.125516
ORM1 orosomucoid 1 0.125516
MINK1 misshapen-like kinase 1 0.124973
CXCL11 chemokine (C-X-C motif) ligand 11 0.124687
PGM3 phosphoglucomutase 3 0.124673
BEAN1 brain expressed, associated with NEDD4, 1 0.124114
HIF3A hypoxia inducible factor 3, alpha subunit 0.123297
MKI67 marker of proliferation Ki-67 0.122904
PDXP pyridoxal (pyridoxine, vitamin B6) phosphatase 0.122598
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.122108
TRIM24 tripartite motif containing 24 0.121982
SUMO4 small ubiquitin-like modifier 4 0.121192
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 0.120475
IFNA1 interferon, alpha 1 0.120335
CLN3 ceroid-lipofuscinosis, neuronal 3 0.120056
MTO1 mitochondrial tRNA translation optimization 1 0.119949
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.119533
FOXRED1 FAD-dependent oxidoreductase domain containing 1 0.11926
ARSH arylsulfatase family, member H 0.118738
SSR2 signal sequence receptor, beta (translocon-associated protein beta) 0.11853
STAT4 signal transducer and activator of transcription 4 0.118241
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 0.117914
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 0.117577
SOX3 SRY (sex determining region Y)-box 3 0.117458
CD274 CD274 molecule 0.117159
LIFR leukemia inhibitory factor receptor alpha 0.117038
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.116914
LARS leucyl-tRNA synthetase 0.116873
FLAD1 flavin adenine dinucleotide synthetase 1 0.116791
MSH5 mutS homolog 5 0.116586
ALDOA aldolase A, fructose-bisphosphate 0.116255
OXT oxytocin/neurophysin I prepropeptide 0.115492
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 0.114858
HESX1 HESX homeobox 1 0.114792
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 0.113711
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 0.113688
ADRB2 adrenoceptor beta 2, surface 0.111839
PPT1 palmitoyl-protein thioesterase 1 0.111592
PAH phenylalanine hydroxylase 0.111371
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 0.111272
PBK PDZ binding kinase 0.111075
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.110644
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.110618
ZNF222 zinc finger protein 222 0.110542
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.110213
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.109851
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 0.109013
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.108664
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.108584
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 0.10502
TRHR thyrotropin-releasing hormone receptor 0.103348
CYTL1 cytokine-like 1 0.103011
GK glycerol kinase 0.102366
GUSB glucuronidase, beta 0.10221
MRI1 methylthioribose-1-phosphate isomerase 1 0.102147
NAGS N-acetylglutamate synthase 0.101238
HPN hepsin 0.100821
DNASE1L3 deoxyribonuclease I-like 3 0.100308
MED12 mediator complex subunit 12 0.100276
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 0.100051
CLDN8 claudin 8 0.09992
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3 0.099887
ARRB1 arrestin, beta 1 0.099428
PDYN prodynorphin 0.097292
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 0.094833
KNG1 kininogen 1 0.094085
PTTG1 pituitary tumor-transforming 1 0.093622
SOX6 SRY (sex determining region Y)-box 6 0.093225
F2 coagulation factor II (thrombin) 0.092173
A4GALT alpha 1,4-galactosyltransferase 0.091989
GRM3 glutamate receptor, metabotropic 3 0.090733
TM4SF5 transmembrane 4 L six family member 5 0.08607
MLX MLX, MAX dimerization protein 0.084851
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae) 0.084174
COL1A2 collagen, type I, alpha 2 0.084134
MLANA melan-A 0.083935
F3 coagulation factor III (thromboplastin, tissue factor) 0.083895
LATS1 large tumor suppressor kinase 1 0.083736
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 0.083656
IVD isovaleryl-CoA dehydrogenase 0.083537
SSTR3 somatostatin receptor 3 0.083497
SIX2 SIX homeobox 2 0.082451
RETN resistin 0.082168
CEL carboxyl ester lipase 0.081684
LRRC25 leucine rich repeat containing 25 0.081684