absent primitive node Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description absence of the regional thickening of cells at the rostral tip of the vertebrate primitive streak through which gastrulating cells migrate anteriorally to form tissues in the future head and neck; this region organizes the formation of the three embryonic layers and establishes the longitudinal axis and the polarity of the embryo (Mammalian Phenotype Ontology, MP_0009331)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009331
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Genes

16 gene mutations causing the absent primitive node phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AMN amnion associated transmembrane protein
EOMES eomesodermin
FGF8 fibroblast growth factor 8 (androgen-induced)
FOXA2 forkhead box A2
FOXH1 forkhead box H1
HTT huntingtin
LEFTY2 left-right determination factor 2
MIXL1 Mix paired-like homeobox
NODAL nodal growth differentiation factor
NSD1 nuclear receptor binding SET domain protein 1
POFUT2 protein O-fucosyltransferase 2
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
SALL4 spalt-like transcription factor 4
SMAD2 SMAD family member 2
WNT3 wingless-type MMTV integration site family, member 3
ZIC3 Zic family member 3