absent lymphocyte Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description absence of the cells involved in adaptive immune reactions of the body in most inflammatory and autoimmune diseases, including B cells, T cells and natural killer cells (Mammalian Phenotype Ontology, MP_0000726)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000726
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Genes

68 gene mutations causing the absent lymphocyte phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ATP11C ATPase, class VI, type 11C
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BATF basic leucine zipper transcription factor, ATF-like
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BLNK B-cell linker
BTK Bruton agammaglobulinemia tyrosine kinase
CARD11 caspase recruitment domain family, member 11
CD22 CD22 molecule
CD247 CD247 molecule
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD4 CD4 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CREBBP CREB binding protein
CYCS cytochrome c, somatic
DCLRE1C DNA cross-link repair 1C
DOCK8 dedicator of cytokinesis 8
EBF1 early B-cell factor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FNIP1 folliculin interacting protein 1
FOXN1 forkhead box N1
FOXP3 forkhead box P3
GON4L gon-4-like (C. elegans)
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL15 interleukin 15
IL17A interleukin 17A
IL17F interleukin 17F
IL2RG interleukin 2 receptor, gamma
IL6 interleukin 6
IL7R interleukin 7 receptor
IRF4 interferon regulatory factor 4
ITPKB inositol-trisphosphate 3-kinase B
JAK3 Janus kinase 3
LAT linker for activation of T cells
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
LYST lysosomal trafficking regulator
MALT1 MALT1 paracaspase
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NKX2-3 NK2 homeobox 3
PAX5 paired box 5
PGM3 phosphoglucomutase 3
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PRDM1 PR domain containing 1, with ZNF domain
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTPRC protein tyrosine phosphatase, receptor type, C
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
SH2D1A SH2 domain containing 1A
SOX4 SRY (sex determining region Y)-box 4
SPI1 Spi-1 proto-oncogene
SYK spleen tyrosine kinase
TBX21 T-box 21
TCF12 transcription factor 12
TCF3 transcription factor 3
TNF tumor necrosis factor
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZEB1 zinc finger E-box binding homeobox 1