absent lymph node germinal center Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description absence of the area of the lymph node secondary follicle where antigen-activated B-cell blasts are stimulated by antigens and proliferate, with the immunoglobulin genes undergoing somatic hypermutation, before the cells migrate away as plasma cells or memory cells (Mammalian Phenotype Ontology, MP_0008523)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008523
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Genes

8 gene mutations causing the absent lymph node germinal center phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BCL6 B-cell CLL/lymphoma 6
CD40LG CD40 ligand
IRF4 interferon regulatory factor 4
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
POU2AF1 POU class 2 associating factor 1
TNF tumor necrosis factor
TRAF2 TNF receptor-associated factor 2
UNC13D unc-13 homolog D (C. elegans)