absent floor plate Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description absence of the specialized glial structure (non-neuronal cells) situated at the ventral midline of the embryonic neural tube; this structure spans the anteroposterior axis from the midbrain to the tail regions, separating the left and right basal plates of the developing neural tube, and serves as an organizer to ventralize tissues in the embryo as well as to guide neuronal positioning and differentiation along the dorsoventral axis of the neural tube (Mammalian Phenotype Ontology, MP_0000926)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000926
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17 gene mutations causing the absent floor plate phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ARL13B ADP-ribosylation factor-like 13B
DISP1 dispatched homolog 1 (Drosophila)
FOXA2 forkhead box A2
GLI2 GLI family zinc finger 2
HHAT hedgehog acyltransferase
IFT57 intraflagellar transport 57
IFT88 intraflagellar transport 88
INTU inturned planar cell polarity protein
ITGB8 integrin, beta 8
NODAL nodal growth differentiation factor
RBL2 retinoblastoma-like 2
SHH sonic hedgehog
STIL SCL/TAL1 interrupting locus
TCTN1 tectonic family member 1
TCTN2 tectonic family member 2
TMEM107 transmembrane protein 107