absent brunner's glands Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description absence of the branched acinotubular glands found in the submucosa of the duodenum located above the Sphincter of Oddi; their main function is to produce a mucus-rich alkaline secretion (containing bicarbonate) to protect the duodenum from the acidic content of chyme, provide an alkaline condition for the intestinal enzymes to be active (thus enabling absorption to take place), and lubricate the intestinal walls; they also secrete urogastrone, which inhibits parietal and chief cells of the stomach from secreting acid and their digestive enzymes (Mammalian Phenotype Ontology, MP_0012520)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0012520
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Genes

1 gene mutations causing the absent brunner's glands phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
PDX1 pancreatic and duodenal homeobox 1