absent b cells Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A severe form of B lymphocytopenia in which the count of B cells is very low or absent. (Human Phenotype Ontology, HP_0005365)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008071
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Genes

47 gene mutations causing the absent b cells phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ATP11C ATPase, class VI, type 11C
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BATF basic leucine zipper transcription factor, ATF-like
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BLNK B-cell linker
BTK Bruton agammaglobulinemia tyrosine kinase
CARD11 caspase recruitment domain family, member 11
CD22 CD22 molecule
CD4 CD4 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CREBBP CREB binding protein
CYCS cytochrome c, somatic
DCLRE1C DNA cross-link repair 1C
DOCK8 dedicator of cytokinesis 8
EBF1 early B-cell factor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FNIP1 folliculin interacting protein 1
GON4L gon-4-like (C. elegans)
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IRF4 interferon regulatory factor 4
JAK3 Janus kinase 3
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
MALT1 MALT1 paracaspase
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NKX2-3 NK2 homeobox 3
PAX5 paired box 5
PGM3 phosphoglucomutase 3
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PRDM1 PR domain containing 1, with ZNF domain
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
SOX4 SRY (sex determining region Y)-box 4
SPI1 Spi-1 proto-oncogene
SYK spleen tyrosine kinase
TCF3 transcription factor 3
TNF tumor necrosis factor
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZEB1 zinc finger E-box binding homeobox 1