abnormality of thrombocytes Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An abnormality of platelets. (Human Phenotype Ontology, HP_0001872)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0001872
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Genes

180 genes associated with the abnormality of thrombocytes phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 2.23649
WDR66 WD repeat domain 66 2.20759
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 2.13114
JMJD1C jumonji domain containing 1C 1.85133
GGT1 gamma-glutamyltransferase 1 1.71126
SH2B3 SH2B adaptor protein 3 1.51574
DNM3 dynamin 3 1.34898
TMCC2 transmembrane and coiled-coil domain family 2 1.29197
LUC7L LUC7-like (S. cerevisiae) 1.27246
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12 1.22392
NRXN2 neurexin 2 1.21598
RCL1 RNA terminal phosphate cyclase-like 1 1.17419
GP1BA glycoprotein Ib (platelet), alpha polypeptide 1.1614
CCND3 cyclin D3 1.15783
TAOK1 TAO kinase 1 1.14364
LRRC16A leucine rich repeat containing 16A 1.08399
EHD3 EH-domain containing 3 1.08248
TMPRSS6 transmembrane protease, serine 6 1.05583
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 1.04957
CD36 CD36 molecule (thrombospondin receptor) 1.02868
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 1.01391
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 0.937096
THPO thrombopoietin 0.879804
TPM4 tropomyosin 4 0.876775
G6PD glucose-6-phosphate dehydrogenase 0.866924
EXOC3L4 exocyst complex component 3-like 4 0.844241
PEAR1 platelet endothelial aggregation receptor 1 0.7407
MEF2C myocyte enhancer factor 2C 0.698331
LOC145837 0.620831
ZFPM2 zinc finger protein, FOG family member 2 0.599896
FAR2 fatty acyl CoA reductase 2 0.536514
HFE hemochromatosis 0.534631
F2R coagulation factor II (thrombin) receptor 0.528881
LIPC lipase, hepatic 0.495598
SLFN14 schlafen family member 14 0.485109
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.47891
CDKN2A cyclin-dependent kinase inhibitor 2A 0.467275
TNNT3 troponin T type 3 (skeletal, fast) 0.465649
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 0.458631
ALPL alkaline phosphatase, liver/bone/kidney 0.43283
SLMO2 slowmo homolog 2 (Drosophila) 0.430746
PNPLA3 patatin-like phospholipase domain containing 3 0.417728
BAK1 BCL2-antagonist/killer 1 0.417635
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase 0.414052
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.413807
DOCK8 dedicator of cytokinesis 8 0.413807
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.411267
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.410912
GRTP1 growth hormone regulated TBC protein 1 0.410769
GCKR glucokinase (hexokinase 4) regulator 0.409551
GPLD1 glycosylphosphatidylinositol specific phospholipase D1 0.407397
ANKMY1 ankyrin repeat and MYND domain containing 1 0.407397
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit 0.405929
CD226 CD226 molecule 0.405929
SGCZ sarcoglycan, zeta 0.405466
CABLES1 Cdk5 and Abl enzyme substrate 1 0.404013
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 0.402225
THADA thyroid adenoma associated 0.401355
IRF1 interferon regulatory factor 1 0.401355
ITPK1 inositol-tetrakisphosphate 1-kinase 0.401355
HLA-DOA major histocompatibility complex, class II, DO alpha 0.401355
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.399462
SLC14A2 solute carrier family 14 (urea transporter), member 2 0.398566
RAD51B RAD51 paralog B 0.398566
BRD3 bromodomain containing 3 0.398566
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.398566
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 0.396812
FEN1 flap structure-specific endonuclease 1 0.396812
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 0.396452
THRB thyroid hormone receptor, beta 0.396088
GLIS3 GLIS family zinc finger 3 0.394783
KALRN kalirin, RhoGEF kinase 0.394504
PLEC plectin 0.394504
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast) 0.393683
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.39267
HLA-B major histocompatibility complex, class I, B 0.391503
DOCK7 dedicator of cytokinesis 7 0.38711
NFE2 nuclear factor, erythroid 2 0.386983
HBA1 hemoglobin, alpha 1 0.384799
DENND4A DENN/MADD domain containing 4A 0.384689
TMEM79 transmembrane protein 79 0.384433
PDIA5 protein disulfide isomerase family A, member 5 0.382633
ACAD10 acyl-CoA dehydrogenase family, member 10 0.381141
BRAP BRCA1 associated protein 0.381141
LDLRAD4 low density lipoprotein receptor class A domain containing 4 0.380504
TRIM58 tripartite motif containing 58 0.379923
SAMM50 SAMM50 sorting and assembly machinery component 0.378764
MME membrane metallo-endopeptidase 0.3773
UBE2L3 ubiquitin-conjugating enzyme E2L 3 0.376528
MFN2 mitofusin 2 0.376528
WDR72 WD repeat domain 72 0.37293
TPM1 tropomyosin 1 (alpha) 0.372362
CDK6 cyclin-dependent kinase 6 0.372031
KIF1B kinesin family member 1B 0.36942
TERT telomerase reverse transcriptase 0.36942
RPS11 ribosomal protein S11 0.36942
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome 0.36942
XPO7 exportin 7 0.36942
LRP2 low density lipoprotein receptor-related protein 2 0.368
PRKCE protein kinase C, epsilon 0.367881
TYMP thymidine phosphorylase 0.367568
RNF145 ring finger protein 145 0.367568
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 0.367568
CCDC162P coiled-coil domain containing 162, pseudogene 0.366372
BAD BCL2-associated agonist of cell death 0.366137
COPZ1 coatomer protein complex, subunit zeta 1 0.366137
IPCEF1 interaction protein for cytohesin exchange factors 1 0.365079
LDHAL6A lactate dehydrogenase A-like 6A 0.363326
PCGF5 polycomb group ring finger 5 0.362178
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.36088
ZNF583 zinc finger protein 583 0.359739
TFR2 transferrin receptor 2 0.358325
CETP cholesteryl ester transfer protein, plasma 0.358075
NEURL1 neuralized E3 ubiquitin protein ligase 1 0.356732
CASC15 cancer susceptibility candidate 15 (non-protein coding) 0.354925
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.35372
MACROD2 MACRO domain containing 2 0.351596
GPC6 glypican 6 0.350599
MMP26 matrix metallopeptidase 26 0.350059
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 0.349738
BCAS3 breast carcinoma amplified sequence 3 0.347228
GALP galanin-like peptide 0.345849
MRVI1 murine retrovirus integration site 1 homolog 0.34437
NCAPH2 non-SMC condensin II complex, subunit H2 0.34437
EPO erythropoietin 0.342223
MMP25 matrix metallopeptidase 25 0.342223
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 0.338502
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 0.33503
FGGY FGGY carbohydrate kinase domain containing 0.326164
DPYD dihydropyrimidine dehydrogenase 0.324368
ITFG3 integrin alpha FG-GAP repeat containing 3 0.32422
EYS eyes shut homolog (Drosophila) 0.323507
PTGER3 prostaglandin E receptor 3 (subtype EP3) 0.322435
DCC DCC netrin 1 receptor 0.320442
PLCB4 phospholipase C, beta 4 0.319291
PRKG1 protein kinase, cGMP-dependent, type I 0.318984
SOX5 SRY (sex determining region Y)-box 5 0.318252
PLA2G2C phospholipase A2, group IIC 0.318182
MYOF myoferlin 0.317973
MPL MPL proto-oncogene, thrombopoietin receptor 0.3177
CDC20 cell division cycle 20 0.3177
FOXP2 forkhead box P2 0.317175
CCDC102B coiled-coil domain containing 102B 0.316922
PARD3B par-3 family cell polarity regulator beta 0.316675
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.313998
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.311953
MIA2 melanoma inhibitory activity 2 0.311136
SP140L SP140 nuclear body protein-like 0.308137
PARK2 parkin RBR E3 ubiquitin protein ligase 0.307596
GCDH glutaryl-CoA dehydrogenase 0.307149
LRRC4B leucine rich repeat containing 4B 0.307113
NPAS3 neuronal PAS domain protein 3 0.306129
APOC1 apolipoprotein C-I 0.306129
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.305245
MICA MHC class I polypeptide-related sequence A 0.304627
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 0.302852
CAPN9 calpain 9 0.302514
TRPV4 transient receptor potential cation channel, subfamily V, member 4 0.302396
MRAS muscle RAS oncogene homolog 0.301383
CECR6 cat eye syndrome chromosome region, candidate 6 0.301117
NELL1 NEL-like 1 (chicken) 0.300885
COL24A1 collagen, type XXIV, alpha 1 0.300741
CD109 CD109 molecule 0.300684
TRAPPC6B trafficking protein particle complex 6B 0.299478
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 0.298679
SP140 SP140 nuclear body protein 0.298331
GRIP1 glutamate receptor interacting protein 1 0.297587
MAK male germ cell-associated kinase 0.295898
OSBPL6 oxysterol binding protein-like 6 0.295461
TSG101 tumor susceptibility 101 0.294219
MED24 mediator complex subunit 24 0.294031
SORBS1 sorbin and SH3 domain containing 1 0.293588
CNTN4 contactin 4 0.293263
PIEZO1 piezo-type mechanosensitive ion channel component 1 0.293227
RALYL RALY RNA binding protein-like 0.292012
ZAN zonadhesin (gene/pseudogene) 0.290565
MYB v-myb avian myeloblastosis viral oncogene homolog 0.262825
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 0.26138
TFRC transferrin receptor 0.256471
SPTA1 spectrin, alpha, erythrocytic 1 0.254558