abnormality of the thyroid gland Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An abnormality of the thyroid gland. (Human Phenotype Ontology, HP_0000820)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0000820
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Genes

134 genes associated with the abnormality of the thyroid gland phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
PDE8B phosphodiesterase 8B 2.35874
DIO1 deiodinase, iodothyronine, type I 2.25054
PDE10A phosphodiesterase 10A 2.09607
LHX3 LIM homeobox 3 1.67051
NFIA nuclear factor I/A 1.52822
FGF7 fibroblast growth factor 7 1.51005
PRDM11 PR domain containing 11 1.43975
INSR insulin receptor 1.40061
NRG1 neuregulin 1 1.30781
MINOS1 mitochondrial inner membrane organizing system 1 1.21315
GLIS3 GLIS family zinc finger 3 1.19958
LPCAT2 lysophosphatidylcholine acyltransferase 2 1.1784
PTPRT protein tyrosine phosphatase, receptor type, T 1.00386
NCKAP5 NCK-associated protein 5 0.950052
C1QTNF6 C1q and tumor necrosis factor related protein 6 0.587536
TSHR thyroid stimulating hormone receptor 0.544445
C6ORF10 chromosome 6 open reading frame 10 0.511323
FOXE1 forkhead box E1 0.451813
CAPZB capping protein (actin filament) muscle Z-line, beta 0.420139
SLAMF6 SLAM family member 6 0.419786
HLA-J major histocompatibility complex, class I, J (pseudogene) 0.399494
TCF19 transcription factor 19 0.394839
CCHCR1 coiled-coil alpha-helical rod protein 1 0.390185
MUC22 mucin 22 0.386514
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 0.386514
FCRL3 Fc receptor-like 3 0.383612
SH2B3 SH2B adaptor protein 3 0.371778
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.370544
ATXN2 ataxin 2 0.369586
FGFR1OP FGFR1 oncogene partner 0.357753
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.356687
MOG myelin oligodendrocyte glycoprotein 0.35327
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 0.351098
CEP128 centrosomal protein 128kDa 0.3494
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 0.349105
DIRC3 disrupted in renal carcinoma 3 0.347077
VAV3 vav 3 guanine nucleotide exchange factor 0.34555
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.34437
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.337283
CNTNAP2 contactin associated protein-like 2 0.337026
TG thyroglobulin 0.332291
FCRL1 Fc receptor-like 1 0.330097
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.317973
TNF tumor necrosis factor 0.316334
NELFE negative elongation factor complex member E 0.30657
SLA Src-like-adaptor 0.300393
RNASET2 ribonuclease T2 0.291601
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor 0.286866
CD5L CD5 molecule-like 0.286232
HLA-B major histocompatibility complex, class I, B 0.285927
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.283851
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.283851
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.281017
C6ORF15 chromosome 6 open reading frame 15 0.278715
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 0.275107
FCRL2 Fc receptor-like 2 0.270947
CFB complement factor B 0.268869
RECQL5 RecQ protein-like 5 0.268658
ZNF804B zinc finger protein 804B 0.268045
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.268045
ASIC2 acid sensing (proton gated) ion channel 2 0.268045
MTF1 metal-regulatory transcription factor 1 0.264544
HCG22 HLA complex group 22 0.263795
LOC100506999 uncharacterized LOC100506999 0.260571
TSHZ2 teashirt zinc finger homeobox 2 0.260571
INPP5B inositol polyphosphate-5-phosphatase, 75kDa 0.257513
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 0.256633
CALD1 caldesmon 1 0.256214
PFKP phosphofructokinase, platelet 0.255808
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 0.255031
CLECL1 C-type lectin-like 1 0.252944
RAB20 RAB20, member RAS oncogene family 0.252944
CALN1 calneuron 1 0.252316
PRKCE protein kinase C, epsilon 0.251143
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 0.249555
ZDHHC17 zinc finger, DHHC-type containing 17 0.24902
LACTB lactamase, beta 0.24902
THSD4 thrombospondin, type I, domain containing 4 0.248007
PCDH15 protocadherin-related 15 0.248007
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.245341
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 0.2451
VAV1 vav 1 guanine nucleotide exchange factor 0.24506
SNAP47 synaptosomal-associated protein, 47kDa 0.244942
AGER advanced glycosylation end product-specific receptor 0.244175
BTNL2 butyrophilin-like 2 0.243807
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa 0.241167
FKTN fukutin 0.240869
TASP1 taspase, threonine aspartase, 1 0.239711
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.238947
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.238718
RBP4 retinol binding protein 4, plasma 0.238443
VMP1 vacuole membrane protein 1 0.238198
TTLL6 tubulin tyrosine ligase-like family member 6 0.237487
TRIM15 tripartite motif containing 15 0.237258
WISP1 WNT1 inducible signaling pathway protein 1 0.237122
STAC SH3 and cysteine rich domain 0.237055
RTKN2 rhotekin 2 0.236833
ANKRD26 ankyrin repeat domain 26 0.236811
DFNB31 deafness, autosomal recessive 31 0.236251
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing 0.235958
CASC15 cancer susceptibility candidate 15 (non-protein coding) 0.235958
CLDN2 claudin 2 0.235351
IL2RA interleukin 2 receptor, alpha 0.235351
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.235155
KIRREL3 kin of IRRE like 3 (Drosophila) 0.235155
DCBLD1 discoidin, CUB and LCCL domain containing 1 0.234961
KLHL29 kelch-like family member 29 0.234961
CHL1 cell adhesion molecule L1-like 0.234961
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 0.23477
URI1 URI1, prefoldin-like chaperone 0.234582
CSMD3 CUB and Sushi multiple domains 3 0.234526
OPCML opioid binding protein/cell adhesion molecule-like 0.234031
DAAM1 dishevelled associated activator of morphogenesis 1 0.233502
RIN2 Ras and Rab interactor 2 0.233416
DKK2 dickkopf WNT signaling pathway inhibitor 2 0.233161
TNNT3 troponin T type 3 (skeletal, fast) 0.232993
CNTN4 contactin 4 0.232827
GPC5 glypican 5 0.232663
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.232663
ERICH1 glutamate-rich 1 0.232027
ERCC5 excision repair cross-complementation group 5 0.23142
MACROD2 MACRO domain containing 2 0.230981
MAN1C1 mannosidase, alpha, class 1C, member 1 0.230838
CARD9 caspase recruitment domain family, member 9 0.229355
KALRN kalirin, RhoGEF kinase 0.223739
RNF144A ring finger protein 144A 0.218319
HCG9 HLA complex group 9 (non-protein coding) 0.210824
CIPC CLOCK-interacting pacemaker 0.202975
ACSF3 acyl-CoA synthetase family member 3 0.202087
TMOD1 tropomodulin 1 0.196891
IRF2BPL interferon regulatory factor 2 binding protein-like 0.194028
LEMD2 LEM domain containing 2 0.193676
CLEC16A C-type lectin domain family 16, member A 0.193676
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.193566