abnormality of the testis Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An anomaly of the testicle (the male gonad). (Human Phenotype Ontology, HP_0000035)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0000035
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Genes

336 genes associated with the abnormality of the testis phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
KITLG KIT ligand 2.04057
DMRT1 doublesex and mab-3 related transcription factor 1 1.57946
BAK1 BCL2-antagonist/killer 1 1.23766
CLPTM1L CLPTM1-like 1.1641
ATF7IP activating transcription factor 7 interacting protein 1.0689
TERT telomerase reverse transcriptase 1.00629
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.716827
LINC00336 long intergenic non-protein coding RNA 336 0.552368
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.546813
RFWD3 ring finger and WD repeat domain 3 0.531208
CENPE centromere protein E, 312kDa 0.456014
MCM3AP minichromosome maintenance complex component 3 associated protein 0.424122
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E 0.411581
HPGDS hematopoietic prostaglandin D synthase 0.407127
UCK2 uridine-cytidine kinase 2 0.403699
PITX1 paired-like homeodomain 1 0.403699
SLC25A44 solute carrier family 25, member 44 0.401639
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 0.398971
PRDM14 PR domain containing 14 0.398896
TEX14 testis expressed 14 0.382599
NBAS neuroblastoma amplified sequence 0.382442
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.378558
PCDH11X protocadherin 11 X-linked 0.377548
IFNLR1 interferon, lambda receptor 1 0.37667
ADD2 adducin 2 (beta) 0.371592
AKAP9 A kinase (PRKA) anchor protein 9 0.371306
EYS eyes shut homolog (Drosophila) 0.371306
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.370544
CDK14 cyclin-dependent kinase 14 0.369765
PCDH9 protocadherin 9 0.366784
LPP LIM domain containing preferred translocation partner in lipoma 0.365228
RARS arginyl-tRNA synthetase 0.363716
CALCR calcitonin receptor 0.36337
MALRD1 MAM and LDL receptor class A domain containing 1 0.362606
LIPG lipase, endothelial 0.362606
SLC51A solute carrier family 51, alpha subunit 0.36125
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 0.360715
ARHGAP35 Rho GTPase activating protein 35 0.359827
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 0.359668
DTNB dystrobrevin, beta 0.358947
ZFAND4 zinc finger, AN1-type domain 4 0.358555
CNTNAP2 contactin associated protein-like 2 0.358325
PDE1A phosphodiesterase 1A, calmodulin-dependent 0.357723
SMAD6 SMAD family member 6 0.357225
AKAP13 A kinase (PRKA) anchor protein 13 0.356708
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.356268
PTPRJ protein tyrosine phosphatase, receptor type, J 0.356178
TRAPPC9 trafficking protein particle complex 9 0.356178
APP amyloid beta (A4) precursor protein 0.356178
KLHL32 kelch-like family member 32 0.356178
CPS1 carbamoyl-phosphate synthase 1, mitochondrial 0.356178
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae) 0.353658
IL7R interleukin 7 receptor 0.353431
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 0.352438
HSP90AA6P heat shock protein 90kDa alpha (cytosolic), class A member 6, pseudogene 0.352438
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) 0.351058
FRMD5 FERM domain containing 5 0.350364
LOC339975 uncharacterized LOC339975 0.350246
METTL2A methyltransferase like 2A 0.349842
SPINT1 serine peptidase inhibitor, Kunitz type 1 0.349842
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.349785
GPR149 G protein-coupled receptor 149 0.349673
CHN2 chimerin 2 0.349673
BSG basigin (Ok blood group) 0.349508
DERA deoxyribose-phosphate aldolase (putative) 0.349453
AIG1 androgen-induced 1 0.349237
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.349237
RYR2 ryanodine receptor 2 (cardiac) 0.349237
C4ORF45 chromosome 4 open reading frame 45 0.349237
C20ORF196 chromosome 20 open reading frame 196 0.349237
MAP2 microtubule-associated protein 2 0.349237
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 0.349237
EGFR epidermal growth factor receptor 0.349237
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 0.349237
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.349237
SLC26A3 solute carrier family 26 (anion exchanger), member 3 0.349131
MCTP1 multiple C2 domains, transmembrane 1 0.348716
CADM1 cell adhesion molecule 1 0.347839
PLK3 polo-like kinase 3 0.347654
RNF144B ring finger protein 144B 0.347338
DNAH6 dynein, axonemal, heavy chain 6 0.347294
CASZ1 castor zinc finger 1 0.347249
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.347118
FAM71D family with sequence similarity 71, member D 0.346691
CDK8 cyclin-dependent kinase 8 0.345507
UBASH3B ubiquitin associated and SH3 domain containing B 0.345249
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 0.345213
ERBB4 erb-b2 receptor tyrosine kinase 4 0.344927
TPK1 thiamin pyrophosphokinase 1 0.344927
ZNF385D zinc finger protein 385D 0.344927
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.344927
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 0.344927
NRXN3 neurexin 3 0.344927
CHD9 chromodomain helicase DNA binding protein 9 0.344927
ADAMTSL3 ADAMTS-like 3 0.344927
PXDNL peroxidasin-like 0.344927
BMPR1B bone morphogenetic protein receptor, type IB 0.344927
ELMO1 engulfment and cell motility 1 0.344927
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 0.344927
SMAD3 SMAD family member 3 0.344822
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.344212
USH2A Usher syndrome 2A (autosomal recessive, mild) 0.34392
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 0.343856
SUSD5 sushi domain containing 5 0.343856
COL25A1 collagen, type XXV, alpha 1 0.343761
PRICKLE1 prickle homolog 1 (Drosophila) 0.343482
CDH13 cadherin 13 0.34339
NOL8 nucleolar protein 8 0.34318
KIAA1671 KIAA1671 0.342936
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.342714
USP45 ubiquitin specific peptidase 45 0.342683
CAPSL calcyphosine-like 0.342527
PAX2 paired box 2 0.342374
DSE dermatan sulfate epimerase 0.342223
P3H2 prolyl 3-hydroxylase 2 0.342223
FAM207A family with sequence similarity 207, member A 0.342074
CSMD1 CUB and Sushi multiple domains 1 0.342074
FAM179B family with sequence similarity 179, member B 0.342044
NRG3 neuregulin 3 0.341781
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.341781
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase 0.341781
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 0.341781
LPA lipoprotein, Lp(a) 0.341781
PTPRD protein tyrosine phosphatase, receptor type, D 0.341781
SDHAF3 succinate dehydrogenase complex assembly factor 3 0.341781
FGF12 fibroblast growth factor 12 0.341781
ALPK3 alpha-kinase 3 0.341781
CCDC67 coiled-coil domain containing 67 0.341781
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.341781
AOX2P aldehyde oxidase 2 pseudogene 0.341781
VIT vitrin 0.341273
RHD Rh blood group, D antigen 0.341218
CLCN6 chloride channel, voltage-sensitive 6 0.341
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.340919
KCNIP1 Kv channel interacting protein 1 0.340813
SECTM1 secreted and transmembrane 1 0.340448
TMEM248 transmembrane protein 248 0.340422
ZBTB7C zinc finger and BTB domain containing 7C 0.34027
MYLK myosin light chain kinase 0.340169
ZNF652 zinc finger protein 652 0.340119
SCFD2 sec1 family domain containing 2 0.340119
CENPP centromere protein P 0.340045
ZNF407 zinc finger protein 407 0.34002
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 0.339704
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 0.339419
FMN2 formin 2 0.339373
ARMC8 armadillo repeat containing 8 0.339211
SOX5 SRY (sex determining region Y)-box 5 0.339211
DCLK1 doublecortin-like kinase 1 0.339211
FRMD4A FERM domain containing 4A 0.339211
LINC00540 long intergenic non-protein coding RNA 540 0.339211
MEMO1 mediator of cell motility 1 0.339211
AGBL1 ATP/GTP binding protein-like 1 0.339165
SPAG16 sperm associated antigen 16 0.338983
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.338983
ADGRA3 adhesion G protein-coupled receptor A3 0.338916
CLSTN2 calsyntenin 2 0.338694
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 0.338673
FAM19A5 family with sequence similarity 19 (chemokine (C-C motif)-like), member A5 0.338607
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.338477
CCSER1 coiled-coil serine-rich protein 1 0.33837
CAMTA1 calmodulin binding transcription activator 1 0.338328
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.338159
CFAP43 cilia and flagella associated protein 43 0.338076
NEGR1 neuronal growth regulator 1 0.33783
EPHB2 EPH receptor B2 0.337769
DENND4B DENN/MADD domain containing 4B 0.337708
PTPRS protein tyrosine phosphatase, receptor type, S 0.337668
PTPRK protein tyrosine phosphatase, receptor type, K 0.337392
PTCH2 patched 2 0.33716
COL13A1 collagen, type XIII, alpha 1 0.337122
FBLN1 fibulin 1 0.337122
SEZ6L seizure related 6 homolog (mouse)-like 0.337122
TFEC transcription factor EC 0.337122
EIF3E eukaryotic translation initiation factor 3, subunit E 0.337122
ASS1 argininosuccinate synthase 1 0.337122
SRD5A3 steroid 5 alpha-reductase 3 0.337122
ESRRG estrogen-related receptor gamma 0.337122
NGEF neuronal guanine nucleotide exchange factor 0.337122
C6ORF89 chromosome 6 open reading frame 89 0.337122
LDB2 LIM domain binding 2 0.337122
TMEM87A transmembrane protein 87A 0.336914
TSPAN15 tetraspanin 15 0.33684
BRD1 bromodomain containing 1 0.336619
HDAC4 histone deacetylase 4 0.336601
PTPRM protein tyrosine phosphatase, receptor type, M 0.336601
TNIK TRAF2 and NCK interacting kinase 0.336583
LOC344887 NmrA-like family domain containing 1 pseudogene 0.335948
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.335761
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.335727
TBC1D22A TBC1 domain family, member 22A 0.335694
MTUS2 microtubule associated tumor suppressor candidate 2 0.33561
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.335593
CLASP2 cytoplasmic linker associated protein 2 0.335544
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.335445
KIF13B kinesin family member 13B 0.335363
LIMCH1 LIM and calponin homology domains 1 0.335363
PRR16 proline rich 16 0.335363
MACROD1 MACRO domain containing 1 0.335363
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 0.335363
DOPEY1 dopey family member 1 0.335363
MLPH melanophilin 0.335363
KIAA1217 KIAA1217 0.335363
OSBPL5 oxysterol binding protein-like 5 0.334917
RERG RAS-like, estrogen-regulated, growth inhibitor 0.334886
GATAD2B GATA zinc finger domain containing 2B 0.334869
MIS18BP1 MIS18 binding protein 1 0.334852
ZFPM2 zinc finger protein, FOG family member 2 0.334782
ECM2 extracellular matrix protein 2, female organ and adipocyte specific 0.334644
RGS7 regulator of G-protein signaling 7 0.334644
SLC39A1 solute carrier family 39 (zinc transporter), member 1 0.334592
PPAP2B phosphatidic acid phosphatase type 2B 0.334507
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase 0.334138
SCHIP1 schwannomin interacting protein 1 0.333715
CADM2 cell adhesion molecule 2 0.333715
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 0.333715
LOC339862 uncharacterized LOC339862 0.333715
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 0.333715
SORCS1 sortilin-related VPS10 domain containing receptor 1 0.333715
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 0.333715
AKNAD1 AKNA domain containing 1 0.333715
UMODL1 uromodulin-like 1 0.333715
PCDH15 protocadherin-related 15 0.333715
FAM71F1 family with sequence similarity 71, member F1 0.333715
NAV2 neuron navigator 2 0.33354
PRKCB protein kinase C, beta 0.333384
WDR72 WD repeat domain 72 0.333245
PRKG1 protein kinase, cGMP-dependent, type I 0.333229
DMPK dystrophia myotonica-protein kinase 0.333016
PLD5 phospholipase D family, member 5 0.332644
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.332484
DFNB31 deafness, autosomal recessive 31 0.332354
MRPL47 mitochondrial ribosomal protein L47 0.332312
ELOVL6 ELOVL fatty acid elongase 6 0.332212
NTM neurotrimin 0.332212
LAMA2 laminin, alpha 2 0.332212
IQCJ IQ motif containing J 0.332212
UBE2W ubiquitin-conjugating enzyme E2W (putative) 0.332212
LUZP2 leucine zipper protein 2 0.332212
ASPA aspartoacylase 0.332212
SBF2 SET binding factor 2 0.332212
LOC728755 uncharacterized LOC728755 0.332212
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 0.332212
ASTN2 astrotactin 2 0.332212
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1 0.332212
TMEM132D transmembrane protein 132D 0.332212
GLIS3 GLIS family zinc finger 3 0.332212
SMAD7 SMAD family member 7 0.332184
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 0.332071
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.331974
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.331822
TMEM183A transmembrane protein 183A 0.331604
SPIDR scaffolding protein involved in DNA repair 0.331591
SCLT1 sodium channel and clathrin linker 1 0.331497
SEZ6 seizure related 6 homolog (mouse) 0.331444
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 0.33143
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.33143
MYO3B myosin IIIB 0.331325
GRM7 glutamate receptor, metabotropic 7 0.331325
ERN2 endoplasmic reticulum to nucleus signaling 2 0.331272
LINC00687 long intergenic non-protein coding RNA 687 0.331168
FAT4 FAT atypical cadherin 4 0.331103
RANBP1 RAN binding protein 1 0.331025
RAD21 RAD21 homolog (S. pombe) 0.330961
TMEM165 transmembrane protein 165 0.330872
MACROD2 MACRO domain containing 2 0.330872
NUP160 nucleoporin 160kDa 0.330872
CCDC174 coiled-coil domain containing 174 0.330872
CNTN5 contactin 5 0.330872
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.330872
LRP5L low density lipoprotein receptor-related protein 5-like 0.330872
ARHGAP15 Rho GTPase activating protein 15 0.330872
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.330872
MINOS1-NBL1 MINOS1-NBL1 readthrough 0.330872
CLIC5 chloride intracellular channel 5 0.330872
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.330872
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.330872
CFAP61 cilia and flagella associated protein 61 0.330872
FAM111B family with sequence similarity 111, member B 0.330872
RELN reelin 0.330872
KIF16B kinesin family member 16B 0.330872
PDZRN3 PDZ domain containing ring finger 3 0.330872
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 0.330872
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.330872
SCUBE1 signal peptide, CUB domain, EGF-like 1 0.330872
LYN LYN proto-oncogene, Src family tyrosine kinase 0.330872
KIAA1456 KIAA1456 0.330872
DCAF4 DDB1 and CUL4 associated factor 4 0.330872
SAMD3 sterile alpha motif domain containing 3 0.330872
FAM163A family with sequence similarity 163, member A 0.330872
THADA thyroid adenoma associated 0.330872
CLOCK clock circadian regulator 0.330872
SCN3A sodium channel, voltage gated, type III alpha subunit 0.330872
SPTBN1 spectrin, beta, non-erythrocytic 1 0.330872
FGF6 fibroblast growth factor 6 0.330872
CD38 CD38 molecule 0.330872
CTIF CBP80/20-dependent translation initiation factor 0.330872
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 0.330872
SGK1 serum/glucocorticoid regulated kinase 1 0.330872
ATXN1 ataxin 1 0.330872
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 0.330872
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.330872
SNAP25 synaptosomal-associated protein, 25kDa 0.330872
FRMD6 FERM domain containing 6 0.330872
FAM189A1 family with sequence similarity 189, member A1 0.330872
PELP1 proline, glutamate and leucine rich protein 1 0.330872
SLIT1 slit homolog 1 (Drosophila) 0.330872
C4ORF22 chromosome 4 open reading frame 22 0.330872
TOX thymocyte selection-associated high mobility group box 0.330872
CSPP1 centrosome and spindle pole associated protein 1 0.330872
NXPH1 neurexophilin 1 0.330872
MAN2B2 mannosidase, alpha, class 2B, member 2 0.330872
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 0.330872
IRAK3 interleukin-1 receptor-associated kinase 3 0.330872
C6ORF7 chromosome 6 open reading frame 7 0.330872
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 0.330872
PADI3 peptidyl arginine deiminase, type III 0.330872
OSBPL1A oxysterol binding protein-like 1A 0.330872
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.330872
PARD3B par-3 family cell polarity regulator beta 0.330872
LINC00578 long intergenic non-protein coding RNA 578 0.330872
PDCL2 phosducin-like 2 0.323861
CHD2 chromodomain helicase DNA binding protein 2 0.323009
IKBIP IKBKB interacting protein 0.321444
APAF1 apoptotic peptidase activating factor 1 0.321444
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 0.319376
ZFYVE1 zinc finger, FYVE domain containing 1 0.318748
TGFBR3 transforming growth factor, beta receptor III 0.318445
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 0.318147
TCF3 transcription factor 3 0.317016
CACHD1 cache domain containing 1 0.3149
CPM carboxypeptidase M 0.3149
NBEA neurobeachin 0.308927
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.307318
BMP6 bone morphogenetic protein 6 0.304685
RGS5 regulator of G-protein signaling 5 0.299941