abnormality of the pancreatic islet cells Gene Set

Dataset HPO Gene-Disease Associations
Category disease or phenotype associations
Type phenotype
Description An abnormality of the islet of Langerhans, i.e., of the regions of the pancreas that contain its endocrine cells. These are the alpha cells, which produce glucagon, the beta cells, which produce insulin and amylin, the delta cells, which produce somatostatin, the PP cells, which produce pancreatic polypeptide, and the epsilon cells, which produce ghrelin. (Human Phenotype Ontology, HP_0006476)
External Link http://compbio.charite.de/hpoweb/showterm?id=HP:0006476
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Genes

14 genes associated with the abnormality of the pancreatic islet cells phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

Symbol Name
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
DIS3L2 DIS3 like 3'-5' exoribonuclease 2
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
GCK glucokinase (hexokinase 4)
GPC3 glypican 3
INS insulin
INSR insulin receptor
ITS Insulinoma tumor suppressor gene locus
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
LBR lamin B receptor
MEN1 multiple endocrine neoplasia I
PAX4 paired box 4
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1