abnormality of the lower urinary tract Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An abnormality of the lower urinary tract. (Human Phenotype Ontology, HP_0010936)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0010936
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Genes

366 genes associated with the abnormality of the lower urinary tract phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
HLA-DRA major histocompatibility complex, class II, DR alpha 3.08361
IL23R interleukin 23 receptor 2.25025
STAT4 signal transducer and activator of transcription 4 2.01121
C6ORF10 chromosome 6 open reading frame 10 1.97993
LPP LIM domain containing preferred translocation partner in lipoma 1.97698
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 1.80285
NOTCH4 notch 4 1.79297
TNXB tenascin XB 1.67583
KIAA1109 KIAA1109 1.6518
OTUD3 OTU deubiquitinase 3 1.47083
DGKK diacylglycerol kinase, kappa 1.45387
ATXN2 ataxin 2 1.4414
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.43008
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 1.42949
ERBB3 erb-b2 receptor tyrosine kinase 3 1.42949
BAG6 BCL2-associated athanogene 6 1.39888
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 1.37008
MCCD1 mitochondrial coiled-coil domain 1 1.34526
C5ORF56 chromosome 5 open reading frame 56 1.33976
HLA-F-AS1 HLA-F antisense RNA 1 1.30523
EHMT2 euchromatic histone-lysine N-methyltransferase 2 1.2532
CLEC16A C-type lectin domain family 16, member A 1.25001
HLA-DMB major histocompatibility complex, class II, DM beta 1.23973
C2 complement component 2 1.23475
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 1.2331
CD58 CD58 molecule 1.22503
NKX2-3 NK2 homeobox 3 1.22464
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 1.21214
CTSH cathepsin H 1.17513
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 1.17291
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 1.17014
IL13 interleukin 13 1.16627
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 1.16627
EVI5 ecotropic viral integration site 5 1.16297
TAGAP T-cell activation RhoGTPase activating protein 1.16011
ZGPAT zinc finger, CCCH-type with G patch domain 1.15548
CFB complement factor B 1.14853
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.12851
TRAF1 TNF receptor-associated factor 1 1.12851
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 1.11203
AHI1 Abelson helper integration site 1 1.1097
TNPO3 transportin 3 1.09351
LACC1 laccase (multicopper oxidoreductase) domain containing 1 1.09255
BTNL2 butyrophilin-like 2 1.08821
PUS10 pseudouridylate synthase 10 1.07644
TNIP1 TNFAIP3 interacting protein 1 1.07572
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1.07068
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.06487
GSDMB gasdermin B 1.06368
FGFR1OP FGFR1 oncogene partner 1.0424
MST1 macrophage stimulating 1 1.03921
MMEL1 membrane metallo-endopeptidase-like 1 1.02893
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.99234
GLIS3 GLIS family zinc finger 3 0.989521
ANKRD55 ankyrin repeat domain 55 0.966492
CD86 CD86 molecule 0.964823
SIRPG signal-regulatory protein gamma 0.956307
IL2RA interleukin 2 receptor, alpha 0.948998
HLA-DMA major histocompatibility complex, class II, DM alpha 0.94703
CCR6 chemokine (C-C motif) receptor 6 0.945766
CD69 CD69 molecule 0.93393
IFIH1 interferon induced with helicase C domain 1 0.931243
PRKD2 protein kinase D2 0.91579
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.909907
METTL1 methyltransferase like 1 0.881851
CDSN corneodesmosin 0.881073
PSORS1C1 psoriasis susceptibility 1 candidate 1 0.860126
POU5F1 POU class 5 homeobox 1 0.859761
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.856119
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.808951
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase 0.808951
SP140 SP140 nuclear body protein 0.808951
PTPN2 protein tyrosine phosphatase, non-receptor type 2 0.797284
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 0.79573
TCF19 transcription factor 19 0.794044
KIF1B kinesin family member 1B 0.788376
SLC30A7 solute carrier family 30 (zinc transporter), member 7 0.788376
BANK1 B-cell scaffold protein with ankyrin repeats 1 0.776997
RNF5 ring finger protein 5, E3 ubiquitin protein ligase 0.761975
BRD2 bromodomain containing 2 0.761257
NCOA5 nuclear receptor coactivator 5 0.760549
SPRED2 sprouty-related, EVH1 domain containing 2 0.757148
PPT2 palmitoyl-protein thioesterase 2 0.730578
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.726349
ZMIZ1 zinc finger, MIZ-type containing 1 0.725475
STAT2 signal transducer and activator of transcription 2, 113kDa 0.719731
LOC100506459 uncharacterized LOC100506459 0.710943
ITLN1 intelectin 1 (galactofuranose binding) 0.696318
JAZF1 JAZF zinc finger 1 0.694617
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 0.676552
C1ORF106 chromosome 1 open reading frame 106 0.676552
ATXN2L ataxin 2-like 0.676552
HORMAD2 HORMA domain containing 2 0.676552
SBNO2 strawberry notch homolog 2 (Drosophila) 0.672654
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 0.665016
ICOSLG inducible T-cell co-stimulator ligand 0.662858
AGER advanced glycosylation end product-specific receptor 0.657798
CD247 CD247 molecule 0.650124
TIMMDC1 translocase of inner mitochondrial membrane domain containing 1 0.650124
MALT1 MALT1 paracaspase 0.650124
IGF2 insulin-like growth factor 2 0.630378
CD6 CD6 molecule 0.630378
PHRF1 PHD and ring finger domains 1 0.616892
DKKL1 dickkopf-like 1 0.615522
MAPK1 mitogen-activated protein kinase 1 0.615522
ZNF767P zinc finger family member 767, pseudogene 0.615522
SKAP2 src kinase associated phosphoprotein 2 0.611595
ICOS inducible T-cell co-stimulator 0.605702
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 0.60335
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.600358
PXK PX domain containing serine/threonine kinase 0.592408
PLEK pleckstrin 0.586494
PVT1 Pvt1 oncogene (non-protein coding) 0.584959
ARHGAP31 Rho GTPase activating protein 31 0.584753
CD40 CD40 molecule, TNF receptor superfamily member 5 0.5836
MERTK MER proto-oncogene, tyrosine kinase 0.572823
MPV17L2 MPV17 mitochondrial membrane protein-like 2 0.572823
CD226 CD226 molecule 0.572823
CLECL1 C-type lectin-like 1 0.572823
SPATA2 spermatogenesis associated 2 0.572823
C6ORF15 chromosome 6 open reading frame 15 0.546973
ADAD1 adenosine deaminase domain containing 1 (testis-specific) 0.545307
ODF3B outer dense fiber of sperm tails 3B 0.542759
BATF basic leucine zipper transcription factor, ATF-like 0.542759
UBASH3A ubiquitin associated and SH3 domain containing A 0.542759
IL7R interleukin 7 receptor 0.542759
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 0.542759
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.537382
LOC100506047 uncharacterized LOC100506047 0.530444
ZFP90 ZFP90 zinc finger protein 0.530444
MLANA melan-A 0.530444
SLC44A4 solute carrier family 44, member 4 0.528809
IL17REL interleukin 17 receptor E-like 0.522136
C5ORF30 chromosome 5 open reading frame 30 0.521436
FAM107A family with sequence similarity 107, member A 0.518187
HLA-F major histocompatibility complex, class I, F 0.504289
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.498792
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.496801
ZBTB46 zinc finger and BTB domain containing 46 0.495598
MANBA mannosidase, beta A, lysosomal 0.495598
SOX5 SRY (sex determining region Y)-box 5 0.495598
PRRC2A proline-rich coiled-coil 2A 0.493279
HSPA1L heat shock 70kDa protein 1-like 0.481531
STK19 serine/threonine kinase 19 0.476834
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.474018
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1 0.474018
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 0.466715
HCG22 HLA complex group 22 0.462367
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.4604
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 0.4604
SPEF2 sperm flagellar 2 0.450694
LOC100294145 uncharacterized LOC100294145 0.449695
NELFE negative elongation factor complex member E 0.444222
SAE1 SUMO1 activating enzyme subunit 1 0.443208
AK5 adenylate kinase 5 0.438718
SUMF1 sulfatase modifying factor 1 0.437499
MSH5 mutS homolog 5 0.435
C1ORF204 chromosome 1 open reading frame 204 0.433116
MPHOSPH9 M-phase phosphoprotein 9 0.433116
TMEM39A transmembrane protein 39A 0.433116
MYNN myoneurin 0.433116
CLSTN2 calsyntenin 2 0.429354
SYK spleen tyrosine kinase 0.426113
ZNF433 zinc finger protein 433 0.424122
PVR poliovirus receptor 0.424122
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.424122
GRB10 growth factor receptor-bound protein 10 0.424122
VAV2 vav 2 guanine nucleotide exchange factor 0.424122
KIF21B kinesin family member 21B 0.424122
GPC5 glypican 5 0.424122
TRIM31 tripartite motif containing 31 0.419059
KANK1 KN motif and ankyrin repeat domains 1 0.415477
DPCR1 diffuse panbronchiolitis critical region 1 0.414637
CSMD1 CUB and Sushi multiple domains 1 0.413807
NDFIP1 Nedd4 family interacting protein 1 0.413807
LEKR1 leucine, glutamate and lysine rich 1 0.413807
LINC01551 long intergenic non-protein coding RNA 1551 0.413807
PDZRN4 PDZ domain containing ring finger 4 0.413807
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.413807
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.413441
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 0.410507
RELN reelin 0.410331
RPL5 ribosomal protein L5 0.410331
FCRL3 Fc receptor-like 3 0.410331
RREB1 ras responsive element binding protein 1 0.410331
NRXN1 neurexin 1 0.409968
MOG myelin oligodendrocyte glycoprotein 0.409271
EGFL6 EGF-like-domain, multiple 6 0.408206
ALPK2 alpha-kinase 2 0.408206
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 0.408206
NLRP11 NLR family, pyrin domain containing 11 0.408206
TRIM2 tripartite motif containing 2 0.408206
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12 0.408206
PLCL2 phospholipase C-like 2 0.408206
LRRC16A leucine rich repeat containing 16A 0.408116
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.407732
TIAM1 T-cell lymphoma invasion and metastasis 1 0.407176
FAM179A family with sequence similarity 179, member A 0.406603
PCSK5 proprotein convertase subtilisin/kexin type 5 0.406588
TLL1 tolloid-like 1 0.406588
AXDND1 axonemal dynein light chain domain containing 1 0.405267
MET MET proto-oncogene, receptor tyrosine kinase 0.405267
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.405267
OPCML opioid binding protein/cell adhesion molecule-like 0.405029
TG thyroglobulin 0.405016
KPNB1 karyopherin (importin) beta 1 0.404166
NCKAP5 NCK-associated protein 5 0.40409
IL12A interleukin 12A 0.40409
LOC100506023 uncharacterized LOC100506023 0.40409
GPR75-ASB3 GPR75-ASB3 readthrough 0.403971
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.403073
POPDC3 popeye domain containing 3 0.403073
SAMD12 sterile alpha motif domain containing 12 0.403073
POU2F3 POU class 2 homeobox 3 0.403006
FHIT fragile histidine triad 0.402875
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.401945
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.401727
HSDL1 hydroxysteroid dehydrogenase like 1 0.401727
ETV6 ets variant 6 0.401477
CDH18 cadherin 18, type 2 0.401039
PCDH7 protocadherin 7 0.400962
DYSF dysferlin 0.400734
FAM69A family with sequence similarity 69, member A 0.40066
ELMO1 engulfment and cell motility 1 0.400586
ERBB4 erb-b2 receptor tyrosine kinase 4 0.400089
PHACTR2 phosphatase and actin regulator 2 0.399953
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 0.399819
TRIM10 tripartite motif containing 10 0.399687
HDAC9 histone deacetylase 9 0.399622
SDCBP2 syndecan binding protein (syntenin) 2 0.399366
NXN nucleoredoxin 0.39918
TBC1D4 TBC1 domain family, member 4 0.398421
CLDN14 claudin 14 0.39831
RNF213 ring finger protein 213 0.398093
PARD3B par-3 family cell polarity regulator beta 0.397761
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.397531
SMAD3 SMAD family member 3 0.397252
EFNA5 ephrin-A5 0.397035
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 0.396667
MCTP2 multiple C2 domains, transmembrane 2 0.396514
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) 0.396463
GRM7 glutamate receptor, metabotropic 7 0.395833
DGKQ diacylglycerol kinase, theta 110kDa 0.395556
DPPA2 developmental pluripotency associated 2 0.395511
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha 0.395376
HEMK1 HemK methyltransferase family member 1 0.395332
RBMS3 RNA binding motif, single stranded interacting protein 3 0.395244
MAML3 mastermind-like 3 (Drosophila) 0.3949
CCHCR1 coiled-coil alpha-helical rod protein 1 0.3949
CYFIP1 cytoplasmic FMR1 interacting protein 1 0.394692
NKAIN2 Na+/K+ transporting ATPase interacting 2 0.394692
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C 0.394692
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.394408
EVA1A eva-1 homolog A (C. elegans) 0.394095
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.39398
CD300A CD300a molecule 0.393942
ZNF423 zinc finger protein 423 0.393515
NSD1 nuclear receptor binding SET domain protein 1 0.393215
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.393173
COL27A1 collagen, type XXVII, alpha 1 0.393048
SLIT3 slit homolog 3 (Drosophila) 0.392019
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 0.391943
DENND1A DENN/MADD domain containing 1A 0.391539
ERG v-ets avian erythroblastosis virus E26 oncogene homolog 0.391503
TGFBR3 transforming growth factor, beta receptor III 0.391468
LRRC4C leucine rich repeat containing 4C 0.391361
PSORS1C2 psoriasis susceptibility 1 candidate 2 0.391255
ANKRD26P3 ankyrin repeat domain 26 pseudogene 3 0.39122
GRIK1 glutamate receptor, ionotropic, kainate 1 0.391081
NRG1 neuregulin 1 0.390944
WBSCR17 Williams-Beuren syndrome chromosome region 17 0.390809
CTNND2 catenin (cadherin-associated protein), delta 2 0.390708
STX8 syntaxin 8 0.390675
E2F5 E2F transcription factor 5, p130-binding 0.390543
MAGEB10 melanoma antigen family B10 0.390445
TNP2 transition protein 2 (during histone to protamine replacement) 0.390125
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.389754
TRAPPC9 trafficking protein particle complex 9 0.389573
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.389544
LOC388210 0.389544
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.389425
CPVL carboxypeptidase, vitellogenic-like 0.389337
MUC22 mucin 22 0.389163
PTCHD1-AS PTCHD1 antisense RNA (head to head) 0.388964
CPE carboxypeptidase E 0.388713
KSR2 kinase suppressor of ras 2 0.387537
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.387478
CADM2 cell adhesion molecule 2 0.387274
MUC21 mucin 21, cell surface associated 0.387217
SYN3 synapsin III 0.387074
ZBTB20 zinc finger and BTB domain containing 20 0.386682
KIAA1211 KIAA1211 0.386655
CPNE4 copine IV 0.386518
AACS acetoacetyl-CoA synthetase 0.385935
RIN2 Ras and Rab interactor 2 0.385453
BRE brain and reproductive organ-expressed (TNFRSF1A modulator) 0.385329
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.385085
TRIM26 tripartite motif containing 26 0.385061
ASB3 ankyrin repeat and SOCS box containing 3 0.384941
APOM apolipoprotein M 0.384472
DYX1C1 dyslexia susceptibility 1 candidate 1 0.384381
A2ML1 alpha-2-macroglobulin-like 1 0.383999
PLXNA2 plexin A2 0.383523
CNTN6 contactin 6 0.383229
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.383084
OSBP2 oxysterol binding protein 2 0.382741
IL6 interleukin 6 0.382681
NCF4 neutrophil cytosolic factor 4, 40kDa 0.382681
EPHA6 EPH receptor A6 0.382662
SFSWAP splicing factor, suppressor of white-apricot family 0.382642
LOC158435 uncharacterized LOC158435 0.382602
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 0.382498
ARHGAP17 Rho GTPase activating protein 17 0.382415
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.382269
ZFP69 ZFP69 zinc finger protein 0.381983
IL7 interleukin 7 0.381527
RAB3B RAB3B, member RAS oncogene family 0.381449
HNRNPLL heterogeneous nuclear ribonucleoprotein L-like 0.380974
RRP1B ribosomal RNA processing 1B 0.380788
ALK anaplastic lymphoma receptor tyrosine kinase 0.380587
ARMC9 armadillo repeat containing 9 0.380054
GFI1 growth factor independent 1 transcription repressor 0.379968
KDM4C lysine (K)-specific demethylase 4C 0.379899
AGBL1 ATP/GTP binding protein-like 1 0.379899
TSPAN16 tetraspanin 16 0.379847
IRAK2 interleukin-1 receptor-associated kinase 2 0.379728
GRIK4 glutamate receptor, ionotropic, kainate 4 0.379593
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough 0.379476
DSCAML1 Down syndrome cell adhesion molecule like 1 0.379459
NOL10 nucleolar protein 10 0.379409
TENM4 teneurin transmembrane protein 4 0.379294
CENPM centromere protein M 0.379278
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 0.379261
CHODL chondrolectin 0.37905
RSPO2 R-spondin 2 0.378986
NPAS3 neuronal PAS domain protein 3 0.378938
C1QB complement component 1, q subcomponent, B chain 0.378224
SUSD3 sushi domain containing 3 0.377808
DOCK2 dedicator of cytokinesis 2 0.377749
SORBS2 sorbin and SH3 domain containing 2 0.377633
CADPS2 Ca++-dependent secretion activator 2 0.377504
FBXO32 F-box protein 32 0.377476
USP8 ubiquitin specific peptidase 8 0.377376
HPGDS hematopoietic prostaglandin D synthase 0.377236
DNM3 dynamin 3 0.377096
LRRK1 leucine-rich repeat kinase 1 0.376973
UNC5B unc-5 homolog B (C. elegans) 0.376648
PTGER3 prostaglandin E receptor 3 (subtype EP3) 0.376528
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.37505
ICAM3 intercellular adhesion molecule 3 0.374155
PDZD2 PDZ domain containing 2 0.371187
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.371018
TTYH2 tweety family member 2 0.369891
IL12RB2 interleukin 12 receptor, beta 2 0.367763
HAPLN1 hyaluronan and proteoglycan link protein 1 0.367568
COL25A1 collagen, type XXV, alpha 1 0.367568
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 0.364408
FAM19A1 family with sequence similarity 19 (chemokine (C-C motif)-like), member A1 0.362254
MXD1 MAX dimerization protein 1 0.355013
HDGFRP3 hepatoma-derived growth factor, related protein 3 0.354604
DIAPH1 diaphanous-related formin 1 0.35393
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 0.353208
LOC440600 uncharacterized LOC440600 0.35196
KLRB1 killer cell lectin-like receptor subfamily B, member 1 0.350407
DSCAM Down syndrome cell adhesion molecule 0.348284
STK39 serine threonine kinase 39 0.346043