abnormality of the level of lipoprotein cholesterol Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An abnormal increase or decrease in the level of lipoprotein cholesterol in the blood. (Human Phenotype Ontology, HP_0010979)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0010979
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Genes

169 genes associated with the abnormality of the level of lipoprotein cholesterol phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
LDLR low density lipoprotein receptor 4.01203
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 3.90488
APOB apolipoprotein B 3.31331
APOC1 apolipoprotein C-I 3.30036
LPA lipoprotein, Lp(a) 3.24138
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.8616
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 2.80956
SUGP1 SURP and G patch domain containing 1 2.59582
LDAH lipid droplet associated hydrolase 2.58317
PCSK9 proprotein convertase subtilisin/kexin type 9 2.56443
HPR haptoglobin-related protein 2.44082
FADS1 fatty acid desaturase 1 2.37685
DOCK7 dedicator of cytokinesis 7 2.27451
LOC157273 uncharacterized LOC157273 2.07622
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 2.06978
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 2.01845
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 2.01405
HNF1A HNF1 homeobox A 2.0035
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 2.00018
TOP1 topoisomerase (DNA) I 1.9211
SLC25A27 solute carrier family 25, member 27 1.9061
TDRD6 tudor domain containing 6 1.87435
USP24 ubiquitin specific peptidase 24 1.84688
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1 1.84321
HLA-DRA major histocompatibility complex, class II, DR alpha 1.84227
NPC1L1 NPC1-like 1 1.75646
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 1.74601
NYNRIN NYN domain and retroviral integrase containing 1.73304
TMEM57 transmembrane protein 57 1.67051
DNAH11 dynein, axonemal, heavy chain 11 1.65004
SCARB1 scavenger receptor class B, member 1 1.6456
HFE hemochromatosis 1.63847
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 1.63258
FADS2 fatty acid desaturase 2 1.59332
PLEC plectin 1.59332
CSNK1G3 casein kinase 1, gamma 3 1.53327
APOH apolipoprotein H (beta-2-glycoprotein I) 1.51005
BRCA2 breast cancer 2, early onset 1.48419
CDKN2B-AS1 CDKN2B antisense RNA 1 1.48419
ZPR1 ZPR1 zinc finger 1.47083
MARC1 mitochondrial amidoxime reducing component 1 1.45654
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 1.40061
BUD13 BUD13 homolog (S. cerevisiae) 1.32954
APOE apolipoprotein E 1.32793
VLDLR very low density lipoprotein receptor 1.32793
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 1.32793
FRK fyn-related Src family tyrosine kinase 1.30781
VMP1 vacuole membrane protein 1 1.30781
EFCAB13 EF-hand calcium binding domain 13 1.29386
AHCYL2 adenosylhomocysteinase-like 2 1.29386
ANXA9 annexin A9 1.28282
EHBP1 EH domain binding protein 1 1.27347
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 1.24751
MTMR3 myotubularin related protein 3 1.24751
DOK7 docking protein 7 1.21853
PSKH1 protein serine kinase H1 1.2123
CBLC Cbl proto-oncogene C, E3 ubiquitin protein ligase 1.20625
PPARA peroxisome proliferator-activated receptor alpha 1.19958
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 1.1784
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 1.1784
COL11A2 collagen, type XI, alpha 2 1.1784
DPEP2 dipeptidase 2 1.16546
CD36 CD36 molecule (thrombospondin receptor) 1.16177
DOCK4 dedicator of cytokinesis 4 1.15352
AR androgen receptor 1.12851
CR1L complement component (3b/4b) receptor 1-like 1.12851
PTPRD protein tyrosine phosphatase, receptor type, D 1.11716
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 1.11203
RNF150 ring finger protein 150 1.08879
GCKR glucokinase (hexokinase 4) regulator 1.08774
DOCK6 dedicator of cytokinesis 6 1.08592
PCSK5 proprotein convertase subtilisin/kexin type 5 1.04365
AP3B2 adaptor-related protein complex 3, beta 2 subunit 1.04365
SYT17 synaptotagmin XVII 1.02638
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 1.02374
SCUBE1 signal peptide, CUB domain, EGF-like 1 1.00059
ZNF664-FAM101A filamin-interacting protein FAM101A 1.00059
JMJD1C jumonji domain containing 1C 1.00059
PDE10A phosphodiesterase 10A 1.00059
LRMP lymphoid-restricted membrane protein 0.98241
RNF213 ring finger protein 213 0.969142
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.969142
TSHZ2 teashirt zinc finger homeobox 2 0.967514
RBMS3 RNA binding motif, single stranded interacting protein 3 0.959521
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.936101
SLC30A4 solute carrier family 30 (zinc transporter), member 4 0.919744
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 0.919744
KDM4C lysine (K)-specific demethylase 4C 0.919744
C6 complement component 6 0.919744
BEND3 BEN domain containing 3 0.885258
C7ORF31 chromosome 7 open reading frame 31 0.864913
TGIF1 TGFB-induced factor homeobox 1 0.82634
ZNF257 zinc finger protein 257 0.80501
TTC27 tetratricopeptide repeat domain 27 0.804323
NTM neurotrimin 0.798387
RPA3 replication protein A3, 14kDa 0.791087
GLIS3 GLIS family zinc finger 3 0.777194
PAMR1 peptidase domain containing associated with muscle regeneration 1 0.759822
FKBP7 FK506 binding protein 7 0.74997
L3MBTL4 l(3)mbt-like 4 (Drosophila) 0.746311
GCSAML germinal center-associated, signaling and motility-like 0.746311
GPR180 G protein-coupled receptor 180 0.738997
TEKT5 tektin 5 0.738997
NUTF2 nuclear transport factor 2 0.733655
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.732349
C11ORF30 chromosome 11 open reading frame 30 0.724077
LOC100506127 putative uncharacterized protein FLJ37770-like 0.722505
AP3S2 adaptor-related protein complex 3, sigma 2 subunit 0.718314
CNTNAP2 contactin associated protein-like 2 0.71647
LUZP2 leucine zipper protein 2 0.712886
ZMIZ1 zinc finger, MIZ-type containing 1 0.707523
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.706786
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.706055
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 0.702479
PRKCA protein kinase C, alpha 0.700738
PROC protein C (inactivator of coagulation factors Va and VIIIa) 0.699708
REPS1 RALBP1 associated Eps domain containing 1 0.698689
FGF14 fibroblast growth factor 14 0.695039
LRRN2 leucine rich repeat neuronal 2 0.689042
ADRA1A adrenoceptor alpha 1A 0.686028
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 0.680272
FAM163A family with sequence similarity 163, member A 0.667695
LRRC3B leucine rich repeat containing 3B 0.663645
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.662069
PLEKHA7 pleckstrin homology domain containing, family A member 7 0.660006
CLDN16 claudin 16 0.659244
PLB1 phospholipase B1 0.646616
IL20RA interleukin 20 receptor, alpha 0.639159
PID1 phosphotyrosine interaction domain containing 1 0.637318
HPGDS hematopoietic prostaglandin D synthase 0.636409
TP63 tumor protein p63 0.636183
LARGE like-glycosyltransferase 0.635061
SGCZ sarcoglycan, zeta 0.630903
LVRN laeverin 0.629837
RPH3A rabphilin 3A 0.628991
RORA RAR-related orphan receptor A 0.628571
NXN nucleoredoxin 0.624663
IKZF2 IKAROS family zinc finger 2 (Helios) 0.623859
LIMCH1 LIM and calponin homology domains 1 0.62227
CERS6 ceramide synthase 6 0.619356
ERCC3 excision repair cross-complementation group 3 0.613833
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 0.613269
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.610679
RYR3 ryanodine receptor 3 0.609408
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10 0.605341
ALDH1B1 aldehyde dehydrogenase 1 family, member B1 0.604135
BAIAP2 BAI1-associated protein 2 0.599285
AP1M2 adaptor-related protein complex 1, mu 2 subunit 0.594972
PPARG peroxisome proliferator-activated receptor gamma 0.594349
SYBU syntabulin (syntaxin-interacting) 0.593884
ADAMTSL1 ADAMTS-like 1 0.592807
KSR2 kinase suppressor of ras 2 0.591742
CTNND2 catenin (cadherin-associated protein), delta 2 0.591138
GBP2 guanylate binding protein 2, interferon-inducible 0.590988
CNTNAP5 contactin associated protein-like 5 0.590091
LYRM4 LYR motif containing 4 0.589942
DPYSL2 dihydropyrimidinase-like 2 0.589942
TLE2 transducin-like enhancer of split 2 0.588613
KCNG3 potassium channel, voltage gated modifier subfamily G, member 3 0.588321
AFAP1L1 actin filament associated protein 1-like 1 0.587303
GRM1 glutamate receptor, metabotropic 1 0.586295
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 0.585012
ALK anaplastic lymphoma receptor tyrosine kinase 0.58198
KIF16B kinesin family member 16B 0.580796
FRMD4A FERM domain containing 4A 0.575658
CREB5 cAMP responsive element binding protein 5 0.573685
ENG endoglin 0.573145
FGFR2 fibroblast growth factor receptor 2 0.57293
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.432155