abnormality of the cerebral white matter Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An abnormality of the cerebral white matter. (Human Phenotype Ontology, HP_0002500)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0002500
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Genes

204 genes associated with the abnormality of the cerebral white matter phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
TRIM65 tripartite motif containing 65 1.1701
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 1.00059
ADAMTS9-AS2 ADAMTS9 antisense RNA 2 1.00059
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1 0.942765
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.942765
TRIM47 tripartite motif containing 47 0.909907
LPP LIM domain containing preferred translocation partner in lipoma 0.899912
CRBN cereblon 0.899912
KIAA1549 KIAA1549 0.827192
CYP4Z2P cytochrome P450, family 4, subfamily Z, polypeptide 2, pseudogene 0.802296
SYN2 synapsin II 0.790435
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 0.729791
ITGA9 integrin, alpha 9 0.71502
PDZD2 PDZ domain containing 2 0.702128
LRRC4C leucine rich repeat containing 4C 0.699708
DNAH9 dynein, axonemal, heavy chain 9 0.680552
LOC100288728 uncharacterized LOC100288728 0.678131
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.646367
GLRX3 glutaredoxin 3 0.640797
MYO7B myosin VIIB 0.620511
TRIM67 tripartite motif containing 67 0.613269
RNF144B ring finger protein 144B 0.602605
WBP2 WW domain binding protein 2 0.595188
FHIT fragile histidine triad 0.592807
ERCC6 excision repair cross-complementation group 6 0.591138
LOC100505841 zinc finger protein 474-like 0.579165
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.572823
LRFN2 leucine rich repeat and fibronectin type III domain containing 2 0.570703
PMEL premelanosome protein 0.569663
LOC100128714 uncharacterized LOC100128714 0.562717
LIMS2 LIM and senescent cell antigen-like domains 2 0.557335
IL21R interleukin 21 receptor 0.551579
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.543523
PPP1R16B protein phosphatase 1, regulatory subunit 16B 0.535562
DOK6 docking protein 6 0.535562
CARS cysteinyl-tRNA synthetase 0.532619
STX8 syntaxin 8 0.531908
LOC646730 uncharacterized LOC646730 0.531207
KDM4C lysine (K)-specific demethylase 4C 0.529832
CDH13 cadherin 13 0.52446
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.521292
UNQ6494 uncharacterized LOC100129066 0.51884
TEX41 testis expressed 41 (non-protein coding) 0.518575
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.517529
SLC35F3 solute carrier family 35, member F3 0.517529
GMDS GDP-mannose 4,6-dehydratase 0.516758
CCDC7 coiled-coil domain containing 7 0.516
CD226 CD226 molecule 0.515749
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 0.512994
TPCN1 two pore segment channel 1 0.512746
NAP1L4 nucleosome assembly protein 1-like 4 0.512746
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.511041
FRMD4A FERM domain containing 4A 0.507792
GPC5 glypican 5 0.504527
AGBL1 ATP/GTP binding protein-like 1 0.504527
LIMCH1 LIM and calponin homology domains 1 0.503898
FAM19A2 family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 0.501857
ACADSB acyl-CoA dehydrogenase, short/branched chain 0.501261
FGD4 FYVE, RhoGEF and PH domain containing 4 0.499816
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.499816
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.497787
SOBP sine oculis binding protein homolog (Drosophila) 0.496801
FCHSD2 FCH and double SH3 domains 2 0.49526
ESRRG estrogen-related receptor gamma 0.493948
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 0.493763
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 0.492667
TET3 tet methylcytosine dioxygenase 3 0.491949
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.486856
CCDC125 coiled-coil domain containing 125 0.485813
PRKG1 protein kinase, cGMP-dependent, type I 0.485639
SERINC5 serine incorporator 5 0.479856
CDK14 cyclin-dependent kinase 14 0.4797
RAB20 RAB20, member RAS oncogene family 0.479232
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.477852
BIN1 bridging integrator 1 0.476654
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.475336
NEB nebulin 0.474332
MFSD12 major facilitator superfamily domain containing 12 0.473907
LGALS9 lectin, galactoside-binding, soluble, 9 0.473346
LRP1B low density lipoprotein receptor-related protein 1B 0.473346
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.473068
RIF1 replication timing regulatory factor 1 0.470675
ZNF264 zinc finger protein 264 0.470675
NPAS3 neuronal PAS domain protein 3 0.470529
LSP1 lymphocyte-specific protein 1 0.469373
CDK2 cyclin-dependent kinase 2 0.46768
SOX5 SRY (sex determining region Y)-box 5 0.467541
TSEN15 TSEN15 tRNA splicing endonuclease subunit 0.467126
ANKRD33B ankyrin repeat domain 33B 0.465899
MACROD2 MACRO domain containing 2 0.465899
RORA RAR-related orphan receptor A 0.465764
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 0.464829
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 0.463519
COBL cordon-bleu WH2 repeat protein 0.463131
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.462874
MGST2 microsomal glutathione S-transferase 2 0.462491
TCERG1L transcription elongation regulator 1-like 0.462491
RNF165 ring finger protein 165 0.459391
XKR4 XK, Kell blood group complex subunit-related family, member 4 0.45903
MEIS2 Meis homeobox 2 0.456794
DOCK1 dedicator of cytokinesis 1 0.454845
TGFBR3 transforming growth factor, beta receptor III 0.454845
ZFYVE28 zinc finger, FYVE domain containing 28 0.453933
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.453036
ADCY2 adenylate cyclase 2 (brain) 0.452924
SHISA6 shisa family member 6 0.452371
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 0.450636
TENM4 teneurin transmembrane protein 4 0.450529
OR1D2 olfactory receptor, family 1, subfamily D, member 2 0.449471
CTBP2 C-terminal binding protein 2 0.448742
CORIN corin, serine peptidase 0.44721
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 0.446709
ACSL1 acyl-CoA synthetase long-chain family member 1 0.444263
RMDN2 regulator of microtubule dynamics 2 0.442563
DMGDH dimethylglycine dehydrogenase 0.442285
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase 0.442285
FLJ40288 uncharacterized FLJ40288 0.440642
CCDC60 coiled-coil domain containing 60 0.437617
PDCD11 programmed cell death 11 0.437027
SYN3 synapsin III 0.435375
ZC3H6 zinc finger CCCH-type containing 6 0.435163
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 0.434533
DACH1 dachshund family transcription factor 1 0.434325
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1 0.433842
TTLL9 tubulin tyrosine ligase-like family member 9 0.433093
SPAG16 sperm associated antigen 16 0.432958
SDK1 sidekick cell adhesion molecule 1 0.432622
RAB5B RAB5B, member RAS oncogene family 0.432555
KLB klotho beta 0.43143
CCDC102B coiled-coil domain containing 102B 0.430781
SH3BP1 SH3-domain binding protein 1 0.430459
TMEM181 transmembrane protein 181 0.430459
ZNF804A zinc finger protein 804A 0.430459
MSRA methionine sulfoxide reductase A 0.430395
DAP death-associated protein 0.430012
DNAH5 dynein, axonemal, heavy chain 5 0.429569
PTPRM protein tyrosine phosphatase, receptor type, M 0.429506
DTNB dystrobrevin, beta 0.429318
SENP7 SUMO1/sentrin specific peptidase 7 0.428943
GLB1 galactosidase, beta 1 0.428202
ACSM5 acyl-CoA synthetase medium-chain family member 5 0.427714
CCDC40 coiled-coil domain containing 40 0.427654
PTCH1 patched 1 0.426872
FTSJ3 FtsJ homolog 3 (E. coli) 0.426221
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.426221
FBXO10 F-box protein 10 0.426221
SGPP2 sphingosine-1-phosphate phosphatase 2 0.426061
SETBP1 SET binding protein 1 0.425822
FBXO5 F-box protein 5 0.425783
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 0.425
PDE11A phosphodiesterase 11A 0.424731
EFCAB11 EF-hand calcium binding domain 11 0.424539
NFIB nuclear factor I/B 0.424122
FBF1 Fas (TNFRSF6) binding factor 1 0.410844
MRPL38 mitochondrial ribosomal protein L38 0.407852
NT5C2 5'-nucleotidase, cytosolic II 0.406884
PMF1 polyamine-modulated factor 1 0.406588
UNC13D unc-13 homolog D (C. elegans) 0.406304
COL25A1 collagen, type XXV, alpha 1 0.405267
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 0.402523
PTGDR prostaglandin D2 receptor (DP) 0.401355
ACOX1 acyl-CoA oxidase 1, palmitoyl 0.400586
CALHM1 calcium homeostasis modulator 1 0.398647
AMZ2P1 archaelysin family metallopeptidase 2 pseudogene 1 0.398647
TRPM1 transient receptor potential cation channel, subfamily M, member 1 0.396981
PRDM16 PR domain containing 16 0.396981
PPP1R36 protein phosphatase 1, regulatory subunit 36 0.393867
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.393472
CHL1 cell adhesion molecule L1-like 0.393048
LEPROTL1 leptin receptor overlapping transcript-like 1 0.392247
FOXP2 forkhead box P2 0.391869
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 0.39115
CNTNAP2 contactin associated protein-like 2 0.389846
PITRM1 pitrilysin metallopeptidase 1 0.389846
IGSF21 immunoglobin superfamily, member 21 0.38808
KIRREL3 kin of IRRE like 3 (Drosophila) 0.387478
LOC285692 uncharacterized LOC285692 0.387478
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 0.386905
GEMIN6 gem (nuclear organelle) associated protein 6 0.386356
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.386356
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.385832
SLC25A44 solute carrier family 25, member 44 0.385085
GNG12 guanine nucleotide binding protein (G protein), gamma 12 0.385085
ICA1L islet cell autoantigen 1,69kDa-like 0.383933
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.383715
KCNK2 potassium channel, two pore domain subfamily K, member 2 0.383084
NCOA2 nuclear receptor coactivator 2 0.382881
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 0.381863
CALCRL calcitonin receptor-like 0.381863
FHOD3 formin homology 2 domain containing 3 0.381086
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.380715
PCGF6 polycomb group ring finger 6 0.380002
MYO6 myosin VI 0.379492
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 0.379327
COLGALT2 collagen beta(1-O)galactosyltransferase 2 0.378529
SH3PXD2A SH3 and PX domains 2A 0.378376
SRSF7 serine/arginine-rich splicing factor 7 0.378224
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.378224
CARF calcium responsive transcription factor 0.378224
AK9 adenylate kinase 9 0.37749
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 0.377208
GALM galactose mutarotase (aldose 1-epimerase) 0.377069
WASF3 WAS protein family, member 3 0.376931
RHBDD1 rhomboid domain containing 1 0.376661