abnormality of movement Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An abnormality of movement with a neurological basis characterized by changes in coordination and speed of voluntary movements. (Human Phenotype Ontology, HP_0100022)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0100022
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Genes

275 genes associated with the abnormality of movement phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
TRIM26 tripartite motif containing 26 0.417635
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 0.41534
MIR137HG MIR137 host gene 0.407397
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.386983
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.384433
SYNE1 spectrin repeat containing, nuclear envelope 1 0.382633
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.381141
ZNRD1 zinc ribbon domain containing 1 0.378008
GPC6 glypican 6 0.376528
MOBP myelin-associated oligodendrocyte basic protein 0.376528
AS3MT arsenite methyltransferase 0.376528
NT5C2 5'-nucleotidase, cytosolic II 0.376528
TENM4 teneurin transmembrane protein 4 0.367568
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.367568
CSMD1 CUB and Sushi multiple domains 1 0.367568
AK8 adenylate kinase 8 0.364972
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 0.361532
ASTN2 astrotactin 2 0.361532
ITGA11 integrin, alpha 11 0.361532
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.361532
TCF4 transcription factor 4 0.356732
DPCR1 diffuse panbronchiolitis critical region 1 0.356732
CFAP221 cilia and flagella associated protein 221 0.35372
RERE arginine-glutamic acid dipeptide (RE) repeats 0.349897
CSMD2 CUB and Sushi multiple domains 2 0.349897
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) 0.348436
BRD2 bromodomain containing 2 0.348436
PRKG1 protein kinase, cGMP-dependent, type I 0.348021
EMP2 epithelial membrane protein 2 0.347205
MIR99AHG mir-99a-let-7c cluster host gene 0.347205
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.346142
PIWIL4 piwi-like RNA-mediated gene silencing 4 0.345206
CPLX2 complexin 2 0.34437
MAN2A2 mannosidase, alpha, class 2A, member 2 0.34437
CEP112 centrosomal protein 112kDa 0.34437
GRM5 glutamate receptor, metabotropic 5 0.34437
FERMT3 fermitin family member 3 0.34437
RYR1 ryanodine receptor 1 (skeletal) 0.342703
NUCB1 nucleobindin 1 0.342156
FLNC filamin C, gamma 0.338632
KIF21B kinesin family member 21B 0.338502
KIF6 kinesin family member 6 0.338502
TLL2 tolloid-like 2 0.338502
PALB2 partner and localizer of BRCA2 0.338502
BMPR1B bone morphogenetic protein receptor, type IB 0.338502
MAP1B microtubule-associated protein 1B 0.338502
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.338502
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.338502
DNM1 dynamin 1 0.338502
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 0.335087
PTCD3 pentatricopeptide repeat domain 3 0.335058
ZNF423 zinc finger protein 423 0.33503
GPR139 G protein-coupled receptor 139 0.33503
NCKAP5 NCK-associated protein 5 0.33503
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.33503
CHMP7 charged multivesicular body protein 7 0.334519
MMP24 matrix metallopeptidase 24 (membrane-inserted) 0.332291
PAWR PRKC, apoptosis, WT1, regulator 0.332291
NAV2 neuron navigator 2 0.332291
LRRC7 leucine rich repeat containing 7 0.332291
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.332291
CFAP43 cilia and flagella associated protein 43 0.332291
STIP1 stress-induced phosphoprotein 1 0.332291
MAPRE1 microtubule-associated protein, RP/EB family, member 1 0.332291
TRPT1 tRNA phosphotransferase 1 0.332291
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.332291
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 0.332291
UNC5B unc-5 homolog B (C. elegans) 0.332291
IL16 interleukin 16 0.332291
NHEG1 neuroblastoma highly expressed 1 0.331917
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.330793
PARD3B par-3 family cell polarity regulator beta 0.330164
GLT8D1 glycosyltransferase 8 domain containing 1 0.330164
FTSJ2 FtsJ RNA methyltransferase homolog 2 (E. coli) 0.330164
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.330164
GRIK1 glutamate receptor, ionotropic, kainate 1 0.330164
C2ORF82 chromosome 2 open reading frame 82 0.330164
CREB5 cAMP responsive element binding protein 5 0.330164
EFCAB8 EF-hand calcium binding domain 8 0.330164
ARSB arylsulfatase B 0.330164
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.330164
KMT2A lysine (K)-specific methyltransferase 2A 0.330164
NT5DC3 5'-nucleotidase domain containing 3 0.330164
KIRREL3 kin of IRRE like 3 (Drosophila) 0.330164
ZMIZ1 zinc finger, MIZ-type containing 1 0.330164
MARK2 MAP/microtubule affinity-regulating kinase 2 0.32992
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 0.329737
KCNIP4 Kv channel interacting protein 4 0.329433
FGF14 fibroblast growth factor 14 0.328953
TCERG1L transcription elongation regulator 1-like 0.32887
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.328434
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 0.328434
FOXP1 forkhead box P1 0.328434
TRIO trio Rho guanine nucleotide exchange factor 0.327306
PKD1L2 polycystic kidney disease 1-like 2 (gene/pseudogene) 0.326976
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 0.326976
MYRFL myelin regulatory factor-like 0.326976
CLEC17A C-type lectin domain family 17, member A 0.326976
NEURL1 neuralized E3 ubiquitin protein ligase 1 0.326976
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.326976
PKD1L3 polycystic kidney disease 1-like 3 0.326976
PRPF3 pre-mRNA processing factor 3 0.326976
CDH13 cadherin 13 0.326976
SULF2 sulfatase 2 0.326976
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 0.326275
LOC344887 NmrA-like family domain containing 1 pseudogene 0.325689
ZNF804A zinc finger protein 804A 0.325689
LOC100652824 0.325689
MYT1L myelin transcription factor 1-like 0.325689
CRYGC crystallin, gamma C 0.325689
HDAC4 histone deacetylase 4 0.325689
NOS1 nitric oxide synthase 1 (neuronal) 0.325689
REEP5 receptor accessory protein 5 0.325689
ZNF544 zinc finger protein 544 0.325689
ELOVL6 ELOVL fatty acid elongase 6 0.325689
FHIT fragile histidine triad 0.325689
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.325168
ATXN2 ataxin 2 0.324851
C14ORF39 chromosome 14 open reading frame 39 0.324786
SH2B3 SH2B adaptor protein 3 0.324468
CELF2 CUGBP, Elav-like family member 2 0.324368
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.324368
NAPRT nicotinate phosphoribosyltransferase 0.324368
RGL1 ral guanine nucleotide dissociation stimulator-like 1 0.324368
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 0.324195
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 0.32319
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.323079
HK1 hexokinase 1 0.322752
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.322752
NXPH1 neurexophilin 1 0.322645
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.32254
PHF2P1 PHD finger protein 2 pseudogene 1 0.322026
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 0.322026
AGBL1 ATP/GTP binding protein-like 1 0.32144
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 0.321159
PLXNA2 plexin A2 0.320884
DOCK10 dedicator of cytokinesis 10 0.320529
PLCL1 phospholipase C-like 1 0.320529
FURIN furin (paired basic amino acid cleaving enzyme) 0.3201
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.319608
ZNF75A zinc finger protein 75a 0.31906
DOCK9 dedicator of cytokinesis 9 0.318539
ATXN1 ataxin 1 0.318539
PTPRJ protein tyrosine phosphatase, receptor type, J 0.318252
DHCR7 7-dehydrocholesterol reductase 0.318111
LARGE like-glycosyltransferase 0.318111
ERICH3 glutamate-rich 3 0.317633
PTPRG protein tyrosine phosphatase, receptor type, G 0.317175
YAE1D1 Yae1 domain containing 1 0.316985
IL20RA interleukin 20 receptor, alpha 0.316798
TLL1 tolloid-like 1 0.316614
PCSK2 proprotein convertase subtilisin/kexin type 2 0.315852
WIPI1 WD repeat domain, phosphoinositide interacting 1 0.315219
GRID2 glutamate receptor, ionotropic, delta 2 0.314953
LOC100132891 0.314563
NADSYN1 NAD synthetase 1 0.31406
DCLK1 doublecortin-like kinase 1 0.313755
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) 0.313635
AAA1 aortic aneurysm, familial abdominal 1 0.3119
PRUNE2 prune homolog 2 (Drosophila) 0.3119
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 0.311692
PEX5L peroxisomal biogenesis factor 5-like 0.311538
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 0.311336
SLIT1 slit homolog 1 (Drosophila) 0.311236
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.311236
GPX6 glutathione peroxidase 6 0.311038
ATP11A ATPase, class VI, type 11A 0.310698
XPO1 exportin 1 0.310508
MYBPC1 myosin binding protein C, slow type 0.310135
NRXN1 neurexin 1 0.309464
TRIOBP TRIO and F-actin binding protein 0.309421
MAP2K3 mitogen-activated protein kinase kinase 3 0.308743
XKR3 XK, Kell blood group complex subunit-related family, member 3 0.308619
MED27 mediator complex subunit 27 0.307672
ALDH1L1-AS2 ALDH1L1 antisense RNA 2 0.307634
KANK2 KN motif and ankyrin repeat domains 2 0.307371
HKDC1 hexokinase domain containing 1 0.30704
LOC63930 uncharacterized LOC63930 0.306932
ACSL1 acyl-CoA synthetase long-chain family member 1 0.306932
ITGA1 integrin, alpha 1 0.306896
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I 0.306824
ZNF385B zinc finger protein 385B 0.306682
GRM7 glutamate receptor, metabotropic 7 0.306334
NPAS3 neuronal PAS domain protein 3 0.305994
PUM2 pumilio RNA-binding family member 2 0.305566
HDGFRP3 hepatoma-derived growth factor, related protein 3 0.304658
THSD7B thrombospondin, type I, domain containing 7B 0.304388
STX8 syntaxin 8 0.303667
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.303528
CNTNAP5 contactin associated protein-like 5 0.303308
NSD1 nuclear receptor binding SET domain protein 1 0.302566
ADAMTSL1 ADAMTS-like 1 0.302489
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 0.302428
CALCR calcitonin receptor 0.301989
KCNIP1 Kv channel interacting protein 1 0.301353
CCSER1 coiled-coil serine-rich protein 1 0.301294
RORA RAR-related orphan receptor A 0.301294
LHFP lipoma HMGIC fusion partner 0.301205
LENG8 leukocyte receptor cluster (LRC) member 8 0.30103
RYR3 ryanodine receptor 3 0.300713
NTM neurotrimin 0.300235
TBC1D22A TBC1 domain family, member 22A 0.300042
GLI2 GLI family zinc finger 2 0.299664
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 0.299451
RUFY4 RUN and FYVE domain containing 4 0.298654
CNTN5 contactin 5 0.298579
FLRT2 fibronectin leucine rich transmembrane protein 2 0.298405
CDCP1 CUB domain containing protein 1 0.297705
XKR4 XK, Kell blood group complex subunit-related family, member 4 0.297401
SAMD3 sterile alpha motif domain containing 3 0.297331
KCTD1 potassium channel tetramerization domain containing 1 0.296809
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.296587
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 0.296478
IQGAP2 IQ motif containing GTPase activating protein 2 0.295585
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain 0.295543
UVRAG UV radiation resistance associated 0.295278
TNR tenascin R 0.295217
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 0.295136
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 0.295116
MYO5B myosin VB 0.295096
TMEM132B transmembrane protein 132B 0.294779
NUAK1 NUAK family, SNF1-like kinase, 1 0.294759
STC2 stanniocalcin 2 0.294506
HNF1B HNF1 homeobox B 0.293956
SLC38A1 solute carrier family 38, member 1 0.293863
NUMB numb homolog (Drosophila) 0.293661
SIRPB1 signal-regulatory protein beta 1 0.293569
GPC5 glypican 5 0.293299
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.293281
DSCC1 DNA replication and sister chromatid cohesion 1 0.293227
ADCK1 aarF domain containing kinase 1 0.293174
LRP1B low density lipoprotein receptor-related protein 1B 0.29305
TP53BP1 tumor protein p53 binding protein 1 0.29305
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like 0.292651
ADCY10 adenylate cyclase 10 (soluble) 0.29248
NXN nucleoredoxin 0.292028
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.291897
AKAP6 A kinase (PRKA) anchor protein 6 0.291493
KRT71 keratin 71, type II 0.291335
CRTAC1 cartilage acidic protein 1 0.290565
IRAK2 interleukin-1 receptor-associated kinase 2 0.289975
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.289975
ZNF516 zinc finger protein 516 0.289689
COX7B2 cytochrome c oxidase subunit VIIb2 0.289268
NCAM2 neural cell adhesion molecule 2 0.289268
CADPS2 Ca++-dependent secretion activator 2 0.288994
CPLX4 complexin 4 0.288859
ZNF385D zinc finger protein 385D 0.2882
MFSD9 major facilitator superfamily domain containing 9 0.287568
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 0.285987
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 0.285987
CPA1 carboxypeptidase A1 (pancreatic) 0.285987
MAP1A microtubule-associated protein 1A 0.285718
E2F3 E2F transcription factor 3 0.284682
KSR2 kinase suppressor of ras 2 0.284682
CPA5 carboxypeptidase A5 0.284682
ZFAT zinc finger and AT hook domain containing 0.284682
MAST3 microtubule associated serine/threonine kinase 3 0.284556
EMP3 epithelial membrane protein 3 0.284556
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 0.283581
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.283463
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.283346
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 0.282883
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 0.282656
CLECL1 C-type lectin-like 1 0.281775
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) 0.281456
CASC15 cancer susceptibility candidate 15 (non-protein coding) 0.280833
POU6F2 POU class 6 homeobox 2 0.280529
LOC100506023 uncharacterized LOC100506023 0.280429
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2 0.280429
SARDH sarcosine dehydrogenase 0.280329
GRIK4 glutamate receptor, ionotropic, kainate 4 0.276416
PPP1R1C protein phosphatase 1, regulatory (inhibitor) subunit 1C 0.273609
GFI1B growth factor independent 1B transcription repressor 0.272355
DENND3 DENN/MADD domain containing 3 0.27014