abnormality of iron homeostasis Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An abnormality of the homeostasis (concentration) of iron cation. (Human Phenotype Ontology, HP_0011031)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0011031
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Genes

228 genes associated with the abnormality of iron homeostasis phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
TF transferrin 2.53415
PCSK7 proprotein convertase subtilisin/kexin type 7 2.16746
SIK3 SIK family kinase 3 2.1393
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 2.11311
SIDT2 SID1 transmembrane family, member 2 2.08709
RAB6B RAB6B, member RAS oncogene family 1.84632
TAGLN transgelin 1.82301
TMPRSS6 transmembrane protease, serine 6 1.74205
HFE hemochromatosis 1.73304
SRPRB signal recognition particle receptor, B subunit 1.7128
APOA5 apolipoprotein A-V 1.66354
ZPR1 ZPR1 zinc finger 1.62005
BUD13 BUD13 homolog (S. cerevisiae) 1.6174
APOA4 apolipoprotein A-IV 1.58391
SELENBP1 selenium binding protein 1 1.42364
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 1.35901
CDV3 CDV3 homolog (mouse) 1.26324
TFR2 transferrin receptor 2 1.16661
LRRC16A leucine rich repeat containing 16A 1.11203
LINC00536 long intergenic non-protein coding RNA 536 1.10648
TYR tyrosinase 1.08891
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 1.04564
ADRA1A adrenoceptor alpha 1A 1.03217
MDN1 MDN1, midasin homolog (yeast) 1.02289
TRAK1 trafficking protein, kinesin binding 1 1.01883
TTC7B tetratricopeptide repeat domain 7B 1.01845
LUZP2 leucine zipper protein 2 1.00059
KLHL13 kelch-like family member 13 1.00059
TCERG1L transcription elongation regulator 1-like 1.00059
TMEM132C transmembrane protein 132C 0.99698
KLF12 Kruppel-like factor 12 0.99698
AGBL1 ATP/GTP binding protein-like 1 0.993537
KIRREL kin of IRRE like (Drosophila) 0.990273
SERPINA9 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9 0.98717
PLXDC2 plexin domain containing 2 0.981095
PARD3B par-3 family cell polarity regulator beta 0.971944
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 0.966449
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2 0.958096
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.947054
LRRC17 leucine rich repeat containing 17 0.919744
RUNX1 runt-related transcription factor 1 0.911485
RFC3 replication factor C (activator 1) 3, 38kDa 0.909447
TENM4 teneurin transmembrane protein 4 0.907455
LMBRD1 LMBR1 domain containing 1 0.896372
GPHN gephyrin 0.876787
DLG2 discs, large homolog 2 (Drosophila) 0.870998
ARSB arylsulfatase B 0.868241
GHR growth hormone receptor 0.868241
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.85193
KIAA1217 KIAA1217 0.844663
UNC5C unc-5 homolog C (C. elegans) 0.823019
SHC4 SHC (Src homology 2 domain containing) family, member 4 0.821408
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.817516
AKAP6 A kinase (PRKA) anchor protein 6 0.817516
ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 0.816759
ACBD3 acyl-CoA binding domain containing 3 0.815267
STOM stomatin 0.811465
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 0.809986
ATXN1 ataxin 1 0.802966
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.7965
COL27A1 collagen, type XXVII, alpha 1 0.790435
LRRC3B leucine rich repeat containing 3B 0.790435
DOCK1 dedicator of cytokinesis 1 0.790435
PHIP pleckstrin homology domain interacting protein 0.790435
NCKAP5 NCK-associated protein 5 0.784165
GRM7 glutamate receptor, metabotropic 7 0.782369
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.778318
SLC44A3 solute carrier family 44, member 3 0.775536
CACHD1 cache domain containing 1 0.767696
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 0.762459
ZBTB20 zinc finger and BTB domain containing 20 0.753299
SATB2 SATB homeobox 2 0.747666
ZNF202 zinc finger protein 202 0.743226
RIMS2 regulating synaptic membrane exocytosis 2 0.743226
MYEOV2 myeloma overexpressed 2 0.743226
TMEM225 transmembrane protein 225 0.726078
EPHA6 EPH receptor A6 0.718314
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 0.697013
KYNU kynureninase 0.687523
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.684556
CSMD1 CUB and Sushi multiple domains 1 0.678743
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.672779
RYR2 ryanodine receptor 2 (cardiac) 0.667145
LINC00371 long intergenic non-protein coding RNA 371 0.664442
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.66233
OR6T1 olfactory receptor, family 6, subfamily T, member 1 0.656743
PTPRM protein tyrosine phosphatase, receptor type, M 0.654545
DPYSL2 dihydropyrimidinase-like 2 0.654304
C10ORF11 chromosome 10 open reading frame 11 0.652395
LINC00189 long intergenic non-protein coding RNA 189 0.648629
CAPN13 calpain 13 0.64787
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 0.642222
PTPRG protein tyrosine phosphatase, receptor type, G 0.641033
TGFBI transforming growth factor, beta-induced, 68kDa 0.639159
CASC15 cancer susceptibility candidate 15 (non-protein coding) 0.638004
GLI3 GLI family zinc finger 3 0.616892
TMCC3 transmembrane and coiled-coil domain family 3 0.611045
LPL lipoprotein lipase 0.598959
MED27 mediator complex subunit 27 0.591289
CTIF CBP80/20-dependent translation initiation factor 0.588175
PDE10A phosphodiesterase 10A 0.586295
CD109 CD109 molecule 0.581268
NELL1 NEL-like 1 (chicken) 0.579512
GBP6 guanylate binding protein family, member 6 0.576102
ZNF592 zinc finger protein 592 0.56762
UHRF1 ubiquitin-like with PHD and ring finger domains 1 0.557335
FAM19A2 family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 0.549767
CHCHD6 coiled-coil-helix-coiled-coil-helix domain containing 6 0.540309
CTTNBP2 cortactin binding protein 2 0.537489
LOC100505776 0.535562
IST1 increased sodium tolerance 1 homolog (yeast) 0.534439
LIPC lipase, hepatic 0.528824
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.527841
FAM13A family with sequence similarity 13, member A 0.519915
GRM1 glutamate receptor, metabotropic 1 0.519107
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.518575
TSHZ3 teashirt zinc finger homeobox 3 0.516251
NCS1 neuronal calcium sensor 1 0.515005
F13A1 coagulation factor XIII, A1 polypeptide 0.513244
MOB3B MOB kinase activator 3B 0.512746
MYO10 myosin X 0.512008
SIRPB2 signal-regulatory protein beta 2 0.511281
CDK5RAP1 CDK5 regulatory subunit associated protein 1 0.510092
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.509159
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.508471
LRTM2 leucine-rich repeats and transmembrane domains 2 0.507344
CHSY3 chondroitin sulfate synthase 3 0.504107
ATXN7L1 ataxin 7-like 1 0.503483
ALMS1 Alstrom syndrome protein 1 0.502867
WRN Werner syndrome, RecQ helicase-like 0.501063
PLXNC1 plexin C1 0.49859
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 0.49859
ESD esterase D 0.498388
LOC100506474 uncharacterized LOC100506474 0.497589
SHISA6 shisa family member 6 0.49432
CCDC162P coiled-coil domain containing 162, pseudogene 0.493948
TREM1 triggering receptor expressed on myeloid cells 1 0.493763
KCTD17 potassium channel tetramerization domain containing 17 0.493212
LPAR5 lysophosphatidic acid receptor 5 0.492848
THSD7A thrombospondin, type I, domain containing 7A 0.491949
FABP3 fatty acid binding protein 3, muscle and heart 0.491949
EDAR ectodysplasin A receptor 0.491241
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.489002
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.488666
MMRN1 multimerin 1 0.488332
NFASC neurofascin 0.487836
ALPK3 alpha-kinase 3 0.486339
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 0.484264
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6 0.480329
ELMOD2 ELMO/CED-12 domain containing 2 0.480171
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 0.479232
NUMB numb homolog (Drosophila) 0.478461
SH3GL2 SH3-domain GRB2-like 2 0.478156
PTPRD protein tyrosine phosphatase, receptor type, D 0.47755
MRPL3 mitochondrial ribosomal protein L3 0.47755
PARK2 parkin RBR E3 ubiquitin protein ligase 0.4771
SOGA1 suppressor of glucose, autophagy associated 1 0.4771
SIM2 single-minded family bHLH transcription factor 2 0.476951
ADGB androglobin 0.475191
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.474474
GCM1 glial cells missing homolog 1 (Drosophila) 0.473907
TSPEAR thrombospondin-type laminin G domain and EAR repeats 0.472515
ALOX5AP arachidonate 5-lipoxygenase-activating protein 0.471968
NALCN sodium leak channel, non selective 0.471116
CNTNAP5 contactin associated protein-like 5 0.469516
CHSY1 chondroitin sulfate synthase 1 0.467959
MEGF11 multiple EGF-like-domains 11 0.467959
KLHL14 kelch-like family member 14 0.467819
OLFM1 olfactomedin 1 0.466714
EIF6 eukaryotic translation initiation factor 6 0.463779
SUGP1 SURP and G patch domain containing 1 0.461984
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.461858
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.460612
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) 0.46012
KDM4B lysine (K)-specific demethylase 4B 0.457141
PALLD palladin, cytoskeletal associated protein 0.457141
LYSMD2 LysM, putative peptidoglycan-binding, domain containing 2 0.457025
C1ORF100 chromosome 1 open reading frame 100 0.453595
DLC1 DLC1 Rho GTPase activating protein 0.452703
TTL tubulin tyrosine ligase 0.452261
IGF1R insulin-like growth factor 1 receptor 0.45128
CLIC5 chloride intracellular channel 5 0.450743
INADL InaD-like (Drosophila) 0.450529
FMN1 formin 1 0.450529
GRIK2 glutamate receptor, ionotropic, kainate 2 0.448846
FAM71B family with sequence similarity 71, member B 0.448846
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.448639
TTC17 tetratricopeptide repeat domain 17 0.448536
ZIC5 Zic family member 5 0.448433
SGCZ sarcoglycan, zeta 0.44792
ETV1 ets variant 1 0.44792
LRRC8A leucine rich repeat containing 8 family, member A 0.447412
TCF12 transcription factor 12 0.444551
PRPF18 pre-mRNA processing factor 18 0.4421
LOC401324 uncharacterized LOC401324 0.441916
PTTG1 pituitary tumor-transforming 1 0.441732
NCOR2 nuclear receptor corepressor 2 0.441275
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 0.440194
NBAS neuroblastoma amplified sequence 0.439838
KLK14 kallikrein-related peptidase 14 0.438588
C9 complement component 9 0.43784
CPN1 carboxypeptidase N, polypeptide 1 0.43747
SUSD1 sushi domain containing 1 0.43747
PZP pregnancy-zone protein 0.437396
METTL13 methyltransferase like 13 0.437396
TGM5 transglutaminase 5 0.437102
RNF157 ring finger protein 157 0.436737
NBEA neurobeachin 0.436016
CORO2A coronin, actin binding protein, 2A 0.435801
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 0.435234
PARVA parvin, alpha 0.433773
SOX13 SRY (sex determining region Y)-box 13 0.43316
CPNE4 copine IV 0.432354
TMOD2 tropomodulin 2 (neuronal) 0.430975
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.430652
CCDC172 coiled-coil domain containing 172 0.430267
VIMP VCP-interacting membrane selenoprotein 0.430267
BCAS1 breast carcinoma amplified sequence 1 0.429381
CADPS Ca++-dependent secretion activator 0.428695
KIAA0319 KIAA0319 0.428264
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 0.426872
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.425664
LTBP1 latent transforming growth factor beta binding protein 1 0.425664
PRLR prolactin receptor 0.425468
TSHZ2 teashirt zinc finger homeobox 2 0.425117
DTNB dystrobrevin, beta 0.424807
ZNF12 zinc finger protein 12 0.424273
ANK2 ankyrin 2, neuronal 0.424122