abnormality of forebrain morphology Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An abnormality of the forebrain, which has as its parts the telencephalon, diencephalon, lateral ventricles and third ventricle. (Human Phenotype Ontology, HP_0100547)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0100547
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Genes

253 genes associated with the abnormality of forebrain morphology phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
HLA-DRA major histocompatibility complex, class II, DR alpha 0.928919
NOTCH4 notch 4 0.575089
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.558775
WNT16 wingless-type MMTV integration site family, member 16 0.425394
FAM3C family with sequence similarity 3, member C 0.41808
TRIM65 tripartite motif containing 65 0.415284
GMDS GDP-mannose 4,6-dehydratase 0.405394
TNPO3 transportin 3 0.402769
STAT4 signal transducer and activator of transcription 4 0.402769
LOC100128714 uncharacterized LOC100128714 0.397271
TRIM47 tripartite motif containing 47 0.382926
SOX5 SRY (sex determining region Y)-box 5 0.38029
PSORS1C1 psoriasis susceptibility 1 candidate 1 0.367266
CPED1 cadherin-like and PC-esterase domain containing 1 0.366608
AGER advanced glycosylation end product-specific receptor 0.359331
TNXB tenascin XB 0.35923
CD247 CD247 molecule 0.358676
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) 0.355735
TNIP1 TNFAIP3 interacting protein 1 0.355735
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.354652
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.354381
WBP2 WW domain binding protein 2 0.35391
SETBP1 SET binding protein 1 0.345428
NPAS3 neuronal PAS domain protein 3 0.34298
HSPA1L heat shock 70kDa protein 1-like 0.333241
WDR41 WD repeat domain 41 0.331439
STK19 serine/threonine kinase 19 0.330407
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 0.328207
PDCD11 programmed cell death 11 0.322464
MSH5 mutS homolog 5 0.321829
GRB10 growth factor receptor-bound protein 10 0.318077
C6ORF10 chromosome 6 open reading frame 10 0.314822
ADAMTS9-AS2 ADAMTS9 antisense RNA 2 0.311139
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 0.311139
PRRC2A proline-rich coiled-coil 2A 0.30875
FBF1 Fas (TNFRSF6) binding factor 1 0.307476
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1 0.303627
FTO fat mass and obesity associated 0.303627
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.303627
MRPL38 mitochondrial ribosomal protein L38 0.303103
NT5C2 5'-nucleotidase, cytosolic II 0.301475
PMF1 polyamine-modulated factor 1 0.300932
UNC13D unc-13 homolog D (C. elegans) 0.300411
COL25A1 collagen, type XXV, alpha 1 0.298516
CRBN cereblon 0.298516
LPP LIM domain containing preferred translocation partner in lipoma 0.298516
OPCML opioid binding protein/cell adhesion molecule-like 0.298104
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 0.293783
PTGDR prostaglandin D2 receptor (DP) 0.291815
CDH18 cadherin 18, type 2 0.291305
DYSF dysferlin 0.290815
ACOX1 acyl-CoA oxidase 1, palmitoyl 0.290577
KIAA1549 KIAA1549 0.289666
AMZ2P1 archaelysin family metallopeptidase 2 pseudogene 1 0.287458
CALHM1 calcium homeostasis modulator 1 0.287458
CYP4Z2P cytochrome P450, family 4, subfamily Z, polypeptide 2, pseudogene 0.28639
SMAD3 SMAD family member 3 0.285028
SYN2 synapsin II 0.284571
PRDM16 PR domain containing 16 0.284571
TRPM1 transient receptor potential cation channel, subfamily M, member 1 0.284571
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) 0.283696
DGKQ diacylglycerol kinase, theta 110kDa 0.282165
RBMS3 RNA binding motif, single stranded interacting protein 3 0.281638
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.281419
PPP1R36 protein phosphatase 1, regulatory subunit 36 0.279321
ZNF423 zinc finger protein 423 0.278764
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.278703
CHL1 cell adhesion molecule L1-like 0.278111
LEPROTL1 leptin receptor overlapping transcript-like 1 0.276994
SLIT3 slit homolog 3 (Drosophila) 0.276675
FOXP2 forkhead box P2 0.276466
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 0.276414
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 0.275465
ITGA9 integrin, alpha 9 0.274573
WBSCR17 Williams-Beuren syndrome chromosome region 17 0.273994
PITRM1 pitrilysin metallopeptidase 1 0.273648
CNTNAP2 contactin associated protein-like 2 0.273648
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.273063
PDZD2 PDZ domain containing 2 0.273022
LRRC4C leucine rich repeat containing 4C 0.272739
IGSF21 immunoglobin superfamily, member 21 0.271291
KIRREL3 kin of IRRE like 3 (Drosophila) 0.270584
LOC285692 uncharacterized LOC285692 0.270584
DNAH9 dynein, axonemal, heavy chain 9 0.270447
LOC100288728 uncharacterized LOC100288728 0.270176
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 0.269911
GEMIN6 gem (nuclear organelle) associated protein 6 0.269267
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.269267
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.268589
SLC25A44 solute carrier family 25, member 44 0.267591
GNG12 guanine nucleotide binding protein (G protein), gamma 12 0.267591
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.266261
ICA1L islet cell autoantigen 1,69kDa-like 0.266055
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.265764
GLRX3 glutaredoxin 3 0.265592
KCNK2 potassium channel, two pore domain subfamily K, member 2 0.264923
NCOA2 nuclear receptor coactivator 2 0.264652
SFSWAP splicing factor, suppressor of white-apricot family 0.264333
CALCRL calcitonin receptor-like 0.263362
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 0.263362
MYO7B myosin VIIB 0.263092
FHOD3 formin homology 2 domain containing 3 0.2624
TRIM67 tripartite motif containing 67 0.262192
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.26194
ARMC9 armadillo repeat containing 9 0.261123
PCGF6 polycomb group ring finger 6 0.261058
TSPAN16 tetraspanin 16 0.260866
RNF144B ring finger protein 144B 0.260866
IRAK2 interleukin-1 receptor-associated kinase 2 0.260719
MYO6 myosin VI 0.260427
NOL10 nucleolar protein 10 0.260324
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 0.260222
CHODL chondrolectin 0.25988
FHIT fragile histidine triad 0.259623
ERCC6 excision repair cross-complementation group 6 0.259409
COLGALT2 collagen beta(1-O)galactosyltransferase 2 0.259236
SH3PXD2A SH3 and PX domains 2A 0.259046
C1QB complement component 1, q subcomponent, B chain 0.258858
SRSF7 serine/arginine-rich splicing factor 7 0.258858
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.258858
CARF calcium responsive transcription factor 0.258858
SUSD3 sushi domain containing 3 0.258344
CADPS2 Ca++-dependent secretion activator 2 0.257968
AK9 adenylate kinase 9 0.257951
FBXO32 F-box protein 32 0.257933
LOC100505841 zinc finger protein 474-like 0.257723
HPGDS hematopoietic prostaglandin D synthase 0.257637
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 0.257602
GALM galactose mutarotase (aldose 1-epimerase) 0.25743
WASF3 WAS protein family, member 3 0.257261
RHBDD1 rhomboid domain containing 1 0.256927
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.256762
LRFN2 leucine rich repeat and fibronectin type III domain containing 2 0.256439
PMEL premelanosome protein 0.256279
LIMS2 LIM and senescent cell antigen-like domains 2 0.254202
IL21R interleukin 21 receptor 0.252999
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.251294
DOK6 docking protein 6 0.249206
PPP1R16B protein phosphatase 1, regulatory subunit 16B 0.249206
CARS cysteinyl-tRNA synthetase 0.24834
STX8 syntaxin 8 0.248131
LOC646730 uncharacterized LOC646730 0.247923
KDM4C lysine (K)-specific demethylase 4C 0.247517
CDH13 cadherin 13 0.24589
IL12RB2 interleukin 12 receptor, beta 2 0.24544
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.244915
UNQ6494 uncharacterized LOC100129066 0.244157
TEX41 testis expressed 41 (non-protein coding) 0.244075
SLC35F3 solute carrier family 35, member F3 0.243751
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.243751
CCDC7 coiled-coil domain containing 7 0.243276
CD226 CD226 molecule 0.243198
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 0.242364
TPCN1 two pore segment channel 1 0.24229
NAP1L4 nucleosome assembly protein 1-like 4 0.24229
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.241783
FRMD4A FERM domain containing 4A 0.240812
AGBL1 ATP/GTP binding protein-like 1 0.239831
GPC5 glypican 5 0.239831
LIMCH1 LIM and calponin homology domains 1 0.239642
FAM19A2 family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 0.239025
ACADSB acyl-CoA dehydrogenase, short/branched chain 0.238845
FGD4 FYVE, RhoGEF and PH domain containing 4 0.238431
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.238431
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.237857
SOBP sine oculis binding protein homolog (Drosophila) 0.237578
FCHSD2 FCH and double SH3 domains 2 0.23714
ESRRG estrogen-related receptor gamma 0.236767
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 0.236714
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 0.236401
TET3 tet methylcytosine dioxygenase 3 0.236196
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.234734
CCDC125 coiled-coil domain containing 125 0.234456
PRKG1 protein kinase, cGMP-dependent, type I 0.23441
SERINC5 serine incorporator 5 0.232883
CDK14 cyclin-dependent kinase 14 0.232841
RAB20 RAB20, member RAS oncogene family 0.232717
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.23235
BIN1 bridging integrator 1 0.23203
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.231678
NEB nebulin 0.23141
MFSD12 major facilitator superfamily domain containing 12 0.231296
LGALS9 lectin, galactoside-binding, soluble, 9 0.231145
LRP1B low density lipoprotein receptor-related protein 1B 0.231145
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.231071
ZNF264 zinc finger protein 264 0.230449
RIF1 replication timing regulatory factor 1 0.230449
LSP1 lymphocyte-specific protein 1 0.230129
CDK2 cyclin-dependent kinase 2 0.229712
TSEN15 TSEN15 tRNA splicing endonuclease subunit 0.229575
ANKRD33B ankyrin repeat domain 33B 0.229272
MACROD2 MACRO domain containing 2 0.229272
RORA RAR-related orphan receptor A 0.229239
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 0.228982
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 0.228613
COBL cordon-bleu WH2 repeat protein 0.228503
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.228431
MGST2 microsomal glutathione S-transferase 2 0.228323
TCERG1L transcription elongation regulator 1-like 0.228323
RNF165 ring finger protein 165 0.227445
XKR4 XK, Kell blood group complex subunit-related family, member 4 0.227343
MEIS2 Meis homeobox 2 0.226706
TGFBR3 transforming growth factor, beta receptor III 0.226155
DOCK1 dedicator of cytokinesis 1 0.226155
ZFYVE28 zinc finger, FYVE domain containing 28 0.225902
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.225651
ADCY2 adenylate cyclase 2 (brain) 0.22562
SHISA6 shisa family member 6 0.225466
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 0.224981
TENM4 teneurin transmembrane protein 4 0.224951
OR1D2 olfactory receptor, family 1, subfamily D, member 2 0.224654
CTBP2 C-terminal binding protein 2 0.22445
CORIN corin, serine peptidase 0.224019
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 0.223878
ACSL1 acyl-CoA synthetase long-chain family member 1 0.223187
RMDN2 regulator of microtubule dynamics 2 0.222705
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase 0.222626
DMGDH dimethylglycine dehydrogenase 0.222626
FLJ40288 uncharacterized FLJ40288 0.222159
CCDC60 coiled-coil domain containing 60 0.221211
SYN3 synapsin III 0.220474
ZC3H6 zinc finger CCCH-type containing 6 0.220404
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 0.220196
DACH1 dachshund family transcription factor 1 0.220127
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1 0.219968
TTLL9 tubulin tyrosine ligase-like family member 9 0.21972
SPAG16 sperm associated antigen 16 0.219675
SDK1 sidekick cell adhesion molecule 1 0.219564
RAB5B RAB5B, member RAS oncogene family 0.219542
KLB klotho beta 0.219169
CCDC102B coiled-coil domain containing 102B 0.218954
ZNF804A zinc finger protein 804A 0.218847
SH3BP1 SH3-domain binding protein 1 0.218847
TMEM181 transmembrane protein 181 0.218847
MSRA methionine sulfoxide reductase A 0.218826
DAP death-associated protein 0.218699
DNAH5 dynein, axonemal, heavy chain 5 0.218551
PTPRM protein tyrosine phosphatase, receptor type, M 0.21853
DTNB dystrobrevin, beta 0.218468
SENP7 SUMO1/sentrin specific peptidase 7 0.218343
GLB1 galactosidase, beta 1 0.218096
ACSM5 acyl-CoA synthetase medium-chain family member 5 0.217934
CCDC40 coiled-coil domain containing 40 0.217913
PTCH1 patched 1 0.217652
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.217435
FBXO10 F-box protein 10 0.217435
FTSJ3 FtsJ homolog 3 (E. coli) 0.217435
SGPP2 sphingosine-1-phosphate phosphatase 2 0.217356
FBXO5 F-box protein 5 0.217219
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 0.216835
PDE11A phosphodiesterase 11A 0.216702
EFCAB11 EF-hand calcium binding domain 11 0.216608
NFIB nuclear factor I/B 0.216402