abnormality of coagulation Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An abnormality of the process of blood coagulation. That is, altered ability or inability of the blood to clot. (Human Phenotype Ontology, HP_0001928)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0001928
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Genes

284 genes associated with the abnormality of coagulation phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
F13A1 coagulation factor XIII, A1 polypeptide 3.3264
F12 coagulation factor XII (Hageman factor) 2.92607
F5 coagulation factor V (proaccelerin, labile factor) 2.87578
PFN3 profilin 3 2.64964
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 2.60985
MCF2L MCF.2 cell line derived transforming sequence-like 2.5383
F7 coagulation factor VII (serum prothrombin conversion accelerator) 2.51292
F10 coagulation factor X 2.32698
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 2.31699
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 2.22968
F13B coagulation factor XIII, B polypeptide 2.22828
EDEM2 ER degradation enhancer, mannosidase alpha-like 2 2.22418
CFHR5 complement factor H-related 5 2.22238
KNG1 kininogen 1 2.21735
RGS14 regulator of G-protein signaling 14 2.18356
ZBTB41 zinc finger and BTB domain containing 41 2.16894
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 2.13751
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 2.02598
SURF4 surfeit 4 2.00832
NSD1 nuclear receptor binding SET domain protein 1 1.94731
CFHR4 complement factor H-related 4 1.91598
FGB fibrinogen beta chain 1.9027
CFHR2 complement factor H-related 2 1.89822
GSS glutathione synthetase 1.84361
ACSS2 acyl-CoA synthetase short-chain family member 2 1.84046
HRG histidine-rich glycoprotein 1.80635
GRK6 G protein-coupled receptor kinase 6 1.7878
FGA fibrinogen alpha chain 1.61724
CFH complement factor H 1.61066
MMP24 matrix metallopeptidase 24 (membrane-inserted) 1.60334
PIGU phosphatidylinositol glycan anchor biosynthesis, class U 1.57154
ITCH itchy E3 ubiquitin protein ligase 1.55278
LMAN2 lectin, mannose-binding 2 1.54953
LY86-AS1 LY86 antisense RNA 1 1.47715
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 1.44336
CKAP5 cytoskeleton associated protein 5 1.4309
ORM1 orosomucoid 1 1.41863
LRP4 low density lipoprotein receptor-related protein 4 1.41196
FGFR4 fibroblast growth factor receptor 4 1.40421
STKLD1 serine/threonine kinase-like domain containing 1 1.38489
UNC5A unc-5 homolog A (C. elegans) 1.35485
DBN1 drebrin 1 1.32861
FLJ33360 FLJ33360 protein 1.32793
KCNT2 potassium channel, sodium activated subfamily T, member 2 1.28088
VWF von Willebrand factor 1.2282
OR9G1 olfactory receptor, family 9, subfamily G, member 1 1.20481
PRR7 proline rich 7 (synaptic) 1.20411
C5ORF56 chromosome 5 open reading frame 56 1.1383
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 1.12851
CNBD2 cyclic nucleotide binding domain containing 2 1.12039
PHF20 PHD finger protein 20 1.09287
CES1 carboxylesterase 1 1.08774
FER1L4 fer-1-like family member 4, pseudogene (functional) 1.08522
NFS1 NFS1 cysteine desulfurase 1.06867
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 1.06634
ROMO1 reactive oxygen species modulator 1 1.06543
F11 coagulation factor XI 1.04848
CPNE1 copine I 1.04651
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 1.04365
RBM12 RNA binding motif protein 12 1.03997
MEAF6 MYST/Esa1-associated factor 6 1.01499
NEGR1 neuronal growth regulator 1 1.01337
PROCR protein C receptor, endothelial 1.00059
NME7 NME/NM23 family member 7 1.00059
RALY RALY heterogeneous nuclear ribonucleoprotein 0.998373
PDGFC platelet derived growth factor C 0.971092
FAM83C family with sequence similarity 83, member C 0.943935
MYH15 myosin, heavy chain 15 0.919744
ATG4C autophagy related 4C, cysteine peptidase 0.906671
PCGF3 polycomb group ring finger 3 0.899912
AHCY adenosylhomocysteinase 0.891833
CD82 CD82 molecule 0.882984
PROC protein C (inactivator of coagulation factors Va and VIIIa) 0.85821
C11ORF49 chromosome 11 open reading frame 49 0.855449
CUX2 cut-like homeobox 2 0.849662
ASIP agouti signaling protein 0.815501
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.800845
DPYD dihydropyrimidine dehydrogenase 0.794052
EIF6 eukaryotic translation initiation factor 6 0.75218
GGT7 gamma-glutamyltransferase 7 0.530474
IL6R interleukin 6 receptor 0.528333
CHMP4B charged multivesicular body protein 4B 0.495126
STXBP5 syntaxin binding protein 5 (tomosyn) 0.442037
ERCC3 excision repair cross-complementation group 3 0.426017
SURF2 surfeit 2 0.425868
JMJD1C jumonji domain containing 1C 0.42469
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.424068
GDF5 growth differentiation factor 5 0.419107
CYP27C1 cytochrome P450, family 27, subfamily C, polypeptide 1 0.417112
NLRP3 NLR family, pyrin domain containing 3 0.408719
GCKR glucokinase (hexokinase 4) regulator 0.396963
NCOA6 nuclear receptor coactivator 6 0.394493
RBM39 RNA binding motif protein 39 0.393578
ERGIC3 ERGIC and golgi 3 0.392737
C20ORF173 chromosome 20 open reading frame 173 0.39183
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.390798
AAR2 AAR2 splicing factor homolog (S. cerevisiae) 0.38786
VAV2 vav 2 guanine nucleotide exchange factor 0.373218
EPB41L4A erythrocyte membrane protein band 4.1 like 4A 0.359285
DCHS2 dachsous cadherin-related 2 0.356494
ASIC2 acid sensing (proton gated) ion channel 2 0.353554
MYO7B myosin VIIB 0.352696
FGG fibrinogen gamma chain 0.350632
STAB2 stabilin 2 0.350097
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.349753
CPS1 carbamoyl-phosphate synthase 1, mitochondrial 0.346449
ANKRD6 ankyrin repeat domain 6 0.345435
GPN1 GPN-loop GTPase 1 0.344549
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.343784
IWS1 IWS1 homolog (S. cerevisiae) 0.341317
CD300LF CD300 molecule-like family member f 0.339904
CHD9 chromodomain helicase DNA binding protein 9 0.338806
ZNF512 zinc finger protein 512 0.338473
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.336091
IRF1 interferon regulatory factor 1 0.335173
C2ORF16 chromosome 2 open reading frame 16 0.334855
ESR1 estrogen receptor 1 0.330644
SPPL2A signal peptide peptidase like 2A 0.328642
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.327649
PLEC plectin 0.326715
CEP250 centrosomal protein 250kDa 0.326152
NRG1 neuregulin 1 0.323363
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 0.322441
TP53INP2 tumor protein p53 inducible nuclear protein 2 0.320348
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 0.318047
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) 0.314321
NDRG3 NDRG family member 3 0.309185
SOGA1 suppressor of glucose, autophagy associated 1 0.307489
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein 0.306578
HGFAC HGF activator 0.306141
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 0.306141
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.30347
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.303022
AGBL1 ATP/GTP binding protein-like 1 0.300419
SPAG4 sperm associated antigen 4 0.300254
ERBB4 erb-b2 receptor tyrosine kinase 4 0.285793
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.284791
C6ORF10 chromosome 6 open reading frame 10 0.271604
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 0.268515
PCCB propionyl CoA carboxylase, beta polypeptide 0.265579
SYNE1 spectrin repeat containing, nuclear envelope 1 0.265579
HDLBP high density lipoprotein binding protein 0.265479
CNTNAP2 contactin associated protein-like 2 0.252773
CNTNAP5 contactin associated protein-like 5 0.251564
HNF4A hepatocyte nuclear factor 4, alpha 0.250004
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.248637
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 0.247744
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 0.245061
UMODL1 uromodulin-like 1 0.24042
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.239705
LPP LIM domain containing preferred translocation partner in lipoma 0.238563
PHACTR2 phosphatase and actin regulator 2 0.237723
C19ORF47 chromosome 19 open reading frame 47 0.236023
TBC1D22A TBC1 domain family, member 22A 0.235507
GCA grancalcin, EF-hand calcium binding protein 0.235423
IL1RN interleukin 1 receptor antagonist 0.232873
MAP3K10 mitogen-activated protein kinase kinase kinase 10 0.232606
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast) 0.23209
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.232027
LRRC4C leucine rich repeat containing 4C 0.231415
CEP128 centrosomal protein 128kDa 0.231356
LGI1 leucine-rich, glioma inactivated 1 0.230554
SEZ6L seizure related 6 homolog (mouse)-like 0.229344
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.227915
AOX2P aldehyde oxidase 2 pseudogene 0.227663
FRY furry homolog (Drosophila) 0.226156
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.225805
PLCH1 phospholipase C, eta 1 0.224216
NFIB nuclear factor I/B 0.223615
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 0.222559
PEX19 peroxisomal biogenesis factor 19 0.222292
COPA coatomer protein complex, subunit alpha 0.222062
TANGO6 transport and golgi organization 6 homolog (Drosophila) 0.221932
OPCML opioid binding protein/cell adhesion molecule-like 0.220821
C10ORF11 chromosome 10 open reading frame 11 0.220557
BTBD9 BTB (POZ) domain containing 9 0.220018
FAM184A family with sequence similarity 184, member A 0.220018
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.219446
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 0.218899
PTPRG protein tyrosine phosphatase, receptor type, G 0.218497
ZRANB1 zinc finger, RAN-binding domain containing 1 0.217917
TPP2 tripeptidyl peptidase II 0.217799
IQSEC1 IQ motif and Sec7 domain 1 0.217706
ZNF423 zinc finger protein 423 0.217636
SPOPL speckle-type POZ protein-like 0.216764
KAZN kazrin, periplakin interacting protein 0.216507
ADCY2 adenylate cyclase 2 (brain) 0.216401
FBN3 fibrillin 3 0.21638
PRKG1 protein kinase, cGMP-dependent, type I 0.216338
DLG3 discs, large homolog 3 (Drosophila) 0.215725
TMEM56-RWDD3 TMEM56-RWDD3 readthrough 0.215567
FASTKD3 FAST kinase domains 3 0.215294
WRNIP1 Werner helicase interacting protein 1 0.215294
ANTXR1 anthrax toxin receptor 1 0.214636
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) 0.214132
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.214027
MDM1 Mdm1 nuclear protein homolog (mouse) 0.212891
TAOK3 TAO kinase 3 0.21259
LOC285768 uncharacterized LOC285768 0.212145
CHN2 chimerin 2 0.212115
TMEM56 transmembrane protein 56 0.211877
MAP6 microtubule-associated protein 6 0.211744
NEB nebulin 0.211715
RAD50 RAD50 homolog (S. cerevisiae) 0.210923
UVSSA UV-stimulated scaffold protein A 0.210075
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 0.208854
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.208738
PEA15 phosphoprotein enriched in astrocytes 15 0.208623
C15ORF27 chromosome 15 open reading frame 27 0.208623
RAP1GAP RAP1 GTPase activating protein 0.206165
SPIRE1 spire-type actin nucleation factor 1 0.20605
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta 0.205599
INPP5K inositol polyphosphate-5-phosphatase K 0.20527
DOCK2 dedicator of cytokinesis 2 0.204425
DCAF8 DDB1 and CUL4 associated factor 8 0.204221
SV2B synaptic vesicle glycoprotein 2B 0.20412
ZFHX4 zinc finger homeobox 4 0.204019
GPR6 G protein-coupled receptor 6 0.203528
AHCYL2 adenosylhomocysteinase-like 2 0.203528
DSCR8 Down syndrome critical region 8 0.202409
DISC1 disrupted in schizophrenia 1 0.201284
ZC3H18 zinc finger CCCH-type containing 18 0.200955
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.200873
FAM134A family with sequence similarity 134, member A 0.200712
NT5C2 5'-nucleotidase, cytosolic II 0.200632
FHIT fragile histidine triad 0.199481
NWD2 NACHT and WD repeat domain containing 2 0.199334
NCALD neurocalcin delta 0.198902
SNPH syntaphilin 0.198831
SP4 Sp4 transcription factor 0.198831
NCK2 NCK adaptor protein 2 0.198412
CSMD1 CUB and Sushi multiple domains 1 0.198208
LRRC28 leucine rich repeat containing 28 0.197545
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 0.197098
RHOBTB1 Rho-related BTB domain containing 1 0.196542
PTPRD protein tyrosine phosphatase, receptor type, D 0.196481
FGD5 FYVE, RhoGEF and PH domain containing 5 0.196361
CDH13 cadherin 13 0.196006
SERINC5 serine incorporator 5 0.196006
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.195774
TM7SF3 transmembrane 7 superfamily member 3 0.195717
CTIF CBP80/20-dependent translation initiation factor 0.195546
SMOC1 SPARC related modular calcium binding 1 0.194773
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.194349
DENND1A DENN/MADD domain containing 1A 0.193887
FMN2 formin 2 0.193887
PDLIM4 PDZ and LIM domain 4 0.193786
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 0.193685
BRSK1 BR serine/threonine kinase 1 0.193438
S100A7A S100 calcium binding protein A7A 0.19334
RIMS2 regulating synaptic membrane exocytosis 2 0.193146
LINC00461 long intergenic non-protein coding RNA 461 0.193002
SLIT3 slit homolog 3 (Drosophila) 0.192907
ADCY10 adenylate cyclase 10 (soluble) 0.192766
DNAAF5 dynein, axonemal, assembly factor 5 0.192304
RGS20 regulator of G-protein signaling 20 0.192168
SYCP1 synaptonemal complex protein 1 0.192034
ALLC allantoicase 0.192034
NCAM2 neural cell adhesion molecule 2 0.191379
MECOM MDS1 and EVI1 complex locus 0.190835
ACSBG2 acyl-CoA synthetase bubblegum family member 2 0.190631
FSTL4 follistatin-like 4 0.190349
TEX11 testis expressed 11 0.190152
ARHGEF37 Rho guanine nucleotide exchange factor (GEF) 37 0.190035
IMMT inner membrane protein, mitochondrial 0.189996
DHRS4L1 dehydrogenase/reductase (SDR family) member 4 like 1 0.189613
LOC285556 uncharacterized LOC285556 0.188139
SLFNL1 schlafen-like 1 0.188037
NCSTN nicastrin 0.187902
GAS8 growth arrest-specific 8 0.186585
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.186372
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.186311
NRXN3 neurexin 3 0.185491
POU2F1 POU class 2 homeobox 1 0.185265
NECAB2 N-terminal EF-hand calcium binding protein 2 0.185265
ITGA9 integrin, alpha 9 0.185126
CRABP1 cellular retinoic acid binding protein 1 0.185126
PABPC1 poly(A) binding protein, cytoplasmic 1 0.184688
ADCY8 adenylate cyclase 8 (brain) 0.184688
PAPD7 PAP associated domain containing 7 0.184422
UNC5CL unc-5 homolog C (C. elegans)-like 0.18429
GPR139 G protein-coupled receptor 139 0.184212
DBX2 developing brain homeobox 2 0.182917
TNN tenascin N 0.178162