abnormality of circulating fibrinogen Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An abnormality of the level of activity of circulating fibrinogen. (Human Phenotype Ontology, HP_0011898)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0011898
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Genes

170 genes associated with the abnormality of circulating fibrinogen phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
FGB fibrinogen beta chain 3.16916
FGA fibrinogen alpha chain 2.93623
C5ORF56 chromosome 5 open reading frame 56 2.54787
IL6R interleukin 6 receptor 2.13953
JMJD1C jumonji domain containing 1C 2.03027
NLRP3 NLR family, pyrin domain containing 3 1.93708
DCHS2 dachsous cadherin-related 2 1.54733
FGG fibrinogen gamma chain 1.51673
CPS1 carbamoyl-phosphate synthase 1, mitochondrial 1.48419
CD300LF CD300 molecule-like family member f 1.44286
CHD9 chromodomain helicase DNA binding protein 9 1.43716
IRF1 interferon regulatory factor 1 1.41648
SPPL2A signal peptide peptidase like 2A 1.36794
PLEC plectin 1.35521
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 1.32793
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 1.29386
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) 1.26545
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 1.21853
HGFAC HGF activator 1.21853
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 1.19958
ERBB4 erb-b2 receptor tyrosine kinase 4 1.13098
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 1.12734
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.04838
PCCB propionyl CoA carboxylase, beta polypeptide 1.03269
SYNE1 spectrin repeat containing, nuclear envelope 1 1.03269
HDLBP high density lipoprotein binding protein 1.03217
CNTNAP2 contactin associated protein-like 2 0.954239
CNTNAP5 contactin associated protein-like 5 0.944405
HNF4A hepatocyte nuclear factor 4, alpha 0.930595
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.919136
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 0.911485
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 0.8881
UMODL1 uromodulin-like 1 0.847234
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.841148
LPP LIM domain containing preferred translocation partner in lipoma 0.831588
PHACTR2 phosphatase and actin regulator 2 0.824663
C19ORF47 chromosome 19 open reading frame 47 0.810722
TBC1D22A TBC1 domain family, member 22A 0.806402
GCA grancalcin, EF-hand calcium binding protein 0.805703
IL1RN interleukin 1 receptor antagonist 0.784165
MAP3K10 mitogen-activated protein kinase kinase kinase 10 0.781779
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast) 0.777194
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.776638
LRRC4C leucine rich repeat containing 4C 0.771265
CEP128 centrosomal protein 128kDa 0.770746
LGI1 leucine-rich, glioma inactivated 1 0.763536
SEZ6L seizure related 6 homolog (mouse)-like 0.751857
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.739827
AOX2P aldehyde oxidase 2 pseudogene 0.737679
FRY furry homolog (Drosophila) 0.724077
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.72096
PLCH1 phospholipase C, eta 1 0.706786
NFIB nuclear factor I/B 0.701084
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 0.691208
PEX19 peroxisomal biogenesis factor 19 0.688736
COPA coatomer protein complex, subunit alpha 0.686623
TANGO6 transport and golgi organization 6 homolog (Drosophila) 0.685437
OPCML opioid binding protein/cell adhesion molecule-like 0.674828
C10ORF11 chromosome 10 open reading frame 11 0.672202
BTBD9 BTB (POZ) domain containing 9 0.666872
FAM184A family with sequence similarity 184, member A 0.666872
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.661291
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 0.656005
PTPRG protein tyrosine phosphatase, receptor type, G 0.652159
ZRANB1 zinc finger, RAN-binding domain containing 1 0.646367
TPP2 tripeptidyl peptidase II 0.645131
IQSEC1 IQ motif and Sec7 domain 1 0.644153
ZNF423 zinc finger protein 423 0.643425
SPOPL speckle-type POZ protein-like 0.634393
KAZN kazrin, periplakin interacting protein 0.631765
ADCY2 adenylate cyclase 2 (brain) 0.630689
FBN3 fibrillin 3 0.630475
PRKG1 protein kinase, cGMP-dependent, type I 0.630049
DLG3 discs, large homolog 3 (Drosophila) 0.623859
TMEM56-RWDD3 TMEM56-RWDD3 readthrough 0.62227
FASTKD3 FAST kinase domains 3 0.619547
WRNIP1 Werner helicase interacting protein 1 0.619547
ANTXR1 anthrax toxin receptor 1 0.612895
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) 0.607797
CUX2 cut-like homeobox 2 0.60709
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.606737
MDM1 Mdm1 nuclear protein homolog (mouse) 0.595442
TAOK3 TAO kinase 3 0.592501
LOC285768 uncharacterized LOC285768 0.588175
CHN2 chimerin 2 0.587883
TMEM56 transmembrane protein 56 0.585631
MAP6 microtubule-associated protein 6 0.58452
NEB nebulin 0.584275
RAD50 RAD50 homolog (S. cerevisiae) 0.577677
UVSSA UV-stimulated scaffold protein A 0.570703
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 0.560832
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.560064
PEA15 phosphoprotein enriched in astrocytes 15 0.559371
C15ORF27 chromosome 15 open reading frame 27 0.559371
RAP1GAP RAP1 GTPase activating protein 0.545725
SPIRE1 spire-type actin nucleation factor 1 0.545167
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta 0.542984
INPP5K inositol polyphosphate-5-phosphatase K 0.541565
DOCK2 dedicator of cytokinesis 2 0.53828
DCAF8 DDB1 and CUL4 associated factor 8 0.537489
SV2B synaptic vesicle glycoprotein 2B 0.537098
ZFHX4 zinc finger homeobox 4 0.53671
GPR6 G protein-coupled receptor 6 0.534811
AHCYL2 adenosylhomocysteinase-like 2 0.534811
DSCR8 Down syndrome critical region 8 0.530515
DISC1 disrupted in schizophrenia 1 0.526276
ZC3H18 zinc finger CCCH-type containing 18 0.525058
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.524758
FAM134A family with sequence similarity 134, member A 0.524164
NT5C2 5'-nucleotidase, cytosolic II 0.523869
FHIT fragile histidine triad 0.519644
NWD2 NACHT and WD repeat domain containing 2 0.519107
NCALD neurocalcin delta 0.517529
SNPH syntaphilin 0.517271
SP4 Sp4 transcription factor 0.517271
NCK2 NCK adaptor protein 2 0.515749
CSMD1 CUB and Sushi multiple domains 1 0.515005
LRRC28 leucine rich repeat containing 28 0.512499
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 0.510802
RHOBTB1 Rho-related BTB domain containing 1 0.508699
PTPRD protein tyrosine phosphatase, receptor type, D 0.508471
FGD5 FYVE, RhoGEF and PH domain containing 5 0.508017
SERINC5 serine incorporator 5 0.50668
CDH13 cadherin 13 0.50668
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.505808
TM7SF3 transmembrane 7 superfamily member 3 0.505592
CTIF CBP80/20-dependent translation initiation factor 0.50495
SMOC1 SPARC related modular calcium binding 1 0.502058
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.50044
FMN2 formin 2 0.49859
DENND1A DENN/MADD domain containing 1A 0.49859
PDLIM4 PDZ and LIM domain 4 0.498187
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 0.497787
BRSK1 BR serine/threonine kinase 1 0.496801
S100A7A S100 calcium binding protein A7A 0.496412
RIMS2 regulating synaptic membrane exocytosis 2 0.495641
LINC00461 long intergenic non-protein coding RNA 461 0.495071
SLIT3 slit homolog 3 (Drosophila) 0.494694
ADCY10 adenylate cyclase 10 (soluble) 0.494133
DNAAF5 dynein, axonemal, assembly factor 5 0.492307
RGS20 regulator of G-protein signaling 20 0.491771
ALLC allantoicase 0.491241
SYCP1 synaptonemal complex protein 1 0.491241
NCAM2 neural cell adhesion molecule 2 0.488666
MECOM MDS1 and EVI1 complex locus 0.486516
ACSBG2 acyl-CoA synthetase bubblegum family member 2 0.485639
FSTL4 follistatin-like 4 0.484434
VAV2 vav 2 guanine nucleotide exchange factor 0.484264
TEX11 testis expressed 11 0.483588
ARHGEF37 Rho guanine nucleotide exchange factor (GEF) 37 0.483087
IMMT inner membrane protein, mitochondrial 0.482921
DHRS4L1 dehydrogenase/reductase (SDR family) member 4 like 1 0.481287
LOC285556 uncharacterized LOC285556 0.475047
SLFNL1 schlafen-like 1 0.474617
NCSTN nicastrin 0.474049
GAS8 growth arrest-specific 8 0.468239
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.467264
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.466989
NRXN3 neurexin 3 0.46326
NECAB2 N-terminal EF-hand calcium binding protein 2 0.462237
POU2F1 POU class 2 homeobox 1 0.462237
CRABP1 cellular retinoic acid binding protein 1 0.461606
ITGA9 integrin, alpha 9 0.461606
ADCY8 adenylate cyclase 8 (brain) 0.459633
PABPC1 poly(A) binding protein, cytoplasmic 1 0.459633
PAPD7 PAP associated domain containing 7 0.458433
UNC5CL unc-5 homolog C (C. elegans)-like 0.457842
GPR139 G protein-coupled receptor 139 0.457491
DBX2 developing brain homeobox 2 0.451606
TNN tenascin N 0.434533