abnormality of cerebral artery Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An anomaly of a cerebral artery. The cerebral arteries comprise three main pairs of arteries and their branches, which supply the cerebrum of the brain. These are the anterior cerebral artery, the middle cerebral artery, and the posterior cerebral artery. (Human Phenotype Ontology, HP_0009145)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0009145
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Genes

233 genes associated with the abnormality of cerebral artery phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
CDKN2B-AS1 CDKN2B antisense RNA 1 0.948523
TRIM65 tripartite motif containing 65 0.509047
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.481507
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.41534
TRIM47 tripartite motif containing 47 0.405929
CNTNAP2 contactin associated protein-like 2 0.397928
CDH13 cadherin 13 0.395772
STARD13 StAR-related lipid transfer (START) domain containing 13 0.385331
WBP2 WW domain binding protein 2 0.379089
EDNRA endothelin receptor type A 0.376528
ZFHX3 zinc finger homeobox 3 0.372031
RNF213 ring finger protein 213 0.372031
BOLL boule-like RNA-binding protein 0.367568
ADGRB3 adhesion G protein-coupled receptor B3 0.366581
FMNL2 formin-like 2 0.360285
ARL6IP6 ADP-ribosylation factor-like 6 interacting protein 6 0.354501
PAPPA2 pappalysin 2 0.351763
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 0.351763
PHF20L1 PHD finger protein 20-like 1 0.350224
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.349133
SPSB4 splA/ryanodine receptor domain and SOCS box containing 4 0.348436
PDCD11 programmed cell death 11 0.348304
ABHD2 abhydrolase domain containing 2 0.347205
UBE2Z ubiquitin-conjugating enzyme E2Z 0.347182
PTPRD protein tyrosine phosphatase, receptor type, D 0.342425
TG thyroglobulin 0.34229
NUDT14 nudix (nucleoside diphosphate linked moiety X)-type motif 14 0.342025
NAA40 N(alpha)-acetyltransferase 40, NatD catalytic subunit 0.341581
EEF1DP3 eukaryotic translation elongation factor 1 delta pseudogene 3 0.340812
C1ORF177 chromosome 1 open reading frame 177 0.339409
A2ML1 alpha-2-macroglobulin-like 1 0.338165
PDGFRL platelet-derived growth factor receptor-like 0.338083
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.337684
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.336902
FBF1 Fas (TNFRSF6) binding factor 1 0.335619
CELA2A chymotrypsin-like elastase family, member 2A 0.33503
BET1L Bet1 golgi vesicular membrane trafficking protein-like 0.33503
TRAPPC11 trafficking protein particle complex 11 0.33503
SPATA5 spermatogenesis associated 5 0.334889
DLG2 discs, large homolog 2 (Drosophila) 0.334459
RYR2 ryanodine receptor 2 (cardiac) 0.334133
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.33194
MRPL38 mitochondrial ribosomal protein L38 0.331825
NCAM1 neural cell adhesion molecule 1 0.331083
TMEM181 transmembrane protein 181 0.330632
NT5C2 5'-nucleotidase, cytosolic II 0.330552
TMPRSS15 transmembrane protease, serine 15 0.330454
SH3TC2 SH3 domain and tetratricopeptide repeats 2 0.330298
PMF1 polyamine-modulated factor 1 0.330164
UNC13D unc-13 homolog D (C. elegans) 0.329791
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 0.329682
DOCK4 dedicator of cytokinesis 4 0.329433
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.32892
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 0.328755
COL25A1 collagen, type XXV, alpha 1 0.328434
PTPRT protein tyrosine phosphatase, receptor type, T 0.327362
ADCY8 adenylate cyclase 8 (brain) 0.327334
FNDC3B fibronectin type III domain containing 3B 0.327058
TNR tenascin R 0.325896
LUZP2 leucine zipper protein 2 0.325896
TMEM71 transmembrane protein 71 0.325816
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 0.325661
UMODL1 uromodulin-like 1 0.325549
CCDC3 coiled-coil domain containing 3 0.325412
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 0.325384
PRMT8 protein arginine methyltransferase 8 0.325008
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 0.324877
TPTE2P1 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 1 0.324864
ADAM17 ADAM metallopeptidase domain 17 0.324799
KIAA0020 KIAA0020 0.324671
ZNF366 zinc finger protein 366 0.324645
SGK1 serum/glucocorticoid regulated kinase 1 0.324594
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 0.324244
BTLA B and T lymphocyte associated 0.323846
ANO3 anoctamin 3 0.323519
NIN ninein (GSK3B interacting protein) 0.323519
LINC00474 long intergenic non-protein coding RNA 474 0.323302
CHRM2 cholinergic receptor, muscarinic 2 0.323257
RHBG Rh family, B glycoprotein (gene/pseudogene) 0.323212
PTGDR prostaglandin D2 receptor (DP) 0.32319
ACOX1 acyl-CoA oxidase 1, palmitoyl 0.322127
ZNF534 zinc finger protein 534 0.321926
NLRP9 NLR family, pyrin domain containing 9 0.321345
RGS13 regulator of G-protein signaling 13 0.321159
AGMO alkylglycerol monooxygenase 0.3201
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.320017
CALHM1 calcium homeostasis modulator 1 0.319448
AMZ2P1 archaelysin family metallopeptidase 2 pseudogene 1 0.319448
PPAPDC1A phosphatidic acid phosphatase type 2 domain containing 1A 0.317904
PRDM16 PR domain containing 16 0.317304
TRPM1 transient receptor potential cation channel, subfamily M, member 1 0.317304
PPT2 palmitoyl-protein thioesterase 2 0.317175
DGCR2 DiGeorge syndrome critical region gene 2 0.316736
ASIC2 acid sensing (proton gated) ion channel 2 0.316023
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 0.315966
PZP pregnancy-zone protein 0.315909
MCC mutated in colorectal cancers 0.315739
HHAT hedgehog acyltransferase 0.314691
EFCAB2 EF-hand calcium binding domain 2 0.314184
ANO6 anoctamin 6 0.314122
PPP1R36 protein phosphatase 1, regulatory subunit 36 0.31305
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.312993
OTOG otogelin 0.3126
CHL1 cell adhesion molecule L1-like 0.311953
SETBP1 SET binding protein 1 0.31094
LEPROTL1 leptin receptor overlapping transcript-like 1 0.31094
FOXP2 forkhead box P2 0.310461
GLIS1 GLIS family zinc finger 1 0.310181
BCL2L2 BCL2-like 2 0.309953
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 0.309552
CSMD3 CUB and Sushi multiple domains 3 0.309162
UBA2 ubiquitin-like modifier activating enzyme 2 0.30866
SULF1 sulfatase 1 0.308256
RBM20 RNA binding motif protein 20 0.308019
PITRM1 pitrilysin metallopeptidase 1 0.307902
BCAN brevican 0.307634
PIKFYVE phosphoinositide kinase, FYVE finger containing 0.307004
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.306061
IGSF21 immunoglobin superfamily, member 21 0.305762
DACT3 dishevelled-binding antagonist of beta-catenin 3 0.305533
LOC285692 uncharacterized LOC285692 0.305119
KIRREL3 kin of IRRE like 3 (Drosophila) 0.305119
TGFA transforming growth factor, alpha 0.304537
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 0.304507
GRID1 glutamate receptor, ionotropic, delta 1 0.304329
ARHGAP44 Rho GTPase activating protein 44 0.30398
GEMIN6 gem (nuclear organelle) associated protein 6 0.303922
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.303922
HEPACAM2 HEPACAM family member 2 0.303894
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.303724
C5ORF56 chromosome 5 open reading frame 56 0.303473
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.303363
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 0.303308
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.303281
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.3028
SLC25A44 solute carrier family 25, member 44 0.302566
GNG12 guanine nucleotide binding protein (G protein), gamma 12 0.302566
HMGA2 high mobility group AT-hook 2 0.30254
UBA6 ubiquitin-like modifier activating enzyme 6 0.302364
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.301835
GRM7 glutamate receptor, metabotropic 7 0.301623
ICA1L islet cell autoantigen 1,69kDa-like 0.301059
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.30077
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.300069
STK32B serine/threonine kinase 32B 0.300042
TTC1 tetratricopeptide repeat domain 1 0.300015
KCNK2 potassium channel, two pore domain subfamily K, member 2 0.299933
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B 0.299933
NCOA2 nuclear receptor coactivator 2 0.299664
IRF8 interferon regulatory factor 8 0.299637
THRB thyroid hormone receptor, beta 0.299346
GMDS GDP-mannose 4,6-dehydratase 0.299138
TMEM165 transmembrane protein 165 0.298679
CALCRL calcitonin receptor-like 0.298381
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 0.298381
PIGR polymeric immunoglobulin receptor 0.298039
MBL2 mannose-binding lectin (protein C) 2, soluble 0.297587
FHOD3 formin homology 2 domain containing 3 0.297424
PRR5L proline rich 5 like 0.297331
SOX5 SRY (sex determining region Y)-box 5 0.297193
CHSY3 chondroitin sulfate synthase 3 0.297102
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.296966
C10ORF35 chromosome 10 open reading frame 35 0.296654
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.296239
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent) 0.296132
PCGF6 polycomb group ring finger 6 0.296089
NGEF neuronal guanine nucleotide exchange factor 0.296046
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 0.29594
PKNOX1 PBX/knotted 1 homeobox 1 0.295856
CCDC132 coiled-coil domain containing 132 0.295543
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.295502
MYO6 myosin VI 0.295461
GYS2 glycogen synthase 2 (liver) 0.29542
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 0.295257
JAKMIP2 janus kinase and microtubule interacting protein 2 0.295157
HUNK hormonally up-regulated Neu-associated kinase 0.294937
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.294603
AGBL1 ATP/GTP binding protein-like 1 0.294506
COLGALT2 collagen beta(1-O)galactosyltransferase 2 0.294276
SH3PXD2A SH3 and PX domains 2A 0.294087
LARGE like-glycosyltransferase 0.293937
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.2939
SRSF7 serine/arginine-rich splicing factor 7 0.2939
CARF calcium responsive transcription factor 0.2939
SPEG SPEG complex locus 0.293734
CASC15 cancer susceptibility candidate 15 (non-protein coding) 0.293734
CETP cholesteryl ester transfer protein, plasma 0.29321
ARHGAP6 Rho GTPase activating protein 6 0.293192
AK9 adenylate kinase 9 0.292998
DRD2 dopamine receptor D2 0.292754
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 0.292651
ARHGAP24 Rho GTPase activating protein 24 0.292514
GALM galactose mutarotase (aldose 1-epimerase) 0.29248
WASF3 WAS protein family, member 3 0.292311
RHBDD1 rhomboid domain containing 1 0.291979
BFSP1 beaded filament structural protein 1, filensin 0.291881
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.291815
FGF17 fibroblast growth factor 17 0.290121
PLXNA2 plexin A2 0.289831
ABLIM1 actin binding LIM protein 1 0.28833
OSBPL8 oxysterol binding protein-like 8 0.2872
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.286536
IL17RB interleukin 17 receptor B 0.284431
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.277916
SIM1 single-minded family bHLH transcription factor 1 0.276257
PON2 paraoxonase 2 0.276178
CCDC102A coiled-coil domain containing 102A 0.275634
PDGFB platelet-derived growth factor beta polypeptide 0.274884
AKAP5 A kinase (PRKA) anchor protein 5 0.274024
CCDC129 coiled-coil domain containing 129 0.270946
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa 0.270712
ZBTB1 zinc finger and BTB domain containing 1 0.269805
TBX18 T-box 18 0.269531
NINJ2 ninjurin 2 0.268156
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 0.267644
TSPAN18 tetraspanin 18 0.26731
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.26709
LLGL2 lethal giant larvae homolog 2 (Drosophila) 0.266182
LRRC16A leucine rich repeat containing 16A 0.266129
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 0.266077
PIEZO1 piezo-type mechanosensitive ion channel component 1 0.263136
GPSM3 G-protein signaling modulator 3 0.260894
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.259393
CNTN5 contactin 5 0.259393
MDS2 myelodysplastic syndrome 2 translocation associated 0.25888
SPTB spectrin, beta, erythrocytic 0.255537
KCNK17 potassium channel, two pore domain subfamily K, member 17 0.255537
KCNIP4 Kv channel interacting protein 4 0.255235
STX2 syntaxin 2 0.255056
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.255026
NRXN3 neurexin 3 0.253681
RBM47 RNA binding motif protein 47 0.253055
CNTN4 contactin 4 0.247411