abnormal white adipose tissue morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels (Mammalian Phenotype Ontology, MP_0002970)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002970
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Genes

215 gene mutations causing the abnormal white adipose tissue morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACACB acetyl-CoA carboxylase beta
ACHE acetylcholinesterase (Yt blood group)
ACOT13 acyl-CoA thioesterase 13
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
AEBP1 AE binding protein 1
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AGTR2 angiotensin II receptor, type 2
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALMS1 Alstrom syndrome protein 1
AMER1 APC membrane recruitment protein 1
ANGPTL2 angiopoietin-like 2
ANGPTL6 angiopoietin-like 6
ANKRD26 ankyrin repeat domain 26
APOC3 apolipoprotein C-III
APOE apolipoprotein E
ARHGAP1 Rho GTPase activating protein 1
ARHGAP5 Rho GTPase activating protein 5
ARID5B AT rich interactive domain 5B (MRF1-like)
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARRDC3 arrestin domain containing 3
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BAG3 BCL2-associated athanogene 3
BBS4 Bardet-Biedl syndrome 4
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRS3 bombesin-like receptor 3
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C3 complement component 3
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBY1 chibby homolog 1 (Drosophila)
CCDC57 coiled-coil domain containing 57
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CES1 carboxylesterase 1
CHD2 chromodomain helicase DNA binding protein 2
CIDEA cell death-inducing DFFA-like effector a
CIDEB cell death-inducing DFFA-like effector b
CIDEC cell death-inducing DFFA-like effector c
CISD2 CDGSH iron sulfur domain 2
CNOT3 CCR4-NOT transcription complex, subunit 3
COL5A3 collagen, type V, alpha 3
CREBBP CREB binding protein
CRHR2 corticotropin releasing hormone receptor 2
CRTC1 CREB regulated transcription coactivator 1
CRTC3 CREB regulated transcription coactivator 3
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSHL1 chorionic somatomammotropin hormone-like 1
CSPG4 chondroitin sulfate proteoglycan 4
CXCL14 chemokine (C-X-C motif) ligand 14
DGAT2 diacylglycerol O-acyltransferase 2
DHCR24 24-dehydrocholesterol reductase
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DOCK7 dedicator of cytokinesis 7
DSG4 desmoglein 4
E2F3 E2F transcription factor 3
EBF1 early B-cell factor 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans)
ERCC1 excision repair cross-complementation group 1
ESR1 estrogen receptor 1
ESRRA estrogen-related receptor alpha
EWSR1 EWS RNA-binding protein 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBN1 fibrillin 1
FEN1 flap structure-specific endonuclease 1
FFAR4 free fatty acid receptor 4
FGF21 fibroblast growth factor 21
FGL1 fibrinogen-like 1
FTO fat mass and obesity associated
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GDF15 growth differentiation factor 15
GDF3 growth differentiation factor 3
GHR growth hormone receptor
GLRA1 glycine receptor, alpha 1
GNAS GNAS complex locus
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GPRC6A G protein-coupled receptor, class C, group 6, member A
GPSM1 G-protein signaling modulator 1
GUCY2C guanylate cyclase 2C
GUSB glucuronidase, beta
HDC histidine decarboxylase
HELLS helicase, lymphoid-specific
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HNF1A HNF1 homeobox A
HRH1 histamine receptor H1
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL18 interleukin 18
INS insulin
INSIG1 insulin induced gene 1
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KDM3A lysine (K)-specific demethylase 3A
KL klotho
KRT71 keratin 71, type II
KSR1 kinase suppressor of ras 1
LBR lamin B receptor
LCLAT1 lysocardiolipin acyltransferase 1
LEF1 lymphoid enhancer-binding factor 1
LEP leptin
LGALS12 lectin, galactoside-binding, soluble, 12
LIPA lipase A, lysosomal acid, cholesterol esterase
LIPE lipase, hormone-sensitive
LMNA lamin A/C
LPIN1 lipin 1
MAPK8 mitogen-activated protein kinase 8
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK3 MAP/microtubule affinity-regulating kinase 3
MBD5 methyl-CpG binding domain protein 5
MC3R melanocortin 3 receptor
MC4R melanocortin 4 receptor
MCOLN1 mucolipin 1
MFSD2A major facilitator superfamily domain containing 2A
MIR378A microRNA 378a
MLXIPL MLX interacting protein-like
MPV17 MpV17 mitochondrial inner membrane protein
MRAP2 melanocortin 2 receptor accessory protein 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCOA3 nuclear receptor coactivator 3
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
NIPBL Nipped-B homolog (Drosophila)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NPY2R neuropeptide Y receptor Y2
NPY4R neuropeptide Y receptor Y4
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR2C2 nuclear receptor subfamily 2, group C, member 2
NTSR1 neurotensin receptor 1 (high affinity)
OMA1 OMA1 zinc metallopeptidase
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OSMR oncostatin M receptor
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCNA proliferating cell nuclear antigen
PCSK1 proprotein convertase subtilisin/kexin type 1
PDYN prodynorphin
PGF placental growth factor
PHF2 PHD finger protein 2
PHYH phytanoyl-CoA 2-hydroxylase
PLA2G1B phospholipase A2, group IB (pancreas)
PLIN1 perilipin 1
PLIN2 perilipin 2
PLSCR3 phospholipid scramblase 3
PLVAP plasmalemma vesicle associated protein
PNPLA2 patatin-like phospholipase domain containing 2
POLG polymerase (DNA directed), gamma
POU3F2 POU class 3 homeobox 2
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRLH prolactin releasing hormone
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PYY peptide YY
RAI1 retinoic acid induced 1
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RASSF9 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
RB1 retinoblastoma 1
RBL1 retinoblastoma-like 1
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RLN3 relaxin 3
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
SAMD4A sterile alpha motif domain containing 4A
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERTAD2 SERTA domain containing 2
SGMS1 sphingomyelin synthase 1
SH3KBP1 SH3-domain kinase binding protein 1
SH3PXD2B SH3 and PX domains 2B
SIK3 SIK family kinase 3
SIM1 single-minded family bHLH transcription factor 1
SIRT1 sirtuin 1
SIRT6 sirtuin 6
SIRT7 sirtuin 7
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SMTN smoothelin
SQSTM1 sequestosome 1
SRA1 steroid receptor RNA activator 1
SSFA2 sperm specific antigen 2
STEAP4 STEAP family member 4
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TBC1D4 TBC1 domain family, member 4
TERF2IP telomeric repeat binding factor 2, interacting protein
TGFB1 transforming growth factor, beta 1
TK2 thymidine kinase 2, mitochondrial
TKT transketolase
TLR2 toll-like receptor 2
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2
TMUB1 transmembrane and ubiquitin-like domain containing 1
TNS2 tensin 2
TP53 tumor protein p53
TRIB1 tribbles pseudokinase 1
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TWIST2 twist family bHLH transcription factor 2
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
VGF VGF nerve growth factor inducible
WRN Werner syndrome, RecQ helicase-like
XDH xanthine dehydrogenase
ZDHHC13 zinc finger, DHHC-type containing 13
ZFP36 ZFP36 ring finger protein
ZMPSTE24 zinc metallopeptidase STE24