abnormal ureteric bud morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the epithelial swelling on the metanephric duct that elongates to invade the adjacent metanephric mesenchyme; interactions between the ureteric bud and the metanephric mesenchyme leads to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue (Mammalian Phenotype Ontology, MP_0006032)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0006032
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Genes

51 gene mutations causing the abnormal ureteric bud morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AMER1 APC membrane recruitment protein 1
ATMIN ATM interactor
BAG6 BCL2-associated athanogene 6
BCL2 B-cell CLL/lymphoma 2
BMP4 bone morphogenetic protein 4
CDH4 cadherin 4, type 1, R-cadherin (retinal)
CTNNBIP1 catenin, beta interacting protein 1
DCHS1 dachsous cadherin-related 1
DLG1 discs, large homolog 1 (Drosophila)
EMX2 empty spiracles homeobox 2
EYA1 EYA transcriptional coactivator and phosphatase 1
FAT4 FAT atypical cadherin 4
FGF10 fibroblast growth factor 10
FGF7 fibroblast growth factor 7
FGFRL1 fibroblast growth factor receptor-like 1
FOXC1 forkhead box C1
FOXD1 forkhead box D1
FRAS1 Fraser extracellular matrix complex subunit 1
GATA3 GATA binding protein 3
GDF11 growth differentiation factor 11
GDNF glial cell derived neurotrophic factor
GFRA1 GDNF family receptor alpha 1
GPC3 glypican 3
GREM1 gremlin 1, DAN family BMP antagonist
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
ILK integrin-linked kinase
ITGA8 integrin, alpha 8
KIF26B kinesin family member 26B
LAMA5 laminin, alpha 5
LAMC1 laminin, gamma 1 (formerly LAMB2)
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LRP4 low density lipoprotein receptor-related protein 4
LZTS2 leucine zipper, putative tumor suppressor 2
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP17 matrix metallopeptidase 17 (membrane-inserted)
NOTCH2 notch 2
NPNT nephronectin
OSR1 odd-skipped related transciption factor 1
PARVA parvin, alpha
PAX2 paired box 2
PBX1 pre-B-cell leukemia homeobox 1
PLXNB1 plexin B1
RET ret proto-oncogene
SALL1 spalt-like transcription factor 1
SIX2 SIX homeobox 2
SLIT2 slit homolog 2 (Drosophila)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TCF21 transcription factor 21
TRPS1 trichorhinophalangeal syndrome I
WNT11 wingless-type MMTV integration site family, member 11
WNT9B wingless-type MMTV integration site family, member 9B